Search Results - "Caccin, Paola"

Hydrogel-in-hydrogel live bioprinting for guidance and control of organoids and organotypic cultures by Urciuolo, Anna, Giobbe, Giovanni Giuseppe, Dong, Yixiao, Michielin, Federica, Brandolino, Luca, Magnussen, Michael, Gagliano, Onelia, Selmin, Giulia, Scattolini, Valentina, Raffa, Paolo, Caccin, Paola, Shibuya, Soichi, Scaglioni, Dominic, Wang, Xuechun, Qu, Ju, Nikolic, Marko, Montagner, Marco, Galea, Gabriel L., Clevers, Hans, Giomo, Monica, De Coppi, Paolo, Elvassore, Nicola

“…Three-dimensional hydrogel-based organ-like cultures can be applied to study development, regeneration, and disease in vitro. However, the control of…”
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adjuvant MF59 induces ATP release from muscle that potentiates response to vaccination by Vono, Maria, Taccone, Marianna, Caccin, Paola, Gallotta, Marilena, Donvito, Giovanna, Falzoni, Simonetta, Palmieri, Emiliano, Pallaoro, Michele, Rappuoli, Rino, Di Virgilio, Francesco, De Gregorio, Ennio, Montecucco, Cesare, Seubert, Anja

“…Vaccines are the most effective agents to control infections. In addition to the pathogen antigens, vaccines contain adjuvants that are used to enhance…”
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Allogenic tissue-specific decellularized scaffolds promote long-term muscle innervation and functional recovery in a surgical diaphragmatic hernia model by Trevisan, Caterina, Maghin, Edoardo, Dedja, Arben, Caccin, Paola, de Cesare, Niccolò, Franzin, Chiara, Boso, Daniele, Pesce, Paola, Caicci, Federico, Boldrin, Francesco, Urbani, Luca, De Coppi, Paolo, Pozzobon, Michela, Pavan, Piero, Piccoli, Martina

“…[Display omitted] Congenital diaphragmatic hernia (CDH) is a neonatal defect in which the diaphragm muscle does not develop properly, thereby raising abdominal…”
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Nidogens are therapeutic targets for the prevention of tetanus by Bercsenyi, Kinga, Schmieg, Nathalie, Bryson, J. Barney, Wallace, Martin, Caccin, Paola, Golding, Matthew, Zanotti, Giuseppe, Greensmith, Linda, Nischt, Roswitha, Schiavo, Giampietro

“…Tetanus neurotoxin (TeNT) is among the most poisonous substances on Earth and a major cause of neonatal death in nonvaccinated areas. TeNT targets the…”
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Snake Phospholipase A2 Neurotoxins Enter Neurons, Bind Specifically to Mitochondria, and Open Their Transition Pores by Rigoni, Michela, Paoli, Marco, Milanesi, Eva, Caccin, Paola, Rasola, Andrea, Bernardi, Paolo, Montecucco, Cesare

“…Snake presynaptic neurotoxins with phospholipase A2 activity are potent inducers of paralysis through inhibition of the neuromuscular junction. These…”
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Generation of a Functioning and Self‐Renewing Diaphragmatic Muscle Construct by Trevisan, Caterina, Fallas, Mario Enrique Alvrez, Maghin, Edoardo, Franzin, Chiara, Pavan, Piero, Caccin, Paola, Chiavegato, Angela, Carraro, Eugenia, Boso, Daniele, Boldrin, Francesco, Caicci, Federico, Bertin, Enrica, Urbani, Luca, Milan, Anna, Biz, Carlo, Lazzari, Lorenza, De Coppi, Paolo, Pozzobon, Michela, Piccoli, Martina

“…Surgical repair of large muscular defects requires the use of autologous graft transfer or prosthetic material. Naturally derived matrices are biocompatible…”
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Decellularized skeletal muscles display neurotrophic effects in three‐dimensional organotypic cultures by Raffa, Paolo, Scattolini, Valentina, Gerli, Mattia Francesco Maria, Perin, Silvia, Cui, Meihua, De Coppi, Paolo, Elvassore, Nicola, Caccin, Paola, Luni, Camilla, Urciuolo, Anna

“…Skeletal muscle decellularization allows the generation of natural scaffolds that retain the extracellular matrix (ECM) mechanical integrity, biological…”
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Customized bioreactor enables the production of 3D diaphragmatic constructs influencing matrix remodeling and fibroblast overgrowth by Maghin, Edoardo, Carraro, Eugenia, Boso, Daniele, Dedja, Arben, Giagante, Mattia, Caccin, Paola, Barna, Raluca Ana-Maria, Bresolin, Silvia, Cani, Alice, Borile, Giulia, Sandrin, Deborah, Romanato, Filippo, Cecchinato, Francesca, Urciuolo, Anna, Sandonà, Dorianna, De Coppi, Paolo, Pavan, Piero G., Piccoli, Martina

“…The production of skeletal muscle constructs useful for replacing large defects in vivo, such as in congenital diaphragmatic hernia (CDH), is still considered…”
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Bothrops snake myotoxins induce a large efflux of ATP and potassium with spreading of cell damage and pain by Cintra-Francischinelli, Mariana, Caccin, Paola, Chiavegato, Angela, Pizzo, Paola, Carmignoto, Giorgio, Angulo, Yamileth, Lomonte, Bruno, Gutiérrez, José María, Montecucco, Cesare, Rappuoli, Rino

“…Myotoxins play a major role in the pathogenesis of the envenomations caused by snake bites in large parts of the world where this is a very relevant public…”
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Equivalent Effects of Snake PLA2 Neurotoxins and Lysophospholipid-Fatty Acid Mixtures by Rigoni, Michela, Caccin, Paola, Gschmeissner, Steve, Koster, Grielof, Postle, Anthony D, Rossetto, Ornella, Schiavo, Giampietro, Montecucco, Cesare

“…Snake presynaptic phospholipase A2 neurotoxins (SPANs) paralyze the neuromuscular junction (NMJ). Upon intoxication, the NMJ enlarges and has a reduced content…”
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Mouse Phrenic Nerve Hemidiaphragm Assay (MPN) by Zanetti, Giulia, Negro, Samuele, Pirazzini, Marco, Caccin, Paola

“…The neuromuscular junction (NMJ) is the specialized synapse by which peripheral motor neurons innervate muscle fibers and control skeletal muscle contraction…”
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Decellularized Skeletal Muscles Support the Generation of In Vitro Neuromuscular Tissue Models by Raffa, Paolo, Easler, Maria, Cecchinato, Francesca, Auletta, Beatrice, Scattolini, Valentina, Perin, Silvia, Gerli, Mattia Francesco Maria, Caccin, Paola, Elvassore, Nicola, De Coppi, Paolo, Urciuolo, Anna

“…Decellularized skeletal muscle (dSkM) constructs have received much attention in recent years due to the versatility of their applications in vitro. In search…”
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Envenomations by Bothrops and Crotalus snakes induce the release of mitochondrial alarmins by Zornetta, Irene, Caccin, Paola, Fernandez, Julián, Lomonte, Bruno, Gutierrez, José María, Montecucco, Cesare

“…Skeletal muscle necrosis is a common manifestation of viperid snakebite envenomations. Venoms from snakes of the genus Bothrops, such as that of B. asper,…”
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Traffic of Botulinum Toxins A and E in Excitatory and Inhibitory Neurons by Verderio, Claudia, Grumelli, Carlotta, Raiteri, Luca, Coco, Silvia, Paluzzi, Silvio, Caccin, Paola, Rossetto, Ornella, Bonanno, Giambattista, Montecucco, Cesare, Matteoli, Michela

“…Botulinum neurotoxins (BoNTs), proteases specific for the SNARE proteins, are used to study the molecular machinery supporting exocytosis and are used to treat…”
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Calcium Influx and Mitochondrial Alterations at Synapses Exposed to Snake Neurotoxins or Their Phospholipid Hydrolysis Products by Rigoni, Michela, Pizzo, Paola, Schiavo, Giampietro, Weston, Anne E., Zatti, Giancarlo, Caccin, Paola, Rossetto, Ornella, Pozzan, Tullio, Montecucco, Cesare

“…Snake presynaptic phospholipase A2 neurotoxins (SPANs) bind to the presynaptic membrane and hydrolyze phosphatidylcholine with generation of…”
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The synaptotagmin juxtamembrane domain is involved in neuroexocytosis by Caccin, Paola, Scorzeto, Michele, Damiano, Nunzio, Marin, Oriano, Megighian, Aram, Montecucco, Cesare

“…•The highly cationic juxtamembrane segment of synaptotagmin juxtamembrane domain was synthesized.•This peptide inhibits neurotransmitter release at the…”
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CFTR corrector C17 is effective in muscular dystrophy, in vivo proof of concept in LGMDR3 by Scano, Martina, Benetollo, Alberto, Nogara, Leonardo, Bondì, Michela, Dalla Barba, Francesco, Soardi, Michela, Furlan, Sandra, Akyurek, Eylem Emek, Caccin, Paola, Carotti, Marcello, Sacchetto, Roberta, Blaauw, Bert, Sandonà, Dorianna

“…Abstract Limb-girdle muscular dystrophy R3 (LGMDR3) is caused by mutations in the SGCA gene coding for α-sarcoglycan (SG). Together with β- γ- and δ-SG, α-SG…”
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Nerve-dependent distribution of subsynaptic type 1 inositol 1,4,5-trisphosphate receptor at the neuromuscular junction by Volpe, Pompeo, Bosutti, Alessandra, Nori, Alessandra, Filadi, Riccardo, Gherardi, Gaia, Trautmann, Gabor, Furlan, Sandra, Massaria, Gabriele, Sciancalepore, Marina, Megighian, Aram, Caccin, Paola, Bernareggi, Annalisa, Salanova, Michele, Sacchetto, Roberta, Sandonà, Dorianna, Pizzo, Paola, Lorenzon, Paola

“…Inositol 1,4,5-trisphosphate receptors (IP3Rs) are enriched at postsynaptic membrane compartments of the neuromuscular junction (NMJ), surrounding the…”
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Muscle phospholipid hydrolysis by Bothrops asper Asp49 and Lys49 phospholipase A2 myotoxins – distinct mechanisms of action by Fernández, Julián, Caccin, Paola, Koster, Grielof, Lomonte, Bruno, Gutiérrez, José M, Montecucco, Cesare, Postle, Anthony D

“…Bothrops snakes are the major cause of ophidian envenomings in Latin America. Their venom contains myotoxins that cause prominent muscle damage, which may lead…”
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Presynaptic enzymatic neurotoxins by Rossetto, Ornella, Morbiato, Laura, Caccin, Paola, Rigoni, Michela, Montecucco, Cesare

“…Botulinum neurotoxins produced by anaerobic bacteria of the genus Clostridium are the most toxic proteins known, with mouse LD50 values in the 1–5 ng/kg range,…”
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