Search Results - "Cabo, R"

A toolbox for the longitudinal assessment of healthspan in aging mice by Bellantuono, I., de Cabo, R., Ehninger, D., Di Germanio, C., Lawrie, A., Miller, J., Mitchell, S. J., Navas-Enamorado, I., Potter, P. K., Tchkonia, T., Trejo, J. L., Lamming, D. W.

“…The number of people aged over 65 is expected to double in the next 30 years. For many, living longer will mean spending more years with the burdens of chronic…”
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Restoration of energy homeostasis by SIRT6 extends healthy lifespan by Roichman, A., Elhanati, S., Aon, M. A., Abramovich, I., Di Francesco, A., Shahar, Y., Avivi, M. Y., Shurgi, M., Rubinstein, A., Wiesner, Y., Shuchami, A., Petrover, Z., Lebenthal-Loinger, I., Yaron, O., Lyashkov, A., Ubaida-Mohien, C., Kanfi, Y., Lerrer, B., Fernández-Marcos, P. J., Serrano, M., Gottlieb, E., de Cabo, R., Cohen, H. Y.

“…Aging leads to a gradual decline in physical activity and disrupted energy homeostasis. The NAD + -dependent SIRT6 deacylase regulates aging and metabolism…”
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A roadmap to build a phenotypic metric of ageing: insights from the Baltimore Longitudinal Study of Aging by Kuo, P.‐L., Schrack, J. A., Shardell, M. D., Levine, M., Moore, A. Z., An, Y., Elango, P., Karikkineth, A., Tanaka, T., Cabo, R., Zukley, L. M., AlGhatrif, M., Chia, C. W., Simonsick, E. M., Egan, J. M., Resnick, S. M., Ferrucci, L.

“…Over the past three decades, considerable effort has been dedicated to quantifying the pace of ageing yet identifying the most essential metrics of ageing…”
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Cytochrome b5 reductase 3 overexpression and dietary nicotinamide riboside supplementation promote distinctive mitochondrial alterations in distal convoluted tubules of mouse kidneys during aging by Pérez‐Rodríguez, M., García‐Verdugo, A., Sánchez‐Mendoza, L. M., Muñoz‐Martín, A., Bolaños, N., Pérez‐Sánchez, C., Moreno, J. A., Burón, M. I., Cabo, R., González‐Reyes, J. A., Villalba, J. M.

“…The kidney undergoes structural and physiological changes with age, predominantly studied in glomeruli and proximal tubules. However, limited knowledge is…”
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Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency by Lopez-Lluch, G, Hunt, N, Jones, B, Zhu, M, Jamieson, H, Hilmer, S, Cascajo, M.V, Allard, J, Ingram, D.K, Navas, P

“…Age-related accumulation of cellular damage and death has been linked to oxidative stress. Calorie restriction (CR) is the most robust, nongenetic intervention…”
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Merkel cells and Meissner's corpuscles in human digital skin display Piezo2 immunoreactivity by García‐Mesa, Y., García‐Piqueras, J., García, B., Feito, J., Cabo, R., Cobo, J., Vega, J. A., García‐Suárez, O.

“…The transformation of mechanical energy into electrical signals is the first step in mechanotransduction in the peripheral sensory nervous system and relies on…”
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NRF2, cancer and calorie restriction by Martín-Montalvo, A, Villalba, J M, Navas, P, de Cabo, R

“…The transcription factor NF-E2-related factor (NRF2) is a key regulator of several enzymatic pathways, including cytoprotective enzymes in highly metabolic…”
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Cytochrome b 5 reductase 3 overexpression and dietary nicotinamide riboside supplementation promote distinctive mitochondrial alterations in distal convoluted tubules of mouse kidneys during aging by Pérez-Rodríguez, M, García-Verdugo, A, Sánchez-Mendoza, L M, Muñoz-Martín, A, Bolaños, N, Pérez-Sánchez, C, Moreno, J A, Burón, M I, de Cabo, R, González-Reyes, J A, Villalba, J M

“…The kidney undergoes structural and physiological changes with age, predominantly studied in glomeruli and proximal tubules. However, limited knowledge is…”
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Identifying Biomarkers for Biological Age: Geroscience and the ICFSR Task Force by LeBrasseur, N K, de Cabo, R, Fielding, R, Ferrucci, L, Rodriguez-Manas, L, Viña, J, Vellas, B

“…The International Conference on Frailty and Sarcopenia Research Task Force met in March 2020, in the shadow of the COVID-19 pandemic, to discuss strategies for…”
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Dysfunctioning mechanical mitral valve prosthesis: When thrombus over pannus makes hinders diagnosis by Barrio Alonso, A.I., López Suarez, R.Y., Álvarez Cabo, R., Ríos Gómez, E.

“…Prosthetic valve obstruction is a rare but potentially lethal complication. The most frequent causes are thrombus and pannus formation, in the absence of…”
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Mechanisms of Vascular Aging: New Perspectives by Ungvari, Zoltan, Kaley, Gabor, de Cabo, Rafael, Sonntag, William E., Csiszar, Anna

“…This review focuses on molecular, cellular, and functional changes that occur in the vasculature during aging; explores the links between mitochondrial…”
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Rational application of adenosine deaminase activity in cerebrospinal fluid for the diagnosis of tuberculous meningitis by Parra-Ruiz, Jorge, Ramos, V., Dueñas, C., Coronado-Álvarez, N. M., Cabo-Magadán, R., Portillo-Tuñón, V., Vinuesa, D., Muñoz-Medina, L., Hernández-Quero, J.

“…Purpose Tuberculous meningitis (TBM) is one of the most serious and difficult to diagnose manifestations of TB. An ADA value >9.5 IU/L has great sensitivity…”
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The development of human digital Meissner’s and Pacinian corpuscles by Feito, J., García-Suárez, O., García-Piqueras, J., García-Mesa, Y., Pérez-Sánchez, A., Suazo, I., Cabo, R., Suárez-Quintanilla, J., Cobo, J., Vega, J.A.

“…Meissner’s and Pacinian corpuscles are cutaneous mechanoreceptors responsible for different modalities of touch. The development of these sensory formations in…”
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Sirtuin activation: a role for plasma membrane in the cell growth puzzle by Crane, Frederick L, Navas, Plácido, Low, Hans, Sun, Iris L, de Cabo, Rafael

“…For more than 20 years, the observation that impermeable oxidants can stimulate cell growth has not been satisfactorily explained. The discovery of sirtuins…”
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Endoneurial-CD34 positive cells define an intermediate layer in human digital Pacinian corpuscles by García-Piqueras, J., García-Suárez, O., Rodríguez-González, M.C., Cobo, J.L., Cabo, R., Vega, J.A., Feito, J.

“…The endoneurial and/or perineurial origin of the outer core; i.e. the concentric and continuous lamellae located outside the complex formed by the axon and the…”
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SIRT1 is essential for normal cognitive function and synaptic plasticity by Michán, Shaday, Li, Ying, Chou, Maggie Meng-Hsiu, Parrella, Edoardo, Ge, Huanying, Long, Jeffrey M, Allard, Joanne S, Lewis, Kaitlyn, Miller, Marshall, Xu, Wei, Mervis, Ronald F, Chen, Jing, Guerin, Karen I, Smith, Lois E H, McBurney, Michael W, Sinclair, David A, Baudry, Michel, de Cabo, Rafael, Longo, Valter D

“…Conservation of normal cognitive functions relies on the proper performance of the nervous system at the cellular and molecular level. The mammalian…”
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ASIC2 is present in human mechanosensory neurons of the dorsal root ganglia and in mechanoreceptors of the glabrous skin by Cabo, R., Alonso, P., Viña, E., Vázquez, G., Gago, A., Feito, J., Pérez-Moltó, F. J., García-Suárez, O., Vega, J. A.

“…Mechanosensory neurons lead to the central nervous system touch, vibration and pressure sensation. They project to the periphery and form different kinds of…”
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Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice by Strong, Randy, Miller, Richard A, Astle, Clinton M, Baur, Joseph A, de Cabo, Rafael, Fernandez, Elizabeth, Guo, Wen, Javors, Martin, Kirkland, James L, Nelson, James F, Sinclair, David A, Teter, Bruce, Williams, David, Zaveri, Nurulain, Nadon, Nancy L, Harrison, David E

“…The National Institute on Aging Interventions Testing Program (ITP) was established to evaluate agents that are hypothesized to increase life span and/or…”
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Calorie restriction attenuates age-related alterations in the plasma membrane antioxidant system in rat liver by De Cabo, R, Cabello, R, Rios, M, López-Lluch, G, Ingram, D.K, Lane, M.A, Navas, P

“…Aging is associated with increased production of reactive oxygen species and oxidation-induced damage to intracellular structures and membranes. Caloric…”
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Immunohistochemical localization of periostin in human gingiva by Cobo, T, Obaya, A, Cal, S, Solares, L, Cabo, R, Vega, J A, Cobo, J

“…The periostin is a matricellular protein expressed in collagen-rich tissues including some dental and periodontal tissues where it is regulated by mechanical…”
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