Genetic risk variants in New Yorkers of Puerto Rican and Dominican Republic heritage with Parkinson’s disease

Genetic risk variants in New Yorkers of Puerto Rican and Dominican Republic heritage with Parkinson’s disease

There is a paucity of genetic characterization in people with Parkinson’s disease (PD) of Latino and Afro-Caribbean descent. Screening LRRK2 and GBA variants in 32 New Yorkers of Puerto Rican ethnicity with PD and in 119 non-Hispanic-non-Jewish European PD cases revealed that Puerto Rican participan...

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Bibliographic Details
Published in:NPJ Parkinson's Disease Vol. 9; no. 1; p. 160
Main Authors: Miltenberger-Miltenyi, Gabriel, Ortega, Roberto A., Domingo, Aloysius, Yadav, Rachita, Nishiyama, Ayumi, Raymond, Deborah, Katsnelson, Viktoriya, Urval, Nikita, Swan, Matthew, Shanker, Vicki, Miravite, Joan, Walker, Ruth H., Bressman, Susan B., Ozelius, Laurie J., Cabassa, José C., Saunders-Pullman, Rachel
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 07-12-2023
Nature Publishing Group
Nature Portfolio
Subjects:
692/499
692/617/375/1718
Age
Biomedical and Life Sciences
Biomedicine
Brief Communication
Ethnicity
Family medical history
Genealogy
Genes
Genetic testing
Genomes
Genomics
Health risk assessment
Hispanic Americans
Mutation
Neurology
Neurosciences
Parkinson's disease
Patients
Self report
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Summary:There is a paucity of genetic characterization in people with Parkinson’s disease (PD) of Latino and Afro-Caribbean descent. Screening LRRK2 and GBA variants in 32 New Yorkers of Puerto Rican ethnicity with PD and in 119 non-Hispanic-non-Jewish European PD cases revealed that Puerto Rican participants were more likely to harbor the LRRK2-p.G2019S variant (15.6% vs. 4.2%, respectively). Additionally, whole exome sequencing of twelve Puerto Rican and Dominican PD participants was performed as an exploratory study.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:2373-8057
2373-8057
DOI:10.1038/s41531-023-00599-6