Search Results - "Cabantous, Sandrine"
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miRNAs may play a major role in the control of gene expression in key pathobiological processes in Chagas disease cardiomyopathy
Published in PLoS neglected tropical diseases (01-12-2020)“…Chronic Chagas disease cardiomyopathy (CCC), an especially aggressive inflammatory dilated cardiomyopathy caused by lifelong infection with the protozoan…”
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IL‐22 and IL‐22 binding protein (IL‐22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections
Published in Hepatology (Baltimore, Md.) (01-04-2015)“…Interleukin (IL)‐22 acts on epithelia, hepatocytes, and pancreatic cells and stimulates innate immunity, tissue protection, and repair. IL‐22 may also cause…”
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Myocardial Infarction–Associated Transcript, a Long Noncoding RNA, Is Overexpressed During Dilated Cardiomyopathy Due to Chronic Chagas Disease
Published in The Journal of infectious diseases (01-07-2016)“…Long noncoding RNAs (lncRNAs) modulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels. Dysregulation of the lncRNA known as…”
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Understanding Human Cerebral Malaria through a Blood Transcriptomic Signature: Evidences for Erythrocyte Alteration, Immune/Inflammatory Dysregulation, and Brain Dysfunction
Published in Mediators of inflammation (2020)“…Background. Cerebral malaria (CM), a reversible encephalopathy affecting young children, is a medical emergency requiring rapid clinical assessment and…”
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Polymorphisms in Genes Affecting Interferon-γ Production and Th1 T Cell Differentiation Are Associated With Progression to Chagas Disease Cardiomyopathy
Published in Frontiers in immunology (07-07-2020)“…Chagas disease, caused by the protozoan , is endemic in Latin America. Thirty percent of infected individuals develop chronic Chagas cardiomyopathy (CCC), an…”
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FOXP3+ Regulatory T Cells in Hepatic Fibrosis and Splenomegaly Caused by Schistosoma japonicum: The Spleen May Be a Major Source of Tregs in Subjects with Splenomegaly
Published in PLoS neglected tropical diseases (01-01-2016)“…Schistosoma eggs cause chronic liver inflammation and a complex disease characterized by hepatic fibrosis (HF) and splenomegaly (SplM). FOXP3+ Tregs could…”
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Corrigendum: Polymorphisms in Genes Affecting Interferon-γ Production and Th1 T Cell Differentiation Are Associated With Progression to Chagas Disease Cardiomyopathy
Published in Frontiers in immunology (10-09-2020)“…[This corrects the article DOI: 10.3389/fimmu.2020.01386.]…”
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IL2RA genetic variants reduce IL-2-dependent responses and aggravate human cutaneous leishmaniasis
Published in The Journal of immunology (1950) (15-03-2015)“…The outcome of Leishmania infections varies substantially, depending on the host and the parasite strain; infection may be asymptomatic or cause mild or severe…”
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Alleles 308A and 238A in the Tumor Necrosis Factor Alpha Gene Promoter Do Not Increase the Risk of Severe Malaria in Children with Plasmodium falciparum Infection in Mali
Published in Infection and Immunity (01-12-2006)“…The hypothesis that tumor necrosis factor (TNF) aggravates malaria in children is supported by observations that TNF polymorphisms and high TNF levels have…”
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Evidence for an important role of host microRNAs in regulating hepatic fibrosis in humans infected with &ITSchistosoma japonicum&IT
Published in International journal for parasitology (01-11-2017)“…MicroRNAs (miRNAs) are short, non-coding RNAs that repress the translation of target gene transcripts. They have been implicated in various activities such as…”
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Evidence for an important role of host microRNAs in regulating hepatic fibrosis in humans infected with Schistosoma japonicum
Published in International journal for parasitology (01-11-2017)“…[Display omitted] •MicroRNAs (miRNAs) regulate liver fibrosis during schistosomiasis infection.•Regulator miRNAs are found in fibrotic livers of humans…”
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IL-17 and IL-22 are associated with protection against human kala azar caused by Leishmania donovani
Published in The Journal of clinical investigation (01-08-2009)“…IL-17 and IL-22 have been shown to increase protection against certain bacteria and fungal pathogens in experimental models. However, no human studies have…”
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Gene Expression Analysis Reveals Genes Common to Cerebral Malaria and Neurodegenerative Disorders
Published in The Journal of infectious diseases (15-09-2017)“…Cerebral malaria, a reversible encephalopathy affecting young children, is a medical emergency requiring urgent clinical assessment and treatment. We performed…”
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Whole-Genome Cardiac DNA Methylation Fingerprint and Gene Expression Analysis Provide New Insights in the Pathogenesis of Chronic Chagas Disease Cardiomyopathy
Published in Clinical infectious diseases (01-10-2017)“…Background. Chagas disease, caused by the protozoan Trypanosoma cruzi, is endemic in Latin America and affects 10 million people worldwide. Approximately 12…”
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GATA1 pathogenic variants disrupt MYH10 silencing during megakaryopoiesis
Published in Journal of thrombosis and haemostasis (01-09-2021)“…Background GATA1 is an essential transcription factor for both polyploidization and megakaryocyte (MK) differentiation. The polyploidization defect observed in…”
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Integration of miRNA and gene expression profiles suggest a role for miRNAs in the pathobiological processes of acute Trypanosoma cruzi infection
Published in Scientific reports (21-12-2017)“…Chagas disease, caused by the parasite Trypanosoma cruzi , is endemic in Latin America. Its acute phase is associated with high parasitism, myocarditis and…”
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