Search Results - "Caballero, Laura"
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Unraveling the complexity of mitochondrial complex I assembly: A dynamic process
Published in Biochimica et biophysica acta (01-07-2016)“…Mammalian complex I is composed of 44 different subunits and its assembly requires at least 13 specific assembly factors. Proper function of the mitochondrial…”
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Cell Survival during Complete Nutrient Deprivation Depends on Lipid Droplet-fueled β-Oxidation of Fatty Acids
Published in The Journal of biological chemistry (27-09-2013)“…Cells exposed to stress of different origins synthesize triacylglycerols and generate lipid droplets (LD), but the physiological relevance of this response is…”
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3
Molecular mechanisms of β-cell dysfunction and death in monogenic forms of diabetes
Published in International review of cell and molecular biology (2021)“…Monogenetic forms of diabetes represent 1%-5% of all diabetes cases and are caused by mutations in a single gene. These mutations, that affect genes involved…”
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Mortality prediction models after radical cystectomy for bladder tumour: A systematic review and critical appraisal
Published in European journal of clinical investigation (01-10-2022)“…Introduction To identify risk‐predictive models for bladder‐specific cancer mortality in patients undergoing radical cystectomy and assess their clinical…”
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Activation of AMPA Receptors Mediates the Antidepressant Action of Deep Brain Stimulation of the Infralimbic Prefrontal Cortex
Published in Cerebral cortex (New York, N.Y. 1991) (01-06-2016)“…Although deep brain stimulation (DBS) has been used with success in treatment-resistant depression, little is known about its mechanism of action. We examined…”
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Zwitter Ionization of Glycine at Outer Space Conditions due to Microhydration by Six Water Molecules
Published in Physical review letters (21-01-2022)“…We investigate glycine microsolvation with water molecules, mimicking astrophysical conditions, in our laboratory by embedding these clusters in helium…”
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TMEM70 functions in the assembly of complexes I and V
Published in Biochimica et biophysica acta. Bioenergetics (01-08-2020)“…Protein complexes from the oxidative phosphorylation (OXPHOS) system are assembled with the help of proteins called assembly factors. We here delineate the…”
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Mutation in mitochondrial complex IV subunit COX5A causes pulmonary arterial hypertension, lactic acidemia, and failure to thrive
Published in Human mutation (01-06-2017)“…COX5A is a nuclear‐encoded subunit of mitochondrial respiratory chain complex IV (cytochrome c oxidase). We present patients with a homozygous pathogenic…”
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An accessible and economical evacuation system for surgical fumes and pneumoperitoneum in laparoscopy during the SARS‐CoV‐2 pandemic
Published in British journal of surgery (01-10-2020)Get full text
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Risperidone administered during adolescence induced metabolic, anatomical and inflammatory/oxidative changes in adult brain: A PET and MRI study in the maternal immune stimulation animal model
Published in European neuropsychopharmacology (01-07-2019)“…•Risperidone at adolescence prevents schizophrenia-related anomalies in a rat model.•Risperidone prevents brain volumetric abnormalities in ventricles and…”
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Unveiling Zwitterionization of Glycine in the Microhydration Limit
Published in ACS omega (18-05-2021)“…Charge separation under solvation stress conditions is a fundamental process that comes in many forms in doped water clusters. Yet, the mechanism of…”
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Mutations in Complex I Assembly Factor TMEM126B Result in Muscle Weakness and Isolated Complex I Deficiency
Published in American journal of human genetics (07-07-2016)“…Mitochondrial complex I deficiency results in a plethora of often severe clinical phenotypes manifesting in early childhood. Here, we report on three…”
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NDUFAF4 variants are associated with Leigh syndrome and cause a specific mitochondrial complex I assembly defect
Published in European journal of human genetics : EJHG (01-11-2017)“…Mitochondrial respiratory chain complex I consists of 44 different subunits and can be subgrouped into three functional modules: the Q-, the P- and the…”
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Mutations in mitochondrial complex I assembly factor NDUFAF3 cause Leigh syndrome
Published in Molecular genetics and metabolism (01-03-2017)“…NDUFAF3 is an assembly factor of mitochondrial respiratory chain complex I. Variants in NDUFAF3 have been identified as a cause of severe multisystem…”
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A Heterozygous NDUFV1 Variant Aggravates Mitochondrial Complex I Deficiency in a Family with a Homoplasmic ND1 Variant
Published in The Journal of pediatrics (01-05-2018)“…We demonstrate that a heterozygous nuclear variant in the gene encoding mitochondrial complex I subunit NDUFV1 aggravates the cellular phenotype in the…”
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De falacias y sofismas: una mirada cáustica sobre el imperio de la ley como axioma
Published in Díkaion (16-08-2022)“…Javier Vilaplana, especialista de extensa trayectoria en litigación, disecciona en este ensayo el concepto de nuevo cuño posverdad en el marco del proceso…”
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Fluoxetine: a case history of its discovery and preclinical development
Published in Expert opinion on drug discovery (01-05-2014)“…Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of…”
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Association of Cellular Adhesion Molecules and Oxidative Stress with Endothelial Function in Obstructive Sleep Apnea
Published in Internal Medicine (01-01-2012)“…Objective To evaluate the impact of oxidative stress and cellular adhesion molecules on ischemic reactive hyperemia (IRH) in patients with OSA. Materials and…”
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Ketamine promotes rapid and transient activation of AMPA receptor-mediated synaptic transmission in the dorsal raphe nucleus
Published in Progress in neuro-psychopharmacology & biological psychiatry (10-01-2019)“…Accumulating evidence indicates that the antidepressant effects of ketamine are, in part, mediated by an increase in the AMPA receptor-mediated…”
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Clinical Audits in Outpatient Clinics for Chronic Obstructive Pulmonary Disease: Methodological Considerations and Workflow
Published in PloS one (06-11-2015)“…Previous clinical audits for chronic obstructive pulmonary disease (COPD) have provided valuable information on the clinical care delivered to patients…”
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