Search Results - "Cañellas, Adrià"

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis by Tauriello, Daniele V. F., Palomo-Ponce, Sergio, Stork, Diana, Berenguer-Llergo, Antonio, Badia-Ramentol, Jordi, Iglesias, Mar, Sevillano, Marta, Ibiza, Sales, Cañellas, Adrià, Hernando-Momblona, Xavier, Byrom, Daniel, Matarin, Joan A., Calon, Alexandre, Rivas, Elisa I., Nebreda, Angel R., Riera, Antoni, Attolini, Camille Stephan-Otto, Batlle, Eduard

“…A combination of TGFβ inhibition and checkpoint-inhibition therapy provokes a potent cytotoxic response against metastatic tumours derived from colorectal…”
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ERK1/2 Signaling Induces Upregulation of ANGPT2 and CXCR4 to Mediate Liver Metastasis in Colon Cancer by Urosevic, Jelena, Blasco, María Teresa, Llorente, Alicia, Bellmunt, Anna, Berenguer-Llergo, Antoni, Guiu, Marc, Cañellas, Adrià, Fernandez, Esther, Burkov, Ivan, Clapés, Maria, Cartanà, Mireia, Figueras-Puig, Cristina, Batlle, Eduard, Nebreda, Angel R, Gomis, Roger R

“…Carcinoma development in colorectal cancer is driven by genetic alterations in numerous signaling pathways. Alterations in the RAS-ERK1/2 pathway are…”
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Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress by Fernández‐Alfara, Marcos, Sibilio, Annarita, Martin, Judit, Tusquets Uxó, Elsa, Malumbres, Marina, Alcalde, Victor, Chanes, Verónica, Cañellas‐Socias, Adrià, Palomo‐Ponce, Sergio, Batlle, Eduard, Méndez, Raúl

“…Tumor growth is influenced by a complex network of interactions between multiple cell types in the tumor microenvironment (TME). These constrained conditions…”
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Mechanisms of metastatic colorectal cancer by Cañellas-Socias, Adrià, Sancho, Elena, Batlle, Eduard

“…Despite extensive research and improvements in understanding colorectal cancer (CRC), its metastatic form continues to pose a substantial challenge, primarily…”
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Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells by Cañellas-Socias, Adrià, Cortina, Carme, Hernando-Momblona, Xavier, Palomo-Ponce, Sergio, Mulholland, Eoghan J., Turon, Gemma, Mateo, Lidia, Conti, Sefora, Roman, Olga, Sevillano, Marta, Slebe, Felipe, Stork, Diana, Caballé-Mestres, Adrià, Berenguer-Llergo, Antonio, Álvarez-Varela, Adrián, Fenderico, Nicola, Novellasdemunt, Laura, Jiménez-Gracia, Laura, Sipka, Tamara, Bardia, Lidia, Lorden, Patricia, Colombelli, Julien, Heyn, Holger, Trepat, Xavier, Tejpar, Sabine, Sancho, Elena, Tauriello, Daniele V. F., Leedham, Simon, Attolini, Camille Stephan-Otto, Batlle, Eduard

“…Around 30–40% of patients with colorectal cancer (CRC) undergoing curative resection of the primary tumour will develop metastases in the subsequent years 1 …”
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Long-term platinum-based drug accumulation in cancer-associated fibroblasts promotes colorectal cancer progression and resistance to therapy by Linares, Jenniffer, Sallent-Aragay, Anna, Badia-Ramentol, Jordi, Recort-Bascuas, Alba, Méndez, Ana, Manero-Rupérez, Noemí, Re, Daniele Lo, Rivas, Elisa I., Guiu, Marc, Zwick, Melissa, Iglesias, Mar, Martinez-Ciarpaglini, Carolina, Tarazona, Noelia, Varese, Monica, Hernando-Momblona, Xavier, Cañellas-Socias, Adrià, Orrillo, Mayra, Garrido, Marta, Saoudi, Nadia, Elez, Elena, Navarro, Pilar, Tabernero, Josep, Gomis, Roger R., Batlle, Eduard, Pisonero, Jorge, Cervantes, Andres, Montagut, Clara, Calon, Alexandre

“…A substantial proportion of cancer patients do not benefit from platinum-based chemotherapy (CT) due to the emergence of drug resistance. Here, we apply…”
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Membrane to cortex attachment determines different mechanical phenotypes in LGR5+ and LGR5- colorectal cancer cells by Conti, Sefora, Venturini, Valeria, Cañellas-Socias, Adrià, Cortina, Carme, Abenza, Juan F., Stephan-Otto Attolini, Camille, Middendorp Guerra, Emily, Xu, Catherine K., Li, Jia Hui, Rossetti, Leone, Stassi, Giorgio, Roca-Cusachs, Pere, Diz-Muñoz, Alba, Ruprecht, Verena, Guck, Jochen, Batlle, Eduard, Labernadie, Anna, Trepat, Xavier

“…Colorectal cancer (CRC) tumors are composed of heterogeneous and plastic cell populations, including a pool of cancer stem cells that express LGR5. Whether…”
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CRISPR Knock-Ins in Organoids to Track Tumor Cell Subpopulations by Cortina, Carme, Cañellas-Socias, Adrià

“…The integration of CRISPR/Cas9 genome editing techniques with organoid technology has revolutionized the field of tumor modeling, enabling the creation of…”
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Cohesin couples transcriptional bursting probabilities of inducible enhancers and promoters by Robles-Rebollo, Irene, Cuartero, Sergi, Canellas-Socias, Adria, Wells, Sarah, Karimi, Mohammad M., Mereu, Elisabetta, Chivu, Alexandra G., Heyn, Holger, Whilding, Chad, Dormann, Dirk, Marguerat, Samuel, Rioja, Inmaculada, Prinjha, Rab K., Stumpf, Michael P. H., Fisher, Amanda G., Merkenschlager, Matthias

“…Innate immune responses rely on inducible gene expression programmes which, in contrast to steady-state transcription, are highly dependent on cohesin. Here we…”
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Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors by Herpers, Bram, Eppink, Berina, James, Mark I, Cortina, Carme, Cañellas-Socias, Adrià, Boj, Sylvia F, Hernando-Momblona, Xavier, Glodzik, Dominik, Roovers, Rob C, van de Wetering, Marc, Bartelink-Clements, Carina, Zondag-van der Zande, Vanessa, Mateos, Jara García, Yan, Kuan, Salinaro, Lucia, Basmeleh, Abdul, Fatrai, Szabolcs, Maussang, David, Lammerts van Bueren, Jeroen J, Chicote, Irene, Serna, Garazi, Cabellos, Laia, Ramírez, Lorena, Nuciforo, Paolo, Salazar, Ramon, Santos, Cristina, Villanueva, Alberto, Stephan-Otto Attolini, Camille, Sancho, Elena, Palmer, Hector G, Tabernero, Josep, Stratton, Michael R, de Kruif, John, Logtenberg, Ton, Clevers, Hans, Price, Leo S, Vries, Robert G J, Batlle, Eduard, Throsby, Mark

“…Patient-derived organoids (PDOs) recapitulate tumor architecture, contain cancer stem cells and have predictive value supporting personalized medicine. Here we…”
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Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy by Álvarez-Varela, Adrián, Novellasdemunt, Laura, Barriga, Francisco M., Hernando-Momblona, Xavier, Cañellas-Socias, Adrià, Cano-Crespo, Sara, Sevillano, Marta, Cortina, Carme, Stork, Diana, Morral, Clara, Turon, Gemma, Slebe, Felipe, Jiménez-Gracia, Laura, Caratù, Ginevra, Jung, Peter, Stassi, Giorgio, Heyn, Holger, Tauriello, Daniele V. F., Mateo, Lidia, Tejpar, Sabine, Sancho, Elena, Stephan-Otto Attolini, Camille, Batlle, Eduard

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