Search Results - "Cañedo, Librada M."

Streptenols F–I Isolated from the Marine-Derived Streptomyces misionensis BAT-10-03-023 by Tarazona, Guillermo, Schleissner, Carmen, Rodríguez, Pilar, Pérez, Marta, Cañedo, Librada M, Cuevas, Carmen

“…A marine-derived bacterium, Streptomyces misionensis BAT-10-03-123, has produced four new streptenol derivatives, F, G, H, and I (1–4), as well as the known…”
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IB-01212, a New Cytotoxic Cyclodepsipeptide Isolated from the Marine Fungus Clonostachys sp. ESNA-A009 by Cruz, Luis J, Insua, Marta Martínez, Baz, Julia Pérez, Trujillo, Martha, Rodriguez-Mias, Ricard A, Oliveira, Eliandre, Giralt, Ernest, Albericio, Fernando, Cañedo, Librada M

“…IB-01212, a new cytotoxic cyclodepsipeptide featuring C 2 symmetry, was isolated from the mycelium extract of Clonostachys sp. ESNA-A009. The amino acid…”
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Total Solid-Phase Synthesis of Marine Cyclodepsipeptide IB-01212 by Cruz, Luis J, Cuevas, Carmen, Cañedo, Librada M, Giralt, Ernest, Albericio, Fernando

“…A suitable combination of synthetic design, orthogonal protecting groups and coupling reagents was used to complete the first known synthesis of the natural…”
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Bacterial Production of a Pederin Analogue by a Free-Living Marine Alphaproteobacterium by Schleissner, Carmen, Cañedo, Librada M, Rodríguez, Pilar, Crespo, Cristina, Zúñiga, Paz, Peñalver, Ana, de la Calle, Fernando, Cuevas, Carmen

“…The polyketide pederin family are cytotoxic compounds isolated from insects, lichen, and marine sponges. During the past decade, different uncultivable…”
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Total Synthesis and Stereochemical Assignment of Baringolin by Just-Baringo, Xavier, Bruno, Paolo, Ottesen, Lars K., Cañedo, Librada M., Albericio, Fernando, Álvarez, Mercedes

“…The thiopeptide antibiotic baringolin has been synthesized, and its structure and stereochemistry have been confirmed. The use of a strategy based on…”
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Genome of Labrenzia sp. PHM005 Reveals a Complete and Active Trans-AT PKS Gene Cluster for the Biosynthesis of Labrenzin by Kačar, Dina, Schleissner, Carmen, Cañedo, Librada M., Rodríguez, Pilar, de la Calle, Fernando, Galán, Beatriz, García, José Luis

“…The complete genome of the strain Labrenzia sp. PHM005, a free-living producer of a pederin analog 18- O -demethyl pederin, hereinafter labrenzin, has been…”
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Identification of trans‐AT polyketide clusters in two marine bacteria reveals cryptic similarities between distinct symbiosis factors by Kačar, Dina, Cañedo, Librada M., Rodríguez, Pilar, González, Elena G., Galán, Beatriz, Schleissner, Carmen, Leopold‐Messer, Stefan, Piel, Jörn, Cuevas, Carmen, Calle, Fernando, García, José L.

“…Summary Glutarimide‐containing polyketides are known as potent antitumoral and antimetastatic agents. The associated gene clusters have only been identified in…”
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New Cytotoxic Indolic Metabolites from a Marine Streptomyces by Sanchez Lopez, J.M, Martinez Insua, M, Perez Baz, J, Fernandez Puentes, J.L, Canedo Hernandez, L.M

“…Three new cytotoxic 3,6-disubstituted indoles (1−3) were isolated from the mycelium of a strain identified as Streptomyces sp. (BL-49-58-005), which was…”
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IB-00208, a new cytotoxic polycyclic xanthone produced by a marine-derived Actinomadura. II. Isolation, physico-chemical properties and structure determination by Rodríguez, Julián Castro, Fernández Puentes, José L, Baz, Julia Pérez, Cañedo, Librada M

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Isolation, Structural Assignment, and Total Synthesis of Barmumycin by Lorente, Adriana, Pla, Daniel, Cañedo, Librada M, Albericio, Fernando, Álvarez, Mercedes

“…Barmumycin was isolated from an extract of the marine actinomycete Streptomyces sp. BOSC-022A and found to be cytotoxic against various human tumor cell lines…”
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Tailoring modifications in labrenzin synthesis: a‐la‐carte production of pathway intermediates by Kačar, Dina, Cañedo, Librada M., Rodríguez, Pilar, Schleissner, Carmen, Calle, Fernando, García, José Luis, Galán, Beatriz

“…Pederin‐family polyketides today constitute a group of more than 30 molecules being produced as natural products by different microorganisms across multitude…”
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In vivo production of pederin by labrenzin pathway expansion by Kačar, Dina, Schleissner, Carmen, Cañedo, Librada M., Rodríguez, Pilar, de la Calle, Fernando, Cuevas, Carmen, Galán, Beatriz, García, José Luis

“…Pederin is a potent polyketide toxin that causes severe skin lesions in humans after contact with insects of genus Paederus. Due to its potent anticancer…”
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Thiocoraline, a novel depsipeptide with antitumor activity produced by a marine Micromonospora. II. Physico-chemical properties and structure determination by Perez Baz, J, Cañedo, L M, Fernández Puentes, J L, Silva Elipe, M V

“…Thiocoraline (1) is a new antitumor antibiotic isolated from the mycelium of Micromonospora sp. L-13-ACM2-092. Its structure was elucidated to be a novel…”
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New Fluvirucinins C1 and C2 Produced by a Marine Derived Actinomycete by Costa, Margarida, Zúñiga, Paz, Peñalver, Ana Ma, Thorsteinsdottir, Margrét, Pérez, Marta, Cañedo, Librada M, Cuevas, Carmen

“…Two new fluvirucin aglycones, named fluvirucinins C, and C2 (1-2), have been isolated from the ethyl acetate mycelial cake extract of the fermentation broth…”
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Radamycin, a novel thiopeptide produced by streptomyces sp. RSP9. II. Physico-chemical properties and structure determination by Castro Rodríguez, Julián, González Holgado, Gloria, Santamaría Sánchez, Ramón I, Cañedo, Librada M

“…The new cyclic peptide antibiotic, radamycin (1) and the known thiopeptide methylsulfomycin I (2) have been isolated from the fermentation broth of a…”
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Purification and Chemical Characterization of a Potent Acaricide and a Closely Related Inactive Metabolite Produced by Eurotium rubrum C47 by Ortiz-Lemus, José F, Campoy, Sonia, Cañedo, Librada M, Liras, Paloma, Martín, Juan F

“…Mites are arthropods and some of them infest dry meat cured products and produce allergic reactions. Some mites, such as , or feed on filamentous fungi that…”
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Synthesis of IB-01211, a Cyclic Peptide Containing 2,4-Concatenated Thia- and Oxazoles, via Hantzsch Macrocyclization by Hernández, Delia, Vilar, Gemma, Riego, Estela, Cañedo, Librada M, Cuevas, Carmen, Albericio, Fernando, Álvarez, Mercedes

“…An efficient and versatile convergent synthesis of IB-01211 based on a combination of peptide and heterocyclic chemistry is described. The key step in the…”
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IB-96212, a novel cytotoxic macrolide produced by a marine Micromonospora. II. Physico-chemical properties and structure determination by Cañedo, L M, Fernández-Puentes, J L, Baz, J P

“…IB-96212, is a new member of spiroketal containing macrolide class of fermentation-derived natural products isolated from mycelial extracts of Micromonospora…”
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PM-94128, a new isocoumarin antitumor agent produced by a marine bacterium by Cañedo, L M, Fernández Puentes, J L, Pérez Baz, J, Acebal, C, de la Calle, F, García Grávalos, D, García de Quesada, T

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4'-N-methyl-5'-hydroxystaurosporine and 5'-hydroxystaurosporine, new indolocarbazole alkaloids from a marine Micromonospora sp. strain by Hernández, L M, Blanco, J A, Baz, J P, Puentes, J L, Millán, F R, Vázquez, F E, Fernández-Chimeno, R I, Grávalos, D G

“…Two new indolocarbazole alkaloids, 4'-N-methyl-5'-hydroxystaurosporine (2) and 5'-hydroxystaurosporine (3), were isolated together with the known staurosporine…”
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