Search Results - "CZIKORA, Istvan"

Peroxynitrite Disrupts Endothelial Caveolae Leading to eNOS Uncoupling and Diminished Flow-Mediated Dilation in Coronary Arterioles of Diabetic Patients by CASSUTO, James, HUIJUAN DOU, CZIKORA, Istvan, SZABO, Andras, PATEL, Vijay S, KAMATH, Vinayak, DE CHANTEMELE, Eric Belin, FEHER, Attila, ROMERO, Maritza J, BAGI, Zsolt

“…Peroxynitrite (ONOO(-)) contributes to coronary microvascular dysfunction in diabetes mellitus (DM). We hypothesized that in DM, ONOO(-) interferes with the…”
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Caveolin-1 prevents sustained angiotensin II-induced resistance artery constriction and obesity-induced high blood pressure by Czikora, Istvan, Feher, Attila, Lucas, Rudolf, Fulton, David J R, Bagi, Zsolt

“…The type 1 angiotensin II (ANG II) receptor (AT1R) undergoes internalization following stimulation by ANG II. Internalization reduces cell surface AT1Rs, and…”
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Epithelial Sodium Channel-α Mediates the Protective Effect of the TNF-Derived TIP Peptide in Pneumolysin-Induced Endothelial Barrier Dysfunction by Czikora, Istvan, Alli, Abdel A, Sridhar, Supriya, Matthay, Michael A, Pillich, Helena, Hudel, Martina, Berisha, Besim, Gorshkov, Boris, Romero, Maritza J, Gonzales, Joyce, Wu, Guangyu, Huo, Yuqing, Su, Yunchao, Verin, Alexander D, Fulton, David, Chakraborty, Trinad, Eaton, Douglas C, Lucas, Rudolf

“…is a major etiologic agent of bacterial pneumonia. Autolysis and antibiotic-mediated lysis of pneumococci induce release of the pore-forming toxin, pneumolysin…”
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Role of growth hormone-releasing hormone in dyslipidemia associated with experimental type 1 diabetes by Romero, Maritza J., Lucas, Rudolf, Dou, Huijuan, Sridhar, Supriya, Czikora, Istvan, Mosieri, Eby M., Rick, Ferenc G., Block, Norman L., Sridhar, Subbaramiah, Fulton, David, Weintraub, Neal L., Bagi, Zsolt, Schally, Andrew V.

“…Dyslipidemia associated with triglyceride-rich lipoproteins (TRLs) represents an important residual risk factor for cardiovascular and chronic kidney disease…”
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TNF Lectin-Like Domain Restores Epithelial Sodium Channel Function in Frameshift Mutants Associated with Pseudohypoaldosteronism Type 1B by Willam, Anita, Aufy, Mohammed, Tzotzos, Susan, El-Malazi, Dina, Poser, Franziska, Wagner, Alina, Unterköfler, Birgit, Gurmani, Didja, Martan, David, Iqbal, Shahid Muhammad, Fischer, Bernhard, Fischer, Hendrik, Pietschmann, Helmut, Czikora, Istvan, Lucas, Rudolf, Lemmens-Gruber, Rosa, Shabbir, Waheed

“…Previous studies have indicated that tumor necrosis factor (TNF) activates amiloride-sensitive epithelial sodium channel (ENaC) current through its lectin-like…”
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Listeriolysin O Causes ENaC Dysfunction in Human Airway Epithelial Cells by Yang, Guang, Pillich, Helena, White, Richard, Czikora, Istvan, Pochic, Isabelle, Yue, Qiang, Hudel, Martina, Gorshkov, Boris, Verin, Alexander, Sridhar, Supriya, Isales, Carlos M, Eaton, Douglas C, Hamacher, Jürg, Chakraborty, Trinad, Lucas, Rudolf

“…Pulmonary permeability edema is characterized by reduced alveolar Na⁺ uptake capacity and capillary barrier dysfunction and is a potentially lethal…”
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TIMAP is a positive regulator of pulmonary endothelial barrier function by Csortos, Csilla, Czikora, Istvan, Bogatcheva, Natalia V, Adyshev, Djanybek M, Poirier, Christophe, Olah, Gabor, Verin, Alexander D

“…TGF-beta-inhibited membrane-associated protein, TIMAP, is expressed at high levels in endothelial cells (EC). It is regarded as a member of the MYPT (myosin…”
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Mini-review: novel therapeutic strategies to blunt actions of pneumolysin in the lungs by Lucas, Rudolf, Czikora, Istvan, Sridhar, Supriya, Zemskov, Evgeny, Gorshkov, Boris, Siddaramappa, Umapathy, Oseghale, Aluya, Lawson, Jonathan, Verin, Alexander, Rick, Ferenc G, Block, Norman L, Pillich, Helena, Romero, Maritza, Leustik, Martin, Schally, Andrew V, Chakraborty, Trinad

“…Severe pneumonia is the main single cause of death worldwide in children under five years of age. The main etiological agent of pneumonia is the G+ bacterium…”
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A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation by Czikora, István, Alli, Abdel, Bao, Hui-Fang, Kaftan, David, Sridhar, Supriya, Apell, Hans-Jürgen, Gorshkov, Boris, White, Richard, Zimmermann, Astrid, Wendel, Albrecht, Pauly-Evers, Meike, Hamacher, Jürg, Garcia-Gabay, Irène, Fischer, Bernhard, Verin, Alexander, Bagi, Zsolt, Pittet, Jean Francois, Shabbir, Waheed, Lemmens-Gruber, Rosa, Chakraborty, Trinad, Lazrak, Ahmed, Matthay, Michael A, Eaton, Douglas C, Lucas, Rudolf

“…Alveolar liquid clearance is regulated by Na(+) uptake through the apically expressed epithelial sodium channel (ENaC) and basolaterally localized…”
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ADAM17 impairs F11R/JAM‐A‐mediated wall shear stress mechanosensing and induces aging‐related inward artery remodeling by Tian, Yanna, Czikora, Istvan, Bagi, Zsolt

“…We sought to determine if lumen narrowing inward arterial remodeling is mediated by impaired endothelial mechanosensing of wall shear stress (WSS) in aging…”
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The adenosine kinase inhibitor ABT‐702 improves coronary vasodilator and left ventricle diastolic dysfunction in obese ZSF1 rats by Davila, Alec, Tian, Yanna, Czikora, Istvan, Bagi, Zsolt

“…Coronary microvascular dysfunction contributes to the development of heart failure with preserved ejection fraction (HFpEF) for which no effective therapies…”
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Protein phosphatase 2A activity is required for functional adherent junctions in endothelial cells by Kása, Anita, Czikora, István, Verin, Alexander D., Gergely, Pál, Csortos, Csilla

“…Reversible Ser/Thr phosphorylation of cytoskeletal and adherent junction (AJ) proteins has a critical role in the regulation of endothelial cell (EC) barrier…”
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ADAM17 impairs arterial fluid shear stress mechanosensing in aged mice by Tian, Yanna, Davila, Alec, Clermont, Andrew, Balogh, Marta Bagine, Czikora, Istvan, Bagi, Zsolt

“…Abstract only Junctional Adhesion Molecule A (F11R/JAM‐A), which can be shed by a disintegrin and metalloproteinase ADAM17, has been implicated in arterial…”
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Pulmonary microvascular dysfunction develops in rodent models of HFpEF by Czikora, Istvan, Davila, Alec C., Tian, Yanna, Belanger, Kasey, O'Connor, Paul, Sullivan, Jennifer C., Bagi, Zsolt

“…Abstract only Pulmonary complications are common in patients with diastolic heart failure, also known as heart failure with preserved ejection fraction…”
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The PDE9A inhibitor PF04447943 improves coronary arteriole vasodilation and left ventricular diastolic dysfunction in HFpEF by Bagi, Zsolt, Weissman, Amanda, Davila, Alec, Balogh, Marta, Tian, Yanna, Czikora, Istvan, Hamdani, Nazha

“…Coronary microvascular dysfunction develops in patients with heart failure with preserved ejection fraction (HFpEF, also known as diastolic heart failure)…”
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Mice with endothelium‐selective deletion of adenosine kinase are protected against pressure overload induced left ventricle contractile dysfunction by Davila, Alec, Tian, Yanna, Czikora, Istvan, Li, Jie, Su, Huabo, Huo, Yuqing, Bagi, Zsolt

“…Microvascular vasodilator dysfunction frequently accompanies myocardial contractile dysfunction, but the mechanistic interrelationship between these…”
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Obesity impairs ADAM17‐mediated vascularization of pericardial adipose tissue in patients with coronary artery disease by Bagi, Zsolt, Balogh, Marta, Davila, Alec, Tian, Yanna, Patel, Vijay, Czikora, Istvan

“…Expansion of pericardial adipose tissue (pAT) correlates with the severity of coronary artery disease in obese patients. Dysfunctional pAT is a significant…”
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Adenosine Kinase Inhibition Augments Conducted Vasodilation and Prevents Left Ventricle Diastolic Dysfunction in Heart Failure With Preserved Ejection Fraction by Davila, Alec, Tian, Yanna, Czikora, Istvan, Li, Jie, Su, Huabo, Huo, Yuqing, Patel, Vijay, Robinson, Vincent, Kapuku, Gaston, Weintraub, Neal, Bagi, Zsolt

“…Heart failure with preserved ejection fraction (HFpEF) is often manifested as impaired cardiovascular reserve. We sought to determine if conducted…”
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Characterization of the effect of TIMAP phosphorylation on its interaction with protein phosphatase 1 by Czikora, István, Kim, Kyung-mi, Kása, Anita, Bécsi, Bálint, Verin, Alexander D., Gergely, Pál, Erdődi, Ferenc, Csortos, Csilla

“…TIMAP, TGF-β inhibited, membrane-associated protein, is highly abundant in endothelial cells (EC). We have shown earlier the involvement of TIMAP in…”
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Arginase 1: an unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury by Lucas, Rudolf, Czikora, Istvàn, Sridhar, Supriya, Zemskov, Evgeny A, Oseghale, Aluya, Circo, Sebastian, Cederbaum, Stephen D, Chakraborty, Trinad, Fulton, David J, Caldwell, Robert W, Romero, Maritza J

“…The integrity of epithelial and endothelial barriers in the lower airspaces of the lungs has to be tightly regulated, in order to prevent leakage and to assure…”
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