Search Results - "CZIKORA, Agnes"

Versatile roles of cysteine persulfides in tumor biology by Borbényi-Galambos, Klaudia, Czikora, Ágnes, Erdélyi, Katalin, Nagy, Péter

“…Rewiring the transsulfuration pathway is recognized as a rapid adaptive metabolic response to environmental conditions in cancer cells to support their…”
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Temporal and Spatial Epigenome Editing Allows Precise Gene Regulation in Mammalian Cells by Kuscu, Cem, Mammadov, Rashad, Czikora, Agnes, Unlu, Hayrunnisa, Tufan, Turan, Fischer, Natasha Lopes, Arslan, Sevki, Bekiranov, Stefan, Kanemaki, Masato, Adli, Mazhar

“…Cell-type specific gene expression programs are tightly linked to epigenetic modifications on DNA and histone proteins. Here, we used a novel CRISPR-based…”
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Importance of the REM (Ras exchange) domain for membrane interactions by RasGRP3 by Czikora, Agnes, Kedei, Noemi, Kalish, Heather, Blumberg, Peter M.

“…RasGRP comprises a family of guanine nucleotide exchange factors, regulating the dissociation of GDP from Ras GTPases to enhance the formation of the active…”
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Synthesis and Evaluation of Dimeric Derivatives of Diacylglycerol–Lactones as Protein Kinase C Ligands by Ohashi, Nami, Kobayashi, Ryosuke, Nomura, Wataru, Kobayakawa, Takuya, Czikora, Agnes, Herold, Brienna K, Lewin, Nancy E, Blumberg, Peter M, Tamamura, Hirokazu

“…Protein kinase C (PKC) mediates a central cellular signal transduction pathway involved in disorders such as cancer and Alzheimer’s disease. PKC is regulated…”
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Reprogrammed transsulfuration promotes basal-like breast tumor progression via realigning cellular cysteine persulfidation by Erdélyi, Katalin, Ditrói, Tamás, Johansson, Henrik J., Czikora, Ágnes, Balog, Noémi, Silwal-Pandit, Laxmi, Ida, Tomoaki, Olasz, Judit, Hajdú, Dorottya, Mátrai, Zoltán, Csuka, Orsolya, Uchida, Koji, Tóvári, József, Engebraten, Olav, Akaike, Takaaki, Dale, Anne-Lise Børresen, Kásler, Miklós, Lehtiö, Janne, Nagy, Péter

“…Basal-like breast cancer (BLBC) is the most aggressive subtype of breast tumors with poor prognosis and limited molecular-targeted therapy options. We show…”
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A Central Role for TRPM4 in Ca2+-Signal Amplification and Vasoconstriction by Csípő, Tamás, Czikora, Ágnes, Fülöp, Gábor Á., Gulyás, Hajnalka, Rutkai, Ibolya, Tóth, Enikő Pásztorné, Pórszász, Róbert, Szalai, Andrea, Bölcskei, Kata, Helyes, Zsuzsanna, Pintér, Erika, Papp, Zoltán, Ungvári, Zoltán, Tóth, Attila

“…Transient receptor potential melastatin-4 (TRPM4) is activated by an increase in intracellular Ca2+ concentration and is expressed on smooth muscle cells…”
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Cystathionine β-synthase overexpression drives metastatic dissemination in pancreatic ductal adenocarcinoma via inducing epithelial-to-mesenchymal transformation of cancer cells by Czikora, Ágnes, Erdélyi, Katalin, Ditrói, Tamás, Szántó, Noémi, Jurányi, Eszter Petra, Szanyi, Szilárd, Tóvári, József, Strausz, Tamás, Nagy, Péter

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest of all cancer types with a constant rise in global incidence. Therefore, better understanding…”
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Poly(ADP-ribose) polymerase-2 depletion reduces doxorubicin-induced damage through SIRT1 induction by Szántó, Magdolna, Rutkai, Ibolya, Hegedűs, Csaba, Czikora, Ágnes, Rózsahegyi, Máté, Kiss, Borbála, Virág, László, Gergely, Pál, Tóth, Attila, Bai, Péter

“…Aims Doxorubicin (DOX) is widely used in cytostatic treatments, although it may cause cardiovascular dysfunction as a side effect. DOX treatment leads to…”
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Vanilloid Receptor-1 (TRPV1) Expression and Function in the Vasculature of the Rat by Tóth, Attila, Czikora, Ágnes, Pásztor, Enikő T., Dienes, Beatrix, Bai, Péter, Csernoch, László, Rutkai, Ibolya, Csató, Viktória, Mányiné, Ivetta S., Pórszász, Róbert, Édes, István, Papp, Zoltán, Boczán, Judit

“…Transient receptor potential (TRP) cation channels are emerging in vascular biology. In particular, the expression of the capsaicin receptor (TRPV1) was…”
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Tissue-specific regulation of microvascular diameter: opposite functional roles of neuronal and smooth muscle located vanilloid receptor-1 by Kark, Tamás, Bagi, Zsolt, Lizanecz, Erzsébet, Pásztor, Eniko T, Erdei, Nóra, Czikora, Agnes, Papp, Zoltán, Edes, István, Pórszász, Róbert, Tóth, Attila

“…The transient receptor potential type V1 channel (vanilloid receptor 1, TRPV1) is a Ca(2+)-permeable nonspecific cation channel activated by various painful…”
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Different desensitization patterns for sensory and vascular TRPV1 populations in the rat: expression, localization and functional consequences by Czikora, Ágnes, Rutkai, Ibolya, Pásztor, Enikő T, Szalai, Andrea, Pórszász, Róbert, Boczán, Judit, Édes, István, Papp, Zoltán, Tóth, Attila

“…TRPV1 is expressed in sensory neurons and vascular smooth muscle cells, contributing to both pain perception and tissue blood distribution. Local…”
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Calcineurin regulates endothelial barrier function by interaction with and dephosphorylation of myosin phosphatase by KOLOZSVARI, Bernadett, BAKO, Eva, BECSI, Bálint, KISS, Andrea, CZIKORA, Agnes, TOTH, Attila, VAMOSI, Gyorgy, GERGELY, Pál, ERDODI, Ferenc

“…Calcineurin (CN) influences myosin phosphorylation and alters endothelial barrier function; however, the molecular mechanism is still obscure. Here we examine…”
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Abstract 4450: Comparison of structural elements in RasGRP3 and RasGRP1 controlling membrane interaction by Czikora, Agnes, Kedei, Noemi, Blumberg, Peter M.

“…RasGRP comprises a family of guanine nucleotide exchange factors that activate small GTPases, regulating the dissociation of GDP from Ras GTPases to enhance…”
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Abstract 1126: Importance of the REM (Ras exchange) motif for membrane interactions by RasGRP3 by Czikora, Agnes, Kedei, Noemi, Blumberg, Peter M.

“…RasGRP comprises a family of guanine nucleotide exchange factors that activate small GTPases, regulating the dissociation of GDP from Ras GTPases to enhance…”
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Vascular metabolism of anandamide to arachidonic acid affects myogenic constriction in response to intraluminal pressure elevation by Czikora, Ágnes, Lizanecz, Erzsébet, Boczán, Judit, Daragó, Andrea, Papp, Zoltán, Édes, István, Tóth, Attila

“…We hypothesized that arachidonic acid produced by anandamide breakdown contributes to the vascular effects of anandamide. Isolated, pressurized rat skeletal…”
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Munc13 Is a Molecular Target of Bryostatin 1 by Blanco, Francisco A, Czikora, Agnes, Kedei, Noemi, You, Youngki, Mitchell, Gary A, Pany, Satyabrata, Ghosh, Anamitra, Blumberg, Peter M, Das, Joydip

“…Bryostatin 1 is a natural macrolide shown to improve neuronal connections and enhance memory in mice. Its mechanism of action is largely attributed to the…”
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Abstract 2373: Analysis of the distinct activities of the C1a and C1b domains of protein kinase C theta by Czikora, Agnes, Pany, Satyabrata, You, Youngki, Saini, Amandeep, Kedei, Noemi, Lewin, Nancy E., Abramovitz, Adelle, Das, Joydip, Blumberg, Peter M.

“…PKC isozymes, the major receptors for tumor-promoting phorbol esters, play a central role in cellular signal transduction downstream of the second messenger…”
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α‑Arylidene Diacylglycerol-Lactones (DAG-Lactones) as Selective Ras Guanine-Releasing Protein 3 (RasGRP3) Ligands by Ann, Jihyae, Czikora, Agnes, Saini, Amandeep S, Zhou, Xiaoling, Mitchell, Gary A, Lewin, Nancy E, Peach, Megan L, Blumberg, Peter M, Lee, Jeewoo

“…Diacylglycerol-lactones have proven to be a powerful template for the design of potent ligands targeting C1 domains, the recognition motif for the cellular…”
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Abstract 3928: Structural basis for the failure of the C1 domain of RasGRP2 to bind phorbol ester by Czikora, Agnes, J. Lundberg, Daniel, E. Lewin, Nancy, Kedei, Noemi, M. Blumberg, Peter

“…C1 domains represent the recognition motif for the second messenger diacylglycerol (DAG) and for the phorbol esters in protein kinase C, RasGRP, and several…”
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Structural determinants of phorbol ester binding activity of the C1a and C1b domains of protein kinase C theta by Czikora, Agnes, Pany, Satyabrata, You, Youngki, Saini, Amandeep S., Lewin, Nancy E., Mitchell, Gary A., Abramovitz, Adelle, Kedei, Noemi, Blumberg, Peter M., Das, Joydip

“…The PKC isozymes represent the most prominent family of signaling proteins mediating response to the ubiquitous second messenger diacylglycerol. Among them,…”
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