Search Results - "CZECH, Joerg"

Novel Inhibitors of Nicotinamide- N -Methyltransferase for the Treatment of Metabolic Disorders by Kannt, Aimo, Rajagopal, Sridharan, Hallur, Mahanandeesha S, Swamy, Indu, Kristam, Rajendra, Dhakshinamoorthy, Saravanakumar, Czech, Joerg, Zech, Gernot, Schreuder, Herman, Ruf, Sven

“…Nicotinamide- -methyltransferase (NNMT) is a cytosolic enzyme catalyzing the transfer of a methyl group from -adenosyl-methionine (SAM) to nicotinamide (Nam)…”
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Novel tricyclic small molecule inhibitors of Nicotinamide N-methyltransferase for the treatment of metabolic disorders by Ruf, Sven, Rajagopal, Sridharan, Kadnur, Sanjay Venkatachalapathi, Hallur, Mahanandeesha S., Rani, Shilpa, Kristam, Rajendra, Swaminathan, Srinivasan, Zope, Bharat Ravindra, Gondrala, Pavan Kumar, Swamy, Indu, Putta, V. P. Rama Kishore, Kandan, Saravanan, Zech, Gernot, Schreuder, Herman, Rudolph, Christine, Elvert, Ralf, Czech, Joerg, Birudukota, Swarnakumari, Siddiqui, M. Amir, Anand, Niranjan Naranapura, Mane, Vishal Subhash, Dittakavi, Sreekanth, Suresh, Juluri, Gosu, Ramachandraiah, Ramesh, Mullangi, Yura, Takeshi, Dhakshinamoorthy, Saravanakumar, Kannt, Aimo

“…Nicotinamide N-methyltransferase (NNMT) is a metabolic regulator that catalyzes the methylation of nicotinamide (Nam) using the co-factor…”
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Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase by Ruf, Sven, Hallur, Mahanandeesha Siddappa, Anchan, Nisha K., Swamy, Indu N., Murugesan, Karthikai Raj, Sarkar, Sayantani, Narasimhulu, Lokesh Kananti, Putta, V.P. Rama Kishore, Shaik, Shama, Chandrasekar, Devaraj Venkatapura, Mane, Vishal Subhash, Kadnur, Sanjay Venkatachalapathi, Suresh, Juluri, Bhamidipati, Ravi Kanth, Singh, Manvi, Burri, Raghunadha Reddy, Kristam, Rajendra, Schreuder, Herman, Czech, Joerg, Rudolph, Christine, Marker, Alexander, Langer, Thomas, Mullangi, Ramesh, Yura, Takeshi, Gosu, Ramachandraiah, Kannt, Aimo, Dhakshinamoorthy, Saravanakumar, Rajagopal, Sridharan

“…Compound 12 Human/mouse NNMT enzymatic inhibition (IC50): 0.58/4.5 µM. Inhibition of MNA in U2OS/3T3L1 cell based assay: 0.3/2.1 µM. Human/mouse metabolic…”
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A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders by Kannt, Aimo, Rajagopal, Sridharan, Kadnur, Sanjay Venkatachalapathi, Suresh, Juluri, Bhamidipati, Ravi Kanth, Swaminathan, Srinivasan, Hallur, Mahanandeesha Siddappa, Kristam, Rajendra, Elvert, Ralf, Czech, Jörg, Pfenninger, Anja, Rudolph, Christine, Schreuder, Herman, Chandrasekar, Devaraj Venkatapura, Mane, Vishal Subhash, Birudukota, Swarnakumari, Shaik, Shama, Zope, Bharat Ravindra, Burri, Raghunadha Reddy, Anand, Niranjan Naranapura, Thakur, Manish Kumar, Singh, Manvi, Parveen, Reejuana, Kandan, Saravanan, Mullangi, Ramesh, Yura, Takeshi, Gosu, Ramachandraiah, Ruf, Sven, Dhakshinamoorthy, Saravanakumar

“…Nicotinamide N-methyltransferase (NNMT) is a cytosolic enzyme that catalyzes the transfer of a methyl group from the co-factor S-adenosyl-L-methionine (SAM)…”
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Novel Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa) from Natural Product Anabaenopeptin by Halland, Nis, Brönstrup, Mark, Czech, Jörg, Czechtizky, Werngard, Evers, Andreas, Follmann, Markus, Kohlmann, Markus, Schiell, Matthias, Kurz, Michael, Schreuder, Herman A, Kallus, Christopher

“…Anabaenopeptins isolated from cyanobacteria were identified as inhibitors of carboxypeptidase TAFIa. Cocrystal structures of these macrocyclic natural product…”
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Fragment Deconstruction of Small, Potent Factor Xa Inhibitors: Exploring the Superadditivity Energetics of Fragment Linking in Protein-Ligand Complexes by Nazaré, Marc, Matter, Hans, Will, David W., Wagner, Michael, Urmann, Matthias, Czech, Jörg, Schreuder, Herman, Bauer, Armin, Ritter, Kurt, Wehner, Volkmar

“…More than just the sum of its parts: The superadditivity effect of fragment linking on ΔG was quantified by deconstructing two fXa inhibitors with congeneric…”
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Sulfamide as Zinc Binding Motif in Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa) by Halland, Nis, Czech, Jörg, Czechtizky, Werngard, Evers, Andreas, Follmann, Markus, Kohlmann, Markus, Schreuder, Herman A, Kallus, Christopher

“…Previously disclosed TAFIa inhibitors having a urea zinc-binding motif were used as the starting point for the development of a novel class of highly potent…”
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Isolation, Co-Crystallization and Structure-Based Characterization of Anabaenopeptins as Highly Potent Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa) by Schreuder, Herman, Liesum, Alexander, Lönze, Petra, Stump, Heike, Hoffmann, Holger, Schiell, Matthias, Kurz, Michael, Toti, Luigi, Bauer, Armin, Kallus, Christopher, Klemke-Jahn, Christine, Czech, Jörg, Kramer, Dan, Enke, Heike, Niedermeyer, Timo H. J., Morrison, Vincent, Kumar, Vasant, Brönstrup, Mark

“…Mature thrombin activatable fibrinolysis inhibitor (TAFIa) is a carboxypeptidase that stabilizes fibrin clots by removing C-terminal arginines and lysines from…”
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Discovery of N‑[4-(1H‑Pyrazolo[3,4‑b]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors by Halland, Nis, Schmidt, Friedemann, Weiss, Tilo, Saas, Joachim, Li, Ziyu, Czech, Jörg, Dreyer, Matthias, Hofmeister, Armin, Mertsch, Katharina, Dietz, Uwe, Strübing, Carsten, Nazare, Marc

“…From a virtual screening starting point, inhibitors of the serum and glucocorticoid regulated kinase 1 were developed through a combination of classical…”
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A Solid Supported Membrane-Based Technology for Electrophysical Screening of B 0 AT1-Modulating Compounds by Gerbeth-Kreul, Carolin, Pommereau, Antje, Ruf, Sven, Kane, Jr, John L, Kuntzweiler, Theresa, Hessler, Gerhard, Engel, Christian K, Shum, Patrick, Wei, LinLi, Czech, Joerg, Licher, Thomas

“…Classical high-throughput screening (HTS) technologies for the analysis of ionic currents across biological membranes can be performed using…”
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Elucidation of the mechanism enabling tumor selective prodrug monotherapy by BOSSLET, K, STRAUB, R, BLUMRICH, M, CZECH, J, GERKEN, M, SPERKER, B, KROEMER, H. K, GESSON, J.-P, KOCH, M, MONNERET, C

“…Elucidation of the mechanism enabling tumor selective PMT in vivo with appropriate glucuronyl-spacer-doxorubicin prodrugs, such as HMR 1826, is important for…”
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Structure-based design of amidinophenylurea-derivatives for factor VIIa inhibition by KLINGLER, Otmar, MATTER, Hans, SCHUDOK, Manfred, DONGHI, Monica, CZECH, Joerg, LORENZ, Martin, NESTLER, Hans Peter, SZILLAT, Hauke, SCHREUDER, Herman

“…The amidinophenylurea scaffold was earlier shown to provide an excellent template for the synthesis of novel and potent inhibitors of the blood coagulation…”
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Design, synthesis, and structure–activity relationship of a new class of amidinophenylurea-based factor VIIa inhibitors by Klingler, Otmar, Matter, Hans, Schudok, Manfred, Bajaj, S.Paul, Czech, Joerg, Lorenz, Martin, Nestler, Hans Peter, Schreuder, Herman, Wildgoose, Peter

“…Selective inhibition of coagulation factor VIIa has recently gained attraction as interesting approach towards antithrombotic treatment. Using parallel…”
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Prodrugs of Anthracyclines for Use in Antibody-Directed Enzyme Prodrug Therapy by Florent, Jean-Claude, Dong, Xia, Gaudel, Gilbert, Mitaku, Sofia, Monneret, Claude, Gesson, Jean-Pierre, Jacquesy, Jean-Claude, Mondon, Martine, Renoux, Brigitte, Andrianomenjanahary, Solo, Michel, Sylvie, Koch, Michel, Tillequin, François, Gerken, Manfred, Czech, Joerg, Straub, Rainer, Bosslet, Klaus

“…A series of new prodrugs of daunorubicin and doxorubicin which are candidates for antibody-directed enzyme prodrug therapy (ADEPT) is reported. These compounds…”
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Innenrücktitelbild: Fragment Deconstruction of Small, Potent Factor Xa Inhibitors: Exploring the Superadditivity Energetics of Fragment Linking in Protein–Ligand Complexes (Angew. Chem. 4/2012) by Nazaré, Marc, Matter, Hans, Will, David W., Wagner, Michael, Urmann, Matthias, Czech, Jörg, Schreuder, Herman, Bauer, Armin, Ritter, Kurt, Wehner, Volkmar

“…Die Superadditivität von Affinitäten beim Verbinden einzelner Fragmente wurde durch systematischen Abbau eines fXa‐Inhibitors quantifiziert. In ihrer Zuschrift…”
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The Change in Research for the Therapy of Tumors by H.-Harald Sedlacek, Dieter Hoffmann, Jörg Czech, Cenek Kolar, Gerhard Seemann, Dettef Güssow, Klaus Bosslet

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The Change in Research for the Therapy of Tumors by H.-Harald Sedlacek, Dieter Hoffmann, Jörg Czech, Cenek Kolar, Gerhard Seemann, Dettef Güssow, Klaus Bosslet

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