Search Results - "CVITKOVIC, Esteban"

ProLindac™ (AP5346): A review of the development of an HPMA DACH platinum Polymer Therapeutic by Nowotnik, David P, Cvitkovic, Esteban

“…ProLindac™ (AP5346) is DACH (diaminocyclohexane) platinum polymer prodrug currently in phase II clinical development. It uses a 25 kDa polymer delivery vehicle…”
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Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition by Henssen, Anton, Althoff, Kristina, Odersky, Andrea, Beckers, Anneleen, Koche, Richard, Speleman, Frank, Schäfers, Simon, Bell, Emma, Nortmeyer, Maike, Westermann, Frank, De Preter, Katleen, Florin, Alexandra, Heukamp, Lukas, Spruessel, Annika, Astrahanseff, Kathy, Lindner, Sven, Sadowski, Natalie, Schramm, Alexander, Astorgues-Xerri, Lucile, Riveiro, Maria E, Eggert, Angelika, Cvitkovic, Esteban, Schulte, Johannes H

“…Targeting BET proteins was previously shown to have specific antitumoral efficacy against MYCN-amplified neuroblastoma. We here assess the therapeutic efficacy…”
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Therapeutic efficacy of the bromodomain inhibitor OTX015/MK-8628 in ALK-positive anaplastic large cell lymphoma: an alternative modality to overcome resistant phenotypes by Boi, Michela, Todaro, Maria, Vurchio, Valentina, Yang, Shao Ning, Moon, John, Kwee, Ivo, Rinaldi, Andrea, Pan, Heng, Crescenzo, Ramona, Cheng, Mangeng, Cerchietti, Leandro, Elemento, Olivier, Riveiro, Maria E, Cvitkovic, Esteban, Bertoni, Francesco, Inghirami, Giorgio

“…Anaplastic large cell lymphomas (ALCL) represent a peripheral T-cell lymphoma subgroup, stratified based on the presence or absence of anaplastic lymphoma…”
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Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells by Serova, Maria, Ghoul, Aïda, Benhadji, Karim A, Faivre, Sandrine, Le Tourneau, Christophe, Cvitkovic, Esteban, Lokiec, Francois, Lord, Janet, Ogbourne, Steven M, Calvo, Fabien, Raymond, Eric

“…PEP005 (ingenol-3-angelate) is a novel anticancer agent extracted from Euphorbia peplus that was previously shown to modulate protein kinase C (PKC), resulting…”
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Epithelial-to-mesenchymal transition and resistance to ingenol 3-angelate, a novel protein kinase C modulator, in colon cancer cells by Ghoul, Aïda, Serova, Maria, Astorgues-Xerri, Lucile, Bieche, Ivan, Bousquet, Guilhem, Varna, Mariana, Vidaud, Michel, Phillips, Edelmira, Weill, Sophie, Benhadji, Karim A, Lokiec, François, Cvitkovic, Esteban, Faivre, Sandrine, Raymond, Eric

“…Acquired resistance to protein kinase C (PKC) modulators may explain the failure of clinical trials in patients with cancer. Herein, we established a human…”
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Repression of cell cycle–related proteins by oxaliplatin but not cisplatin in human colon cancer cells by Voland, Carole, Bord, Annie, Péleraux, Annick, Pénarier, Géraldine, Carrière, Dominique, Galiègue, Sylvaine, Cvitkovic, Esteban, Jbilo, Omar, Casellas, Pierre

“…Oxaliplatin (Eloxatin) is a third-generation platinum derivative with an in vitro and in vivo spectrum of activity distinct from that of cisplatin, especially…”
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Cellular Pharmacology of the Combination of the DNA Topoisomerase I Inhibitor SN-38 and the Diaminocyclohexane Platinum Derivative Oxaliplatin by Zeghari-Squalli, N, Raymond, E, Cvitkovic, E, Goldwasser, F

“…CPT-11, a DNA topoisomerase I inhibitor, and oxaliplatin, a diaminocyclohexane platinum derivative, are cytotoxic agents that have demonstrated clinical…”
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Long-Term Disease-Free Survivors in Metastatic Undifferentiated Carcinoma of Nasopharyngeal Type by FANDI, A, BACHOUCHI, M, AZLI, N, TAAMMA, A, BOUSSEN, H, WIBAULT, P, ESCHWEGE, F, ARMAND, J.-P, SIMON, J, CVITKOVIC, E

“…To review incidence and analyze profile of long-term complete responders among patients with undifferentiated carcinoma of nasopharyngeal type (UCNT) treated…”
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Combination of Oxaliplatin Plus Irinotecan in Patients With Gastrointestinal Tumors: Results of Two Independent Phase I Studies With Pharmacokinetics by Wasserman, Ernesto, Cuvier, Caroline, Lokiec, François, Goldwasser, François, Kalla, Salima, Méry-Mignard, Dominique, Ouldkaci, Mahmoud, Besmaine, Amine, Dupont-André, Ghislaine, Mahjoubi, Mondher, Marty, Michel, Misset, Jean-Louis, Cvitkovic, Esteban

“…Two phase I studies of the oxaliplatin and irinotecan combination were performed in advanced gastrointestinal cancer patients to characterize the safety and…”
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Pharmacokinetics and Pharmacodynamics of the Novel Marine-derived Anticancer Agent Ecteinascidin 743 in a Phase I Dose-finding Study by VAN KESTEREN, Charlotte, CVITKOVIC, Esteban, HILLEBRAND, Michael J. X, ROSING, Hilde, BEIJNEN, Jos H, TAAMMA, Adelkrim, LOPEZ-LAZARO, Luis, JIMENO, Jose M, GUZMAN, Cecilia, MATHOT, Ron A. A, SCHELLENS, Jan H. M, MISSET, Jean-Louis, BRAIN, Etienne

“…Ecteinascidin (ET) 743 is an anticancer agent derived from the Caribbean tunicate Ecteinascidia turbinata . Preclinical studies revealed activity of ET-743…”
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Phase I and Pharmacokinetic Study of Irofulven Administered Weekly or Biweekly in Advanced Solid Tumor Patients by ALEXANDRE, Jérome, RAYMOND, Eric, MACDONALD, John R, MISSET, Jean-Louis, CVITKOVIC, Esteban, KACI, Mahmoud Ould, BRAIN, Etienne C, LOKIEC, Francois, KAHATT, Carmen, FAIVRE, Sandrine, YOVINE, Alejandro, GOLDWASSER, Francois, SMITH, Sheri L

“…Purpose: We performed a Phase I and pharmacokinetic study to determine the maximum tolerated dose of irofulven (6-hydroxymethylacylfulvene; MGI-114, MGI…”
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Pharmacokinetics, Metabolism, and Routes of Excretion of Intravenous Irofulven in Patients with Advanced Solid Tumors by PACI, Angelo, REZAI, Keyvan, WEEMS, Gary, VASSAL, Gilles, LOKIEC, Francois, DEROUSSENT, Alain, DE VALERIOLA, Dominique, RE, Micheline, WEILL, Sophie, CVITKOVIC, Esteban, KAHATT, Carmen, SHAH, Ajit, WATERS, Stephen

“…Irofulven is currently in Phase 2 clinical trials against a wide variety of solid tumors and has demonstrated activity in ovarian, prostate, gastrointestinal,…”
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Characterization and Multiparameter Analysis of Visual Adverse Events in Irofulven Single-Agent Phase I and II Trials by RAYMOND, Eric, KAHATT, Carmen, CULLEN, Michael, MISSET, Jean-Louis, CVITKOVIC, Esteban, RIGOLET, Marie Hélène, SUTHERLAND, William, LOKIEC, Francois, ALEXANDRE, Jérome, TOMBAL, Bertrand, ELMAN, Michael, LEE, Michael S, MACDONALD, John R

“…Purpose: Irofulven (6-hydroxymethylacylfulvene) is a novel agent, derived from illudin S, with potent apoptotic effects in preclinical models. In the Phase I…”
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The BET Bromodomain Inhibitor OTX015 Affects Pathogenetic Pathways in Preclinical B-cell Tumor Models and Synergizes with Targeted Drugs by Boi, Michela, Gaudio, Eugenio, Bonetti, Paola, Kwee, Ivo, Bernasconi, Elena, Tarantelli, Chiara, Rinaldi, Andrea, Testoni, Monica, Cascione, Luciano, Ponzoni, Maurilio, Mensah, Afua Adjeiwaa, Stathis, Anastasios, Stussi, Georg, Riveiro, María Eugenia, Herait, Patrice, Inghirami, Giorgio, Cvitkovic, Esteban, Zucca, Emanuele, Bertoni, Francesco

“…In cancer cells, the epigenome is often deregulated, and inhibition of the bromodomain and extra-terminal (BET) family of bromodomain-containing proteins is a…”
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OTX015 (MK‐8628), a novel BET inhibitor, displays in vitro and in vivo antitumor effects alone and in combination with conventional therapies in glioblastoma models by Berenguer‐Daizé, Caroline, Astorgues‐Xerri, Lucile, Odore, Elodie, Cayol, Mylène, Cvitkovic, Esteban, Noel, Kay, Bekradda, Mohamed, MacKenzie, Sarah, Rezai, Keyvan, Lokiec, François, Riveiro, Maria E., Ouafik, L'Houcine

“…Bromodomain and extraterminal (BET) bromodomain (BRD) proteins are epigenetic readers that bind to acetylated lysine residues on chromatin, acting as…”
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Irinotecan plus Oxaliplatin: a Promising Combination for Advanced Colorectal Cancer by Wasserman, Ernesto, Sutherland, William, Cvitkovic, Esteban

“…The standard treatment for advanced colorectal cancer (CRC) has been 5-fluorouracil (5-FU)—based chemotherapy. However, addition of irinotecan, a topoisomerase…”
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OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis by Astorgues-Xerri, Lucile, Riveiro, Maria E, Tijeras-Raballand, Annemilaï, Serova, Maria, Rabinovich, Gabriel A, Bieche, Ivan, Vidaud, Michel, de Gramont, Armand, Martinet, Mathieu, Cvitkovic, Esteban, Faivre, Sandrine, Raymond, Eric

“…Abstract Background Galectin-1 (Gal1), a carbohydrate-binding protein is implicated in cancer cell proliferation, invasion and tumour angiogenesis. Several…”
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Phase I Population Pharmacokinetic Assessment of the Oral Bromodomain Inhibitor OTX015 in Patients with Haematologic Malignancies by Odore, Elodie, Lokiec, François, Cvitkovic, Esteban, Bekradda, Mohamed, Herait, Patrice, Bourdel, Fabrice, Kahatt, Carmen, Raffoux, Emmanuel, Stathis, Anastasios, Thieblemont, Catherine, Quesnel, Bruno, Cunningham, David, Riveiro, Maria E., Rezaï, Keyvan

“…Background and Objectives OTX015 (MK-8628) is a novel inhibitor of the bromodomain and extraterminal (BET)-bromodomain (BRD) protein family, binding…”
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Epigenetic Control of Mitochondrial Fission Enables Self-Renewal of Stem-like Tumor Cells in Human Prostate Cancer by Civenni, Gianluca, Bosotti, Roberto, Timpanaro, Andrea, Vàzquez, Ramiro, Merulla, Jessica, Pandit, Shusil, Rossi, Simona, Albino, Domenico, Allegrini, Sara, Mitra, Abhishek, Mapelli, Sarah N., Vierling, Luca, Giurdanella, Martina, Marchetti, Martina, Paganoni, Alyssa, Rinaldi, Andrea, Losa, Marco, Mira-Catò, Enrica, D'Antuono, Rocco, Morone, Diego, Rezai, Keyvan, D'Ambrosio, Gioacchino, Ouafik, L’Houcine, Mackenzie, Sarah, Riveiro, Maria E., Cvitkovic, Esteban, Carbone, Giuseppina M., Catapano, Carlo V.

“…Cancer stem cells (CSCs) contribute to disease progression and treatment failure in human cancers. The balance among self-renewal, differentiation, and…”
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Phase I/II Study of Escalating Doses of Vinorelbine in Combination With Oxaliplatin in Patients With Advanced Non–Small-Cell Lung Cancer by MONNET, Isobelle, SOULIE, Patrick, DE CREMOUX, Hubert, SALTIEL-VOISIN, Sabine, BEKRADDA, Mohammed, SALTIEL, Jean-Claude, BRAIN, Etienne, DUPONT-ANDRE, Ghislaine, CVITKOVIC, Esteban

“…Oxaliplatin is a platinum compound active in non-small-cell lung cancer (NSCLC) patients, and vinorelbine (VNB) is an active reference agent. This phase I/II…”
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