Search Results - "CUTHBERTSON, D"

The direct arylation of allylic sp3 C–H bonds via organic and photoredox catalysis by Cuthbertson, James D., MacMillan, David W. C.

“…Photoredox and organic catalysis are combined to achieve broadly effective direct arylation of allylic carbon–hydrogen bonds under mild conditions; this…”
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Palladium-Catalyzed Enantioselective C–H Activation of Aliphatic Amines Using Chiral Anionic BINOL-Phosphoric Acid Ligands by Smalley, Adam P, Cuthbertson, James D, Gaunt, Matthew J

“…The design of an enantioselective Pd­(II)-catalyzed C–H amination reaction is described. The use of a chiral BINOL phosphoric acid ligand enables the…”
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Exercise Training Reduces Liver Fat and Increases Rates of VLDL Clearance But Not VLDL Production in NAFLD by Shojaee-Moradie, F, Cuthbertson, D. J, Barrett, M, Jackson, N. C, Herring, R, Thomas, E. L, Bell, J, Kemp, G. J, Wright, J, Umpleby, A. M

“…Context: Randomized controlled trials in nonalcoholic fatty liver disease (NAFLD) have shown that regular exercise, even without calorie restriction, reduces…”
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Redox-neutral organocatalytic Mitsunobu reactions by Beddoe, Rhydian H, Andrews, Keith G, Magné, Valentin, Cuthbertson, James D, Saska, Jan, Shannon-Little, Andrew L, Shanahan, Stephen E, Sneddon, Helen F, Denton, Ross M

“…Nucleophilic substitution reactions of alcohols are among the most fundamental and strategically important transformations in organic chemistry. For over half…”
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What have human experimental overfeeding studies taught us about adipose tissue expansion and susceptibility to obesity and metabolic complications? by Cuthbertson, D J, Steele, T, Wilding, J P, Halford, J C, Harrold, J A, Hamer, M, Karpe, F

“…Overfeeding experiments, in which we impose short-term positive energy balance, help unravel the cellular, physiological and behavioural adaptations to…”
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Silver(I)- or Copper(II)-Mediated Dearomatization of Aromatic Ynones: Direct Access to Spirocyclic Scaffolds by James, Michael J., Cuthbertson, James D., O'Brien, Peter, Taylor, Richard J. K., Unsworth, William P.

“…A high‐yielding silver(I)‐ or copper(II)‐catalyzed dearomatizing spirocyclization strategy allows the conversion of simple aromatic compounds that contain…”
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Emerging and Established Therapeutic Approaches for Nonalcoholic Fatty Liver Disease by Brown, Emily, Hydes, T., Hamid, A., Cuthbertson, D.J.

“…Nonalcoholic fatty liver disease (NAFLD), more recently referred to as metabolic-associated fatty liver disease, refers to a disease spectrum ranging from…”
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Exercise reduces liver fat and improves surrogate measures of liver fibrosis in people with non-alcoholic fatty liver disease: Pooled analysis from randomised controlled trials by Keating, S., Cuthbertson, D., Pugh, C., Stine, J.

“…Results: Eighty-eight participants (54 exercise training, 34 standard clinical care) were included with mean (SD) age 51 (11) years, body mass index (BMI) 33.3…”
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Presentation, management and outcomes in acute pituitary apoplexy: a large single-centre experience from the United Kingdom by Bujawansa, S., Thondam, S. K., Steele, C., Cuthbertson, D. J., Gilkes, C. E., Noonan, C., Bleaney, C. W., MacFarlane, I. A., Javadpour, M., Daousi, C.

“…Summary Objective To study the presentation, management and outcomes and to apply retrospectively the Pituitary Apoplexy Score (PAS) (United Kingdom (UK)…”
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Impact of bariatric surgery on physical functioning in obese adults by Steele, T, Cuthbertson, D. J, Wilding, J. P. H

“…Obesity is associated with a profound impairment in the ability to perform the basic physical activities required for everyday function. This impacts on…”
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Energy balance and metabolic changes with sodium-glucose co-transporter 2 inhibition by Rajeev, S. P., Cuthbertson, D. J., Wilding, J. P. H.

“…Sodium‐glucose co‐transporter 2 (SGLT2) inhibitors are the latest addition to the class of oral glucose‐lowering drugs. They have been rapidly adopted into…”
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Metabolically healthy and unhealthy obesity: differential effects on myocardial function according to metabolic syndrome, rather than obesity by Dobson, R, Burgess, M I, Sprung, V S, Irwin, A, Hamer, M, Jones, J, Daousi, C, Adams, V, Kemp, G J, Shojaee-Moradie, F, Umpleby, M, Cuthbertson, D J

“…Background: The term ‘metabolically healthy obese (MHO)’ is distinguished using body mass index (BMI), yet BMI is a poor index of adiposity. Some…”
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Current and Emerging Biomarkers and Imaging Modalities for Nonalcoholic Fatty Liver Disease: Clinical and Research Applications by Hydes, T., Brown, E., Hamid, A., Bateman, A.C., Cuthbertson, D.J.

“…Nonalcoholic fatty liver disease (NAFLD) is a metabolic disorder that frequently coexists with obesity, metabolic syndrome, and type 2 diabetes. The NAFLD…”
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Dynapenic obesity and the risk of incident Type 2 diabetes: the English Longitudinal Study of Ageing by Cuthbertson, D. J., Bell, J. A., Ng, S. Y., Kemp, G. J., Kivimaki, M., Hamer, M.

“…Aim Obesity is a well‐established risk factor for developing Type 2 diabetes. Evidence suggests that sarcopenia, the age‐related decline in muscle mass and…”
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Serial surveillance of carcinoid heart disease: factors associated with echocardiographic progression and mortality by Dobson, R, Burgess, M I, Valle, J W, Pritchard, D M, Vora, J, Wong, C, Chadwick, C, Keevi, B, Adaway, J, Hofmann, U, Poston, G J, Cuthbertson, D J

“…Background: Carcinoid heart disease is a complication of metastatic neuroendocrine tumours (NETs). We sought to identify factors associated with…”
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Exercise-induced improvements in liver fat and endothelial function are not sustained 12 months following cessation of exercise supervision in nonalcoholic fatty liver disease by Pugh, C J A, Sprung, V S, Jones, H, Richardson, P, Shojaee-Moradie, F, Umpleby, A M, Green, D J, Cable, N T, Trenell, M I, Kemp, G J, Cuthbertson, D J

“…Supervised exercise reduces liver fat and improves endothelial function, a surrogate of cardiovascular disease (CVD) risk, in nonalcoholic fatty liver disease…”
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Dynapenic Abdominal Obesity as a Risk Factor for Falls by Dowling, L, McCloskey, E, Cuthbertson, D J, Walsh, J S

“…Obesity and low muscle strength (dynapenia) are independently associated with greater falls risk. It remains unclear whether dynapenia and obesity have an…”
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Alterations of a serum marker of collagen X in growing children with osteogenesis imperfecta by Nicol, L.E., Coghlan, R.F., Cuthbertson, D., Nagamani, Sandesh C.S., Lee, B., Olney, R.C., Horton, W., Orwoll, E.

“…Abnormalities in the structure and/or processing of type I collagen cause osteogenesis imperfecta and result in bone fragility, abnormal bone growth and short…”
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Poor glycaemic control and ectopic fat deposition mediates the increased risk of non-alcoholic steatohepatitis in high-risk populations with type 2 diabetes: Insights from Bayesian-network modelling by Waddell, T, Namburete, A, Duckworth, P, Fichera, A, Telford, A, Thomaides-Brears, H, Cuthbertson, D J, Brady, M

“…An estimated 55.5% and 37.3% of people globally with type 2 diabetes (T2D) will have concomitant non-alcoholic fatty liver disease (NAFLD) and the more severe…”
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Collagen synthesis in human musculoskeletal tissues and skin by Babraj, J A, Cuthbertson, D J R, Smith, K, Langberg, H, Miller, B, Krogsgaard, M R, Kjaer, M, Rennie, M J

“…We have developed a direct method for the measurement of human musculoskeletal collagen synthesis on the basis of the incorporation of stable isotope-labeled…”
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