Search Results - "CUSAN, LIONEL"

Screening decreases prostate cancer mortality: 11-year follow-up of the 1988 Quebec prospective randomized controlled trial by Labrie, Fernand, Candas, Bernard, Cusan, Lionel, Gomez, Jose Luis, Bélanger, Alain, Brousseau, G., Chevrette, Eric, Lévesque, Jacques

“…PURPOSE This clinical trial is aimed at evaluating the impact of prostate cancer screening on cancer‐specific mortality. SUBJECTS AND METHODS Forty‐six…”
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Marked Decline in Serum Concentrations of Adrenal C19 Sex Steroid Precursors and Conjugated Androgen Metabolites During Aging by Labrie, Fernand, Bélanger, Alain, Cusan, Lionel, Gomez, José-Luis, Candas, Bernard

“…The present data show a dramatic decline in the circulating levels of dehydroepiandrosterone (DHEA), DHEA-sulfate (DHEA-S), androst-5-ene-3β,17β-diol (5-diol),…”
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Screening decreases prostate cancer death: First analysis of the 1988 Quebec Prospective Randomized Controlled Trial by Labrie, Fernand, Candas, Bernard, Dupont, André, Cusan, Lionel, Gomez, Jose-Luis, Suburu, Raul E., Diamond, Pierre, Lévesque, Jacques, Belanger, Alain

“…BACKGROUND The 46,193 men aged 45 to 80 years registered in the electoral roll of Quebec City and its Metropolitan area were randomized in November 1988…”
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Activity and Safety of the Antiestrogen EM-800, the Orally Active Precursor of Acolbifene, in Tamoxifen-Resistant Breast Cancer by LABRIE, Fernand, CHAMPAGNE, Pierre, L'ESPERANCE, Bernard, DUFRESNE, Jean, LATREILLE, Jean, ROBERT, Jean, SAMSON, Benoit, JOLIVET, Jacques, YELLE, Louise, CUSAN, Lionel, DIAMOND, Pierre, CANDAS, Bernard, LABRIE, Claude, ROY, Jean, LAVERDIERE, Jacques, PROVENCHER, Louise, POTVIN, Martin, DROLET, Yvan, POLLAK, Michael, PANASCI, Lawrence

“…To determine the efficacy and safety of EM-800 (SCH-57050), the precursor of acolbifene, a new, highly potent, orally active, pure antiestrogen in the mammary…”
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Comparison of residual C-19 steroids in plasma and prostatic tissue of human, rat and guinea pig after castration: unique importance of extratesticular androgens in men by Bélanger, B, Bélanger, A, Labrie, F, Dupont, A, Cusan, L, Monfette, G

“…The concentrations of dehydroepiandrosterone (DHEA), its sulfate (DHEAS), androstenedione (A-dione), testosterone (T) and dihydrotestosterone (DHT) have been…”
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Physiological Changes in Dehydroepiandrosterone Are Not Reflected by Serum Levels of Active Androgens and Estrogens But of Their Metabolites: Intracrinology by Labrie, Fernand, Bélanger, Alain, Cusan, Lionel, Candas, Bernard

“…This study analyzes in detail the serum concentration of the active androgens and estrogens, as well as a series of free and conjugated forms of their…”
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EM-652 (SCH 57068), a third generation SERM acting as pure antiestrogen in the mammary gland and endometrium by Labrie, Fernand, Labrie, Claude, Bélanger, Alain, Simard, Jacques, Gauthier, Sylvain, Luu-The, Van, Mérand, Yves, Giguere, Vincent, Candas, Bernard, Luo, Shouqi, Martel, Céline, Singh, Shankar Mohan, Fournier, Marc, Coquet, Agnès, Richard, Virgile, Charbonneau, Ronald, Charpenet, Gilles, Tremblay, André, Tremblay, Gilles, Cusan, Lionel, Veilleux, Raymonde

“…Breast cancer is the most frequent cancer in women while it is the second cause of cancer death. Estrogens are well recognized to play the predominant role in…”
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The impact of family history on early detection of prostate cancer by Narod, Steven A, Dupont, André, Cusan, Lionel, Diamond, Pierre, Gomez, José-Luis, Suburu, Raul, Labrie, Fernand

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Evaluation of prostatic specific antigen and digital rectal examination as screening tests for prostate cancer by Candas, Bernard, Cusan, Lionel, Gomez, Jose-Luis, Diamond, Pierre, Suburu, Raul E., Lévesque, Jacques, Brousseau, Ghislain, Bélanger, Alain, Labrie, Fernand

“…BACKGROUND The 11,811 first visits and 46,751 annual follow‐up visits performed since 1988 were analyzed in order to assess the efficacy of serum prostatic…”
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Relative Importance of the Adenohypophyseal and Gonadal Sites of Inhibitory Action of LHRH Agonists by Séguin, Carl, Bélanger, Alain, Cusan, Lionel, Pelletier, Georges, Reeves, Jerry J., Lefebvre, Fleur-Ange, Kelly, Paul A., Labrie, Fernand

“…Assessment of the role of endogenous LH release and direct gonadal action of LHRH agonists in the loss of gonadal LH receptors induced by treatment with…”
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Stimulatory Effect of Luteinizing Hormone and Human Chorionic Gonadotropin on Testicular Prolactin Receptor Levels by Kelly, P A, Séguin, C, Cusan, L, Labrie, F

“…A possible effect of LH or hCG on testicular prolactin receptor levels was investigated in hypophysectomized adult rats. Hypophysectomy leads to a progressive…”
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Screening decreases prostate cancer mortality: II-year follow-up of the 1988 Quebec prospective randomized controlled trial by LABRIE, Fernand, CANDAS, Bernard, CUSAN, Lionel, GOMEZ, Jose Luis, BELANGER, Alain, BROUSSEAU, G, CHEVRETTE, Eric, LEVESQUE, Jacques

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Combination of screening and preoperative endocrine therapy: the potential for an important decrease in prostate cancer mortality by Labrie, F, Cusan, L, Gomez, J L, Diamond, P, Candas, B

“…Prostate cancer is the second cause of cancer death in men in the Western world; its medical and social impact is comparable to that of breast cancer in women…”
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The impact of family history on early detection of prostate cancer by Narod, Steven A, Dupont, André, Cusan, Lionel, Diamond, Pierre, Gomez, José-Luis, Suburu, Raul, Labrie, Fernand

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Effects of flutamide and aminoglutethimide on plasma 5 alpha-reduced steroid glucuronide concentrations in castrated patients with cancer of the prostate by Brochu, M, Bélanger, A, Dupont, A, Cusan, L, Labrie, F

“…Plasma levels of androstane-3 alpha, 17 beta-diol glucuronide (3 alpha-diol-G) and androsterone glucuronide (ADT-G) have been found to be effective markers of…”
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Inhibitory effects of long term treatment with a luteinizing hormone-releasing hormone agonist on the pituitary-gonadal axis in male and female rats by Cusan, L, Auclair, C, Belanger, A, Ferland, L, Kelly, P A, Seguin, C, Labrie, F

“…Following previous observations of the potent antifertility effects of acute treatment with LHRH or its agonistic analogs in male and female rats, this study…”
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Extremely rapid degradation of [3H] methionine-enkephalin by various rat tissues in vivo and in vitro by Dupont, A, Cusan, L, Garon, M, Alvarado-Urbina, G, Labrie, F

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Evidence for a role of endorphins in stress- and suckling-induced prolactin release in the rat by Ferland, L, Kledzik, G S, Cusan, L, Labrie, F

“…Injection of the opiate antagonist naloxone completely prevented the rise of serum prolactin induced by ether stress in intact male rats. Naloxone also led to…”
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Combination therapy with castration and flutamide: today's treatment of choice for prostate cancer by Labrie, F, Dupont, A, Cusan, L, Manhès, G, Bergeron, N, Lacourcière, Y, Pineault, S, Bélanger, A, Monfette, G, Emond, J

“…In order to achieve a more complete blockade of androgens of both testicular and adrenal origins, 223 patients with advanced prostate cancer (stage D2 with…”
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Combination therapy with flutamide and castration (LHRH agonist or orchiectomy) in previously untreated patients with clinical stage D2 prostate cancer: today's therapy of choice by Labrie, F, Dupont, A, Cusan, L, Giguere, M, Bergeron, N, Borsanyi, J P, Lacourciere, Y, Belanger, A, Emond, J, Monfette, G

“…One hundred and ninety-nine patients with clinical stage D2 prostate cancer who had not received previous endocrine therapy or chemotherapy were treated with…”
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