Search Results - "CURTIS, T. M"

Microvascular lesions of diabetic retinopathy: clues towards understanding pathogenesis? by Curtis, T M, Gardiner, T A, Stitt, A W

“…Retinopathy is a major complication of diabetes mellitus and this condition remains a leading cause of blindness in the working population of developed…”
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Hyperglycaemia-induced pro-inflammatory responses by retinal Müller glia are regulated by the receptor for advanced glycation end-products (RAGE) by Zong, H, Ward, M, Madden, A, Yong, P. H, Limb, G. A, Curtis, T. M, Stitt, A. W

“…Aims/hypothesis Up-regulation of the receptor for AGEs (RAGE) and its ligands in diabetes has been observed in various tissues. Here, we sought to determine…”
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Müller glial dysfunction during diabetic retinopathy in rats is linked to accumulation of advanced glycation end-products and advanced lipoxidation end-products by Curtis, T. M., Hamilton, R., Yong, P.-H., McVicar, C. M., Berner, A., Pringle, R., Uchida, K., Nagai, R., Brockbank, S., Stitt, A. W.

“…Aims/hypothesis The impact of AGEs and advanced lipoxidation end-products (ALEs) on neuronal and Müller glial dysfunction in the diabetic retina is not well…”
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Oxidative stress and reduced glutamine synthetase activity in the absence of inflammation in the cortex of mice with experimental allergic encephalomyelitis by Castegna, A, Palmieri, L, Spera, I, Porcelli, V, Palmieri, F, Fabis-Pedrini, M.J, Kean, R.B, Barkhouse, D.A, Curtis, M.T, Hooper, D.C

“…Abstract Pathological changes occur in areas of CNS tissue remote from inflammatory lesions in multiple sclerosis (MS) and its animal model experimental…”
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The role of lipids and protein kinase Cs in the pathogenesis of diabetic retinopathy by Curtis, T. M., Scholfield, C. N.

“…Diabetic retinopathy is one of the most common complications of diabetes and is a major cause of new blindness in the working‐age population of developed…”
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PAR-2 Regulates Dental Pulp Inflammation Associated with Caries by Lundy, F.T., About, I., Curtis, T.M., McGahon, M.K., Linden, G.J., Irwin, C.R., El Karim, I.A.

“…Protease-activated receptors (PARs) are G-protein-coupled receptors that are activated enzymatically by proteolysis of an N-terminal domain. The cleavage and…”
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Simultaneous, long-term monitoring of valve and cardiac activity in the blue mussel Mytilus edulis exposed to copper by CURTIS, T. M, WILLIAMSON, R, DEPLEDGE, M. H

“…Valve and cardiac activity were simultaneously measured in the blue mussel (Mytilus edulis) in response to 10 d copper exposure. Valve movements, heart rates…”
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Advanced glycation end products and diabetic retinopathy by Chen, M, Curtis, T M, Stitt, A W

“…Diabetic retinopathy (DR) has a complex pathogenesis which is impacted by a raft of systemic abnormalities and tissue-specific alterations occurring in…”
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Substrates modified by advanced glycation end-products cause dysfunction and death in retinal pericytes by reducing survival signals mediated by platelet-derived growth factor by STITT, A. W, HUGHES, S.-J, CANNING, P, LYNCH, O, COX, O, FRIZZELL, N, THORPE, S. R, COTTER, T. G, CURTIS, T. M, GARDINER, T. A

“…Premature death of retinal pericytes is a pathophysiological hallmark of diabetic retinopathy. Among the mechanisms proposed for pericyte death is exposure to…”
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Immunological isolation and characterization of neuronal progenitors from human dental pulp: A laboratory‐based investigation by McMillan, Hayley P., Lundy, Fionnuala T., Dunne, Orla M., McLoughlin, Kiran John, About, Imad, Curtis, T. M., El Karim, Ikhlas

“…Aims Dental pulp stem cells (DPSCs) contain a population of stem cells with a broad range of differentiation potentials, as well as more lineage‐committed…”
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Diabetes-induced activation of protein kinase C inhibits store-operated Ca2+ uptake in rat retinal microvascular smooth muscle by CURTIS, T. M, MAJOR, E. H, TRIMBLE, E. R, SCHOLFIELD, C. N

“…To assess the effects of diabetes-induced activation of protein kinase C (PKC) on voltage-dependent and voltage-independent Ca2+ influx pathways in retinal…”
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Silver-haired bat rabies virus variant does not induce apoptosis in the brain of experimentally infected mice by Yan, Mikhail Prosniak, Mark T Curtis, Mark L Weiss, Milosz Faber, Bernhard Dietzschold, Zhen F Fu, Xiuzhen

“…To examine whether induction of apoptosis plays a role in the pathogenesis of street rabies, we compared the distribution of viral antigens, histopathology,…”
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The initial mode of action of copper on the cardiac physiology of the blue mussel, Mytilus edulis by CURTIS, T. M, WILLIAMSON, R, DEPLEDGE, M. H

“…Previous studies have shown that low levels of copper (down to 0.8 microM) induce bradycardia in the blue mussel (Mytilus edulis) and that this is not caused…”
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Prion disease (PrP-A117V) presenting with ataxia instead of dementia by MASTRIANNI, J. A, CURTIS, M. T, OBERHOLTZER, J. C, DA COSTA, M. M, DEARMOND, S, PRUSINER, S. B, GARBERN, J. Y

“…Gerstmann-Sträussler-Scheinker disease (GSS) is caused by several different point mutations of the prion protein (PrP) gene, each of which generally produces a…”
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Suitability of invertebrate and vertebrate cells in a portable impedance-based toxicity sensor: Temperature mediated impacts on long-term survival by Curtis, T.M., Collins, A.M., Gerlach, B.D., Brennan, L.M., Widder, M.W., van der Schalie, W.H., Vo, N.T.K., Bols, N.C.

“…[Display omitted] •Cell-based biosensors have limited field use because of high storage requirements.•We screened cells for extended storage…”
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Heterogeneity in Cytosolic Calcium Regulation among Different Microvascular Smooth Muscle Cells of the Rat Retina by Scholfield, C.Norman, Curtis, Tim M.

“…Rat retinae were dissociated to yield intact microvessels 7 to 42 μm in diameter. These were loaded with fura-2 AM and single fragments anchored down in a…”
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Effects of the organophosphorous pesticide, dimethoate, on cardiac and acetylcholinesterase (AChE) activity in the shore crab Carcinus maenas by Lundebye, A.-K., Curtis, T.M., Braven, J., Depledge, M.H.

“…The potential use of biochemical and physiological responses as biomarkers of organophosphate exposure and/or effect were assessed in the shore crab ( Carcinus…”
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Ca2+ sparks promote myogenic tone in retinal arterioles by Kur, J, Bankhead, P, Scholfield, CN, Curtis, TM, McGeown, JG

“…Background and Purpose Ca2+ imaging reveals subcellular Ca2+ sparks and global Ca2+ waves/oscillations in vascular smooth muscle. It is well established that…”
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Evaluation of N ε-(3-formyl-3,4-dehydropiperidino)lysine as a novel biomarker for the severity of diabetic retinopathy by Zhang, X, Lai, Y, McCance, D. R, Uchida, K, McDonald, D. M, Gardiner, T. A, Stitt, A. W, Curtis, T. M

“…Aims/hypothesis Recent studies suggest that oxidative stress should be monitored alongside HbA₁c to identify subgroups of diabetic patients at high risk of…”
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Transient Ca2+-Activated Cl- Currents with Endothelin in Isolated Arteriolar Smooth Muscle Cells of the Choroid by Curtis, Tim M, Scholfield, C. Norman

“…To characterize the effects of endothelin (ET)-1 on the Ca2+-activated Cl- conductance of choroidal arteriolar smooth muscle. Microvascular smooth muscle cells…”
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