Search Results - "CURTIN, F"

In silico and in vitro screening for potential anticancer candidates targeting GPR120 by Pal, Ajay, Curtin, James F., Kinsella, Gemma K.

“…[Display omitted] •GPR120 (short isoform) homology model used for docking-based virtual screening (DBVS) of ligand database.•Combination approach of in silico…”
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Multiple sclerosis—new chances? by Curtin, F

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Cold Atmospheric Plasma Induces ATP-Dependent Endocytosis of Nanoparticles and Synergistic U373MG Cancer Cell Death by He, Zhonglei, Liu, Kangze, Manaloto, Eline, Casey, Alan, Cribaro, George P., Byrne, Hugh J., Tian, Furong, Barcia, Carlos, Conway, Gillian E., Cullen, Patrick J., Curtin, James F.

“…Gold nanoparticles (AuNP) have potential as both diagnostic and therapeutic vehicles. However, selective targeting and uptake in cancer cells remains…”
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Non-thermal atmospheric plasma induces ROS-independent cell death in U373MG glioma cells and augments the cytotoxicity of temozolomide by Conway, Gillian E, Casey, Alan, Milosavljevic, Vladimir, Liu, Yupeng, Howe, Orla, Cullen, Patrick J, Curtin, James F

“…Background: Non-thermal atmospheric plasma (NTAP) is an ionised gas produced under high voltage that can generate short-lived chemically active species and…”
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Synthesis of cationic liposome nanoparticles using a thin film dispersed hydration and extrusion method by Cazzolla, Alessandro, Mondala, Julie Rose Mae, Wanigasekara, Janith, Carroll, Joanna, Daly, Noah, Tiwari, Brijesh, Casey, Alan, Curtin, James F

“…Liposome nanoparticles can carry a wide range of therapeutic molecules including small molecules and nucleic acid-based therapeutics. Potential benefits…”
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Three-Dimensional (3D) in vitro cell culture protocols to enhance glioblastoma research by Wanigasekara, Janith, Carroll, Lara J, Cullen, Patrick J, Tiwari, Brijesh, Curtin, James F

“…Three-dimensional (3D) cell culture models can help bridge the gap between in vitro cell cultures and in vivo responses by more accurately simulating the…”
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Regulation and measurement of oxidative stress in apoptosis by Curtin, James F, Donovan, Maryanne, Cotter, Thomas G

“…Cells are constantly generating reactive oxygen species (ROS) during aerobic metabolism. As a consequence, each cell is equipped with an extensive antioxidant…”
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Inactivation efficacy of atmospheric air plasma and airborne acoustic ultrasound against bacterial biofilms by Patange, Apurva D., Simpson, Jeremy C., Curtin, James F., Burgess, Catherine M., Cullen, P. J., Tiwari, Brijesh K.

“…Biofilms are complex microbial communities that present serious contamination risks to our environment and health. In this study, atmospheric air plasma and…”
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Cold Atmospheric Plasma induces accumulation of lysosomes and caspase-independent cell death in U373MG glioblastoma multiforme cells by Conway, Gillian E., He, Zhonglei, Hutanu, Ana Lacramioara, Cribaro, George Paul, Manaloto, Eline, Casey, Alan, Traynor, Damien, Milosavljevic, Vladimir, Howe, Orla, Barcia, Carlos, Murray, James T., Cullen, Patrick J., Curtin, James F.

“…Room temperature Cold Atmospheric Plasma (CAP) has shown promising efficacy for the treatment of cancer but the exact mechanisms of action remain unclear. Both…”
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A novel, rapid, seedless, in situ synthesis method of shape and size controllable gold nanoparticles using phosphates by Liu, Kangze, He, Zhonglei, Curtin, James F., Byrne, Hugh J., Tian, Furong

“…We hereby report a novel synthesis method of size and shape controllable gold nanoparticles that is rapid, in situ and seedless. Unlike most currently employed…”
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HMGB1 mediates endogenous TLR2 activation and brain tumor regression by Curtin, James F, Liu, Naiyou, Candolfi, Marianela, Xiong, Weidong, Assi, Hikmat, Yagiz, Kader, Edwards, Matthew R, Michelsen, Kathrin S, Kroeger, Kurt M, Liu, Chunyan, Muhammad, A K M Ghulam, Clark, Mary C, Arditi, Moshe, Comin-Anduix, Begonya, Ribas, Antoni, Lowenstein, Pedro R, Castro, Maria G

“…Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor that carries a 5-y survival rate of 5%. Attempts at eliciting a clinically relevant…”
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Treg depletion inhibits efficacy of cancer immunotherapy: implications for clinical trials by Curtin, James F, Candolfi, Marianela, Fakhouri, Tamer M, Liu, Chunyan, Alden, Anderson, Edwards, Matthew, Lowenstein, Pedro R, Castro, Maria G

“…Regulatory T lymphocytes (Treg) infiltrate human glioblastoma (GBM); are involved in tumor progression and correlate with tumor grade. Transient elimination of…”
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Structure based prediction of a novel GPR120 antagonist based on pharmacophore screening and molecular dynamics simulations by Pal, Ajay, Curtin, James F., Kinsella, Gemma K.

“…[Display omitted] •Hypothesis of the important residues in conserving the GPR120S “ionic-lock”.•Computational model targeting W277 and N313 for virtual…”
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Ursolic Acid Inhibits Collective Cell Migration and Promotes JNK-Dependent Lysosomal Associated Cell Death in Glioblastoma Multiforme Cells by Conway, Gillian E, Zizyte, Deimante, Mondala, Julie Rose Mae, He, Zhonglei, Lynam, Lorna, Lecourt, Mathilde, Barcia, Carlos, Howe, Orla, Curtin, James F

“…Ursolic acid (UA) is a bioactive compound which has demonstrated therapeutic efficacy in a variety of cancer cell lines. UA activates various signalling…”
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Quantitative reagent-free detection of fibrinogen levels in human blood plasma using Raman spectroscopy by Poon, Kelvin W C, Lyng, Fiona M, Knief, Peter, Howe, Orla, Meade, Aidan D, Curtin, James F, Byrne, Hugh J, Vaughan, Joe

“…Fibrinogen assays are commonly used as part of clinical screening tests to investigate haemorrhagic states, for detection of disseminated intravascular…”
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Gene therapy and targeted toxins for glioma by Castro, Maria G, Candolfi, Marianela, Kroeger, Kurt, King, Gwendalyn D, Curtin, James F, Yagiz, Kader, Mineharu, Yohei, Assi, Hikmat, Wibowo, Mia, Ghulam Muhammad, A K M, Foulad, David, Puntel, Mariana, Lowenstein, Pedro R

“…The most common primary brain tumor in adults is glioblastoma. These tumors are highly invasive and aggressive with a mean survival time of 15-18 months from…”
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B Cells Are Critical to T-cell—Mediated Antitumor Immunity Induced by a Combined Immune-Stimulatory/Conditionally Cytotoxic Therapy for Glioblastoma by Candolfi, Marianela, Curtin, James F, Yagiz, Kader, Assi, Hikmat, Wibowo, Mia K, Alzadeh, Gabrielle E, Foulad, David, Muhammad, AKM G, Salehi, Sofia, Keech, Naomi, Puntel, Mariana, Liu, Chunyan, Sanderson, Nicholas R, Kroeger, Kurt M, Dunn, Robert, Martins, Gislaine, Lowenstein, Pedro R, Castro, Maria G

“…Abstract We have demonstrated that modifying the tumor microenvironment through intratumoral administration of adenoviral vectors (Ad) encoding the conditional…”
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Hyperbranched Poly(β-amino ester)s (HPAEs) Structure Optimisation for Enhanced Gene Delivery: Non-Ideal Termination Elimination by Li, Yinghao, He, Zhonglei, Lyu, Jing, Wang, Xianqing, Qiu, Bei, Lara-Sáez, Irene, Zhang, Jing, Zeng, Ming, Xu, Qian, A, Sigen, Curtin, James F., Wang, Wenxin

“…Many polymeric gene delivery nano-vectors with hyperbranched structures have been demonstrated to be superior to their linear counterparts. The higher delivery…”
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Plasmacytoid Dendritic Cells in the Tumor Microenvironment: Immune Targets for Glioma Therapeutics by Candolfi, Marianela, King, Gwendalyn D, Yagiz, Kader, Curtin, James F, Mineharu, Yohei, Muhammad, AKM Ghulam, Foulad, David, Kroeger, Kurt M, Barnett, Nick, Josien, Regis, Lowenstein, Pedro R, Castro, Maria G

“…Abstract Adenovirus-mediated delivery of the immune-stimulatory cytokine Flt3L and the conditionally cytotoxic thymidine kinase (TK) induces tumor regression…”
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Release of HMGB1 in Response to Proapoptotic Glioma Killing Strategies: Efficacy and Neurotoxicity by CANDOLFI, Marianela, YAGIZ, Kader, CURTIN, James F, KING, Gwendalyn D, LERNER, Jonathan, SATO, Katsuaki, MINEHARU, Yohei, WEIDONG XIONG, LOWENSTEIN, Pedro R, CASTRO, Maria G, FOULAD, David, ALZADEH, Gabrielle E, TESARFREUND, Matthew, GHULAM MUHAMMAD, A. K. M, PUNTEL, Mariana, KROEGER, Kurt M, CHUNYAN LIU, LEE, Sharon

“…Purpose: In preparation for a phase I clinical trial using a combined cytotoxic/immunotherapeutic strategy with adenoviruses (Ad) expressing Flt3L (Ad-Flt3L)…”
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