Search Results - "CURRIER, Nicolas"

The Eye As a Biomarker for Alzheimer's Disease by Lim, Jeremiah K H, Li, Qiao-Xin, He, Zheng, Vingrys, Algis J, Wong, Vickie H Y, Currier, Nicolas, Mullen, Jamie, Bui, Bang V, Nguyen, Christine T O

“…Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in dementia and eventual death. It is the leading cause of dementia and the…”
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Targeted Drug Delivery with an Integrin-Binding Knottin-Fc-MMAF Conjugate Produced by Cell-Free Protein Synthesis by Currier, Nicolas V, Ackerman, Shelley E, Kintzing, James R, Chen, Rishard, Filsinger Interrante, Maria, Steiner, Alexander, Sato, Aaron K, Cochran, Jennifer R

“…Antibody-drug conjugates (ADC) have generated significant interest as targeted therapeutics for cancer treatment, demonstrating improved clinical efficacy and…”
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Convective forces increase rostral delivery of intrathecal radiotracers and antisense oligonucleotides in the cynomolgus monkey nervous system by Sullivan, Jenna M, Mazur, Curt, Wolf, Daniel A, Horky, Laura, Currier, Nicolas, Fitzsimmons, Bethany, Hesterman, Jacob, Pauplis, Rachel, Haller, Scott, Powers, Berit, Tayefeh, Leighla, DeBrosse-Serra, Bea, Hoppin, Jack, Kordasiewicz, Holly, Swayze, Eric E, Verma, Ajay

“…The intrathecal (IT) dosing route introduces drugs directly into the CSF to bypass the blood-brain barrier and gain direct access to the CNS. We evaluated the…”
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Cystine-knot peptides: emerging tools for cancer imaging and therapy by Ackerman, Shelley E, Currier, Nicolas V, Bergen, Jamie M, Cochran, Jennifer R

“…Cystine-knot miniproteins, also known as knottins, constitute a large family of structurally related peptides with diverse amino acid sequences and biological…”
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Dynamic expression of a LEF-EGFP Wnt reporter in mouse development and cancer by Currier, Nicolas, Chea, Kathleen, Hlavacova, Mirka, Sussman, Daniel J., Seldin, David C., Dominguez, Isabel

“…We have characterized a transgenic mouse line in which enhanced green fluorescent protein (EGFP) is expressed under the control of multimerized LEF‐1…”
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Impact of radionuclide selection in radiation dosimetry for intrathecally administered imaging tracers by Hesterman, Jacob, Kost, Susan, Sullivan, Jenna, Currier, Nicolas

“…Introduction: Intrathecal (IT) administration is experiencing renewed interest as a potential delivery method for large molecules, such as antisense…”
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Incidence of Venous Thromboembolic Events Among Amyotrophic Lateral Sclerosis Patients in a US Health Insurance Claims Database (P4.6-003) by Kupelian, Varant, Viscidi, Emma, Hall, Sue, Li, Li, Eaton, Susan, Dilley, Anne, Currier, Nicolas, Ferguson, Toby, Fanning, Laura

“…Abstract only…”
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Increased Risk of Venous Thromboembolism in Patients With Amyotrophic Lateral Sclerosis: Results From a US Insurance Claims Database Study by Kupelian, Varant, Viscidi, Emma, Hall, Susan, Li, Li, Eaton, Susan, Dilley, Anne, Currier, Nicolas, Ferguson, Toby, Fanning, Laura

“…Reduced mobility in patients with amyotrophic lateral sclerosis (ALS) is hypothesized to increase the risk of venous thromboembolism (VTE). A few small,…”
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Polyglutamine (CAG) Intermediate Repeat Expansions in ATXN2 is Associated with a More Aggressive Form of ALS Across Multiple Independent Cohorts (2094) by McMillan, Corey, Tsai, Ellen, Hurt, Jessica, Wuu, Joanne, Ford, Alice, Van Deerlin, Vivianna, Elman, Lauren, Quinn, Colin, McCluskey, Leo, Liu, Mei, Chang, Ih, Rademakers, Rosa, Van Blitterswijk, Marka, Sun, Chao, Consortium, CReATe, Benatar, Michael, Harms, Matthew, Currier, Nicolas

“…Abstract only…”
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Skin Blood Flow Measured By LSCI Demonstrates Treatment Effect of Chronic Transfusion Protocol in Sickle Cell Disease by Currier, Nicolas V, Dent, Gersham, Swerdlow, Paul S., Birkhoff, Willem, Burggraaf, Jacobus, de Vries, Jaspert, Neelavalli, Jaladhar, Shahid, Muhammad, Yadav, Brijesh K, Hobbs, William E., Verma, Ajay

“…Background: Vascular complications such as stroke and pulmonary hypertension are central features of sickle cell disease (SCD) pathophysiology and are…”
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CK2 as a positive regulator of Wnt signalling and tumourigenesis by Seldin, David C, Landesman-Bollag, Esther, Farago, Marganit, Currier, Nicolas, Lou, David, Dominguez, Isabel

“…CK2 is upregulated in rapidly dividing cells including most human tumours. Transgenic overexpression of CK2 in lymphoid or mammary lineages predisposes to…”
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Oncogenic Signaling Pathways Activated in DMBA-Induced Mouse Mammary Tumors by Currier, Nicolas, Solomon, Sandra E., Demicco, Elizabeth G., Chang, Donny L. F., Farago, Marganit, Ying, Haoqiang, Dominguez, Isabel, Sonenshein, Gail E., Cardiff, Robert D., Xiao, Zhi-Xiong Jim, Sherr, David H., Seldin, David C.

“…Only about 5% of human breast cancers can be attributed to inheritance of breast cancer susceptibility genes, while the balance are considered to be sporadic…”
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Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor by JANI, Jitesh P, FINN, Richard S, MORRIS, Joel, MOYER, James D, PUSTILNIK, Leslie R, RAFIDI, Kristina, RALSTON, Sherry, ROSSI, Ann Marie K, STEYN, Stefanus J, WAGNER, Larry, WINTER, Steven M, BHATTACHARYA, Samit K, CAMPBELL, Mary, COLEMAN, Kevin G, CONNELL, Richard D, CURRIER, Nicolas, EMERSON, Erling O, FLOYD, Eugenia, HARRIMAN, Shawn, KATH, John C

“…Amplification and overexpression of erbB2 (Her-2/neu) proto-oncogene has been linked to human malignancies including tumors of the breast, ovary, and stomach…”
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Eμ-BRD2 transgenic mice develop B-cell lymphoma and leukemia by Greenwald, Rebecca J., Tumang, Joseph R., Sinha, Anupama, Currier, Nicolas, Cardiff, Robert D., Rothstein, Thomas L., Faller, Douglas V., Denis, Gerald V.

“…Transgenic mice with lymphoid-restricted overexpression of the double bromodomain protein bromodomain-containing 2 (Brd2) develop splenic B-cell lymphoma and,…”
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Serine /threonine kinase CK2 and Wnt signaling in carcinogen-induced mouse mammary tumorigenesis by Currier, Nicolas Vix

“…Breast cancer incidence appears to vary with diet and other environmental influences, including carcinogen exposure. However, the effects of environmental…”
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Serine/threonine kinase CK2 and Wnt signaling in carcinogen-induced mouse mammary tumorigenesis by Currier, Nicolas Vix

“…Breast cancer incidence appears to vary with diet and other environmental influences, including carcinogen exposure. However, the effects of environmental…”
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