Search Results - "CURIEL, David T"

Adenoviral vector vaccine platforms in the SARS-CoV-2 pandemic by Mendonça, Samir Andrade, Lorincz, Reka, Boucher, Paul, Curiel, David T.

“…Adenoviral vectors have been explored as vaccine agents for a range of infectious diseases, and their ability to induce a potent and balanced immune response…”
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A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2 by Hassan, Ahmed O., Kafai, Natasha M., Dmitriev, Igor P., Fox, Julie M., Smith, Brittany K., Harvey, Ian B., Chen, Rita E., Winkler, Emma S., Wessel, Alex W., Case, James Brett, Kashentseva, Elena, McCune, Broc T., Bailey, Adam L., Zhao, Haiyan, VanBlargan, Laura A., Dai, Ya-Nan, Ma, Meisheng, Adams, Lucas J., Shrihari, Swathi, Danis, Jonathan E., Gralinski, Lisa E., Hou, Yixuan J., Schäfer, Alexandra, Kim, Arthur S., Keeler, Shamus P., Weiskopf, Daniela, Baric, Ralph S., Holtzman, Michael J., Fremont, Daved H., Curiel, David T., Diamond, Michael S.

“…The coronavirus disease 2019 pandemic has made deployment of an effective vaccine a global health priority. We evaluated the protective activity of a…”
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Long-term correction of hemophilia B using adenoviral delivery of CRISPR/Cas9 by Stephens, Calvin J., Lauron, Elvin J., Kashentseva, Elena, Lu, Zhi Hong, Yokoyama, Wayne M., Curiel, David T.

“…Hemophilia B (HB) is a life-threatening inherited disease caused by mutations in the FIX gene, leading to reduced protein function and abnormal blood clotting…”
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Targeted in vivo knock-in of human alpha-1-antitrypsin cDNA using adenoviral delivery of CRISPR/Cas9 by Stephens, Calvin J., Kashentseva, Elena, Everett, William, Kaliberova, Lyudmila, Curiel, David T.

“…Serum deficiency diseases such as alpha-1-antitrypsin deficiency are characterized by reduced function of serum proteins, caused by deleterious genetic…”
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An intranasal vaccine durably protects against SARS-CoV-2 variants in mice by Hassan, Ahmed O., Shrihari, Swathi, Gorman, Matthew J., Ying, Baoling, Yaun, Dansu, Raju, Saravanan, Chen, Rita E., Dmitriev, Igor P., Kashentseva, Elena, Adams, Lucas J., Mann, Colin, Davis-Gardner, Meredith E., Suthar, Mehul S., Shi, Pei-Yong, Saphire, Erica Ollmann, Fremont, Daved H., Curiel, David T., Alter, Galit, Diamond, Michael S.

“…SARS-CoV-2 variants that attenuate antibody neutralization could jeopardize vaccine efficacy. We recently reported the protective activity of an intranasally…”
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Mesenchymal Stem Cells Successfully Deliver Oncolytic Virotherapy to Diffuse Intrinsic Pontine Glioma by Chastkofsky, Michael I, Pituch, Katarzyna C, Katagi, Hiroaki, Zannikou, Markella, Ilut, Liliana, Xiao, Ting, Han, Yu, Sonabend, Adam M, Curiel, David T, Bonner, Erin R, Nazarian, Javad, Horbinski, Craig M, James, C David, Saratsis, Amanda M, Hashizume, Rintaro, Lesniak, Maciej S, Balyasnikova, Irina V

“…Diffuse intrinsic pontine glioma (DIPG) is among the deadliest of pediatric brain tumors. Radiotherapy is the standard-of-care treatment for DIPG, but offers…”
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A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques by Hassan, Ahmed O., Feldmann, Friederike, Zhao, Haiyan, Curiel, David T., Okumura, Atsushi, Tang-Huau, Tsing-Lee, Case, James Brett, Meade-White, Kimberly, Callison, Julie, Chen, Rita E., Lovaglio, Jamie, Hanley, Patrick W., Scott, Dana P., Fremont, Daved H., Feldmann, Heinz, Diamond, Michael S.

“…The deployment of a vaccine that limits transmission and disease likely will be required to end the coronavirus disease 2019 (COVID-19) pandemic. We recently…”
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Radiation-induced cell signaling: inside-out and outside-in by Valerie, Kristoffer, Yacoub, Adly, Hagan, Michael P, Curiel, David T, Fisher, Paul B, Grant, Steven, Dent, Paul

“…Exposure of tumor cells to clinically relevant doses of ionizing radiation causes DNA damage as well as mitochondria-dependent generation of reactive oxygen…”
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The N-Terminal Domain of SIRT1 Is a Positive Regulator of Endogenous SIRT1-Dependent Deacetylation and Transcriptional Outputs by Ghisays, Fiorella, Brace, Cynthia S., Yackly, Shawn M., Kwon, Hyock Joo, Mills, Kathryn F., Kashentseva, Elena, Dmitriev, Igor P., Curiel, David T., Imai, Shin-ichiro, Ellenberger, Tom

“…The NAD+-dependent protein deacetylase SIRT1 regulates energy metabolism, responses to stress, and aging by deacetylating many different proteins, including…”
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A Gorilla Adenovirus-Based Vaccine against Zika Virus Induces Durable Immunity and Confers Protection in Pregnancy by Hassan, Ahmed O., Dmitriev, Igor P., Kashentseva, Elena A., Zhao, Haiyan, Brough, Douglas E., Fremont, Daved H., Curiel, David T., Diamond, Michael S.

“…The teratogenic potential of Zika virus (ZIKV) has made the development of an effective vaccine a global health priority. Here, we generate two gorilla…”
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Engineering a Novel Modular Adenoviral mRNA Delivery Platform Based on Tag/Catcher Bioconjugation by Geng, Kexin, Rice-Boucher, Paul J, Kashentseva, Elena A, Dmitriev, Igor P, Lu, Zhi Hong, Goedegebuure, S Peter, Gillanders, William E, Curiel, David T

“…mRNA vaccines have attracted widespread research attention with clear advantages in terms of molecular flexibility, rapid development, and potential for…”
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In vivo editing of the pan-endothelium by immunity evading simian adenoviral vector by Lorincz, Reka, Alvarez, Aluet Borrego, Walkey, Christopher J., Mendonça, Samir A., Lu, Zhi Hong, Martinez, Alexa E., Ljungberg, Cecilia, Heaney, Jason D., Lagor, William R., Curiel, David T.

“…Biological applications deriving from the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 site-specific nuclease system continue to…”
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Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity by Dash, Rupesh, Azab, Belal, Quinn, Bridget A, Shen, Xuening, Wang, Xiang-Yang, Das, Swadesh K, Rahmani, Mohamed, Wei, Jun, Hedvat, Michael, Dent, Paul, Dmitriev, Igor P, Curiel, David T, Grant, Steven, Wu, Bainan, Stebbins, John L, Pellecchia, Maurizio, Reed, John C, Sarkar, Devanand, Fisher, Paul B

“…Limited options are available for treating patients with advanced prostate cancer (PC). Melanoma differentiation associated gene-7/interleukin-24…”
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In Vitro and In Vivo Efficacy of a Stroma-Targeted, Tumor Microenvironment Responsive Oncolytic Adenovirus in Different Preclinical Models of Cancer by Alfano, Ana, Cafferata, Eduardo G A, Gangemi, Mariela, Nicola Candia, Alejandro, Malnero, Cristian M, Bermudez, Ismael, Lopez, Mauricio Vargas, Ríos, Gregorio David, Rotondaro, Cecilia, Cuneo, Nicasio, Curiel, David T, Podhajcer, Osvaldo L, Lopez, Maria Veronica

“…More than one million women are diagnosed annually worldwide with a gynecological cancer. Most gynecological cancers are diagnosed at a late stage, either…”
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Mesenchymal progenitor cells as cellular vehicles for delivery of oncolytic adenoviruses by Komarova, Svetlana, Kawakami, Yosuke, Stoff-Khalili, Mariam A, Curiel, David T, Pereboeva, Larisa

“…Natural and genetically modified oncolytic viruses have been systematically tested as anticancer therapeutics. Among this group, conditionally replicative…”
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Phase III Pivotal comparative clinical trial of intranasal (iNCOVACC) and intramuscular COVID 19 vaccine (Covaxin®) by Singh, Chandramani, Verma, Savita, Reddy, Prabhakar, Diamond, Michael S., Curiel, David T., Patel, Chintan, Jain, Manish Kumar, Redkar, Sagar Vivek, Bhate, Amit Suresh, Gundappa, Vivek, Konatham, Rambabu, Toppo, Leelabati, Joshi, Aniket Chandrakant, Kushwaha, Jitendra Singh, Singh, Ajit Pratap, Bawankule, Shilpa, Ella, Raches, Prasad, Sai, Ganneru, Brunda, Chiteti, Siddharth Reddy, Kataram, Sreenivas, Vadrevu, Krishna Mohan

“…One of the most preferable characteristics for a COVID-19 vaccine candidate is the ability to reduce transmission and infection of SARS-CoV-2, in addition to…”
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Species D human adenovirus type 9 exhibits better virus-spread ability for antitumor efficacy among alternative serotypes by Uchino, Junji, Curiel, David T, Ugai, Hideyo

“…Species C human adenovirus serotype 5 (HAdV-C5) is widely used as a vector for cancer gene therapy, because it efficiently transduces target cells. A variety…”
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A Novel Piggyback Strategy for mRNA Delivery Exploiting Adenovirus Entry Biology by Lee, Myungeun, Rice-Boucher, Paul J, Collins, Logan Thrasher, Wagner, Ernst, Aulisa, Lorenzo, Hughes, Jeffrey, Curiel, David T

“…Molecular therapies exploiting mRNA vectors embody enormous potential, as evidenced by the utility of this technology for the context of the COVID-19 pandemic…”
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Adenovirus platform enhances transduction efficiency of human mesenchymal stem cells: An opportunity for cellular carriers of targeted TRAIL-based TR3 biologics in ovarian cancer by Kuroki, Lindsay M, Jin, Xingjian, Dmitriev, Igor P, Kashentseva, Elena A, Powell, Matthew A, Mutch, David G, Dietz, Allan B, Curiel, David T, Hawkins, William G, Spitzer, Dirk

“…Clinical application of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-based cancer therapeutics has not reached optimal potencies in part due…”
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Prolonged prophylactic protection from botulism with a single adenovirus treatment promoting serum expression of a VHH-based antitoxin protein by Mukherjee, Jean, Dmitriev, Igor, Debatis, Michelle, Tremblay, Jacqueline M, Beamer, Gillian, Kashentseva, Elena A, Curiel, David T, Shoemaker, Charles B

“…Current therapies for most acute toxin exposures are limited to administration of polyclonal antitoxin serum. We have shown that VHH-based neutralizing agents…”
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