Search Results - "CUNNINGHAM, JESSICA"

Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer by Zhang, Jingsong, Cunningham, Jessica J., Brown, Joel S., Gatenby, Robert A.

“…Abiraterone treats metastatic castrate-resistant prostate cancer by inhibiting CYP17A, an enzyme for testosterone auto-production. With standard dosing,…”
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Evolution-based mathematical models significantly prolong response to abiraterone in metastatic castrate-resistant prostate cancer and identify strategies to further improve outcomes by Zhang, Jingsong, Cunningham, Jessica, Brown, Joel, Gatenby, Robert

“…Abiraterone acetate is an effective treatment for metastatic castrate-resistant prostate cancer (mCRPC), but evolution of resistance inevitably leads to…”
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Optimal control to develop therapeutic strategies for metastatic castrate resistant prostate cancer by Cunningham, Jessica J., Brown, Joel S., Gatenby, Robert A., Staňková, Kateřina

“…•Optimal control is applied to a game theoretic model of prostate cancer treatment.•Current clinical treatment schedules are compared to novel optimized…”
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Darwinian Dynamics of Intratumoral Heterogeneity: Not Solely Random Mutations but Also Variable Environmental Selection Forces by Lloyd, Mark C, Cunningham, Jessica J, Bui, Marilyn M, Gillies, Robert J, Brown, Joel S, Gatenby, Robert A

“…Spatial heterogeneity in tumors is generally thought to result from branching clonal evolution driven by random mutations that accumulate during tumor…”
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Evaluation of the oxidase like activity of nanoceria and its application in colorimetric assays by Hayat, Akhtar, Cunningham, Jessica, Bulbul, Gonca, Andreescu, Silvana

“…[Display omitted] •The oxidase mimetic properties of nanoceria against phenolics are demonstrated.•Colorimetric detection using a nanoceria assay is…”
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Asymptomatic Myometrial Dehiscence in Pregnancy by Cunningham, Jessica G., Summerell, Lauren, Mather, Andrew, Balica, Adrian

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Observations of Ramadan fasting in the initial year after bariatric surgery by Wafa, Ala, Cunningham, Jessica G., Shagan, Ali, Naji, Suleiman, Friwan, Rawad, Abunnaja, Salim

“…Ramadan is considered to be the holiest month of the Islamic religion. Hundreds of millions of Muslims practice the commitments of Ramadan, which include the…”
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A call for integrated metastatic management by Cunningham, Jessica J.

“…Metastatic disease remains invariably fatal. Until truly curative therapies are developed, can clinical oncology benefit from lessons learned in pest…”
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Cytoplasmic convection currents and intracellular temperature gradients by Howard, Rachel, Scheiner, Aaron, Cunningham, Jessica, Gatenby, Robert

“…Intracellular thermometry has recently demonstrated temperatures in the nucleus, mitochondria, and centrosome to be significantly higher than those of the…”
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Optimal control to reach eco-evolutionary stability in metastatic castrate-resistant prostate cancer by Cunningham, Jessica, Thuijsman, Frank, Peeters, Ralf, Viossat, Yannick, Brown, Joel, Gatenby, Robert, Staňková, Kateřina

“…In the absence of curative therapies, treatment of metastatic castrate-resistant prostate cancer (mCRPC) using currently available drugs can be improved by…”
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Frequency-dependent interactions determine outcome of competition between two breast cancer cell lines by Freischel, Audrey R., Damaghi, Mehdi, Cunningham, Jessica J., Ibrahim-Hashim, Arig, Gillies, Robert J., Gatenby, Robert A., Brown, Joel S.

“…Tumors are highly dynamic ecosystems in which diverse cancer cell subpopulations compete for space and resources. These complex, often non-linear interactions…”
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Spatial vs. non-spatial eco-evolutionary dynamics in a tumor growth model by You, Li, Brown, Joel S., Thuijsman, Frank, Cunningham, Jessica J., Gatenby, Robert A., Zhang, Jingsong, Staňková, Kateřina

“…•Cancer is an evolutionary spatial game in which different cell types compete for resources to proliferate and survive.•This paper analyzes a spatial game of…”
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Preoperative and early adjuvant weight loss medications in bariatric surgery patients with body mass index over 60 or suboptimal initial response to surgery by Cunningham, Jessica G, Szoka, Nova, Tabone, Lawrence E, Cox, Stephanie, Aylward, Laura, Abunnaja, Salim

“…Few studies have examined the adjuvant use of antiobesity medications with surgery, especially in the pre- and early postoperative periods. Evaluate the impact…”
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Mutations in ARL2BP, a protein required for ciliary microtubule structure, cause syndromic male infertility in humans and mice by Moye, Abigail R, Bedoni, Nicola, Cunningham, Jessica G, Sanzhaeva, Urikhan, Tucker, Eric S, Mathers, Peter, Peter, Virginie G, Quinodoz, Mathieu, Paris, Liliana P, Coutinho-Santos, Luísa, Camacho, Pedro, Purcell, Madeleine G, Winkelmann, Abbie C, Foster, James A, Pugacheva, Elena N, Rivolta, Carlo, Ramamurthy, Visvanathan

“…Cilia are evolutionarily conserved hair-like structures with a wide spectrum of key biological roles, and their dysfunction has been linked to a growing class…”
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JNK signaling is required for proper tangential migration and laminar allocation of cortical interneurons by Myers, Abigail K, Cunningham, Jessica G, Smith, Skye E, Snow, John P, Smoot, Catherine A, Tucker, Eric S

“…The precise migration of cortical interneurons is essential for the formation and function of cortical circuits, and disruptions to this key developmental…”
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Response to Mistry by Zhang, Jingsong, Cunningham, Jessica J., Brown, Joel S., Gatenby, Robert A.

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Early construction of the thalamocortical axon pathway requires c‐Jun N‐terminal kinase signaling within the ventral forebrain by Cunningham, Jessica G., Scripter, James D., Nti, Stephany A., Tucker, Eric S.

“…Background Thalamocortical connectivity is essential for normal brain function. This important pathway is established during development, when thalamic axons…”
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Fighting microbial pathogens by integrating host ecosystem interactions and evolution by Burmeister, Alita R., Hansen, Elsa, Cunningham, Jessica J., Rego, E. Hesper, Turner, Paul E., Weitz, Joshua S., Hochberg, Michael E.

“…Successful therapies to combat microbial diseases and cancers require incorporating ecological and evolutionary principles. Drawing upon the fields of ecology…”
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Aggregation Effects and Population-Based Dynamics as a Source of Therapy Resistance in Cancer by Brown, Joel S., Cunningham, Jessica J., Gatenby, Robert A.

“…Objective: Evolution of resistance allows cancer cells to adapt and continue proliferating even when therapy is initially very effective. Most investigations…”
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Resistance is not the end: lessons from pest management by Whelan, Christopher J., Cunningham, Jessica J.

“…The “war on cancer” began over 40 years ago with the signing of the National Cancer Act of 1971. Currently, complete eradication has proven possible in early…”
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