Search Results - "CUMMINS, James E"

Preclinical Testing of Candidate Topical Microbicides for Anti-Human Immunodeficiency Virus Type 1 Activity and Tissue Toxicity in a Human Cervical Explant Culture by CUMMINS, James E, GUARNER, Jeannette, FLOWERS, Lisa, GUENTHNER, Patricia C, BARTLETT, Jeanine, MORKEN, Timothy, GROHSKOPF, Lisa A, PAXTON, Lynn, DEZZUTTI, Charlene S

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Charlene Susan Dezzutti (1964-2018) Virologist with a Passion for HIV Prevention by Hillier, Sharon L, Cummins, Jr, James E, Rohan, Lisa C

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Biological and Technical Variables Affecting Immunoassay Recovery of Cytokines from Human Serum and Simulated Vaginal Fluid: A Multicenter Study by Fichorova, Raina N, Richardson-Harman, Nicola, Alfano, Massimo, Belec, Laurent, Carbonneil, Cedric, Chen, Silvia, Cosentino, Lisa, Curtis, Kelly, Dezzutti, Charlene S, Donoval, Betty, Doncel, Gustavo F, Donaghay, Melissa, Grivel, Jean-Charles, Guzman, Esmeralda, Hayes, Madeleine, Herold, Betsy, Hillier, Sharon, Lackman-Smith, Carol, Landay, Alan, Margolis, Leonid, Mayer, Kenneth H, Pasicznyk, Jenna-Malia, Pallansch-Cokonis, Melanie, Poli, Guido, Reichelderfer, Patricia, Roberts, Paula, Rodriguez, Irma, Saidi, Hela, Sassi, Rosaria Rita, Shattock, Robin, Cummins, Jr, James E

“…The increase of proinflammatory cytokines in vaginal secretions may serve as a surrogate marker of unwanted inflammatory reaction to microbicide products…”
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Biomedical, socio-behavioral, and implementation science gaps in multipurpose prevention technology research by Cummins, James E., Allen, C. Leigh, Lee, Sonia, Senn, Theresa E.

“…There is strong global need for the development of Multipurpose Prevention Technologies (MPTs) that prevent HIV, pregnancy, and/or other sexually transmitted…”
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Multisite Comparison of Anti-Human Immunodeficiency Virus Microbicide Activity in Explant Assays Using a Novel Endpoint Analysis by Richardson-Harman, Nicola, Lackman-Smith, Carol, Fletcher, Patricia S, Anton, Peter A, Bremer, James W, Dezzutti, Charlene S, Elliott, Julie, Grivel, Jean-Charles, Guenthner, Patricia, Gupta, Phalguni, Jones, Maureen, Lurain, Nell S, Margolis, Leonid B, Mohan, Swarna, Ratner, Deena, Reichelderfer, Patricia, Roberts, Paula, Shattock, Robin J, Cummins, James E. Jr

“…Microbicide candidates with promising in vitro activity are often advanced for evaluations using human primary tissue explants relevant to the in vivo mucosal…”
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Development of a Comprehensive Human Immunodeficiency Virus Type 1 Screening Algorithm for Discovery and Preclinical Testing of Topical Microbicides by LACKMAN-SMITH, Carol, OSTERLING, Clay, WATSON, Karen M, CUMMINS, James E, SANDERS-BEER, Brigitte E, LUCKENBAUGH, Katherine, MANKOWSKI, Marie, SNYDER, Beth, LEWIS, Gareth, PAULL, Jeremy, PROFY, Albert, PTAK, Roger G, BUCKHEIT, Robert W

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A Human Colorectal Explant Culture to Evaluate Topical Microbicides for the Prevention of HIV Infection by Abner, Sheila R. , Guenthner, Patricia C. , Guarner, Jeannette , Hancock, Kelly A. , Cummins, James E. , Fink, Aaron , Gilmore, G. Thomas , Staley, Charles , Ward, Albert , Ali, Odessa , Binderow, Sander , Cohen, Stephen , Grohskopf, Lisa A. , Paxton, Lynn , Hart, Clyde E. , Dezzutti, Charlene S. 

“…A human colorectal explant culture was developed to assess the safety and efficacy of topical microbicides proposed for use in humans. Because any product…”
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Biomarkers of Cervicovaginal Inflammation for the Assessment of Microbicide Safety by Cummins, James E., Doncel, Gustavo F.

“…The human cervicovaginal mucosa is the primary target of HIV-1 infection during male to female transmission. This tissue contains the the full spectrum of cell…”
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Safety and anti-HIV assessments of natural vaginal cleansing products in an established topical microbicides in vitro testing algorithm by Lackman-Smith, Carol S, Snyder, Beth A, Marotte, Katherine M, Osterling, Mark C, Mankowski, Marie K, Jones, Maureen, Nieves-Duran, Lourdes, Richardson-Harman, Nicola, Cummins, Jr, James E, Sanders-Beer, Brigitte E

“…At present, there is no effective vaccine or other approved product for the prevention of sexually transmitted human immunodeficiency virus type 1 (HIV-1)…”
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Cervical and Prostate Primary Epithelial Cells Are Not Productively Infected but Sequester Human Immunodeficiency Virus Type 1 by Dezzutti, Charlene S., Guenthner, Patricia C., Cummins, James E., Cabrera, Thania, Marshall, James H., Dillberger, Alexa, Lal, Renu B.

“…Primary prostate and cervical epithelial cells and epithelial cell lines were examined for human immunodeficiency virus type 1 (HIV-1) infection or…”
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Mucosal and Systemic Antibody Responses in Humans Infected with Simian Foamy Virus by CUMMINS, James E, BONEVA, Roumiana S, SWITZER, William M, CHRISTENSEN, Logan L, SANDSTROM, Paul, HENEINE, Walid, CHAPMAN, Louisa E, DEZZUTTI, Charlene S

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Mucosal innate immune factors in secretions from high-risk individuals immunized with a bivalent gp120 vaccine by Cummins, Jr, James E, Denniston, Maxine, Mayer, Kenneth H, Pickard, Robert, Novak, Richard M, Graham, Parrie, Gurwith, Marc, Orelind, Karen, Ackers, Marta L, Dezzutti, Charlene S

“…This study examined the effect of an HIV vaccine on mucosal innate factor expression. Serum, gingival fluid, and genital mucosal secretions were collected from…”
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Detection of Infectious Human Immunodeficiency Virus Type 1 in Female Genital Secretions by a Short-Term Culture Method by CUMMINS, James E, VILLANUEVA, Julie M, HART, Clyde E, DEZZUTTI, Charlene S, EVANS-STRICKFADEN, Tammy, SESAY, Shekou M, ABNER, Sheila R, BUSH, Timothy J, GREEN, Timothy A, LENNOX, Jeffrey L, WRIGHT, Thomas, FOLKS, Thomas M

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Inhibition of HIV-1 Replication by Amphotericin B Methyl Ester: SELECTION FOR RESISTANT VARIANTS by Waheed, Abdul A, Ablan, Sherimay D, Mankowski, Marie K, Cummins, James E, Ptak, Roger G, Schaffner, Carl P, Freed, Eric O

“…Membrane cholesterol plays an important role in human immunodeficiency virus type 1 (HIV-1) particle production and infectivity. Here, we have investigated the…”
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Mucosal innate immune factors in the female genital tract are associated with vaginal HIV-1 shedding independent of plasma viral load by Cummins, James E, Christensen, Logan, Lennox, Jeffery L, Bush, Timothy J, Wu, Zhiwei, Malamud, Daniel, Evans-Strickfaden, Tammy, Siddig, Aladin, Caliendo, Angela M, Hart, Clyde E, Dezzutti, Charlene S

“…Recent studies indicate that mucosal innate immune factors modulate HIV-1 infection in vitro. Our interest was to examine the levels of innate mucosal factors…”
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In Vitro Preclinical Testing of Nonoxynol-9 as Potential Anti-Human Immunodeficiency Virus Microbicide: a Retrospective Analysis of Results from Five Laboratories by BEER, Brigitte E, DONCEL, Gustavo F, RICHARDSON-HARMAN, Nicola, PALLANSCH, Luke A, LACKMAN-SMITH, Carol, OSTERLING, Clay, MANKOWSKI, Marie, MILLER, Shendra R, CATALONE, Bradley J, WELSH, Patricia A, HOWETT, Mary K, WIGDAHL, Brian, KREBS, Fred C, TURPIN, Jim A, REICHELDERFER, Patricia, SHATTOCK, Robin J, FLETCHER, Patricia S, BUCKHEIT, Robert W, WATSON, Karen, DEZZUTTI, Charlene S, CUMMINS, James E, BROMLEY, Ena

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Inhibition of HIV-1 Replication by Amphotericin B Methyl Ester by Waheed, Abdul A., Ablan, Sherimay D., Mankowski, Marie K., Cummins, James E., Ptak, Roger G., Schaffner, Carl P., Freed, Eric O.

“…Membrane cholesterol plays an important role in human immunodeficiency virus type 1 (HIV-1) particle production and infectivity. Here, we have investigated the…”
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HIV-1/Simian Immunodeficiency Virus Infection of Human and Nonhuman Primate Lymphocytes Results in the Migration of CD2+ T Cells into the Intestine of Engrafted SCID Mice by Donze, Hollie Hale, Cummins, James E., Jr, Schwiebert, Rebecca S, Kantele, Anu, Han, Yuncheng, Fultz, Patricia N, Jackson, Susan, Mestecky, Jiri

“…Increased lymphocytic infiltration of intestinal tissues has been observed in patients infected with HIV-1 and in SIV-infected rhesus macaques. To determine…”
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Human and Nonhuman Primate Lymphocytes Engrafted into SCID Mice Reside in Unique Mesenteric Lymphoid Structures by Donze, Hollie Hale, Cummins, James E., Jr, Schwiebert, Rebecca S, Fultz, Patricia N, Jackson, Susan, Mestecky, Jiri

“…The present study compares the location and phenotype of B lineage lymphocytes in tissues from SCID mice engrafted with PBMC of human, chimpanzee, and…”
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Biomarkers for Evaluating Vaginal Microbicides and Contraceptives: Discovery and Early Validation by Mauck, Christine K.

“…A biomarker has been defined as "a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic…”
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