Search Results - "CULLEN, L."

Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics by Schmid, Cullen L., Kennedy, Nicole M., Ross, Nicolette C., Lovell, Kimberly M., Yue, Zhizhou, Morgenweck, Jenny, Cameron, Michael D., Bannister, Thomas D., Bohn, Laura M.

“…Biased agonism has been proposed as a means to separate desirable and adverse drug responses downstream of G protein-coupled receptor (GPCR) targets. Herein,…”
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Ligand and Target Discovery by Fragment-Based Screening in Human Cells by Parker, Christopher G., Galmozzi, Andrea, Wang, Yujia, Correia, Bruno E., Sasaki, Kenji, Joslyn, Christopher M., Kim, Arthur S., Cavallaro, Cullen L., Lawrence, R. Michael, Johnson, Stephen R., Narvaiza, Iñigo, Saez, Enrique, Cravatt, Benjamin F.

“…Advances in the synthesis and screening of small-molecule libraries have accelerated the discovery of chemical probes for studying biological processes. Still,…”
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Diversification of Acrylamide Polymers via Direct Transamidation of Unactivated Tertiary Amides by Trachsel, Lucca, Konar, Debabrata, Hillman, Jason D., Davidson, Cullen L. G., Sumerlin, Brent S.

“…Postpolymerization modification offers a versatile strategy for synthesizing complex macromolecules, yet modifying acrylamide polymers like…”
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Effectiveness of Workplace Interventions in Return-to-Work for Musculoskeletal, Pain-Related and Mental Health Conditions: An Update of the Evidence and Messages for Practitioners by Cullen, K. L., Irvin, E., Collie, A., Clay, F., Gensby, U., Jennings, P. A., Hogg-Johnson, S., Kristman, V., Laberge, M., McKenzie, D., Newnam, S., Palagyi, A., Ruseckaite, R., Sheppard, D. M., Shourie, S., Steenstra, I., Van Eerd, D., Amick, B. C.

“…Purpose The objective of this systematic review was to synthesize evidence on the effectiveness of workplace-based return-to-work (RTW) interventions and work…”
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How Does Transcranial Magnetic Stimulation Influence Glial Cells in the Central Nervous System? by Cullen, Carlie L, Young, Kaylene M

“…Transcranial magnetic stimulation (TMS) is widely used in the clinic, and while it has a direct effect on neuronal excitability, the beneficial effects…”
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Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria by Brust, Tarsis F, Morgenweck, Jenny, Kim, Susy A, Rose, Jamie H, Locke, Jason L, Schmid, Cullen L, Zhou, Lei, Stahl, Edward L, Cameron, Michael D, Scarry, Sarah M, Aubé, Jeffrey, Jones, Sara R, Martin, Thomas J, Bohn, Laura M

“…Agonists targeting the kappa opioid receptor (KOR) have been promising therapeutic candidates because of their efficacy for treating intractable itch and…”
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Low Density Lipoprotein-Receptor Related Protein 1 Is Differentially Expressed by Neuronal and Glial Populations in the Developing and Mature Mouse Central Nervous System by Auderset, Loic, Cullen, Carlie L, Young, Kaylene M

“…The low density lipoprotein-receptor related protein 1 (LRP1) is a large endocytic cell surface receptor that is known to interact with a variety of ligands,…”
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Collective and network approaches to leadership: Special issue introduction by Cullen-Lester, Kristin L., Yammarino, Francis J.

“…In this introduction to the special issue on collective and network approaches to leadership, we begin by discussing the state of research and practice in this…”
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Functional selectivity at the μ-opioid receptor: implications for understanding opioid analgesia and tolerance by Raehal, Kirsten M, Schmid, Cullen L, Groer, Chad E, Bohn, Laura M

“…Opioids are the most effective analgesic drugs for the management of moderate or severe pain, yet their clinical use is often limited because of the onset of…”
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Serotonin, But Not N -Methyltryptamines, Activates the Serotonin 2A Receptor Via a β-Arrestin2/Src/Akt Signaling Complex In Vivo by Schmid, Cullen L., Bohn, Laura M.

“…Hallucinogens mediate many of their psychoactive effects by activating serotonin 2A receptors (5-HT 2A R). Although serotonin is the cognate endogenous…”
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Agonist-directed signaling of the serotonin 2A receptor depends on β-arrestin-2 interactions in vivo by Schmid, Cullen L, Raehal, Kirsten M, Bohn, Laura M

“…Visual and auditory hallucinations accompany certain neuropsychiatric disorders, such as schizophrenia, and they also can be induced by the use or abuse of…”
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Employees' Adaptability and Perceptions of Change-Related Uncertainty: Implications for Perceived Organizational Support, Job Satisfaction, and Performance by Cullen, Kristin L., Edwards, Bryan D., Casper, Wm. Camron, Gue, Kevin R.

“…Purpose The literature on organizational change has increasingly recognized that characteristics of change recipients influence their reactions to workplace…”
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Comparison of morphine, oxycodone and the biased MOR agonist SR-17018 for tolerance and efficacy in mouse models of pain by Pantouli, Fani, Grim, Travis W., Schmid, Cullen L., Acevedo-Canabal, Agnes, Kennedy, Nicole M., Cameron, Michael D., Bannister, Thomas D., Bohn, Laura M.

“…The mu opioid receptor-selective agonist, SR-17018, preferentially activates GTPγS binding over βarrestin2 recruitment in cellular assays, thereby…”
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VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas aeruginosa by Hamrick, Jodie C, Docquier, Jean-Denis, Uehara, Tsuyoshi, Myers, Cullen L, Six, David A, Chatwin, Cassandra L, John, Kaitlyn J, Vernacchio, Salvador F, Cusick, Susan M, Trout, Robert E L, Pozzi, Cecilia, De Luca, Filomena, Benvenuti, Manuela, Mangani, Stefano, Liu, Bin, Jackson, Randy W, Moeck, Greg, Xerri, Luigi, Burns, Christopher J, Pevear, Daniel C, Daigle, Denis M

“…As shifts in the epidemiology of β-lactamase-mediated resistance continue, carbapenem-resistant (CRE) and carbapenem-resistant (CRPA) are the most urgent…”
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Development of Functionally Selective, Small Molecule Agonists at Kappa Opioid Receptors by Zhou, Lei, Lovell, Kimberly M., Frankowski, Kevin J., Slauson, Stephen R., Phillips, Angela M., Streicher, John M., Stahl, Edward, Schmid, Cullen L., Hodder, Peter, Madoux, Franck, Cameron, Michael D., Prisinzano, Thomas E., Aubé, Jeffrey, Bohn, Laura M.

“…The kappa opioid receptor (KOR) is widely expressed in the CNS and can serve as a means to modulate pain perception, stress responses, and affective reward…”
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Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase by Farha, Maya A., Czarny, Tomasz L., Myers, Cullen L., Worrall, Liam J., French, Shawn, Conrady, Deborah G., Wang, Yang, Oldfield, Eric, Strynadka, Natalie C. J., Brown, Eric D.

“…Drug combinations are valuable tools for studying biological systems. Although much attention has been given to synergistic interactions in revealing…”
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G protein signaling–biased mu opioid receptor agonists that produce sustained G protein activation are noncompetitive agonists by Stahl, Edward L., Schmid, Cullen L., Acevedo-Canabal, Agnes, Read, Cai, Grim, Travis W., Kennedy, Nicole M., Bannister, Thomas D., Bohn, Laura M.

“…The ability of a ligand to preferentially promote engagement of one signaling pathway over another downstream of GPCR activation has been referred to as…”
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Inverse Miniemulsion Enables the Continuous-Flow Synthesis of Controlled Ultra-High Molecular Weight Polymers by Davidson, Cullen L. G., Lott, Megan E., Trachsel, Lucca, Wong, Alexander J., Olson, Rebecca A., Pedro, Diego I., Sawyer, W. Gregory, Sumerlin, Brent S.

“…We report the controlled synthesis of ultra-high molecular weight (UHMW) polymers (M n ≥ 106 g/mol) via continuous flow in a tubular reactor. At high monomer…”
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A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal by Grim, Travis W, Schmid, Cullen L, Stahl, Edward L, Pantouli, Fani, Ho, Jo-Hao, Acevedo-Canabal, Agnes, Kennedy, Nicole M, Cameron, Michael D, Bannister, Thomas D, Bohn, Laura M

“…It has been demonstrated that opioid agonists that preferentially act at μ-opioid receptors to activate G protein signaling over βarrestin2 recruitment produce…”
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A social network perspective on workplace inclusion: The role of network closure, network centrality, and need for affiliation by Grosser, Travis J., Sterling, Christopher M., Piplani, Rohit S., Cullen‐Lester, Kristin L., Floyd, Theresa M.

“…Organizations are increasingly recognizing the important role employee inclusion perceptions play in promoting positive employee attitudes and behaviors…”
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