Search Results - "CUI, YINGHONG"

Adipocyte Gi signaling is essential for maintaining whole-body glucose homeostasis and insulin sensitivity by Wang, Lei, Pydi, Sai P., Zhu, Lu, Barella, Luiz F., Cui, Yinghong, Gavrilova, Oksana, Bence, Kendra K., Vernochet, Cecile, Wess, Jürgen

“…Adipocyte dysfunction links obesity to insulin resistance and type 2 diabetes. Adipocyte function is regulated by receptor-mediated activation of…”
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Adipocyte Gq signaling is a regulator of glucose and lipid homeostasis in mice by Kimura, Takefumi, Pydi, Sai P., Wang, Lei, Haspula, Dhanush, Cui, Yinghong, Lu, Huiyan, König, Gabriele M., Kostenis, Evi, Steinberg, Gregory R., Gavrilova, Oksana, Wess, Jürgen

“…Obesity is the major driver of the global epidemic in type 2 diabetes (T2D). In individuals with obesity, impaired insulin action leads to increased lipolysis…”
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β-Arrestin-1 is required for adaptive β-cell mass expansion during obesity by Barella, Luiz F., Rossi, Mario, Pydi, Sai P., Meister, Jaroslawna, Jain, Shanu, Cui, Yinghong, Gavrilova, Oksana, Fulgenzi, Gianluca, Tessarollo, Lino, Wess, Jürgen

“…Obesity is the key driver of peripheral insulin resistance, one of the key features of type 2 diabetes (T2D). In insulin-resistant individuals, the expansion…”
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Clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells by Meister, Jaroslawna, Bone, Derek B. J., Knudsen, Jonas R., Barella, Luiz F., Velenosi, Thomas J., Akhmedov, Dmitry, Lee, Regina J., Cohen, Amanda H., Gavrilova, Oksana, Cui, Yinghong, Karsenty, Gerard, Chen, Min, Weinstein, Lee S., Kleinert, Maximilian, Berdeaux, Rebecca, Jensen, Thomas E., Richter, Erik A., Wess, Jürgen

“…Activation of the sympathetic nervous system causes pronounced metabolic changes that are mediated by multiple adrenergic receptor subtypes. Systemic treatment…”
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Establishment and Characterization of Testis Organoids with Proliferation and Differentiation of Spermatogonial Stem Cells into Spermatocytes and Spermatids by Zhang, Dong, Jin, Wencong, Cui, Yinghong, He, Zuping

“…Organoids play pivotal roles in uncovering the molecular mechanisms underlying organogenesis, intercellular communication, and high-throughput drug screening…”
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Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake by Nakajima, Ken-ichiro, Cui, Zhenzhong, Li, Chia, Meister, Jaroslawna, Cui, Yinghong, Fu, Ou, Smith, Adam S., Jain, Shalini, Lowell, Bradford B., Krashes, Michael J., Wess, Jürgen

“…Agouti-related peptide (AgRP) neurons of the hypothalamus play a key role in regulating food intake and body weight, by releasing three different orexigenic…”
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OIP5 Interacts with NCK2 to Mediate Human Spermatogonial Stem Cell Self-Renewal and Apoptosis through Cell Cyclins and Cycle Progression and Its Abnormality Is Correlated with Male Infertility by Cui, Yinghong, Chen, Wei, Du, Li, He, Zuping

“…Spermatogonial stem cells (SSCs) have important applications in both reproduction and regenerative medicine. Nevertheless, specific genes and signaling…”
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Zbtb40 Deficiency Leads to Morphological and Phenotypic Abnormalities of Spermatocytes and Spermatozoa and Causes Male Infertility by Cui, Yinghong, Zhou, Mingqing, He, Quanyuan, He, Zuping

“…Studies on the gene regulation of spermatogenesis are of unusual significance for maintaining male reproduction and treating male infertility. Here, we have…”
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MAP4K4/JNK Signaling Pathway Stimulates Proliferation and Suppresses Apoptosis of Human Spermatogonial Stem Cells and Lower Level of MAP4K4 Is Associated with Male Infertility by Wan, Cailin, Chen, Wei, Cui, Yinghong, He, Zuping

“…Spermatogonial stem cells (SSCs) serve as a foundation for spermatogenesis and they are essential for male fertility. The fate of SSC is determined by genetic…”
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Intraislet glucagon signaling is critical for maintaining glucose homeostasis by Zhu, Lu, Dattaroy, Diptadip, Pham, Jonathan, Wang, Lingdi, Barella, Luiz F., Cui, Yinghong, Wilkins, Kenneth J., Roth, Bryan L., Hochgeschwender, Ute, Matschinsky, Franz M., Kaestner, Klaus H., Doliba, Nicolai M., Wess, Jürgen

“…Glucagon, a hormone released from pancreatic α cells, plays a key role in maintaining proper glucose homeostasis and has been implicated in the pathophysiology…”
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Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis by Pydi, Sai P., Jain, Shanu, Tung, Wesley, Cui, Yinghong, Zhu, Lu, Sakamoto, Wataru, Jain, Shalini, Abel, Brent S., Skarulis, Monica C., Liu, Jie, Huynh, Thanh, Pacak, Karel, Caron, Marc G., Gavrilova, Oksana, Finkel, Toren, Wess, Jürgen

“…β-Arrestins are major regulators of G protein-coupled receptor-mediated signaling processes. Their potential roles in regulating adipocyte function in vivo…”
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Intra-islet α-cell Gs signaling promotes glucagon release by Liu, Liu, El, Kimberley, Dattaroy, Diptadip, Barella, Luiz F., Cui, Yinghong, Gray, Sarah M., Guedikian, Carla, Chen, Min, Weinstein, Lee S., Knuth, Emily, Jin, Erli, Merrins, Matthew J., Roman, Jeffrey, Kaestner, Klaus H., Doliba, Nicolai, Campbell, Jonathan E., Wess, Jürgen

“…Glucagon, a hormone released from pancreatic α-cells, is critical for maintaining euglycemia and plays a key role in the pathophysiology of diabetes. To…”
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β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions by Zhu, Lu, Almaça, Joana, Dadi, Prasanna K., Hong, Hao, Sakamoto, Wataru, Rossi, Mario, Lee, Regina J., Vierra, Nicholas C., Lu, Huiyan, Cui, Yinghong, McMillin, Sara M., Perry, Nicole A., Gurevich, Vsevolod V., Lee, Amy, Kuo, Bryan, Leapman, Richard D., Matschinsky, Franz M., Doliba, Nicolai M., Urs, Nikhil M., Caron, Marc G., Jacobson, David A., Caicedo, Alejandro, Wess, Jürgen

“…β-arrestins are critical signalling molecules that regulate many fundamental physiological functions including the maintenance of euglycemia and peripheral…”
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Author Correction: Intra-islet α-cell Gs signaling promotes glucagon release by Liu, Liu, EI, Kimberley, Dattaroy, Diptadip, Barella, Luiz F., Cui, Yinghong, Gray, Sarah M., Guedikian, Carla, Chen, Min, Weinstein, Lee S., Knuth, Emily, Jin, Erli, Merrins, Matthew J., Roman, Jeffrey, Kaestner, Klaus H., Doliba, Nicolai, Campbell, Jonathan E., Wess, Jürgen

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Isovitexin reduces carcinogenicity and stemness in hepatic carcinoma stem-like cells by modulating MnSOD and FoxM1 by Cao, Xiaocheng, Liu, Lihua, Yuan, Qing, Li, Xiang, Cui, Yinghong, Ren, Kaiqun, Zou, Chang, Chen, A, Xu, Chang, Qiu, Yebei, Quan, Meifang, Zhang, Jiansong, Cao, Jianguo, Chen, Xiangding

“…Manganese superoxide dismutase (MnSOD) upregulating FoxM1 have previously been demonstrated promoting lung cancer stemness. Isovitexin exhibits antitumor…”
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A Novel Experimental Strategy to Assess the Metabolic Effects of Selective Activation of a Gq-Coupled Receptor in Hepatocytes In Vivo by Hua Li, Jian, Jain, Shalini, McMillin, Sara M, Cui, Yinghong, Gautam, Dinesh, Sakamoto, Wataru, Lu, Huiyan, Jou, William, McGuinness, Owen P, Gavrilova, Oksana, Wess, Jürgen

“…Increased hepatic glucose production is a key pathophysiological feature of type 2 diabetes. Like all other cell types, hepatocytes express many G…”
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KLF2 controls proliferation and apoptosis of human spermatogonial stem cells via targeting GJA1 by Chen, Wei, Cui, Yinghong, Li, Chunyun, He, Caimei, Du, Li, Liu, Wei, He, Zuping

“…Human spermatogonial stem cells (SSCs) are essential for spermatogenesis and male fertility. However, molecular mechanisms regulating fate determinations of…”
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Chrysin Inhibits Proinflammatory Factor-Induced EMT Phenotype and Cancer Stem Cell-Like Features in HeLa Cells by Blocking the NF-κB/Twist Axis by Dong, Weilei, Chen, A, Chao, Xiaocheng, Li, Xiang, Cui, YingHong, Xu, Chang, Cao, Jianguo, Ning, Yingxia

“…TNF-α and TGF-β associated epithelial-mesenchymal transition (EMT) occurs via NF-κB-dependent transcriptional upregulation of Twist1.Chrysin (ChR) is a major…”
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Hsa-miR-1908-3p Mediates the Self-Renewal and Apoptosis of Human Spermatogonial Stem Cells via Targeting KLF2 by Chen, Wei, Cui, Yinghong, Liu, Bang, Li, Chunyun, Du, Li, Tang, Ruiling, Qin, Lulu, Jiang, Yiqun, Li, Jian, Yu, Xing, He, Quanyuan, He, Zuping

“…Spermatogenesis depends on precise epigenetic and genetic regulation of spermatogonial stem cells (SSCs). However, it remains largely unknown about the roles…”
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8-bromo-7-methoxychrysin Reversed M2 Polarization of Tumor-associated Macrophages Induced by Liver Cancer Stem-like Cells by Sun, Shuwen, Cui, Yinghong, Ren, Kaiqun, Quan, Meifang, Song, Zhenwei, Zou, Hui, Li, Duo, Zheng, Yu, Cao, Jianguo

“…Hepatocellular carcinoma (HCC) is related to chronic liver inflammation. M2 polarization of tumor-associated macrophages (TAMs) in the tumor microenvironment…”
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