Search Results - "CUCCHI, Ulisse"

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death by Magnaghi, Paola, D'Alessio, Roberto, Valsasina, Barbara, Avanzi, Nilla, Rizzi, Simona, Asa, Daniela, Gasparri, Fabio, Cozzi, Liviana, Cucchi, Ulisse, Orrenius, Christian, Polucci, Paolo, Ballinari, Dario, Perrera, Claudia, Leone, Antonella, Cervi, Giovanni, Casale, Elena, Xiao, Yang, Wong, Chihunt, Anderson, Daniel J, Galvani, Arturo, Donati, Daniele, O'Brien, Tom, Jackson, Peter K, Isacchi, Antonella

“…The VCP ATPase has been linked to cancer, but the lack of well-defined, selective inhibitors has limited further investigation. A million-molecule screen now…”
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A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action by Campaner, Elena, Rustighi, Alessandra, Zannini, Alessandro, Cristiani, Alberto, Piazza, Silvano, Ciani, Yari, Kalid, Ori, Golan, Gali, Baloglu, Erkan, Shacham, Sharon, Valsasina, Barbara, Cucchi, Ulisse, Pippione, Agnese Chiara, Lolli, Marco Lucio, Giabbai, Barbara, Storici, Paola, Carloni, Paolo, Rossetti, Giulia, Benvenuti, Federica, Bello, Ezia, D’Incalci, Maurizio, Cappuzzello, Elisa, Rosato, Antonio, Del Sal, Giannino

“…The prolyl isomerase PIN1, a critical modifier of multiple signalling pathways, is overexpressed in the majority of cancers and its activity strongly…”
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An antibody-drug conjugate directed to the ALK receptor demonstrates efficacy in preclinical models of neuroblastoma by Sano, Renata, Krytska, Kateryna, Larmour, Colleen E, Raman, Pichai, Martinez, Daniel, Ligon, Gwenda F, Lillquist, Jay S, Cucchi, Ulisse, Orsini, Paolo, Rizzi, Simona, Pawel, Bruce R, Alvarado, Diego, Mossé, Yael P

“…Enthusiasm for the use of antibody-drug conjugates (ADCs) in cancer therapy has risen over the past few years. The success of this therapeutic approach relies…”
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Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase by Colombo, Riccardo, Caldarelli, Marina, Mennecozzi, Milena, Giorgini, Maria Laura, Sola, Francesco, Cappella, Paolo, Perrera, Claudia, Depaolini, Stefania Re, Rusconi, Luisa, Cucchi, Ulisse, Avanzi, Nilla, Bertrand, Jay Aaron, Bossi, Roberto Tiberio, Pesenti, Enrico, Galvani, Arturo, Isacchi, Antonella, Colotta, Francesco, Donati, Daniele, Moll, Jürgen

“…MPS1 kinase is a key regulator of the spindle assembly checkpoint (SAC), a mitotic mechanism specifically required for proper chromosomal alignment and…”
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Abstract 5805: A novel platform of diversified payloads to drive ADC innovation by Orsini, Paolo, Salsa, Matteo, Rizzi, Simona, Cucchi, Ulisse, Faiardi, Daniela, Burocchi, Alessia, Ciavolella, Antonella, Lupi, Rosita, Gasparri, Fabio, Valsasina, Barbara

“…Abstract First generation of antibody drug conjugates (ADCs) for anticancer therapy has been described more than two decades ago with gemtuzumab-ozogamicin…”
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NMS-P937, an orally available, specific small-molecule polo-like kinase 1 inhibitor with antitumor activity in solid and hematologic malignancies by Valsasina, Barbara, Beria, Italo, Alli, Cristina, Alzani, Rachele, Avanzi, Nilla, Ballinari, Dario, Cappella, Paolo, Caruso, Michele, Casolaro, Alessia, Ciavolella, Antonella, Cucchi, Ulisse, De Ponti, Anna, Felder, Eduard, Fiorentini, Francesco, Galvani, Arturo, Gianellini, Laura M, Giorgini, Maria L, Isacchi, Antonella, Lansen, Jaqueline, Pesenti, Enrico, Rizzi, Simona, Rocchetti, Maurizio, Sola, Francesco, Moll, Jürgen

“…Polo-like kinase 1 (PLK1) is a serine/threonine protein kinase considered to be the master player of cell-cycle regulation during mitosis. It is indeed…”
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Identification of unprecedented ATP-competitive choline kinase inhibitors by Quartieri, Francesca, Nesi, Marcella, Avanzi, Nilla R., Borghi, Daniela, Casale, Elena, Corti, Emiliana, Cucchi, Ulisse, Donati, Daniele, Fasolini, Marina, Felder, Eduard R., Galvani, Arturo, Giorgini, Maria L., Lomolino, Antonio, Menichincheri, Maria, Orrenius, Christian, Perrera, Claudia, Re Depaolini, Stefania, Riccardi-Sirtori, Federico, Salsi, Enea, Isacchi, Antonella, Gnocchi, Paola

“…[Display omitted] In this article we describe the identification of unprecedented ATP-competitive ChoKα inhibitors starting from initial hit NMS-P830 that…”
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Thiol-peptide level and proteomic changes in response to cadmium toxicity in Oryza sativa L. roots by Aina, Roberta, Labra, Massimo, Fumagalli, Pietro, Vannini, Candida, Marsoni, Milena, Cucchi, Ulisse, Bracale, Marcella, Sgorbati, Sergio, Citterio, Sandra

“…In the present study, rice seedlings were exposed to a range of Cd concentrations (0.1 μM, 1 μM, 10 μM, 100 μM and 1 mM) for 15 days and a combination of…”
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Abstract 4790: Identification and characterization of ATP-mimetic choline kinase inhibitors by Gnocchi, Paola, Quartieri, Francesca, Badari, Alessandra, Bosotti, Roberta, Casale, Elena, Corti, Emiliana, Cristiani, Cinzia G., Cucchi, Ulisse, Gasparri, Fabio, Gianellini, Laura M., Giorgini, Laura M., Montemartini, Marisa, Mion, Giuliana, Nesi, Marcella, Orrenius, Christian, Re, Claudia E., Donati, Daniele, Felder, Eduard R., Galvani, Arturo, Isacchi, Antonella

“…Abstract Introduction: Choline kinase alpha (ChoKα), the first enzyme in the Kennedy pathway that catalyzes the phosphorylation of free choline to…”
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Structural Insight into Maternal Embryonic Leucine Zipper Kinase (MELK) Conformation and Inhibition toward Structure-Based Drug Design by Canevari, Giulia, Re Depaolini, Stefania, Cucchi, Ulisse, Bertrand, Jay A, Casale, Elena, Perrera, Claudia, Forte, Barbara, Carpinelli, Patrizia, Felder, Eduard R

“…Maternal embryonic leucine zipper kinase (MELK) is upregulated in several types of tumor, including breast, prostate, and brain tumors. Its expression is…”
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Abstract 734: Thienoindoles: New highly promising agents for antibody-drug conjugates generation by Caruso, Michele, Gasparri, Fabio, Valsasina, Barbara, Albanese, Clara, Beria, Italo, Candiani, Ilaria, Ciomei, Marina, Colombo, Nicoletta, Cribioli, Sabrina, Cucchi, Ulisse, Felder, Eduard, Fraietta, Ivan, Galvani, Arturo, Isacchi, Antonella, Marsiglio, Aurelio, Orsini, Paolo, Perego, Rita, Rizzi, Simona, Tomasi, Attilio, Troiani, Sonia, Visco, Carlo, Donati, Daniele

“…Abstract Thienoindoles are a new proprietary class of highly potent DNA minor groove alkylating agents. This class is characterized by a fused thiophene ring…”
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Abstract 2690: A novel antibody-drug conjugate directed to the ALK receptor tyrosine kinase demonstrates efficacy in models of neuroblastoma by Sano, Renata, Krytska, Kateryna, Larmour, Colleen, Ligon, Gwenda F., Lillquist, Jay S., Cucchi, Ulisse, Orsini, Paolo, Rizzi, Simona, McMahon, Gerald, Alvarado, Diego, Mosse, Yael P.

“…Abstract Activated ALK by mutation or amplification is a validated therapeutic target in a subset of patients with high-risk neuroblastoma, and tyrosine kinase…”
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Phosphorylation of TCTP as a Marker for Polo-like Kinase-1 Activity In Vivo by CUCCHI, Ulisse, GIANELLINI, Laura M, GIORGINI, Maria L, CAPPELLA, Paolo, BERIA, Italo, VALSASINA, Barbara, DE PONTI, Anna, SOLA, Francesco, ALZANI, Rachele, PATTON, Veronica, PEZZONI, Alice, TROIANI, Sonia, SACCARDO, Maria B, RIZZI, Simona

“…Polo-like kinase 1 (PLK1) is the master regulator of mitosis and a target for anticancer therapy. To develop a marker of PLK1 activity in cells and tumour…”
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Abstract A149: NMS-P945, a highly active payload for antibody drug conjugates generation by Gasparri, Fabio, Caruso, Michele, Beria, Italo, Colombo, Nicoletta, Orsini, Paolo, Perego, Rita, Rizzi, Simona, Cucchi, Ulisse, Troiani, Sonia, Riccardi Sirtori, Federico, Albanese, Clara, Marsiglio, Aurelio, Fraietta, Ivan, Sola, Francesco, Ciomei, Marina, Cribioli, Sabrina, Visco, Carlo, Felder, Eduard Rudolf, Isacchi, Antonella, Pesenti, Enrico, Galvani, Arturo, Donati, Daniele, Valsasina, Barbara

“…Abstract Antibody-drug conjugates (ADCs) are increasingly employed in different oncology settings with more than forty products in clinical evaluation at…”
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Targeting Integrin αVβ3 with Theranostic RGD‐Camptothecin Conjugates Bearing a Disulfide Linker: Biological Evaluation Reveals a Complex Scenario by Pina, Arianna, Dal Corso, A., Caruso, Michele, Belvisi, Laura, Arosio, Daniela, Zanella, Simone, Gasparri, Fabio, Albanese, Clara, Cucchi, Ulisse, Fraietta, Ivan, Marsiglio, Aurelio, Pignataro, Luca, Donati, Daniele, Gennari, Cesare

“…Theranostic RGD‐camptothecin conjugates, possessing a disulfide linker and a fluorescent naphthalimide moiety, were synthesized and biologically evaluated. The…”
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Abstract 822: Thienoindoles, a novel class of DNA minor groove alkylating agents highly suited for the generation of novel antibody drug conjugates (ADCs) by Valsasina, Barbara, Gasparri, Fabio, Beria, Italo, Colombo, Nicoletta, Orsini, Paolo, Perego, Rita, Rizzi, Simona, Cucchi, Ulisse, Albanese, Clara, Marsiglio, Aurelio, Fraietta, Ivan, Ciomei, Marina, Cribioli, Sabrina, Visco, Carlo, Felder, Eduard R., Isacchi, Antonella, Pesenti, Enrico A., Galvani, Arturo, Donati, Daniele, Caruso, Michele

“…Abstract The rapidly growing field of Antibody-Drug Conjugates (ADCs) has recently spurred the study of novel drug payloads. In particular, much interest has…”
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Targeting Integrin α V β 3 with Theranostic RGD-Camptothecin Conjugates Bearing a Disulfide Linker: Biological Evaluation Reveals a Complex Scenario by Pina, Arianna, Dal Corso, A., Caruso, Michele, Belvisi, Laura, Arosio, Daniela, Zanella, Simone, Gasparri, Fabio, Albanese, Clara, Cucchi, Ulisse, Fraietta, Ivan, Marsiglio, Aurelio, Pignataro, Luca, Donati, Daniele, Gennari, Cesare

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Abstract 2940: Identification of potent VCP/p97/CDC48 inhibitors with distinct biochemical mechanisms including a reversible, allosteric inhibitor that activates the unfolded protein response, induce autophagy and cancer cell death by Magnaghi, Paola, D'Alessio, Roberto, Valsasina, Barbara, Avanzi, Nilla R., Rizzi, Simona, Asa, Daniela, Gasparri, Fabio, Cozzi, Liviana, Cucchi, Ulisse, Orrenius, Cristian, Polucci, Paolo, Ballinari, Dario, Perrera, Claudia, Leone, Antonella, Cervi, Giovanni, Galvani, Arturo, Donati, Daniele, O'Brien, Tom, Jackson, Peter K., Isacchi, Antonella

“…Abstract Valosin Containing Protein (VCP), also called p97 in mammals and cdc48 in yeast, is an ubiquitously expressed and essential AAA ATPase important in…”
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