Search Results - "CRUZADO, Josep M"

Preformed circulating HLA-specific memory B cells predict high risk of humoral rejection in kidney transplantation by Lúcia, Marc, Luque, Sergi, Crespo, Elena, Melilli, Edoardo, Cruzado, Josep M, Martorell, Jaume, Jarque, Marta, Gil-Vernet, Salvador, Manonelles, Anna, Grinyó, Josep M, Bestard, Oriol

“…The accurate evaluation of donor-specific antibodies (DSAs) has allowed a precise identification of sensitized patients at risk of antibody-mediated rejection…”
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Molecular Mechanisms of Kidney Injury and Repair by Rayego-Mateos, Sandra, Marquez-Expósito, Laura, Rodrigues-Diez, Raquel, Sanz, Ana B, Guiteras, Roser, Doladé, Nuria, Rubio-Soto, Irene, Manonelles, Anna, Codina, Sergi, Ortiz, Alberto, Cruzado, Josep M, Ruiz-Ortega, Marta, Sola, Anna

“…Chronic kidney disease (CKD) will become the fifth global cause of death by 2040, thus emphasizing the need to better understand the molecular mechanisms of…”
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A New CYP3A53 and CYP3A422 Cluster Influencing Tacrolimus Target Concentrations: A Population Approach by Andreu, Franc, Colom, Helena, Elens, Laure, van Gelder, Teun, van Schaik, Ronald H. N., Hesselink, Dennis A., Bestard, Oriol, Torras, Joan, Cruzado, Josep M., Grinyó, Josep M., Lloberas, Nuria

“…Background Single nucleotide polymorphisms (SNPs) in the CYP3A5 and CYP3A4 genes have been reported to be an important cause of variability in the…”
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Antioxidant and Anti-Inflammatory Strategies Based on the Potentiation of Glutathione Peroxidase Activity Prevent Endothelial Dysfunction in Chronic Kidney Disease by Vera, Manel, Torramade-Moix, Sergi, Martin-Rodriguez, Susana, Cases, Aleix, Cruzado, Josep M., Rivera, Jose, Escolar, Gines, Palomo, Marta, Diaz-Ricart, Maribel

“…Background/Aims: Accelerated atherosclerosis in chronic kidney disease (CKD) is preceded by endothelial dysfunction (ED), which exhibits a proinflammatory and…”
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Fatty kidney: emerging role of ectopic lipid in obesity-related renal disease by de Vries, Aiko P J, Dr, Ruggenenti, Piero, MD, Ruan, Xiong Z, PhD, Praga, Manuel, MD, Cruzado, Josep M, MD, Bajema, Ingeborg M, MD, D'Agati, Vivette D, MD, Lamb, Hildo J, MD, Barlovic, Drazenka Pongrac, MD, Hojs, Radovan, MD, Abbate, Manuela, MSc, Rodriquez, Rosa, MD, Mogensen, Carl Erik, MD, Porrini, Esteban, MD

“…Summary The global increase in chronic kidney disease (CKD) parallels the obesity epidemic. Obesity conveys a gradual but independent risk of progression of…”
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Non-proteinuric pathways in loss of renal function in patients with type 2 diabetes by Porrini, Esteban, Dr, Ruggenenti, Piero, MD, Mogensen, Carl Erik, MD, Barlovic, Drazenka Pongrac, MD, Praga, Manuel, MD, Cruzado, Josep M, MD, Hojs, Radovan, MD, Abbate, Manuela, MsC, de Vries, Aiko P J, MD

“…Summary Largely on the basis of data from patients with type 1 diabetes, the natural history of diabetic renal disease has been classified as a sequence of…”
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ALUminating the Path of Atherosclerosis Progression: Chaos Theory Suggests a Role for Alu Repeats in the Development of Atherosclerotic Vascular Disease by Hueso, Miguel, Cruzado, Josep, Torras, Joan, Navarro, Estanislao

“…Atherosclerosis (ATH) and coronary artery disease (CAD) are chronic inflammatory diseases with an important genetic background; they derive from the cumulative…”
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The combination of CYP3A422 and CYP3A53 single-nucleotide polymorphisms determines tacrolimus dose requirement after kidney transplantation by Lloberas, Nuria, Elens, Laure, Llaudó, Ines, Padullés, Ariadna, van Gelder, Teun, Hesselink, Dennis A, Colom, Helena, Andreu, Franc, Torras, Joan, Bestard, Oriol, Cruzado, Josep M, Gil-Vernet, Salvador, van Schaik, Ron, Grinyó, Josep M

“…INTRODUCTIONTacrolimus (Tac) has a narrow therapeutic window and shows large between-patient pharmacokinetic variability. As a result, over-immunosuppression…”
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Human Urine-Derived Renal Progenitors for Personalized Modeling of Genetic Kidney Disorders by Lazzeri, Elena, Ronconi, Elisa, Angelotti, Maria Lucia, Peired, Anna, Mazzinghi, Benedetta, Becherucci, Francesca, Conti, Sara, Sansavini, Giulia, Sisti, Alessandro, Ravaglia, Fiammetta, Lombardi, Duccio, Provenzano, Aldesia, Manonelles, Anna, Cruzado, Josep M, Giglio, Sabrina, Roperto, Rosa Maria, Materassi, Marco, Lasagni, Laura, Romagnani, Paola

“…The critical role of genetic and epigenetic factors in the pathogenesis of kidney disorders is gradually becoming clear, and the need for disease models that…”
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Translational value of animal models of kidney failure by Ortiz, Alberto, Sanchez-Niño, Maria D., Izquierdo, Maria C., Martin-Cleary, Catalina, Garcia-Bermejo, Laura, Moreno, Juan A., Ruiz-Ortega, Marta, Draibe, Juliana, Cruzado, Josep M., Garcia-Gonzalez, Miguel A., Lopez-Novoa, Jose M., Soler, Maria J., Sanz, Ana B.

“…Acute kidney injury (AKI) and chronic kidney disease (CKD) are associated with decreased renal function and increased mortality risk, while the therapeutic…”
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siRNA-silencing of CD40 attenuates unilateral ureteral obstruction-induced kidney injury in mice by Narváez, Alonso, Guiteras, Roser, Sola, Anna, Manonelles, Anna, Morote, Juan, Torras, Juan, Grinyó, Josep M, Cruzado, Josep M

“…The costimulatory CD40-CD40L pathway plays a role in kidney inflammation. We have previously reported that renal CD40 upregulation precedes cellular…”
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Pre-transplant donor-specific T-cell alloreactivity is strongly associated with early acute cellular rejection in kidney transplant recipients not receiving T-cell depleting induction therapy by Crespo, Elena, Lucia, Marc, Cruzado, Josep M, Luque, Sergio, Melilli, Edoardo, Manonelles, Anna, Lloberas, Nuria, Torras, Joan, Grinyó, Josep M, Bestard, Oriol

“…Preformed T-cell immune-sensitization should most likely impact allograft outcome during the initial period after kidney transplantation, since donor-specific…”
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Integrated miRNA/mRNA Counter-Expression Analysis Highlights Oxidative Stress-Related Genes CCR7 and FOXO1 as Blood Markers of Coronary Arterial Disease by Hueso, Miguel, Mallén, Adrián, Casas, Ángela, Guiteras, Jordi, Sbraga, Fabrizio, Blasco-Lucas, Arnau, Lloberas, Núria, Torras, Joan, Cruzado, Josep M, Navarro, Estanislao

“…Our interest in the mechanisms of atherosclerosis progression (ATHp) has led to the recent identification of 13 miRNAs and 1285 mRNAs whose expression was…”
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Guiding the starting dose of the once-daily formulation of tacrolimus in " de novo" adult renal transplant patients: a population approach by Fernández-Alarcón, Beatriz, Nolberger, Oscar, Vidal-Alabró, Anna, Rigo-Bonnin, Raul, Grinyó, Josep M, Melilli, Edoardo, Montero, Nuria, Manonelles, Anna, Coloma, Ana, Favà, Alex, Codina, Sergi, Cruzado, Josep M, Colom, Helena, Lloberas, Nuria

“…The once-daily extended-release tacrolimus formulation (ER-Tac) has demonstrated similar efficacy and safety to the twice-daily immediate-release formulation…”
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Chronic Kidney Disease-Associated Inflammation Increases the Risks of Acute Kidney Injury and Mortality after Cardiac Surgery by Casas, Angela, Mallén, Adrián, Blasco-Lucas, Arnau, Sbraga, Fabrizio, Guiteras, Jordi, Bolaños, Núria, Castaño, Esther, Torras, Joan, Cruzado, Josep M, Navarro, Estanislao, Hueso, Miguel

“…Cardiovascular mortality increases with decreasing renal function although the cause is yet unknown. Here, we have investigated whether low chronic…”
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Prediction of Free from Total Mycophenolic Acid Concentrations in Stable Renal Transplant Patients: A Population-Based Approach by Colom, Helena, Andreu, Franc, van Gelder, Teun, Hesselink, Dennis A, de Winter, Brenda C. M., Bestard, Oriol, Torras, Joan, Cruzado, Josep M., Grinyó, Josep M., Lloberas, Núria

“…Background A population pharmacokinetic (PK) protein-binding model was developed to (1) predict free mycophenolic acid (fMPA) based on total MPA (tMPA)…”
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Mammalian target of rapamycin pathway blockade slows progression of diabetic kidney disease in rats by LLOBERAS, Nuria, CRUZADO, Josep M, FRANQUESA, Marcella, HERRERO-FRESNEDA, Immaculada, TORRAS, Joan, ALPEROVICH, Gabriela, RAMA, Inés, VIDAL, August, GRINYO, Josep M

“…Recent data suggest that the phosphatidylinositol 3-kinase (PI3-K)/Akt/mammalian target of rapamycin (mTOR) pathway is important in diabetic nephropathy. The…”
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Reversal Unilateral Ureteral Obstruction: A Mice Experimental Model by Narváez Barros, Alonso, Guiteras, Roser, Sola, Anna, Manonelles, Anna, Morote, Juan, Cruzado, Josep M

“…Reversible unilateral ureteral obstruction (R-UUO) is a model of renal injury used to study the structural and functional recovery of the kidneys after relief…”
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Unveiling ncRNA regulatory axes in atherosclerosis progression by Navarro, Estanislao, Mallén, Adrian, Cruzado, Josep M., Torras, Joan, Hueso, Miguel

“…Completion of the human genome sequencing project highlighted the richness of the cellular RNA world, and opened the door to the discovery of a plethora of…”
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Decreased Kidney Graft Survival in Low Immunological Risk Patients Showing Inflammation in Normal Protocol Biopsies by Ortiz, Fernanda, Gelpi, Rosana, Helanterä, Ilkka, Melilli, Edoardo, Honkanen, Eero, Bestard, Oriol, Grinyo, Josep M, Cruzado, Josep M

“…The pros and cons for implementing protocol biopsies (PB) after kidney transplantation are still a matter of debate. We aimed to address the frequency of…”
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