Search Results - "CROWDER, Robert J"

Relationship Between Plasma Estradiol Levels and Estrogen-Responsive Gene Expression in Estrogen Receptor–Positive Breast Cancer in Postmenopausal Women by DUNBIER, Anita K, ANDERSON, Helen, PARKER, Joel S, PEROU, Charles M, ELLIS, Matthew J, DOWSETT, Mitch, GHAZOUI, Zara, FOLKERD, Elizabeth J, A'HERN, Roger, CROWDER, Robert J, HOOG, Jeremy, SMITH, Ian E, OSIN, Peter, NERURKAR, Ashutosh

“…PURPOSE To determine whether plasma estradiol (E2) levels are related to gene expression in estrogen receptor (ER)-positive breast cancers in postmenopausal…”
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Phosphatidylinositol 3-Kinase and Akt Protein Kinase Are Necessary and Sufficient for the Survival of Nerve Growth Factor-Dependent Sympathetic Neurons by Crowder, Robert J, Freeman, Robert S

“…Recent studies have suggested a role for phosphatidylinositol (PI) 3-kinase in cell survival, including the survival of neurons. We used rat sympathetic…”
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Dok-6, a Novel p62 Dok Family Member, Promotes Ret-mediated Neurite Outgrowth by Crowder, Robert J, Enomoto, Hideki, Yang, Mao, Johnson, Jr, Eugene M, Milbrandt, Jeffrey

“…Activation of Ret, the receptor-tyrosine kinase for the glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs), results in the recruitment…”
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Tyrosine 981, a Novel Ret Autophosphorylation Site, Binds c-Src to Mediate Neuronal Survival by Encinas, Mario, Crowder, Robert J, Milbrandt, Jeffrey, Johnson, Jr, Eugene M

“…The glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) are neurotrophic factors that influence several aspects of the developing and…”
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The Long and Short Isoforms of Ret Function as Independent Signaling Complexes by Tsui-Pierchala, Brian A., Ahrens, Rebecca C., Crowder, Robert J., Milbrandt, Jeffrey, Johnson, Eugene M.

“…Ret, the receptor tyrosine kinase for the glial cell line-derived neurotrophic factor family ligands (GFLs), is alternatively spliced to yield at least two…”
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Long-range function of secreted small nucleolar RNAs that direct 2′-O-methylation by Rimer, Jamie M., Lee, Jiyeon, Holley, Christopher L., Crowder, Robert J., Chen, Delphine L., Hanson, Phyllis I., Ory, Daniel S., Schaffer, Jean E.

“…Small nucleolar RNAs (snoRNAs) are noncoding RNAs that guide chemical modifications of structural RNAs. Whereas snoRNAs primarily localize in the nucleolus,…”
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Preclinical modeling of combined phosphatidylinositol-3-kinase inhibition with endocrine therapy for estrogen receptor-positive breast cancer by Sanchez, Cesar G, Ma, Cynthia X, Crowder, Robert J, Guintoli, Therese, Phommaly, Chanpheng, Gao, Feng, Lin, Li, Ellis, Matthew J

“…Inhibition of phosphatidylinositol-3-kinase (PI3K) induces apoptosis when combined with estrogen deprivation in estrogen receptor (ER)-positive breast cancer…”
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PIK3CA and PIK3CB Inhibition Produce Synthetic Lethality when Combined with Estrogen Deprivation in Estrogen Receptor―Positive Breast Cancer by CROWDER, Robert J, PHOMMALY, Chanpheng, SNIDER, Jacqueline, DAVIES, Sherri R, OLSON, John A, WATSON, Mark A, SAPORITA, Anthony, WEBER, Jason D, ELLIS, Matthew J, YU TAO, HOOG, Jeremy, JINGQIN LUO, PEROU, Charles M, PARKER, Joel S, MILLER, Melinda A, HUNTSMAN, David G, LI LIN

“…Several phosphoinositide 3-kinase (PI3K) catalytic subunit inhibitors are currently in clinical trial. We therefore sought to examine relationships between…”
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Successful targeting of ErbB2 receptors—is PTEN the key? by Crowder, Robert J., Lombardi, Donald P., Ellis, Matthew J.

“…Women with ErbB2-positive breast cancer have a poor prognosis, and frequently, chemotherapy treatment is ineffective. The ErbB2-targeted antibody trastuzumab…”
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Importance of PI3-kinase pathway in response/resistance to aromatase inhibitors by Ma, Cynthia X., Crowder, Robert J., Ellis, Matthew J.

“…► PIK3CA mutation is the most common genetic event in ER+ breast cancer. ► PI3K pathway activation is implicated in endocrine therapy resistance. ► PI3K…”
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ER and PI3K independently modulate endocrine resistance in ER-positive breast cancer by Van Tine, Brian A, Crowder, Robert J, Ellis, Matthew J

“…Endocrine therapy-resistant estrogen receptor-positive (ER(+)) breast cancer is the most common cause of breast cancer death. Miller and colleagues demonstrate…”
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NGF deprivation-induced gene expression: after ten years, where do we stand? by Freeman, Robert S, Burch, Robert L, Crowder, Robert J, Lomb, David J, Schoell, Matthew C, Straub, Jennifer A, Xie, Liang

“…Nerve growth factor (NGF) is required for the survival of developing sympathetic and sensory neurons. In the absence of NGF, these neurons undergo protein…”
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Treating breast cancer through novel inhibitors of the phosphatidylinositol 3'-kinase pathway by Crowder, Robert J, Ellis, Matthew J

“…Recent studies indicate that constitutive signaling through the phosphatidylinositol 3'-kinase (PI3K) pathway is a cause of treatment resistance in breast…”
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Expression of the SM‐20 Gene Promotes Death in Nerve Growth Factor‐Dependent Sympathetic Neurons by Lipscomb, Elizabeth A., Sarmiere, Patrick D., Crowder, Robert J., Freeman, Robert S.

“…: Sympathetic neurons undergo apoptosis when deprived of nerve growth factor (NGF). Inhibitors of RNA or protein synthesis block this death, suggesting that…”
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Abstract PD6-4: ESR1 gene fusions implicated in endocrine therapy resistance of ER+ breast cancer by Shao, Jieya, Zhang, Jin, Crowder, Robert J, Goncalves, Rodrigo, Phommaly, Chanpheng, Perou, Charles M, Maher, Christopher A, Thompson, E Aubrey, Ellis, Matthew J

“…Abstract Background. We recently identified an in-frame ESR1 translocation in a tumor and PDX pair from a patient with endocrine therapy resistant advanced…”
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Glycogen Synthase Kinase-3β Activity Is Critical for Neuronal Death Caused by Inhibiting Phosphatidylinositol 3-Kinase or Akt but Not for Death Caused by Nerve Growth Factor Withdrawal by Crowder, Robert J., Freeman, Robert S.

“…Numerous studies reveal that phosphatidylinositol (PI) 3-kinase and Akt protein kinase are important mediators of cell survival. However, the…”
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Abstract 5478: Combination of fulvestrant with the allosteric Akt inhibitor MK-2206 promotes anti-tumor activity in estrogen deprivation-resistant estrogen receptor positive breast cancer by Sanchez, Cesar G., Crowder, Robert J., Phommaly, Chanpheng, Ellis, Matthew J.

“…Abstract Introduction: Activation of the phosphatidylinositol-3-kinase (PI3K)/Akt pathway through gene mutation, most frequently in PIK3CA, is common in…”
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Reaction of Trifluoroacetaldehyde with Amino Acids, Nucleotides, Lipid Nucleophiles, and Their Analogs by Yin, Hequn, Crowder, Robert J, Jones, Jeffrey P, Anders, M. W

“…Trihaloacetaldehydes are used as sedatives, are key intermediates in the metabolism of 1,1,1,2-tetrahaloethanes, some of which are chlorofluorocarbon…”
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Abstract LB-423: Whole genome comparisons of pre- and post- aromatase inhibitor treatment in estrogen receptor positive breast cancer by Ellis, Matthew J., Li, Ding, Shen, Dong, Luo, Jingqin, Suman, Vera J., Wallis, John W., Van Tine, Brian A., Hoog, Jeremy, Crowder, Robert J., Snider, Jacqueline E., Ballman, Karla, Chen, Ken, Koboldt, Daniel C., Schierding, William S., McMichael, Joshua F., Miller, Christopher A., Kandoth, Cyriac, Lu, Charles, Harris, Christopher C., McLellan, Michael D., Wendl, Michael C., DeSchryver, Katherine, Allred, D. Craig, Esserman, Laura, Unzeitig, Gary, Margenthaler, Julie, Babiera, G.V., Marcom, P. Kelly, Guenther, J.M., Leitch, Marilyn, Hunt, Kelly, Olson, John, Tao, Yu, Fulton, Lucinda L., Fulton, Robert S., Harrison, Michelle, Oberkfell, Ben, Du, Feiyu, Demeter, Ryan, Griffith, Malachi, Vickery, Tammi L., McDonald, Sandra A., Watson, Mark, Dooling, David J., Ota, David, Chang, Li-Wei, Bose, Ron, Ley, Timothy J., Wilson, Richard K., Mardis, Elaine R.

“…Abstract Background: Estrogen receptors are over-expressed in around 70% of breast cancer cases. The genetic changes that occur during aromatase inhibitor (AI)…”
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The survival of sympathetic neurons promoted by potassium depolarization, but not by cyclic AMP, requires Phosphatidylinositol 3-kinase and Akt by CROWDER, R. J, FREEMAN, R. S

“…Phosphatidylinositol (PI) 3-kinase and Akt protein kinase mediate trophic factor-dependent survival in certain neurons. However, a role for these enzymes in…”
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