Search Results - "CROUZY, SERGE"

A Homozygous Ancestral SVA-Insertion-Mediated Deletion in WDR66 Induces Multiple Morphological Abnormalities of the Sperm Flagellum and Male Infertility by Kherraf, Zine-Eddine, Amiri-Yekta, Amir, Dacheux, Denis, Karaouzène, Thomas, Coutton, Charles, Christou-Kent, Marie, Martinez, Guillaume, Landrein, Nicolas, Le Tanno, Pauline, Fourati Ben Mustapha, Selima, Halouani, Lazhar, Marrakchi, Ouafi, Makni, Mounir, Latrous, Habib, Kharouf, Mahmoud, Pernet-Gallay, Karin, Gourabi, Hamid, Robinson, Derrick R., Crouzy, Serge, Blum, Michael, Thierry-Mieg, Nicolas, Touré, Aminata, Zouari, Raoudha, Arnoult, Christophe, Bonhivers, Mélanie, Ray, Pierre F.

“…Multiple morphological abnormalities of the sperm flagellum (MMAF) is a severe form of male infertility defined by the presence of a mosaic of anomalies,…”
Get full text

A Mechanistic Rationale Approach Revealed the Unexpected Chemoselectivity of an Artificial Ru-Dependent Oxidase: A Dual Experimental/Theoretical Approach by Lopez, Sarah, Mayes, David Michael, Crouzy, Serge, Cavazza, Christine, Leprêtre, Chloé, Moreau, Yohann, Burzlaff, Nicolai, Marchi-Delapierre, Caroline, Ménage, Stéphane

“…Artificial enzymes represent an attractive alternative to design abiotic biocatalysis. EcNikA-Ru1, an artificial metalloenzyme developed by embedding a…”
Get full text

Quaternary Structure of Fur Proteins, a New Subfamily of Tetrameric Proteins by Pérard, Julien, Covès, Jacques, Castellan, Mathieu, Solard, Charles, Savard, Myriam, Miras, Roger, Galop, Sandra, Signor, Luca, Crouzy, Serge, Michaud-Soret, Isabelle, de Rosny, Eve

“…The ferric uptake regulator (Fur) belongs to the family of the DNA-binding metal-responsive transcriptional regulators. Fur is a global regulator found in all…”
Get full text

Inter-Site Cooperativity of Calmodulin N-Terminal Domain and Phosphorylation Synergistically Improve the Affinity and Selectivity for Uranyl by Beccia, Maria Rosa, Sauge-Merle, Sandrine, Brémond, Nicolas, Lemaire, David, Henri, Pierre, Battesti, Christine, Guilbaud, Philippe, Crouzy, Serge, Berthomieu, Catherine

“…Uranyl-protein interactions participate in uranyl trafficking or toxicity to cells. In addition to their qualitative identification, thermodynamic data are…”
Get full text

Model Peptides Based on the Binding Loop of the Copper Metallochaperone Atx1:  Selectivity of the Consensus Sequence MxCxxC for Metal Ions Hg(II), Cu(I), Cd(II), Pb(II), and Zn(II) by Rousselot-Pailley, Pierre, Sénèque, Olivier, Lebrun, Colette, Crouzy, Serge, Boturyn, Didier, Dumy, Pascal, Ferrand, Michel, Delangle, Pascale

“…The amino acid sequence MxCxxC is conserved in many soft-metal transporters that are involved in the control of the intracellular concentration of ions such as…”
Get full text

Copper(II)-Complex Directed Regioselective Mono-p-Toluenesulfonylation of Cyclomaltoheptaose at a Primary Hydroxyl Group Position: An NMR and Molecular Dynamics-Aided Design by Law, Ho, Benito, Juan M, García Fernández, José M, Jicsinszky, Laszlo, Crouzy, Serge, Defaye, Jacques

“…Interactions between cyclomaltoheptaose (β-cyclodextrin, βCD) and p-toluenesulfonyl chloride (TsCl) were investigated using MD simulations, both in vacuum,…”
Get full text

The Q-loop Disengages from the First Intracellular Loop during the Catalytic Cycle of the Multidrug ABC Transporter BmrA by Dalmas, Olivier, Orelle, Cédric, Foucher, Anne-Emmanuelle, Geourjon, Christophe, Crouzy, Serge, Di Pietro, Attilio, Jault, Jean-Michel

“…The ATP-binding cassette is the most abundant family of transporters including many medically relevant members and gathers both importers and exporters…”
Get full text

Is the cytoplasmic loop of MerT, the mercuric ion transport protein, involved in mercury transfer to the mercuric reductase? by Rossy, Emmanuel, Sénèque, Olivier, Lascoux, David, Lemaire, David, Crouzy, Serge, Delangle, Pascale, Covès, Jacques

“…In MerT, the mercury transporter, a first cysteine pair, located in the first trans-membrane helix, receives mercury from the periplasm. Then, a second…”
Get full text

Dynamics and Stability of the Metal Binding Domains of the Menkes ATPase and Their Interaction with Metallochaperone HAH1 by Arumugam, Karthik, Crouzy, Serge

“…Human copper-ATPases ATP7A and ATP7B are essential for intracellular copper homeostasis. The main roles of the Menkes protein, ATP7A, are the delivery of…”
Get full text

A fragment-based drug discovery strategy applied to the identification of NDM-1 β-lactamase inhibitors by Caburet, Jérémy, Boucherle, Benjamin, Bourdillon, Sofiane, Simoncelli, Giorgia, Verdirosa, Federica, Docquier, Jean-Denis, Moreau, Yohann, Krimm, Isabelle, Crouzy, Serge, Peuchmaur, Marine

“…Hydrolysis of β-lactam drugs, a major class of antibiotics, by serine or metallo-β-lactamases (SBL or MBL) is one of the main mechanisms for antibiotic…”
Get full text

Hybrid Amyloid‐Based Redox Hydrogel for Bioelectrocatalytic H2 Oxidation by Duraffourg, Nicolas, Leprince, Maxime, Crouzy, Serge, Hamelin, Olivier, Usson, Yves, Signor, Luca, Cavazza, Christine, Forge, Vincent, Albertin, Luca

“…An artificial amyloid‐based redox hydrogel was designed for mediating electron transfer between a [NiFeSe] hydrogenase and an electrode. Starting from a…”
Get full text

Hybrid Amyloid‐Based Redox Hydrogel for Bioelectrocatalytic H 2 Oxidation by Duraffourg, Nicolas, Leprince, Maxime, Crouzy, Serge, Hamelin, Olivier, Usson, Yves, Signor, Luca, Cavazza, Christine, Forge, Vincent, Albertin, Luca

“…An artificial amyloid‐based redox hydrogel was designed for mediating electron transfer between a [NiFeSe] hydrogenase and an electrode. Starting from a…”
Get full text

Tyrosine metabolism: identification of a key residue in the acquisition of prephenate aminotransferase activity by 1β aspartate aminotransferase by Giustini, Cecile, Graindorge, Matthieu, Cobessi, David, Crouzy, Serge, Robin, Adeline, Curien, Gilles, Matringe, Michel

“…Alternative routes for the post‐chorismate branch of the biosynthetic pathway leading to tyrosine exist, the 4‐hydroxyphenylpyruvate or the arogenate route…”
Get full text

The carbon monoxide dehydrogenase accessory protein CooJ is a histidine-rich multidomain dimer containing an unexpected Ni(II)-binding site by Alfano, Marila, Pérard, Julien, Carpentier, Philippe, Basset, Christian, Zambelli, Barbara, Timm, Jennifer, Crouzy, Serge, Ciurli, Stefano, Cavazza, Christine

“…Activation of nickel enzymes requires specific accessory proteins organized in multiprotein complexes controlling metal transfer to the active site…”
Get full text

Extracellular Blockade of K+ Channels by Tea by Crouzy, Serge, Bernèche, Simon, Roux, Benoît

“…TEA is a classical blocker of K+ channels. From mutagenesis studies, it has been shown that external blockade by TEA is strongly dependent upon the presence of…”
Get full text

Mercury Trithiolate Binding (HgS3) to a de Novo Designed Cyclic Decapeptide with Three Preoriented Cysteine Side Chains by Sénèque, Olivier, Rousselot-Pailley, Pierre, Pujol, Anaïs, Boturyn, Didier, Crouzy, Serge, Proux, Olivier, Manceau, Alain, Lebrun, Colette, Delangle, Pascale

“…Mercury­(II) is an unphysiological soft ion with high binding affinity for thiolate ligands. Its toxicity lies in the interactions with low molecular weight…”
Get full text

Short oligopeptides with three cysteine residues as models of sulphur-rich Cu(i)- and Hg(ii)-binding sites in proteins by Mesterházy, Edit, Lebrun, Colette, Crouzy, Serge, Jancsó, Attila, Delangle, Pascale

“…The essential Cu(i) and the toxic Hg(ii) ions possess similar coordination properties, and therefore, similar cysteine rich proteins participate in the control…”
Get full text

Short oligopeptides with three cysteine residues as models of sulphur-rich Cu(i)- and Hg(ii)-binding sites in proteinsElectronic supplementary information (ESI) available. See DOI: 10.1039/c8mt00113h by Mesterházy, Edit, Lebrun, Colette, Crouzy, Serge, Jancsó, Attila, Delangle, Pascale

“…The essential Cu( i ) and the toxic Hg( ii ) ions possess similar coordination properties, and therefore, similar cysteine rich proteins participate in the…”
Get full text

Characterization of the Bubblegum acyl-CoA synthetase of Microchloropsis gaditana by Billey, Elodie, Magneschi, Leonardo, Leterme, Sébastien, Bedhomme, Mariette, Andres-Robin, Amélie, Poulet, Laurent, Michaud, Morgane, Finazzi, Giovanni, Dumas, Renaud, Crouzy, Serge, Laueffer, Frédéric, Fourage, Laurent, Rébeillé, Fabrice, Amato, Alberto, Collin, Séverine, Jouhet, Juliette, Maréchal, Eric

“…The metabolic pathways of glycerolipids are well described in cells containing chloroplasts limited by a two-membrane envelope but not in cells containing…”
Get full text

4-hydroxyphenylpyruvate dioxygenase catalysis: identification of catalytic residues and production of a hydroxylated intermediate shared with a structurally unrelated enzyme by Raspail, Corinne, Graindorge, Matthieu, Moreau, Yohann, Crouzy, Serge, Lefèbvre, Bertrand, Robin, Adeline Y, Dumas, Renaud, Matringe, Michel

“…4-Hydroxyphenylpyruvate dioxygenase (HPPD) catalyzes the conversion of 4-hydroxyphenylpyruvate (HPP) into homogentisate. HPPD is the molecular target of very…”
Get full text