Search Results - "CROTTY, Shane"

Pre-existing immunity to SARS-CoV-2: the knowns and unknowns by Sette, Alessandro, Crotty, Shane

“…T cell reactivity against SARS-CoV-2 was observed in unexposed people; however, the source and clinical relevance of the reactivity remains unknown. It is…”
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Immunological memory to SARS‐CoV‐2 infection and COVID‐19 vaccines by Sette, Alessandro, Crotty, Shane

“…Immunological memory is the basis of protective immunity provided by vaccines and previous infections. Immunological memory can develop from multiple branches…”
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The 1-1-1 fallacy by Crotty, Shane

“…T‐cell help to B cells is a fundamental aspect of adaptive immunity and the generation of B‐cell memory (memory B cells and plasma cells). Follicular helper…”
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Factors in B cell competition and immunodominance by Abbott, Robert K., Crotty, Shane

“…The majority of all vaccines work by inducing protective antibody responses. The mechanisms by which the B cells responsible for producing protective…”
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Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection by Dan, Jennifer M, Mateus, Jose, Kato, Yu, Hastie, Kathryn M, Yu, Esther Dawen, Faliti, Caterina E, Grifoni, Alba, Ramirez, Sydney I, Haupt, Sonya, Frazier, April, Nakao, Catherine, Rayaprolu, Vamseedhar, Rawlings, Stephen A, Peters, Bjoern, Krammer, Florian, Simon, Viviana, Saphire, Erica Ollmann, Smith, Davey M, Weiskopf, Daniela, Sette, Alessandro, Crotty, Shane

“…Understanding immune memory to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for improving diagnostics and vaccines and for…”
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Cutting edge: STAT1 is required for IL-6-mediated Bcl6 induction for early follicular helper cell differentiation by Choi, Youn Soo, Eto, Danelle, Yang, Jessica A, Lao, Christopher, Crotty, Shane

“…Bcl6 is required for CD4 T cell differentiation into T follicular helper cells (Tfh). In this study, we examined the role of IL-6 in early processes of in vivo…”
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Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo by Kato, Yu, Abbott, Robert K., Freeman, Brian L., Haupt, Sonya, Groschel, Bettina, Silva, Murillo, Menis, Sergey, Irvine, Darrell J., Schief, William R., Crotty, Shane

“…How antigen valency affects B cells in vivo during immune responses is not well understood. Here, using HIV immunogens with defined valencies ranging from 1 to…”
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LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6 by Choi, Youn Soo, Gullicksrud, Jodi A, Xing, Shaojun, Zeng, Zhouhao, Shan, Qiang, Li, Fengyin, Love, Paul E, Peng, Weiqun, Xue, Hai-Hui, Crotty, Shane

“…Follicular helper T cells (T FH cells) are specialized effector CD4 + T cells that help B cells develop germinal centers and memory. Crotty and colleagues show…”
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Dengue virus infection elicits highly polarized CX3CR1⁺ cytotoxic CD4⁺ T cells associated with protective immunity by Weiskopf, Daniela, Bangs, Derek J., Sidney, John, Kolla, Ravi V., De Silva, Aruna D., de Silva, Aravinda M., Crotty, Shane, Peters, Bjoern, Sette, Alessandro

“…Dengue virus (DENV) is a rapidly spreading pathogen with unusual pathogenesis, and correlates of protection from severe dengue disease and vaccine efficacy…”
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Comparative analysis of activation induced marker (AIM) assays for sensitive identification of antigen-specific CD4 T cells by Reiss, Samantha, Baxter, Amy E, Cirelli, Kimberly M, Dan, Jennifer M, Morou, Antigoni, Daigneault, Audrey, Brassard, Nathalie, Silvestri, Guido, Routy, Jean-Pierre, Havenar-Daughton, Colin, Crotty, Shane, Kaufmann, Daniel E

“…The identification and study of antigen-specific CD4 T cells, both in peripheral blood and in tissues, is key for a broad range of immunological research,…”
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IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation by Eto, Danelle, Lao, Christopher, DiToro, Daniel, Barnett, Burton, Escobar, Tania C, Kageyama, Robin, Yusuf, Isharat, Crotty, Shane

“…Cytokines are important modulators of lymphocytes, and both interleukin-21 (IL-21) and IL-6 have proposed roles in T follicular helper (Tfh) differentiation,…”
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BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanisms by Hatzi, Katerina, Nance, J Philip, Kroenke, Mark A, Bothwell, Marcella, Haddad, Elias K, Melnick, Ari, Crotty, Shane

“…Follicular helper T cells (Tfh cells) are required for T cell help to B cells, and BCL6 is the defining transcription factor of Tfh cells. However, the…”
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Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination by Tam, Hok Hei, Melo, Mariane B., Kang, Myungsun, Pelet, Jeisa M., Ruda, Vera M., Foley, Maria H., Hu, Joyce K., Kumari, Sudha, Crampton, Jordan, Baldeon, Alexis D., Sanders, Rogier W., Moore, John P., Crotty, Shane, Langer, Robert, Anderson, Daniel G., Chakraborty, Arup K., Irvine, Darrell J.

“…Natural infections expose the immune system to escalating antigen and inflammation over days to weeks, whereas nonlive vaccines are single bolus events. We…”
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HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen by Jardine, Joseph G., Kulp, Daniel W., Havenar-Daughton, Colin, Sarkar, Anita, Briney, Bryan, Sok, Devin, Sesterhenn, Fabian, Ereño-Orbea, June, Kalyuzhniy, Oleksandr, Deresa, Isaiah, Hu, Xiaozhen, Spencer, Skye, Jones, Meaghan, Georgeson, Erik, Adachi, Yumiko, Kubitz, Michael, deCamp, Allan C., Julien, Jean-Philippe, Wilson, Ian A., Burton, Dennis R., Crotty, Shane, Schief, William R.

“…Induction of broadly neutralizing antibodies (bnAbs) is a major HIV vaccine goal. Germline-targeting immunogens aim to initiate bnAb induction by activating…”
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NVX-CoV2373 vaccination induces functional SARS-CoV-2–specific CD4+ and CD8+ T cell responses by Rydyznski Moderbacher, Carolyn, Kim, Christina, Mateus, Jose, Plested, Joyce, Zhu, Mingzhu, Cloney-Clark, Shane, Weiskopf, Daniela, Sette, Alessandro, Fries, Louis, Glenn, Gregory, Crotty, Shane

“…NVX-CoV2373 is an adjuvanted recombinant full-length SARS-CoV-2 spike trimer protein vaccine demonstrated to be protective against COVID-19 in efficacy trials…”
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CXCL13 is a plasma biomarker of germinal center activity by Havenar-Daughton, Colin, Lindqvist, Madelene, Heit, Antje, Wu, Jennifer E., Reiss, Samantha M., Kendric, Kayla, Bélanger, Simon, Kasturi, Sudhir Pai, Landais, Elise, Akondy, Rama S., McGuire, Helen M., Bothwell, Marcella, Vagefi, Parsia A., Scully, Eileen, Tomarasm, Georgia D., Davis, Mark M., Poignard, Pascal, Ahmed, Rafi, Walker, Bruce D., Pulendran, Bali, McElrath, M. Juliana, Kaufmann, Daniel E., Crotty, Shane

“…Significantly higher levels of plasma CXCL13 [chemokine (C-X-C motif) ligand 13] were associated with the generation of broadly neutralizing antibodies (bnAbs)…”
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Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis by Gaddis, Dalia E., Padgett, Lindsey E., Wu, Runpei, McSkimming, Chantel, Romines, Veronica, Taylor, Angela M., McNamara, Coleen A., Kronenberg, Mitchell, Crotty, Shane, Thomas, Michael J., Sorci-Thomas, Mary G., Hedrick, Catherine C.

“…Regulatory T (Treg) cells contribute to the anti-inflammatory response during atherogenesis. Here we show that during atherogenesis Treg cells lose Foxp3…”
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Allergen-specific immunotherapy modulates the balance of circulating Tfh and Tfr cells by Schulten, Veronique, PhD, Tripple, Victoria, BSc, Seumois, Grégory, PhD, Qian, Yu, PhD, Scheuermann, Richard H., PhD, Fu, Zheng, PhD, Locci, Michela, PhD, Rosales, Sandy, BSc, Vijayanand, Pandurangan, MD, Sette, Alessandro, PhD, Alam, Rafeul, MD, Crotty, Shane, PhD, Peters, Bjoern, PhD

“…Capsule summary Follicular helper T cells (Tfh cells) are a CD4 T cell subset essential for germinal center formation and B cell responses, although their role…”
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Increased Peripheral Blood Neutrophil Activation Phenotypes and Neutrophil Extracellular Trap Formation in Critically Ill Coronavirus Disease 2019 (COVID-19) Patients: A Case Series and Review of the Literature by Masso-Silva, Jorge A, Moshensky, Alexander, Lam, Michael T Y, Odish, Mazen F, Patel, Arjun, Xu, Le, Hansen, Emily, Trescott, Samantha, Nguyen, Celina, Kim, Roy, Perofsky, Katherine, Perera, Samantha, Ma, Lauren, Pham, Josephine, Rolfsen, Mark, Olay, Jarod, Shin, John, Dan, Jennifer M, Abbott, Robert K, Ramirez, Sydney, Alexander, Thomas H, Lin, Grace Y, Fuentes, Ana Lucia, Advani, Ira, Gunge, Deepti, Pretorius, Victor, Malhotra, Atul, Sun, Xin, Duran, Jason, Hepokoski, Mark, Crotty, Shane, Coufal, Nicole G, Meier, Angela, Crotty Alexander, Laura E

“…Abstract Background Increased inflammation has been well defined in coronavirus disease 2019 (COVID-19), while definitive pathways driving severe forms of this…”
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Design and validation of HIV peptide pools for detection of HIV-specific CD4+ and CD8+ T cells by Al-Kolla, Rita, Grifoni, Alba, Crotty, Shane, Sette, Alessandro, Gianella, Sara, Dan, Jennifer

“…Reagents to monitor T cell responses to the entire HIV genome, based on well characterized epitopes, are missing. Evaluation of HIV-specific T cell responses…”
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