Search Results - "CROSBY, Katherine"

Analysis of Receptor Tyrosine Kinase ROS1-Positive Tumors in Non―Small Cell Lung Cancer: Identification of a FIG-ROS1 Fusion by RIMKUNAS, Victoria M, CROSBY, Katherine E, DAIQIANG LI, YERONG HU, KELLY, Meghan E, GU, Ting-Lei, MACK, Jennifer S, SILVER, Matthew R, XINMIN ZHOU, HAACK, Herbert

“…To deepen our understanding of mutant ROS1 expression, localization, and frequency in non-small cell lung cancer (NSCLC), we developed a highly specific and…”
Get full text

Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers by Katayama, Ryohei, Shaw, Alice T, Khan, Tahsin M, Mino-Kenudson, Mari, Solomon, Benjamin J, Halmos, Balazs, Jessop, Nicholas A, Wain, John C, Yeo, Alan Tien, Benes, Cyril, Drew, Lisa, Saeh, Jamal Carlos, Crosby, Katherine, Sequist, Lecia V, Iafrate, A John, Engelman, Jeffrey A

“…Most anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancers (NSCLCs) are highly responsive to treatment with ALK tyrosine kinase inhibitors…”
Get more information

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers by Cantley, Lewis C, Wong, Kwok-Kin, Engelman, Jeffrey A, Chen, Liang, Tan, Xiaohong, Crosby, Katherine, Guimaraes, Alexander R, Upadhyay, Rabi, Maira, Michel, McNamara, Kate, Perera, Samanthi A, Song, Youngchul, Chirieac, Lucian R, Kaur, Ramneet, Lightbown, Angela, Simendinger, Jessica, Li, Timothy, Padera, Robert F, García-Echeverría, Carlos, Weissleder, Ralph, Mahmood, Umar

“…Somatic mutations that activate phosphoinositide 3-kinase (PI3K) have been identified in the p110-α catalytic subunit (encoded by PIK3CA). They are most…”
Get full text

PIK3CA/PTEN Mutations and Akt Activation As Markers of Sensitivity to Allosteric mTOR Inhibitors by MERIC-BERNSTAM, Funda, AKCAKANAT, Argun, PHAN, Alexandria T, WOLFF, Robert A, GUPTA, Sanjay, MILLS, Gordon B, YAO, James, HUIQIN CHEN, DO, Kim-Anh, SANGAI, Takafumi, ADKINS, Farrell, GONZALEZ-ANGULO, Ana Maria, RASHID, Asif, CROSBY, Katherine, MEI DONG

“…We sought to determine whether phosphoinositide 3-kinase (PI3K) pathway mutation or activation state and rapamycin-induced feedback loop activation of Akt is…”
Get full text

Diagnosis of NUT Midline Carcinoma Using a NUT-specific Monoclonal Antibody by HAACK, Herbert, JOHNSON, Laura A, CHANG, Martin C, ASTER, Jon C, FRENCH, Christopher A, FRY, Christopher J, CROSBY, Katherine, POLAKIEWICZ, Roberto D, STELOW, Edward B, HONG, Seung-Mo, SCHWARTZ, Brian E, CAMERON, Michael J, RUBIN, Mark A

“…NUT midline carcinoma (NMC) is a uniformly lethal malignancy that is defined by rearrangement of the nuclear protein in testis (NUT) gene on chromosome 15q14…”
Get full text

Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinoma by Gu, Ting-Lei, Deng, Xiaxing, Huang, Feizhou, Tucker, Meghan, Crosby, Katherine, Rimkunas, Victoria, Wang, Yi, Deng, Gang, Zhu, Lei, Tan, Zhiping, Hu, Yerong, Wu, Chunlin, Nardone, Julie, MacNeill, Joan, Ren, Jianmin, Reeves, Cynthia, Innocenti, Gregory, Norris, Brett, Yuan, Jin, Yu, Jian, Haack, Herbert, Shen, Baiyong, Peng, Chenghong, Li, Hongwei, Zhou, Xinmin, Liu, Xunyang, Rush, John, Comb, Michael J

“…Cholangiocarcinoma, also known as bile duct cancer, is the second most common primary hepatic carcinoma with a median survival of less than 2 years. The…”
Get full text

mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice by Guertin, David A., Stevens, Deanna M., Saitoh, Maki, Kinkel, Stephanie, Crosby, Katherine, Sheen, Joon-Ho, Mullholland, David J., Magnuson, Mark A., Wu, Hong, Sabatini, David M.

“…mTOR complex 2 (mTORC2) contains the mammalian target of rapamycin (mTOR) kinase and the Rictor regulatory protein and phosphorylates Akt. Whether this…”
Get full text

Genomic delineation and description of species and within-species lineages in the genus Pantoea by Crosby, Katherine C, Rojas, Mariah, Sharma, Parul, Johnson, Marcela A, Mazloom, Reza, Kvitko, Brian H, Smits, Theo H M, Venter, Stephanus N, Coutinho, Teresa A, Heath, Lenwood S, Palmer, Marike, Vinatzer, Boris A

“…As the name of the genus ("of all sorts and sources") suggests, this genus includes bacteria with a wide range of provenances, including plants, animals,…”
Get full text

Identification of Anaplastic Lymphoma Kinase as a Potential Therapeutic Target in Ovarian Cancer by HONG REN, TAN, Zhi-Ping, YI ZHANG, ZHOU, Xin-Min, GU, Ting-Lei, YANG, Yi-Feng, COMB, Michael J, XIN ZHU, CROSBY, Katherine, HAACK, Herbert, REN, Jian-Min, BEAUSOLEIL, Sean, MORITZ, Albrecht, INNOCENTI, Gregory, RUSH, John

“…Ovarian cancer is the leading cause of death from gynecologic cancer. Improvement in the clinical outcome of patients is likely to be achieved by the…”
Get full text

Mutation-Specific Antibodies for the Detection of EGFR Mutations in Non–Small-Cell Lung Cancer by JIAN YU, KANE, Susan, FERRANTE, Michelle, WAN CHEUNG CHEUNG, XIQIANG HONG, CHIRIEAC, Lucian R, SHOLL, Lynette M, HAACK, Herbert, SMITH, Bradley L, POLAKIEWICZ, Roberto D, YI TAN, GU, Ting-Lei, JIONG WU, LODA, Massimo, XINMIN ZHOU, COMB, Michael J, BENEDETTINI, Elisa, DAIQIANG LI, REEVES, Cynthia, INNOCENTI, Gregory, WETZEL, Randy, CROSBY, Katherine, BECKER, Alison

“…Purpose: Activating mutations within the tyrosine kinase domain of epidermal growth factor receptor (EGFR) are found in approximately 10% to 20% of…”
Get full text

Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs by Rong, Liwei, Livingstone, Mark, Sukarieh, Rami, Petroulakis, Emmanuel, Gingras, Anne-Claude, Crosby, Katherine, Smith, Bradley, Polakiewicz, Roberto D, Pelletier, Jerry, Ferraiuolo, Maria A, Sonenberg, Nahum

“…Eukaryotic initiation factor (eIF) 4E, the mRNA 5'-cap-binding protein, mediates the association of eIF4F with the mRNA 5'-cap structure to stimulate…”
Get full text

Akt/cAMP-Responsive Element Binding Protein/Cyclin D1 Network: A Novel Target for Prostate Cancer Inhibition in Transgenic Adenocarcinoma of Mouse Prostate Model Mediated by Nexrutine, a Phellodendron Amurense Bark Extract by KUMAR, Addanki P, BHASKARAN, Shylesh, GANAPATHY, Manonmani, CROSBY, Katherine, DAVIS, Michael D, KOCHUNOV, Peter, SCHOOLFIELD, John, YEH, I-Tien, TROYER, Dean A, GHOSH, Rita

“…Purpose: Development of prostate cancer prevention strategies is an important priority to overcome high incidence, morbidity, and mortality. Recently, we…”
Get full text

Imatinib-Induced Regression of AIDS-Related Kaposi's Sarcoma by KOON, Henry B, BUBLEY, Glenn J, EGORIN, Merrill J, TAHAN, Steven R, DEZUBE, Bruce J, PANTANOWITZ, Liron, MASIELLO, David, SMITH, Brad, CROSBY, Katherine, PROPER, Joann, WEEDEN, Will, MILLER, Thomas E, CHATIS, Pamela

“…Activation of the platelet-derived growth factor (PDGF) and c-kit receptors has been proposed as important in mediating the growth of AIDS-related Kaposi's…”
Get full text

Regulation of Cox-2 by Cyclic AMP Response Element Binding Protein in Prostate Cancer: Potential Role for Nexrutine by Ghosh, Rita, Garcia, Gretchen E., Crosby, Katherine, Inoue, Hiroyasu, Thompson, Ian M., Troyer, Dean A., Kumar, Addanki P.

“…We recently showed that NexrutineR, a Phellodendron amurense bark extract, suppresses proliferation of prostate cancer cell lines and tumor development in the…”
Get full text

Antibody-Based Profiling of the Phosphoinositide 3-Kinase Pathway in Clinical Prostate Cancer by THOMAS, George V, HORVATH, Steve, SMITH, Bradley L, CROSBY, Katherine, LEBEL, Lori A, SCHRAGE, Matthew, SAID, Jonathan, DE KERNION, Jean, REITER, Robert E, SAWYERS, Charles L

“…Purpose: As kinase inhibitors transition from the laboratory to patients, it is imperative to develop biomarkers that can be used in the clinic. The primary…”
Get full text

Abstract 5689: Characterization of immune infiltrate and checkpoint protein expression patterns in murine syngeneic tumors via multiplex immunohistochemistry by Ziello, Jennifer, Klein, Sarah, Crosby, Katherine

“…Abstract Murine syngeneic tumor models are increasingly utilized for preclinical immuno-oncology studies as immunotherapeutic strategies continue to make…”
Get full text

Atlanto‐occipital subluxation in an adult Thoroughbred gelding by Barnes, Hattie K., Crosby, Katherine, Talbot, Alison, Baldwin, Christopher M.

“…Summary A 13‐year‐old gelding was referred to the University of Liverpool Equine Hospital for further investigation of ataxia and neck pain following a…”
Get full text

An ErbB3 Antibody, MM-121, Is Active in Cancers with Ligand-Dependent Activation by SCHOEBERL, Birgit, FABER, Anthony C, FULGHAM, Aaron, SONG, Youngchul, NIELSEN, Ulrik B, ENGELMAN, Jeffrey A, WONG, Kwok-Kin, DANAN LI, LIANG, Mei-Chih, CROSBY, Katherine, ONSUM, Matthew, BURENKOVA, Olga, PACE, Emily, WALTON, Zandra, LIN NIE

“…ErbB3 is a critical activator of phosphoinositide 3-kinase (PI3K) signaling in epidermal growth factor receptor (EGFR; ErbB1), ErbB2 [human epidermal growth…”
Get full text

PD-1 blockade activates conventional CD4 T cells and the innate immune response during glioblastoma eradication by Klein, Sarah, Ziello, Jennifer, Speranza, Maria, Gokhale, Prafulla, Kirschmeier, Paul, Crosby, Katherine, Freeman, Gordon, Reardon, David

“…Abstract Blockade of immune cell co-inhibitory receptor PD-1 using monoclonal antibodies enables anti-tumor immune responses in various solid tumors and…”
Get full text

Abstract 290: Development and characterization of antibodies specific for the SS18-SSX fusion protein in synovial sarcoma by Desilets, Curtis, Chen, Fang, Comeau, Christopher, Costa, Katrina, Crosby, Katherine, Ferrante, Michelle, Grange, Christopher, Patrikas, Maggie, McBride, Matthew, Baranov, Esther, Hornick, Jason, Kadoch, Cigall

“…Abstract Synovial sarcoma (SS) is a soft tissue cancer characterized by the fusion of the SS18 gene, which encodes for a subunit of the BAF ATP-dependent…”
Get full text