Search Results - "CROOK, Tim"

Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer by Delage, Barbara, Fennell, Dean A., Nicholson, Linda, McNeish, Iain, Lemoine, Nicholas R., Crook, Tim, Szlosarek, Peter W.

“…Arginine, a semi‐essential amino acid in humans, is critical for the growth of human cancers, particularly those marked by de novo chemoresistance and a poor…”
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DRAM, a p53-Induced Modulator of Autophagy, Is Critical for Apoptosis by Crighton, Diane, Wilkinson, Simon, O'Prey, Jim, Syed, Nelofer, Smith, Paul, Harrison, Paul R., Gasco, Milena, Garrone, Ornella, Crook, Tim, Ryan, Kevin M.

“…Inactivation of cell death is a major step in tumor development, and p53, a tumor suppressor frequently mutated in cancer, is a critical mediator of cell…”
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A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer by Girardini, Javier E., Napoli, Marco, Piazza, Silvano, Rustighi, Alessandra, Marotta, Carolina, Radaelli, Enrico, Capaci, Valeria, Jordan, Lee, Quinlan, Phil, Thompson, Alastair, Mano, Miguel, Rosato, Antonio, Crook, Tim, Scanziani, Eugenio, Means, Anthony R., Lozano, Guillermina, Schneider, Claudio, Del Sal, Giannino

“…TP53 missense mutations dramatically influence tumor progression, however, their mechanism of action is still poorly understood. Here we demonstrate the…”
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Fesoterodine treatment of pediatric patients with neurogenic detrusor overactivity: A 24-week, randomized, open-label, phase 3 study by Kitta, Takeya, Darekar, Amanda, Malhotra, Bimal, Shahin, Mohamed H., Jones, Philip, Lindsay, Monica, Mallen, Sharon, Nieto, Alejandra, Crook, Tim J.

“…Neurogenic detrusor overactivity (NDO) can damage the upper urinary tract leading to chronic renal impairment. Antimuscarinic therapy is used to improve…”
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The efficacy and safety of tofacitinib in Asian patients with moderate to severe chronic plaque psoriasis: a Phase 3, randomized, double-blind, placebo-controlled study by Zhang, JianZhong, Tsai, Tsen-Fang, Lee, Min-Geol, Zheng, Min, Wang, Gang, Jin, HongZhong, Gu, Jun, Li, RuoYu, Liu, QuanZhong, Chen, Jin, Tu, CaiXia, Qi, ChunMei, Zhu, Hua, Ports, William C, Crook, Tim

“…Highlights • Tofacitinib is an oral Janus kinase inhibitor. • Tofacitinib showed superior efficacy vs placebo in Asian patients with psoriasis. • No unexpected…”
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Prognostic and Therapeutic Impact of Argininosuccinate Synthetase 1 Control in Bladder Cancer as Monitored Longitudinally by PET Imaging by ALLEN, Michael D, PHUONG LUONG, LATTANZIO, Laura, CHMIELEWSKA-KASSASSIR, Malgorzata, TOMLINSON, Ian, ROYLANCE, Rebecca, WHITAKER, Hayley C, WARREN, Anne Y, NEAL, David, FREZZA, Christian, BELTRAN, Luis, JONES, Louise J, HUDSON, Chantelle, CHELALA, Claude, WU, Bor-Wen, BOMALASKI, John S, JACKSON, Robert C, LU, Yong-Jie, CROOK, Tim, LEMOINE, Nicholas R, MATHER, Stephen, FOSTER, Julie, SOSABOWSKI, Jane, LEYTON, Julius, AVRIL, Norbert, LI, Chien-Feng, SZLOSAREK, Peter W, DELAGE, Barbara, GHAZALY, Essam, CUTTS, Rosalind, MING YUAN, SYED, Nelofer, LO NIGRO, Cristiana

“…Targeted therapies have yet to have significant impact on the survival of patients with bladder cancer. In this study, we focused on the urea cycle enzyme…”
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Metabolomic profiling identifies distinct phenotypes for ASS1 positive and negative GBM by Mörén, Lina, Perryman, Richard, Crook, Tim, Langer, Julia K, Oneill, Kevin, Syed, Nelofer, Antti, Henrik

“…Tumour cells have a high demand for arginine. However, a subset of glioblastomas has a defect in the arginine biosynthetic pathway due to epigenetic silencing…”
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Tanezumab Reduces Pain in Women with Interstitial Cystitis/Bladder Pain Syndrome and Patients with Nonurological Associated Somatic Syndromes by Nickel, J. Curtis, Mills, Ian W, Crook, Tim J, Jorga, Anamaria, Smith, Michael D, Atkinson, Gary, Krieger, John N

“…Purpose We performed pooled analyses from 3 small, clinical trials of tanezumab in patients with urological chronic pelvic pain, including chronic…”
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Vocalizing the Angels of Mons: Audio Dramas as Propaganda in the Great War of 1914 to 1918 by Crook, Tim

“…Sound drama production prior to the onset of the “Radio Age” underwent a pioneering development during the Great War. This was achieved by the making,…”
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Cancer Epigenetics: New Therapies and New Challenges by Hatzimichael, Eleftheria, Crook, Tim

“…Cancer is nowadays considered to be both a genetic and an epigenetic disease. The most well studied epigenetic modification in humans is DNA methylation;…”
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The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP by Sal, Giannino Del, Mantovani, Fiamma, Tocco, Francesca, Girardini, Javier, Smith, Paul, Gasco, Milena, Lu, Xin, Crook, Tim

“…The tumor-suppressor function of p53 relies on its transcriptional activity, which is modulated by post-translational modifications and interactions with…”
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iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53 by Lu, Xin, Bergamaschi, Daniele, Samuels, Yardena, Sullivan, Alexandra, Zvelebil, Marketa, Breyssens, Hilde, Bisso, Andrea, Del Sal, Giannino, Syed, Nelofer, Smith, Paul, Gasco, Milena, Crook, Tim

“…iASPP is one of the most evolutionarily conserved inhibitors of p53, whereas ASPP1 and ASPP2 are activators of p53. We show here that, in addition to the…”
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Preliminary Assessment of Safety and Efficacy in Proof-of-Concept, Randomized Clinical Trial of Tanezumab for Chronic Prostatitis/Chronic Pelvic Pain Syndrome by Nickel, J. Curtis, Atkinson, Gary, Krieger, John N, Mills, Ian W, Pontari, Michel, Shoskes, Daniel A, Crook, Tim J

“…Objective To assess the efficacy and safety of tanezumab, a humanized monoclonal antibody directed against the pain-mediating neurotrophin, nerve growth…”
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Epigenetic silencing of argininosuccinate synthetase confers resistance to platinum‐induced cell death but collateral sensitivity to arginine auxotrophy in ovarian cancer by Nicholson, Linda J., Smith, Paul R., Hiller, Louise, Szlosarek, Peter W., Kimberley, Christopher, Sehouli, Jalid, Koensgen, Dominique, Mustea, Alexander, Schmid, Peter, Crook, Tim

“…Evidence indicates that acquired resistance of cancers to chemotherapeutic agents can occur via epigenetic mechanisms. Down‐regulation of expression of…”
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ASPP1 and ASPP2: Common Activators of p53 Family Members by Bergamaschi, Daniele, Samuels, Yardena, Jin, Boquan, Duraisingham, Sai, Crook, Tim, Lu, Xin

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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ASPP Proteins Specifically Stimulate the Apoptotic Function of p53 by Samuels-Lev, Yardena, O'Connor, Daniel J., Bergamaschi, Daniele, Trigiante, Giuseppe, Hsieh, Jung-Kuang, Zhong, Shan, Campargue, Isabelle, Naumovski, Louie, Crook, Tim, Lu, Xin

“…We identified a family of proteins termed ASPP. ASPP1 is a protein homologous to 53BP2, the C-terminal half of ASPP2. ASPP proteins interact with p53 and…”
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In vivo Loss of Expression of Argininosuccinate Synthetase in Malignant Pleural Mesothelioma Is a Biomarker for Susceptibility to Arginine Depletion by SZLOSAREK, Peter W, KLABATSA, Astero, FENNELL, Dean A, PALLASKA, Arben, SHEAFF, Michael, SMITH, Paul, CROOK, Tim, GRIMSHAW, Matthew J, STEELE, Jeremy P, RUDD, Robin M, BALKWILL, Frances R

“…Purpose: Malignant pleural mesothelioma (MPM) is an increasing health burden on many societies worldwide and, being generally resistant to conventional…”
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Correction to: Metabolomic profiling identifies distinct phenotypes for ASS1 positive and negative GBM by Mörén, Lina, Perryman, Richard, Crook, Tim, Langer, Julia K, Oneill, Kevin, Syed, Nelofer, Antti, Henrik

“…In the original publication of this article [1], published on 8 February 2018, it was noticed that the acknowledgement of the source of the drug ADI-PEG20 was…”
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Paclitaxel resistance increases oncolytic adenovirus efficacy via upregulated CAR expression and dysfunctional cell cycle control by Ingemarsdotter, Carin K., Tookman, Laura A., Browne, Ashley, Pirlo, Katrina, Cutts, Rosalind, Chelela, Claude, Khurrum, Karisma F., Leung, Elaine Y.L., Dowson, Suzanne, Webber, Lee, Khan, Iftekhar, Ennis, Darren, Syed, Nelofer, Crook, Tim R., Brenton, James D., Lockley, Michelle, McNeish, Iain A.

“…Resistance to paclitaxel chemotherapy frequently develops in ovarian cancer. Oncolytic adenoviruses are a novel therapy for human malignancies that are being…”
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Polo-like kinase Plk2 is an epigenetic determinant of chemosensitivity and clinical outcomes in ovarian cancer by Syed, Nelofer, Coley, Helen M, Sehouli, Jalid, Koensgen, Dominique, Mustea, Alexander, Szlosarek, Peter, McNeish, Iain, Blagden, Sarah P, Schmid, Peter, Lovell, David P, Hatzimichael, Eleftheria, Crook, Tim

“…Resistance to platinum- and taxane-based chemotherapy remains a major clinical impediment to effective management of epithelial ovarian cancer (EOC). To gain…”
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