Search Results - "CROKER, Byron P"

Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice by Choi, Seung-Chul, Brown, Josephine, Gong, Minghao, Ge, Yong, Zadeh, Mojgan, Li, Wei, Croker, Byron P, Michailidis, George, Garrett, Timothy J, Mohamadzadeh, Mansour, Morel, Laurence

“…The autoimmune disease systemic lupus erythematosus (SLE) is characterized by the production of pathogenic autoantibodies. It has been postulated that gut…”
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Endothelial dysfunction as a potential contributor in diabetic nephropathy by Nakagawa, Takahiko, Tanabe, Katsuyuki, Croker, Byron P, Johnson, Richard J, Grant, Maria B, Kosugi, Tomoki, Li, Qiuhong

“…Diabetic nephropathy and retinopathy are serious complications of diabetes, but the mechanisms involved in the progression of these entities are unknown. In…”
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Protective effects of exogenous bilirubin on ischemia-reperfusion injury in the isolated, perfused rat kidney by Adin, Christopher A, Croker, Byron P, Agarwal, Anupam

“…Heme oxygenase-1 (HO-1) is induced as an adaptive and protective response to tissue injury. HO-1 degrades heme into carbon monoxide (CO) and biliverdin; the…”
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Endothelial injury due to eNOS deficiency accelerates the progression of chronic renal disease in the mouse by Nakayama, Takahiro, Sato, Waichi, Kosugi, Tomoki, Zhang, Li, Campbell-Thompson, Martha, Yoshimura, Ashio, Croker, Byron P, Johnson, Richard J, Nakagawa, Takahiko

“…The vascular endothelium expresses endothelial nitric oxide synthase (eNOS) that generates nitric oxide (NO) to help maintain vascular integrity due to its…”
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Endothelial von Willebrand Factor Release Due to eNOS Deficiency Predisposes to Thrombotic Microangiopathy in Mouse Aging Kidney by Nakayama, Takahiro, Sato, Waichi, Yoshimura, Ashio, Zhang, Li, Kosugi, Tomoki, Campbell-Thompson, Martha, Kojima, Hideto, Croker, Byron P, Nakagawa, Takahiko

“…Endothelial dysfunction is critical in the decline of renal function with. By using endothelial nitric oxide synthase knockout (eNOSKO) mice, we tested the…”
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Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane by Barker, Tolga T, Lee, Pui Y, Kelly-Scumpia, Kindra M, Weinstein, Jason S, Nacionales, Dina C, Kumagai, Yutaro, Akira, Shizuo, Croker, Byron P, Sobel, Eric S, Reeves, Westley H, Satoh, Minoru

“…Diffuse alveolar hemorrhage is an uncommon, yet often fatal, complication of systemic lupus erythematosus (SLE). Advances in the treatment of alveolar…”
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The Major Murine Systemic lupus erythematosus Susceptibility Locus, Sle1, is a Cluster of Functionally Related Genes by Morel, Laurence, Blenman, Kim R., Croker, Byron P., Wakeland, Edward K.

“…The major murine systemic lupus erythematosus (SLE) susceptibility locus Sle1 is syntenic to a chromosomal region linked with SLE susceptibility in multiple…”
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Genetic Reconstitution of Systemic Lupus Erythematosus Immunopathology with Polycongenic Murine Strains by Morel, Laurence, Croker, Byron P., Blenman, Kim R., Mohan, Chandra, Huang, Guanling, Gilkeson, Gary, Wakeland, Edward K.

“…We previously produced three congenic strains carrying lupus susceptibility genes (Sle1-Sle3) from the lupus-prone NZM2410 mouse on the C57BL/6 background and…”
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Normalization of CD4+ T cell metabolism reverses lupus by Yin, Yiming, Choi, Seung-Chul, Xu, Zhiwei, Perry, Daniel J, Seay, Howard, Croker, Byron P, Sobel, Eric S, Brusko, Todd M, Morel, Laurence

“…Systemic lupus erythematosus (SLE) is an autoimmune disease in which autoreactive CD4(+) T cells play an essential role. CD4(+) T cells rely on glycolysis for…”
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Glucose Oxidation Is Critical for CD4+ T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus by Yin, Yiming, Choi, Seung-Chul, Xu, Zhiwei, Zeumer, Leilani, Kanda, Nathalie, Croker, Byron P, Morel, Laurence

“…We have previously shown that CD4(+) T cells from B6.Sle1Sle2.Sle3 lupus mice and patients present a high cellular metabolism, and a treatment combining…”
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The pivotal role of VEGF on glomerular macrophage infiltration in advanced diabetic nephropathy by Sato, Waichi, Kosugi, Tomoki, Zhang, Li, Roncal, Carlos A, Heinig, Marcelo, Campbell-Thompson, Martha, Yuzawa, Yukio, Atkinson, Mark A, Grant, Maria B, Croker, Byron P, Nakagawa, Takahiko

“…A growing body of evidence implicates inflammation in the development of diabetic nephropathy. We recently reported that diabetic endothelial nitric oxide…”
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Soluble Flt-1 gene therapy ameliorates albuminuria but accelerates tubulointerstitial injury in diabetic mice by Kosugi, Tomoki, Nakayama, Takahiro, Li, Qiuhong, Chiodo, Vince A, Zhang, Li, Campbell-Thompson, Martha, Grant, Maria, Croker, Byron P, Nakagawa, Takahiko

“…VEGF is recognized as a major mediator in the development of diabetic nephropathy. Soluble Flt-1 (sFlt-1) is the endogenous inhibitor of VEGF, and recently…”
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IL-10 regulation of lupus in the NZM2410 murine model by Blenman, Kim R M, Duan, Byian, Xu, Zhiwei, Wan, Suigui, Atkinson, Mark A, Flotte, Terence R, Croker, Byron P, Morel, Laurence

“…Multiple studies have reported high levels of IL-10 in SLE patients and in murine models of lupus. IL-10 is a regulatory cytokine mainly produced by B cells,…”
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Effects of voluntary wheel running on the kidney at baseline and after ischaemia–reperfusion‐induced acute kidney injury: a strain difference comparison by Moningka, Natasha C., Cunningham, Jr, Mark W., Sterling, Myrline, West, Crystal A., Verlander, Jill W., Croker, Byron P., Ahlgren, Joslyn, Hayward, Linda, Baylis, Chris

“…Key points The impact of exercise on functional proteins critical for proper blood vessel health in the kidney is not well understood. Using rats of different…”
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Interleukin 10 Attenuates Neointimal Proliferation and Inflammation in Aortic Allografts by a Heme Oxygenase-Dependent Pathway by Chen, Sifeng, Kapturczak, Matthias H., Wasserfall, Clive, Glushakova, Olena Y., Campbell-Thompson, Martha, Deshane, Jessy S., Joseph, Reny, Cruz, Pedro E., Hauswirth, William W., Madsen, Kirsten M., Croker, Byron P., Berns, Kenneth I., Atkinson, Mark A., Flotte, Terence R., Tisher, C. Craig, Agarwal, Anupam

“…Interleukin 10 (IL-10) is a pleiotropic cytokine with well known antiinflammatory, immunosuppressive, and immunostimulatory properties. Chronic allograft…”
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Effects of ischemia-reperfusion injury on renal ammonia metabolism and the collecting duct by Han, Ki-Hwan, Kim, Hye-Young, Croker, Byron P, Reungjui, Sirirat, Lee, Su-Youn, Kim, Jin, Handlogten, Mary E, Adin, Christopher A, Weiner, I David

“…Acute renal injury induces metabolic acidosis, but its specific effects on the collecting duct, the primary site for urinary ammonia secretion, the primary…”
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Microarray Analysis of Gene Expression in the Kidneys of New- and Post-Onset Diabetic NOD Mice by WILSON, Karen H. S, ECKENRODE, Sarah E, LI, Quan-Zhen, RUAN, Qing-Guo, PING YANG, SHI, Jing-Da, DAVOODI-SEMIROMI, Abdoreza, MCINDOE, Richard A, CROKER, Byron P, SHE, Jin-Xiong

“…Microarray Analysis of Gene Expression in the Kidneys of New- and Post-Onset Diabetic NOD Mice Karen H.S. Wilson 1 , Sarah E. Eckenrode 1 , Quan-Zhen Li 1 ,…”
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The Lupus Susceptibility Gene Pbx1 Regulates the Balance between Follicular Helper T Cell and Regulatory T Cell Differentiation by Choi, Seung-Chul, Hutchinson, Tarun E, Titov, Anton A, Seay, Howard R, Li, Shiwu, Brusko, Todd M, Croker, Byron P, Salek-Ardakani, Shahram, Morel, Laurence

“…Pbx1 controls chromatin accessibility to a large number of genes and is entirely conserved between mice and humans. The Pbx1-d dominant-negative isoform is…”
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Gene delivery in renal tubular epithelial cells using recombinant adeno-associated viral vectors by SIFENG CHEN, AGARWAL, Anupam, HAUSWIRTH, William W, BERNS, Kenneth I, TISHER, C. Craig, GLUSHAKOVA, Olena Y, JORGENSEN, Marda S, SALGAR, Shashikumar K, POIRIER, Amy, FLOTTE, Terence R, CROKER, Byron P, MADSEN, Kirsten M, ATKINSON, Mark A

“…Gene therapy has the potential to provide a therapeutic strategy for numerous renal diseases such as diabetic nephropathy, chronic rejection, Alport syndrome,…”
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The major murine systemic lupus erythematosus susceptibility locus, Sle1 , is a cluster of functionally related genes by Morel, Laurence, Blenman, Kim R., Croker, Byron P., Wakeland, Edward K.

“…The major murine systemic lupus erythematosus (SLE) susceptibility locus Sle1 is syntenic to a chromosomal region linked with SLE susceptibility in multiple…”
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