Search Results - "CRIBBS, D. H"

DNA prime-protein boost increased the titer, avidity and persistence of anti-Aβ antibodies in wild-type mice by Davtyan, H, Mkrtichyan, M, Movsesyan, N, Petrushina, I, Mamikonyan, G, Cribbs, D H, Agadjanyan, M G, Ghochikyan, A

“…Recently, we reported that a DNA vaccine, composed of three copies of a self B cell epitope of amyloid-β (Aβ 42 ) and the foreign T-cell epitope, Pan DR…”
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DNA, but not protein vaccine based on mutated BORIS antigen significantly inhibits tumor growth and prolongs the survival of mice by Mkrtichyan, M, Ghochikyan, A, Loukinov, D, Davtyan, H, Ichim, T E, Cribbs, D H, Lobanenkov, V V, Agadjanyan, M G

“…The ideal immunological target for cancer vaccine development would meet the criteria of tumor specificity, immunogenicity and vital dependency of the tumor on…”
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Immunodominant epitope and properties of pyroglutamate-modified Aβ-specific antibodies produced in rabbits by Acero, G, Manoutcharian, K, Vasilevko, V, Munguia, M.E, Govezensky, T, Coronas, G, Luz-Madrigal, A, Cribbs, D.H, Gevorkian, G

“…Abstract N-truncated and N-modified forms of amyloid beta (Aβ) peptide are found in diffused and dense core plaques in Alzheimer's disease (AD) and Down's…”
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Active immunization with tau epitope in a mouse model of tauopathy induced strong antibody response together with improvement in short memory and pSer396-tau pathology by Joly-Amado, A., Davtyan, H., Serraneau, K., Jules, P., Zitnyar, A., Pressman, E., Zagorski, K., Antonyan, T., Hovakimyan, A., Paek, H.J., Gordon, M.N., Cribbs, D.H., Petrovsky, N., Agadjanyan, M.G., Ghochikyan, A., Morgan, D.

“…Abnormal tau hyperphosphorylation and its aggregation into neurofibrillary tangles are a hallmark of tauopathies, neurodegenerative disorders that include…”
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Inflammatory changes parallel the early stages of Alzheimer disease by Parachikova, A, Agadjanyan, M.G, Cribbs, D.H, Blurton-Jones, M, Perreau, V, Rogers, J, Beach, T.G, Cotman, C.W

“…Abstract Alzheimer disease (AD) is the most prominent cause of dementia in the elderly. To determine changes in the AD brain that may mediate the transition…”
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Aβ Immunotherapy Leads to Clearance of Early, but Not Late, Hyperphosphorylated Tau Aggregates via the Proteasome by Oddo, Salvatore, Billings, Lauren, Kesslak, J.Patrick, Cribbs, David H., LaFerla, Frank M.

“…Amyloid-β (Aβ) plaques and neurofibrillary tangles are the hallmark neuropathological lesions of Alzheimer's disease (AD). Using a triple transgenic model…”
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A Monoclonal Antibody to Amyloid Precursor Protein Induces Neuronal Apoptosis by Rohn, Troy T., Ivins, Kathryn J., Bahr, Ben A., Cotman, Carl W., Cribbs, David H.

“…: Although there is considerable evidence suggesting that altered metabolism of β‐amyloid precursor protein (APP) and accumulation of its β‐amyloid fragment…”
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Localization and Cell Association of C1q in Alzheimer's Disease Brain by Afagh, Arman, Cummings, Brian J., Cribbs, David H., Cotman, Carl W., Tenner, Andrea J.

“…The complement protein, C1q, has been shown to bind to fibrillar β-amyloid, resulting in the activation of the classical complement pathway. C1q has also been…”
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Microlithographic determination of axonal/dendritic polarity in cultured hippocampal neurons by Stenger, David A., Hickman, James J., Bateman, Karen E., Ravenscroft, Melissa S., Ma, Wu, Pancrazio, Joseph J., Shaffer, Kara, Schaffner, Anne E., Cribbs, David H., Cotman, Carl W.

“…High resolution substrates, created using patterned self-assembled monolayers, are shown to direct axonal and dendritic process extension at the level of a…”
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The mouse C1q A-chain sequence alters beta-amyloid-induced complement activation by Webster, S.D, Tenner, A.J, Poulos, T.L, Cribbs, D.H

“…In transgenic models of Alzheimer’s disease (AD) neuronal loss has not been widely observed. The loss of neurons in AD may be due to chronic activation of…”
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Widespread neuronal expression of the presenilin-1 early-onset Alzheimer's disease gene in the murine brain by Cribbs, DH, Chen, LS, Bende, SM, LaFerla, FM

“…Mutations in the presenilin-1 (S182) gene have been genetically linked to early-onset Alzheimer's disease. To clarify the underlying molecular mechanism…”
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Cross-linking of Concanavalin A receptors on cortical neurons induces programmed cell death by Cribbs, D.H, Kreng, V.M, Anderson, A.J, Cotman, C.W

“…The loss of neurons by programmed cell death is a normal feature of the nervous system during development and has recently been implicated as a major mechanism…”
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Novel amyloid-beta specific scFv and VH antibody fragments from human and mouse phage display antibody libraries by Medecigo, M, Manoutcharian, K, Vasilevko, V, Govezensky, T, Munguia, M.E, Becerril, B, Luz-Madrigal, A, Vaca, L, Cribbs, D.H, Gevorkian, G

“…Abstract Anti-amyloid immunotherapy has been proposed as an appropriate therapeutic approach for Alzheimer's disease (AD). Significant efforts have been made…”
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Heparan sulfate and chondroitin sulfate glycosaminoglycan attenuate β-amyloid(25–35) induced neurodegeneration in cultured hippocampal neurons by Woods, Alisa G., Cribbs, David H., Whittemore, Edward R., Cotman, Carl W.

“…β-Amyloid peptide has been reported to be toxic to neurons in vitro and in vivo. The fragment of the β1–42 peptide believed to be responsible for this toxicity…”
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Cross-linking of NCAM receptors on neurons induces programmed cell death by Azizeh, B.Y, Cribbs, D.H, Kreng, V.M, Cotman, C.W

“…Programmed cell death has been implicated in the loss of neurons that occurs in many neurodegenerative diseases. This has led to an increased interest in the…”
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Structure-activity analyses of beta-amyloid peptides: contributions of the beta 25-35 region to aggregation and neurotoxicity by Pike, C J, Walencewicz-Wasserman, A J, Kosmoski, J, Cribbs, D H, Glabe, C G, Cotman, C W

“…The neurodegeneration of Alzheimer's disease has been theorized to be mediated, at least in part, by insoluble aggregates of beta-amyloid protein that are…”
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Complement activation by cross-linked truncated and chimeric full-length β-amyloid by Cribbs, David H, Velazquez, Peter, Soreghan, Brian, Glabe, Charles G, Tenner, Andrea J

“…THE activation of complement by β-amyloid (Ab) has been implicated in the local inflammatory response in Alzheimerʼs disease. To assess the structural…”
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Epitope mapping and neuroprotective properties of a human single chain FV antibody that binds an internal epitope of amyloid-beta 1-42 by Solórzano-Vargas, R.S., Vasilevko, V., Acero, G., Ugen, K.E., Martinez, R., Govezensky, T., Vazquez-Ramirez, R., Kubli-Garfias, C., Cribbs, D.H., Manoutcharian, K., Gevorkian, G.

“…Active and passive immunotherapy targeted at the amyloid-beta (Aβ) peptide has been proposed as therapeutic approach against Alzheimer's disease (AD), and…”
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Injury induces presenilin-1 gene expression in mouse brain by Cribbs, D H, Chen, L S, Cotman, C W, LaFerla, F M

“…Information regarding the genetic factors and environmental conditions that influence presenilin-1 (PS-1) gene expression is essential for the elucidation of…”
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Activation of Caspase-8 in the Alzheimer's Disease Brain by Rohn, Troy T., Head, Elizabeth, Nesse, William H., Cotman, Carl W., Cribbs, David H.

“…Recent studies support the activation of apoptotic pathways in the Alzheimer's disease (AD) brain. Neurons committed to apoptosis may do so by either…”
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