Search Results - "CRAWFORD, D. H. G"

The role of macrophages in the development of biliary injury in a lipopolysaccharide-aggravated hepatic ischaemia-reperfusion model by Reiling, J., Bridle, K.R., Schaap, F.G., Jaskowski, L., Santrampurwala, N., Britton, L.J., Campbell, C.M., Jansen, P.L.M., Damink, S.W.M. Olde, Crawford, D.H.G., Dejong, C.H.C., Fawcett, J.

“…Endotoxins, in the form of lipopolysaccharides (LPS), are potent inducers of biliary injury. However the mechanism by which injury develops remains unclear. We…”
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Duodenal expression of iron transport molecules in untreated haemochromatosis subjects by Stuart, K A, Anderson, G J, Frazer, D M, Powell, L W, McCullen, M, Fletcher, L M, Crawford, D H G

“…Background and aims: In HFE associated hereditary haemochromatosis, the duodenal enterocyte behaves as if iron deficient and previous reports have shown…”
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Patient-focused outcomes following detection in a hospital-based screening programme for C282Y haemochromatosis by McCullen, M. A., Fletcher, L. M., Dimeski, G., Pink, A., Powell, L. W., Crawford, D. H. G., Hickman, P. E.

“…Background:  Haemochromatosis is a common genetic disease in populations of a northern European origin. However, there is uncertainty as to whether it is a…”
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Automated measurement of unsaturated iron binding capacity is an effective screening strategy for C282Y homozygous haemochromatosis by Hickman, P E, Hourigan, L F, Powell, L W, Cordingley, F, Dimeski, G, Ormiston, B, Shaw, J, Ferguson, W, Johnson, M, Ascough, J, McDonell, K, Pink, A, Crawford, D H G

“…BACKGROUND C282Y hereditary haemochromatosis is an appropriate condition for population screening. Transferrin saturation, the best screening test to date, is…”
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Evidence for altered hepatic matrix degradation in genetic haemochromatosis by George, D K, Ramm, G A, Powell, L W, Fletcher, L M, Walker, N I, Cowley, L L, Crawford, D H G

“…Background—Altered matrix degradation contributes to fibrosis in some liver diseases but the role of matrix degradation in fibrogenesis associated with genetic…”
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Overseas liver transplantation for hepatitis C in Japanese patients: a comparison with patients from Australia/New Zealand by Sugo, H, Balderson, G.A, Crawford, D.H.G, Fawcett, J, Lynch, S.V, Strong, R.W, Futagawa, S

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Pathogenesis and assessment of malnutrition in liver disease by Crawford, D H, Cuneo, R C, Shepherd, R W

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Activation of Pancreatic Stellate Cells in Human and Experimental Pancreatic Fibrosis by Haber, Paul S., Keogh, Gregory W., Apte, Minoti V., Moran, Corey S., Stewart, Nancy L., Crawford, Darrell H.G., Pirola, Romano C., McCaughan, Geoffrey W., Ramm, Grant A., Wilson, Jeremy S.

“…The mechanisms of pancreatic fibrosis are poorly understood. In the liver, stellate cells play an important role in fibrogenesis. Similar cells have recently…”
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Expression of HLA-linked hemochromatosis in subjects homozygous or heterozygous for the C282Y mutation by Crawford, Darrell H.G., Jazwinska, Elizabeth C., Cullen, Lara M., Powell, Lawrie W.

“…Background & Aims: In the absence of a genetic test, diagnostic criteria for hereditary hemochromatosis have been imprecise. The identification of the HFE gene…”
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Contribution of Hepatic Parenchymal and Nonparenchymal Cells to Hepatic Fibrogenesis in Biliary Atresia by Ramm, Grant A., Nair, Visalini G., Bridle, Kim R., Shepherd, Ross W., Crawford, Darrell H.G.

“…Extrahepatic biliary atresia is a severe neonatal liver disease resulting from a sclerosing cholangiopathy of unknown etiology. Although biliary obstruction…”
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Excess iron induces hepatic oxidative stress and transforming growth factor β1 in genetic hemochromatosis by Houglum, K, Ramm, G A, Crawford, D H, Witztum, J L, Powell, L W, Chojkier, M

“…Genetic hemochromatosis (GH) is associated with excess iron deposition in hepatocytes, which results in progressive hepatic injury. The pathogenesis of hepatic…”
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Distribution of transferrin saturation in an Australian population: Relevance to the early diagnosis of hemochromatosis by McLaren, Christine E., McLachlan, Geoffrey J., Halliday, June W., Webb, Sonja I., Leggett, Barbara A., Jazwinska, Elizabeth C., Crawford, Darrell H.G., Gordeuk, Victor R., McLaren, Gordon D., Powell, Lawrie W.

“…Background & Aims: An elevated transferrin saturation is the earliest phenotypic abnormality in hereditary hemochromatosis. Determination of transferrin…”
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The C282Y mutation in the haemochromatosis gene (HFE) and hepatitis C virus infection are independent cofactors for porphyria cutanea tarda in Australian patients by Stuart, Katherine A., Busfield, Frances, Jazwinska, Elizabeth C., Gibson, Peter, Butterworth, Lesley A., Cooksley, W.Graham, Powell, Lawrie W., Crawford, Darrell H.G.

“…Background/Aim: Whether mutations in the putative haemochromatosis gene (HFE) and hepatitis C virus act independently to precipitate porphyria cutanea tarda is…”
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Hepatic stellate cell activation in genetic haemochromatosis: Lobular distribution, effect of increasing hepatic iron and response to phlebotomy by Ramm, Grant A., Crawford, Darrell H.G., Powell, Lawrie W., Walker, Neal I., Fletcher, Linda M., Halliday, June W.

“…Background/Aims: Activated hepatic stellate cells produce increased levels of collagen in animal models of chronic iron overload; however, their role in human…”
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Elevated serum type IV collagen: a sensitive indicator of the presence of cirrhosis in haemochromatosis by George, D.Keith, Ramm, Grant A, Walker, Neal I, Powell, Lawrie W, Crawford, Darrell H.G

“…Background/Aim: Hereditary haemochromatosis can now be diagnosed by genetic testing, although determining the presence or absence of cirrhosis remains crucial…”
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Evidence that myofibroblast-like cells are the cellular source of capsular collagen in hepatocellular carcinoma by OOI, L. P. J, CRAWFORD, D. H. G, GOTLEY, D. C, CLOUSTON, A. D, STRONG, R. W, GOBE, G. C, HALLIDAY, J. W, BRIDLE, K. R, RAMM, G. A

“…The prognosis for patients with hepatocellular carcinoma is poor although tumour encapsulation has been associated with improved survival and disease-free…”
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Linkage disequilibrium analysis in Australian haemochromatosis patients indicates bipartite association with clinical expression by Pratiwi, Rarastoeti, Fletcher, Linda M, Pyper, Wendy R, Do, Kim-Anh, Crawford, Darrell H.G, Powell, Lawrie W, Jazwinska, Elizabeth C

“…Backgroundl Aims: Hereditary haemochromatosis shows a wide variation in phenotypic expression, which is thought to be due, in part, to genetic factors. A…”
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Evidence that the ancestral haplotype in Australian hemochromatosis patients may be associated with a common mutation in the gene by CRAWFORD, D. H. G, POWELL, L. W, LEGGETT, B. A, FRANCIS, J. S, FLETCHER, L. M, WEBB, S. I, HALLIDAY, J. W, JAZWINSKA, E. C

“…Hemochromatosis (HC) is a common inherited disorder of iron metabolism for which neither the gene nor biochemical defect have yet been identified. The aim of…”
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Body composition in nonalcoholic cirrhosis: the effect of disease etiology and severity on nutritional compartments by Crawford, D H, Shepherd, R W, Halliday, J W, Cooksley, G W, Golding, S D, Cheng, W S, Powell, L W

“…Previous studies of body composition in cirrhosis have either measured only one body compartment, used alcoholic subjects, or not corrected body composition…”
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Antibacterial-induced hepatoxicity : Incidence, prevention and management by GEORGE, D. K, CRAWFORD, D. H. G

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