Search Results - "CRANE, Ana"

Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells by Hawkins, Finn J., Suzuki, Shingo, Beermann, Mary Lou, Barillà, Cristina, Wang, Ruobing, Villacorta-Martin, Carlos, Berical, Andrew, Jean, J.C., Le Suer, Jake, Matte, Taylor, Simone-Roach, Chantelle, Tang, Yang, Schlaeger, Thorsten M., Crane, Ana M., Matthias, Nadine, Huang, Sarah X.L., Randell, Scott H., Wu, Joshua, Spence, Jason R., Carraro, Gianni, Stripp, Barry R., Rab, Andras, Sorsher, Eric J., Horani, Amjad, Brody, Steven L., Davis, Brian R., Kotton, Darrell N.

“…The derivation of tissue-specific stem cells from human induced pluripotent stem cells (iPSCs) would have broad reaching implications for regenerative…”
Get full text

Prospective isolation of NKX2-1-expressing human lung progenitors derived from pluripotent stem cells by Hawkins, Finn, Kramer, Philipp, Jacob, Anjali, Driver, Ian, Thomas, Dylan C, McCauley, Katherine B, Skvir, Nicholas, Crane, Ana M, Kurmann, Anita A, Hollenberg, Anthony N, Nguyen, Sinead, Wong, Brandon G, Khalil, Ahmad S, Huang, Sarah Xl, Guttentag, Susan, Rock, Jason R, Shannon, John M, Davis, Brian R, Kotton, Darrell N

“…It has been postulated that during human fetal development, all cells of the lung epithelium derive from embryonic, endodermal, NK2 homeobox 1-expressing…”
Get full text

Targeted correction and restored function of the CFTR gene in cystic fibrosis induced pluripotent stem cells by Crane, Ana M, Kramer, Philipp, Bui, Jacquelin H, Chung, Wook Joon, Li, Xuan Shirley, Gonzalez-Garay, Manuel L, Hawkins, Finn, Liao, Wei, Mora, Daniela, Choi, Sangbum, Wang, Jianbin, Sun, Helena C, Paschon, David E, Guschin, Dmitry Y, Gregory, Philip D, Kotton, Darrell N, Holmes, Michael C, Sorscher, Eric J, Davis, Brian R

“…Recently developed reprogramming and genome editing technologies make possible the derivation of corrected patient-specific pluripotent stem cell…”
Get full text

Highly Efficient Gene Editing of Cystic Fibrosis Patient-Derived Airway Basal Cells Results in Functional CFTR Correction by Suzuki, Shingo, Crane, Ana M., Anirudhan, Varada, Barillà, Cristina, Matthias, Nadine, Randell, Scott H., Rab, Andras, Sorscher, Eric J., Kerschner, Jenny L., Yin, Shiyi, Harris, Ann, Mendel, Matthew, Kim, Kenneth, Zhang, Lei, Conway, Anthony, Davis, Brian R.

“…There is a strong rationale to consider future cell therapeutic approaches for cystic fibrosis (CF) in which autologous proximal airway basal stem cells,…”
Get full text

Caspase activity mediates the differentiation of embryonic stem cells by Fujita, Jun, Crane, Ana M, Souza, Marlon K, Dejosez, Marion, Kyba, Michael, Flavell, Richard A, Thomson, James A, Zwaka, Thomas P

“…Embryonic stem cells (ESCs) are capable of indefinite self-renewal while retaining the ability to differentiate to any of the three germ layers that give rise…”
Get full text

Gene Correction of iPSCs from a Wiskott-Aldrich Syndrome Patient Normalizes the Lymphoid Developmental and Functional Defects by Laskowski, Tamara J., Van Caeneghem, Yasmine, Pourebrahim, Rasoul, Ma, Chao, Ni, Zhenya, Garate, Zita, Crane, Ana M., Li, Xuan Shirley, Liao, Wei, Gonzalez-Garay, Manuel, Segovia, Jose Carlos, Paschon, David E., Rebar, Edward J., Holmes, Michael C., Kaufman, Dan, Vandekerckhove, Bart, Davis, Brian R.

“…Wiskott-Aldrich syndrome (WAS) is an X-linked primary immunodeficiency disease caused by mutations in the gene encoding the WAS protein (WASp). Here, induced…”
Get full text

Assembly, Maturation, and Turnover of KATP Channel Subunits by Crane, Ana, Aguilar-Bryan, Lydia

“…ATP-sensitive K+, or KATP, channels are comprised of KIR6.x and sulfonylurea receptor (SUR) subunits that assemble as octamers, (KIR/SUR)4. The assembly…”
Get full text

Homology Requirements for Efficient, Footprintless Gene Editing at the CFTR Locus in Human iPSCs with Helper-dependent Adenoviral Vectors by Palmer, Donna J, Grove, Nathan C, Ing, Jordan, Crane, Ana M, Venken, Koen, Davis, Brian R, Ng, Philip

“…Helper-dependent adenoviral vectors mediate high efficiency gene editing in induced pluripotent stem cells without needing a designer nuclease thereby avoiding…”
Get full text

Clinical and Molecular Characterization of a Dominant Form of Congenital Hyperinsulinism Caused by a Mutation in the High-Affinity Sulfonylurea Receptor by THORNTON, Paul S, MACMULLEN, Courtney, GANGULY, Arupa, RUCHELLI, Eduardo, STEINKRAUSS, Linda, CRANE, Ana, AGUILAR-BRYAN, Lydia, STANLEY, Charles A

“…Clinical and Molecular Characterization of a Dominant Form of Congenital Hyperinsulinism Caused by a Mutation in the High-Affinity Sulfonylurea Receptor Paul…”
Get full text

cAMP-Activated Protein Kinase-Independent Potentiation of Insulin Secretion by cAMP Is Impaired in SUR1 Null Islets by NAKAZAKI, Mitsuhiro, CRANE, Ana, MIN HU, SEGHERS, Victor, ULLRICH, Susanne, AGUILAR-BRYAN, Lydia, BRYAN, Joseph

“…cAMP-Activated Protein Kinase-Independent Potentiation of Insulin Secretion by cAMP Is Impaired in SUR1 Null Islets Mitsuhiro Nakazaki 1 , Ana Crane 2 , Min Hu…”
Get full text

Hyperinsulinism of Infancy: Novel ABCC8 and KCNJ11 Mutations and Evidence for Additional Locus Heterogeneity by Tornovsky, Sharona, Crane, Ana, Cosgrove, Karen E., Hussain, Khalid, Lavie, Judith, Heyman, Ma’ayan, Nesher, Yaron, Kuchinski, Na’ama, Ben-Shushan, Etti, Shatz, Olga, Nahari, Efrat, Potikha, Tamara, Zangen, David, Tenenbaum-Rakover, Yardena, de Vries, Liat, Argente, Jesús, Gracia, Ricardo, Landau, Heddy, Eliakim, Alon, Lindley, Keith, Dunne, Mark J., Aguilar-Bryan, Lydia, Glaser, Benjamin

“…Hyperinsulinism of infancy is a genetically heterogeneous disease characterized by dysregulation of insulin secretion resulting in severe hypoglycemia. To…”
Get full text

Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells by Jacob, Anjali, Morley, Michael, Hawkins, Finn, McCauley, Katherine B., Jean, J.C., Heins, Hillary, Na, Cheng-Lun, Weaver, Timothy E., Vedaie, Marall, Hurley, Killian, Hinds, Anne, Russo, Scott J., Kook, Seunghyi, Zacharias, William, Ochs, Matthias, Traber, Katrina, Quinton, Lee J., Crane, Ana, Davis, Brian R., White, Frances V., Wambach, Jennifer, Whitsett, Jeffrey A., Cole, F. Sessions, Morrisey, Edward E., Guttentag, Susan H., Beers, Michael F., Kotton, Darrell N.

“…Lung alveoli, which are unique to air-breathing organisms, have been challenging to generate from pluripotent stem cells (PSCs) in part because there are…”
Get full text

The C Terminus of SUR1 Is Required for Trafficking of KATP Channels by Sharma, N, Crane, A, Clement, 4th, J P, Gonzalez, G, Babenko, A P, Bryan, J, Aguilar-Bryan, L

“…In beta cells from the pancreas, ATP-sensitive potassium channels, or K ATP channels, are composed of two subunits, SUR1 and K IR 6.2, assembled in a (SUR1/K…”
Get full text

In vitro generation of functional T-cells starting from gene-corrected wiskott-aldrich syndrome human iPSC by Van Caeneghem, Yasmine, Pourebrahimabadi, Rasoul, Laskowski, Tamara, Garate, Zita, Crane, Ana, Segovia, Jose Carlos, Holmes, Michael, Vandekerckhove, Bart, Davis, Brian

Get full text

185. Targeted Correction and Restored Function of CFTR Gene in Cystic Fibrosis Induced Pluripotent Stem Cells by Davis, Brian R., Crane, Ana M., Kramer, Philipp, Bui, Jacquelin H., Joon Chung, Wook, Shirley Li, Xuan, Gonzalez-Garay, Manuel L., Hawkins, Finn, Liao, Wei, Mora, Daniela, Wang, Jianbin, Sun, Helena C., Paschon, David E., Guschin, Dmitry Y., Gregory, Philip D., Kotton, Darrell N., Holmes, Michael C., Sorscher, Eric J.

Get full text

Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells by Garate, Zita, Quintana-Bustamante, Oscar, Crane, Ana M., Olivier, Emmanuel, Poirot, Laurent, Galetto, Roman, Kosinski, Penelope, Hill, Collin, Kung, Charles, Agirre, Xabi, Orman, Israel, Cerrato, Laura, Alberquilla, Omaira, Rodriguez-Fornes, Fatima, Fusaki, Noemi, Garcia-Sanchez, Felix, Maia, Tabita M., Ribeiro, Maria L., Sevilla, Julian, Prosper, Felipe, Jin, Shengfang, Mountford, Joanne, Guenechea, Guillermo, Gouble, Agnes, Bueren, Juan A., Davis, Brian R., Segovia, Jose C.

“…Pyruvate kinase deficiency (PKD) is a rare erythroid metabolic disease caused by mutations in the PKLR gene. Erythrocytes from PKD patients show an energetic…”
Get full text

Assembly, maturation, and turnover of K(ATP) channel subunits by Crane, Ana, Aguilar-Bryan, Lydia

“…ATP-sensitive K(+), or K(ATP), channels are comprised of K(IR)6.x and sulfonylurea receptor (SUR) subunits that assemble as octamers, (K(IR)/SUR)(4). The…”
Get full text

Familial hyperinsulinism and pancreatic β-cell ATP-sensitive potassium channels by Sharma, Nidhi, Crane, Ana, Gonzalez, Gabriela, Bryan, Joseph, Aguilar-Bryan, Lydia

“…Familial hyperinsulinism and pancreatic β-cell ATP-sensitive potassium channels. Familial hyperinsulinism, also known as persistent hyperinsulinemic…”
Get full text

Effective Cryopreservation and Long-Term Storage of Primary Human Hepatocytes with Recovery of Viability, Differentiation, and Replicative Potential by R. Mark Adams, Mary Wang, Ana Maria Crane, Bridgette Brown, Gretchen J. Darlington, Fred D. Ledley

“…Despite reports of successful cryopreservation of primary human hepatocytes, existing methods do not produce sufficient recovery of viable cells to meet the…”
Get full text

Overexpression of human methylmalonyl CoA mutase in mice after in vivo gene transfer with asialoglycoprotein/polylysine/DNA complexes by Stankovics, J, Crane, A M, Andrews, E, Wu, C H, Wu, G Y, Ledley, F D

“…Methylmalonic acidemia resulting from genetic deficiency of methylmalonyl CoA mutase (MCM) is an often fatal metabolic disease. Somatic gene therapy for this…”
Get more information