Search Results - "CRAFT, Joseph"

206 T cells and tissue injury in lupus by Craft, Joseph

“…Tissue injury is a major cause of morbidity and mortality in SLE. Yet, there is limited knowledge of the mechanistic pathways that cause organ damage in lupus…”
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Follicular helper T cells in immunity and systemic autoimmunity by Craft, Joseph E.

“…Aberrant T-cell help has been implicated in the expansion of self-reactive B-cell clones and subsequent autoantibody production in many systemic autoimmune…”
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The multifaceted role of CD4+ T cells in CD8+ T cell memory by Laidlaw, Brian J., Craft, Joseph E., Kaech, Susan M.

“…Key Points Following immunization, CD4 + T cells promote the induction of a robust primary CD8 + T cell response through numerous mechanisms, including…”
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CD301b+ Dermal Dendritic Cells Drive T Helper 2 Cell-Mediated Immunity by Kumamoto, Yosuke, Linehan, Melissa, Weinstein, Jason S., Laidlaw, Brian J., Craft, Joseph E., Iwasaki, Akiko

“…Unlike other types of T helper (Th) responses, whether the development of Th2 cells requires instruction from particular subset of dendritic cells (DCs)…”
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High-plex protein and whole transcriptome co-mapping at cellular resolution with spatial CITE-seq by Liu, Yang, DiStasio, Marcello, Su, Graham, Asashima, Hiromitsu, Enninful, Archibald, Qin, Xiaoyu, Deng, Yanxiang, Nam, Jungmin, Gao, Fu, Bordignon, Pino, Cassano, Marco, Tomayko, Mary, Xu, Mina, Halene, Stephanie, Craft, Joseph E., Hafler, David, Fan, Rong

“…In this study, we extended co-indexing of transcriptomes and epitopes (CITE) to the spatial dimension and demonstrated high-plex protein and whole…”
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Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells by Bosurgi, Lidia, Cao, Y. Grace, Cabeza-Cabrerizo, Mar, Tucci, Andrea, Hughes, Lindsey D., Kong, Yong, Weinstein, Jason S., Licona-Limon, Paula, Schmid, Edward T., Pelorosso, Facundo, Gaglian, Nicola

“…Tissue repair is a subset of a broad repertoire of interleukin-4 (IL-4)– and IL-13–dependent host responses during helminth infection. Here we show that IL-4…”
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Identification of a T follicular helper cell subset that drives anaphylactic IgE by Gowthaman, Uthaman, Chen, Jennifer S, Zhang, Biyan, Flynn, William F, Lu, Yisi, Song, Wenzhi, Joseph, Julie, Gertie, Jake A, Xu, Lan, Collet, Magalie A, Grassmann, Jessica D S, Simoneau, Tregony, Chiang, David, Berin, M Cecilia, Craft, Joseph E, Weinstein, Jason S, Williams, Adam, Eisenbarth, Stephanie C

“…Cross-linking of high-affinity immunoglobulin E (IgE) results in the life-threatening allergic reaction anaphylaxis. Yet the cellular mechanisms that induce B…”
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Dynamic signaling by T follicular helper cells during germinal center B cell selection by Shulman, Ziv, Gitlin, Alexander D., Weinstein, Jason S., Lainez, Begoña, Esplugues, Enric, Flavell, Richard A., Craft, Joseph E., Nussenzweig, Michel C.

“…T follicular helper (TFH) cells select high-affinity, antibody-producing B cells for clonal expansion in germinal centers (GCs), but the nature of their…”
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Spatial profiling of chromatin accessibility in mouse and human tissues by Deng, Yanxiang, Bartosovic, Marek, Ma, Sai, Zhang, Di, Kukanja, Petra, Xiao, Yang, Su, Graham, Liu, Yang, Qin, Xiaoyu, Rosoklija, Gorazd B., Dwork, Andrew J., Mann, J. John, Xu, Mina L., Halene, Stephanie, Craft, Joseph E., Leong, Kam W., Boldrini, Maura, Castelo-Branco, Gonçalo, Fan, Rong

“…Cellular function in tissue is dependent on the local environment, requiring new methods for spatial mapping of biomolecules and cells in the tissue context 1…”
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Dissecting the immune cell mayhem that drives lupus pathogenesis by Craft, Joseph E

“…The autoimmune disease systemic lupus erythematosus (SLE) results from an inability of the immune system to discriminate between certain self-antigens and…”
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Single-cell RNA sequencing unveils an IL-10-producing helper subset that sustains humoral immunity during persistent infection by Xin, Gang, Zander, Ryan, Schauder, David M., Chen, Yao, Weinstein, Jason S., Drobyski, William R., Tarakanova, Vera, Craft, Joseph, Cui, Weiguo

“…During chronic viral infection, the inflammatory function of CD4 T-cells becomes gradually attenuated. Concurrently, Th1 cells progressively acquire the…”
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The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice by Tang, Wei, Lu, Yi, Tian, Qing-Yun, Zhang, Yan, Guo, Feng-Jin, Liu, Guang-Yi, Syed, Nabeel Muzaffar, Lai, Yongjie, Lin, Edward Alan, Kong, Li, Su, Jeffrey, Yin, Fangfang, Ding, Ai-Hao, Zanin-Zhorov, Alexandra, Dustin, Michael L., Tao, Jian, Craft, Joseph, Yin, Zhinan, Feng, Jian Q., Abramson, Steven B., Yu, Xiu-Ping, Liu, Chuan-ju

“…The growth factor progranulin (PGRN) has been implicated in embryonic development, tissue repair, tumorigenesis, and inflammation, but its receptors remain…”
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Artificial Intelligence and the Softer Side of Medicine by Craft, 3rd, Joseph A

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The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity by Chan, Pamela Y., Silva, Eugenio A. Carrera, De Kouchkovsky, Dimitri, Joannas, Leonel D., Hao, Liming, Hu, Donglei, Huntsman, Scott, Eng, Celeste, Licona-Limón, Paula, Weinstein, Jason S., Herbert, De'Broski R., Craft, Joseph E., Flavell, Richard A., Repetto, Silvia, Correale, Jorge, Burchard, Esteban G., Torgerson, Dara G., Ghosh, Sourav, Rothlin, Carla V.

“…Host responses against metazoan parasites or an array of environmental substances elicit type 2 immunity. Despite its protective function, type 2 immunity also…”
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Multimodality Imaging to Diagnose Loeffler Endocarditis by Jelwan, Yara, Kawar, Hani, Larue, Shane, Craft, Joseph, Rao, Anupama

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Accessory Mitral Valve Tissue and Internal Mammary Artery Stenosis: Unique Considerations After Cardiac Arrest by Craft, 3rd, Joseph A, Reidy, Michael R, Craft, 4th, Joseph A, Pieper, Stephen J, Donnelly, Julianne E

“…A man with recurrent syncope and remote aortic coarctation repair experienced cardiac arrest with exercise stress testing. Critical coronary stenosis was…”
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From T to B and back again: positive feedback in systemic autoimmune disease by Shlomchik, Mark J, Craft, Joseph E, Mamula, Mark J

“…Systemic lupus erythematosus, a prototypical systemic autoimmune disease, is the result of a series of interactions within the immune system that ultimately…”
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Georgia Abortion Law and Our Commitment to Patients by Craft, Joseph E., Crow, Mary K., Lockshin, Michael D., Salmon, Jane E., Diamond, Betty, Elkon, Keith B., Flood, Joseph, Fox, David A., Gabriel, Sherine E., Gilkeson, Gary S., Hahn, Bevra H., Hardin, John, Koopman, William J., Seaman, William E., Wofsy, David, Sergent, John S., Uknis, Audrey B., Weinblatt, Michael E.

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PPARγ negatively regulates T cell activation to prevent follicular helper T cells and germinal center formation by Park, Hong-Jai, Kim, Do-Hyun, Choi, Jin-Young, Kim, Won-Ju, Kim, Ji Yun, Senejani, Alireza G, Hwang, Soo Seok, Kim, Lark Kyun, Tobiasova, Zuzana, Lee, Gap Ryol, Craft, Joseph, Bothwell, Alfred L M, Choi, Je-Min

“…Peroxisome proliferator-activated receptor gamma (PPARγ) is a transcription factor that regulates lipid and glucose metabolism. Although studies of PPARγ…”
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STAT3 Deletion during Hematopoiesis Causes Crohn's Disease-like Pathogenesis and Lethality: A Critical Role of STAT3 in Innate Immunity by Welte, Thomas, Samuel S. M. Zhang, Wang, Tian, Zhang, Zhiyuan, David G. T. Hesslein, Yin, Zhinan, Kano, Arihiro, Iwamoto, Yoshiki, Li, En, Craft, Joseph E., Alfred L. M. Bothwell, Fikrig, Erol, Koni, Pandelakis A., Flavell, Richard A., Fu, Xin-Yuan

“…Signal transducer and activator of transcription 3 (STAT3) is a key transcriptional mediator for many cytokines and is essential for normal embryonic…”
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