Search Results - "CRABBE, Thomas"

Intermolecular Autolytic Cleavage Can Contribute to the Activation of Progelatinase A by Cell Membranes (∗) by Atkinson, Susan J., Crabbe, Thomas, Cowell, Susan, Ward, Robin V., Butler, Michael J., Sato, Hiroshi, Seiki, Motoharu, Reynolds, John J., Murphy, Gillian

“…Membrane-type matrix metalloproteinase (MT-MMP) messenger RNA and protein expression were shown to be elevated in human fibroblasts following treatment with…”
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The activity of the tissue inhibitors of metalloproteinases is regulated by C-terminal domain interactions: A kinetic analysis of the inhibition of gelatinase A by Willenbrock, Frances, Crabbe, Thomas, Slocombe, Patrick M, Sutton, Chris W, Docherty, Andrew J. P, Cockett, Mark I, O'Shea, Mark, Brocklehurst, Keith, Phillips, Ian R, Murphy, Gillian

“…The cloning and expression of the full-length tissue inhibitor of metalloproteinase 2 (TIMP-2), delta 187-194TIMP-2, and delta 128-194TIMP-2 and the…”
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Biochemical characterization of matrilysin. Activation conforms to the stepwise mechanisms proposed for other matrix metalloproteinases by Crabbe, Thomas, Willenbrock, Frances, Eaton, Di, Hynds, Peter, Carne, Alexander F, Murphy, Gillian, Docherty, Andrew J. P

“…The latent precursor of matrilysin (EC 3.4.24.23; punctuated metalloproteinase (PUMP) was purified from transfected mouse myeloma cell conditioned medium and…”
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The TIMP2 Membrane Type 1 Metalloproteinase “Receptor” Regulates the Concentration and Efficient Activation of Progelatinase A by Butler, Georgina S., Butler, Michael J., Atkinson, Susan J., Will, Horst, Tamura, Tatsuya, van Westrum, Steven Schade, Crabbe, Thomas, Clements, John, d'Ortho, Marie-Pia, Murphy, Gillian

“…We have used C-terminal domain mutants to further define the role of interactions of progelatinase A and membrane type 1 matrix metalloproteinase (MT1 MMP) in…”
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The TIMP2 membrane type 1 metalloproteinase "receptor" regulates the concentration and efficient activation of progelatinase A. A kinetic study by Butler, G S, Butler, M J, Atkinson, S J, Will, H, Tamura, T, Schade van Westrum, S, Crabbe, T, Clements, J, d'Ortho, M P, Murphy, G

“…We have used C-terminal domain mutants to further define the role of interactions of progelatinase A and membrane type 1 matrix metalloproteinase (MT1 MMP) in…”
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An in vivo model for screening peptidomimetic inhibitors of gelatinase A by Chander, S K, Antoniw, P, Beeley, N R, Boyce, B, Crabbe, T, Docherty, A J, Leonard, J, Mason, B, Millar, K, Millican, A T

“…Gelatinase A, a matrix metalloproteinase, is frequently associated with human solid tumors, and its secretion and activation in the tumor milieu is considered…”
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Gelatinases A and B by Murphy, G, Crabbe, T

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Dissecting the role of matrix metalloproteinases (MMP) and integrin αvβ3 in angiogenesis in vitro : Absence of hemopexin C domain bioactivity, but membrane-type 1-MMP and αvβ3 are critical by NISATO, Riccardo E, HOSSEINI, Ghamartaj, PEPPER, Michael S, SIRRENBERG, Christian, BUTLER, Georgina S, CRABBE, Thomas, DOCHERTY, Andrew J. P, WIESNER, Matthias, MURPHY, Gillian, OVERALL, Christopher M, GOODMAN, Simon L

“…Abstract Matrix metalloproteinase (MMP)-2 and its hemopexin C domain autolytic fragment (also called PEX) have been proposed to be crucial for angiogenesis…”
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The Secretion of Active Recombinant Human Gastric Lipase bySaccharomyces cerevisiae by Crabbe, Thomas, Weir, A.Neil, Walton, E.Fintan, Brown, Michael E., Sutton, Christopher W., Tretout, Nathalie, Bonnerjea, Julian, Lowe, Peter A., Yarranton, Geoffrey T.

“…The expression of the complete human gastric lipase (HGL) gene inSaccharomyces cerevisiaegrown in defined medium resulted in the secretion of active…”
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Regulation of matrix metalloproteinase activity by Murphy, G, Willenbrock, F, Crabbe, T, O'Shea, M, Ward, R, Atkinson, S, O'Connell, J, Docherty, A

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Dissecting the role of matrix metalloproteinases (MMP) and integrin alpha(v)beta3 in angiogenesis in vitro: absence of hemopexin C domain bioactivity, but membrane-Type 1-MMP and alpha(v)beta3 are critical by Nisato, Riccardo E, Hosseini, Ghamartaj, Sirrenberg, Christian, Butler, Georgina S, Crabbe, Thomas, Docherty, Andrew J P, Wiesner, Matthias, Murphy, Gillian, Overall, Christopher M, Goodman, Simon L, Pepper, Michael S

“…Matrix metalloproteinase (MMP)-2 and its hemopexin C domain autolytic fragment (also called PEX) have been proposed to be crucial for angiogenesis. Here, we…”
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Human progelatinase A can be activated by matrilysin by Crabbe, Thomas, Smith, Bryan, O'Connell, James, Docherty, Andrew

“…The activation of human progelatinase A by other matrix metalloproteinases was studied by following both the loss of its N-terminal propeptide and the…”
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The C-terminal (haemopexin-like) domain structure of human gelatinase A (MMP2): structural implications for its function by Gohlke, Ulrich, Gomis-Rüth, Franz-Xaver, Crabbe, Thomas, Murphy, Gillian, Docherty, Andrew J.P., Bode, Wolfram

“…In common with most other matrix metalloproteinases, gelatinase A has a non-catalytic C-terminal domain that displays sequence homology to haemopexin. Crystals…”
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Reciprocated matrix metalloproteinase activation: A process performed by interstitial collagenase and progelatinase A by Crabbe, Thomas, O'Connell, James P, Smith, Bryan J, Docherty, Andrew J. P

“…Gelatinase A, a member of the matrix metalloproteinase (MMP) family, is secreted possessing an 80 amino acid N-terminal propeptide that must be removed in…”
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Mutation of the Active Site Glutamic Acid of Human Gelatinase A: Effects on Latency, Catalysis, and the Binding of Tissue Inhibitor of Metalloproteinases-1 by Crabbe, Thomas, Zucker, Stanley, Cockett, Mark I, Willenbrock, Frances, Tickle, Simon, O'Connell, James P, Scothern, Janeen M, Murphy, Gillian, Docherty, Andrew J. P

“…Human gelatinase A, a member of the matrix metalloproteinase family, is secreted from cells as the M(r) 72,000 latent precursor, progelatinase A. The autolytic…”
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The TIMP2 Membrane Type 1 Metalloproteinase “Receptor” Regulates the Concentration and Efficient Activation of Progelatinase A by Georgina S. Butler, Michael J. Butler, Susan J. Atkinson, Horst Will, Tatsuya Tamura, Steven Schade van Westrum, Thomas Crabbe, John Clements, Marie-Pia d’Ortho, Gillian Murphy

“…We have used C-terminal domain mutants to further define the role of interactions of progelatinase A and membrane type 1 matrix metalloproteinase (MT1 MMP) in…”
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Human progelatinase A can be activated by autolysis at a rate that is concentration‐dependent and enhanced by heparin bound to the C‐terminal domain by CRABBE, Thomas, IOANNOU, Chris, DOCHERTY, Andrew J. P.

“…Activation of the latent precursor of human gelatinase A (progelatinase A) was investigated using recombinant proenzyme purified from culture medium…”
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An analysis of the conformational changes that accompany the activation and inhibition of gelatinase A by Crabbe, Thomas, Kelly, Sharon M., Price, Nicholas C.

“…The latent precursors of the matrix metalloproteinases (MMPs) are converted by (4-aminophenylmercuric)acetate to active forms that lose their propeptide as a…”
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The secretion of active recombinant human gastric lipase by Saccharomyces cerevisiae by Crabbe, T, Weir, A N, Walton, E F, Brown, M E, Sutton, C W, Tretout, N, Bonnerjea, J, Lowe, P A, Yarranton, G T

“…The expression of the complete human gastric lipase (HGL) gene in Saceharomyces cerevisiae grown in defined medium resulted in the secretion of active…”
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