Search Results - "COYLE, A. J."

Blockade of CCR4 in a humanized model of asthma reveals a critical role for DC‐derived CCL17 and CCL22 in attracting Th2 cells and inducing airway inflammation by Perros, F., Hoogsteden, H. C., Coyle, A. J., Lambrecht, B. N., Hammad, H.

“…Background:  As Th2 type lymphocytes orchestrate the cardinal features of allergic asthma, inhibiting their recruitment to the lungs could be of therapeutic…”
Get full text

Building a New Biomedical Ecosystem: Pfizer's Centers for Therapeutic Innovation by Patel, A C, Coyle, A J

“…It is becoming increasingly clear that to significantly enhance research and development productivity and innovation, new external partnerships are essential…”
Get full text

A mouse GM-CSF receptor antibody attenuates neutrophilia in mice exposed to cigarette smoke by BOTELHO, F. M, NIKOTA, J. K, SLEEMAN, M. A, BAUER, C, DAVIS, N. H. E, COHEN, E. S, ANDERSON, I. K, COYLE, A. J, KOLBECK, R, HUMBLES, A. A, STÄMPFLI, M. R

“…We investigated the role of granulocyte-macrophage colony-stimulating factor (GM-CSF) in a subchronic exposure model of cigarette smoke (CS)-induced…”
Get full text

Correlation of cutaneous disease activity with type 1 interferon gene signature and interferon β in dermatomyositis by Huard, C., Gullà, S.V., Bennett, D.V., Coyle, A.J., Vleugels, R.A., Greenberg, S.A.

“…Summary Background Dermatomyositis (DM) is an autoimmune disease primarily affecting skin and muscle. Objectives The purpose of this study was to determine…”
Get full text

Interleukin-4 is required for the induction of lung Th2 mucosal immunity by Coyle, A J, Le Gros, G, Bertrand, C, Tsuyuki, S, Heusser, C H, Kopf, M, Anderson, G P

“…Aerosol antigen challenge of ovalbumin-sensitized mice induced an eosinophilic airway inflammation that was dependent on interleukin (IL)-5 and CD4+, but not…”
Get more information

Immunoreactivity profile of peripheral blood mononuclear cells from patients with ragweed-induced allergic rhinitis by Sun, J., Wong, B., Cundall, M., Goncharova, S., Conway, M., Dalrymple, A., Coyle, A. J., Waserman, S., Jordana, M.

“…Summary Background Seasonal rhinitis is manifested by a series of nasal symptoms in response to exposure to seasonal allergens including ragweed pollen…”
Get full text

IL-5 deficiency abolishes aspects of airway remodelling in a murine model of lung inflammation by Trifilieff, A., Fujitani, Y., Coyle, A. J., Kopf, M., Bertrand, C.

“…Background and objectives Lung remodelling is a recognized feature of chronic asthma. In the present study, we have used IL‐5‐deficient mice to evaluate the…”
Get full text

Correlation of cutaneous disease activity with type 1 interferon gene signature and interferon [beta] in dermatomyositis by Huard, C, Gulla, SV, Bennett, DV, Coyle, AJ, Vleugels, RA, Greenberg, SA

“…Summary Background Dermatomyositis (DM) is an autoimmune disease primarily affecting skin and muscle. Objectives The purpose of this study was to determine…”
Get full text

Regulation and Function of T1/ST2 Expression on CD4+ T Cells: Induction of Type 2 Cytokine Production by T1/ST2 Cross-Linking by Meisel, Christian, Bonhagen, Kerstin, Lohning, Max, Coyle, Anthony J, Gutierrez-Ramos, Jose-Carlos, Radbruch, Andreas, Kamradt, Thomas

“…The orphan receptor T1/ST2, a member of the IL-1R family, is preferentially expressed on the surface of murine Th2 cells. In this study, we analyzed the…”
Get full text

The lung cytokine microenvironment influences molecular events in the lymph nodes during Th1 and Th2 respiratory mucosal sensitization to antigen in vivo by RITZ, S. A., CUNDALL, M. J., GAJEWSKA, B. U., SWIRSKI, F. K., WILEY, R. E., ALVAREZ, D., COYLE, A. J., STAMPFLI, M. R., JORDANA, M.

“…SUMMARY Originally defined by their patterns of cytokine production, Th1 and Th2 cells have been described more recently to express other genes differentially…”
Get full text

Virus-specific CD8+ cells can switch to interleukin 5 production and induce airway eosinophilia by Coyle, A J, Erard, F, Bertrand, C, Walti, S, Pircher, H, Le Gros, G

“…Virus infections of the lung are thought to predispose individuals to asthma, a disease characterized by eosinophil infiltration of the airways. CD8+ T cells…”
Get full text

Mouse Eotaxin Expression Parallels Eosinophil Accumulation during Lung Allergic Inflammation but It Is Not Restricted to a Th2-Type Response by Gonzalo, J.-A, Jia, G-Q, Aguirre, V, Friend, D, Coyle, A.J, Jenkins, N.A, Lin, G-S, Katz, H, Lichtman, A, Copeland, N, Kopf, M, Gutierrez-Ramos, J.-C

“…A model of lung eosinophilia based on the repeated exposure of mice to aerosolized OVA has been used to identify C–C chemokine genes expressed at stages of…”
Get full text

Non-redundant functional groups of chemokines operate in a coordinate manner during the inflammatory response in the lung by Gutierrez-Ramos, J.-C., Lloyd, C., Kapsenberg, M. L., Gonzalo, J. A., Coyle, A. J.

“…The understanding of the relative contribution of particular chemokines to the selective accumulation of leukocyte subsets to an organ site during an…”
Get full text

Inhalation of a harmless antigen (ovalbumin) elicits immune activation but divergent immunoglobulin and cytokine activities in mice by Swirski, F. K., Gajewska, B. U., Alvarez, D., Ritz, S. A., Cundall, M. J., Cates, E. C., Coyle, A. J., Gutierrez-Ramos, J.-C., Inman, M. D., Jordana, M., Stämpfli, M. R.

“…Background Exposure to aerosolized harmless antigen such as ovalbumin (OVA) has previously been shown to induce inhalation tolerance, a state characterized by…”
Get full text

IKKε and TBK1 are essential components of the IRF3 signaling pathway by Fitzgerald, Katherine A., McWhirter, Sarah M., Faia, Kerrie L., Rowe, Daniel C., Latz, Eicke, Golenbock, Douglas T., Coyle, Anthony J., Liao, Sha-Mei, Maniatis, Tom

“…The transcription factors interferon regulatory factor 3 (IRF3) and NF- Kappa B are required for the expression of many genes involved in the innate immune…”
Get full text

Activation of the Fas receptor on lung eosinophils leads to apoptosis and the resolution of eosinophilic inflammation of the airways by Tsuyuki, S, Bertrand, C, Erard, F, Trifilieff, A, Tsuyuki, J, Wesp, M, Anderson, G P, Coyle, A J

“…While considerable progress has been made in understanding the events by which eosinophils accumulate in various pathophysiological conditions, the mechanisms…”
Get full text

Cutting Edge: The Related Molecules CD28 and Inducible Costimulator Deliver Both Unique and Complementary Signals Required for Optimal T Cell Activation by Gonzalo, Jose-Angel, Delaney, Tracy, Corcoran, Justin, Goodearl, Andrew, Gutierrez-Ramos, Jose Carlos, Coyle, Anthony J

“…Optimal T cell activation requires engagement of CD28 with its counterligands B7-1 and B7-2. Inducible costimulator (ICOS) is the third member of the…”
Get full text

Comparison of Na+-dependent glutamate transport activity in synaptosomes, C6 glioma, and Xenopus oocytes expressing excitatory amino acid carrier 1 (EAAC1) by Dowd, L A, Coyle, A J, Rothstein, J D, Pritchett, D B, Robinson, M B

“…Several subtypes of sodium-dependent high affinity (SDHA) glutamate transporters have been pharmacologically differentiated in brain tissue. Recently, four…”
Get more information

Resolution of Bronchial Hyperresponsiveness and Pulmonary Inflammation Is Associated with IL-3 and Tissue Leukocyte Apoptosis by Lloyd, Clare M, Gonzalo, Jose-Angel, Nguyen, Trang, Delaney, Tracy, Tian, Jane, Oettgen, Hans, Coyle, Anthony J, Gutierrez-Ramos, Jose-Carlos

“…We have used two models of murine pulmonary inflammation to investigate the signals responsible for the resolution of bronchial hyperresponsiveness (BHR). Both…”
Get full text

Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan by Girardin, Stephen E., Boneca, Ivo G., Leticia A. M. Carneiro, Antignac, Aude, Jéhanno, Muguette, Viala, Jérôme, Tedin, Karsten, Taha, Muhamed-Kheir, Labigne, Agnès, Zähringer, Ulrich, Coyle, Anthony J., DiStefano, Peter S., Bertin, John, Sansonetti, Philippe J., Philpott, Dana J.

“…Although the role of Toll-like receptors in extracellular bacterial sensing has been investigated intensively, intracellular detection of bacteria through Nod…”
Get full text