Search Results - "COXON, Amy"

t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway by Kaye, Frederic J, Tonon, Giovanni, Modi, Sanjay, Wu, Lizi, Kubo, Akihito, Coxon, Amy B, Komiya, Takefumi, O'Neil, Kevin, Stover, Kristen, El-Naggar, Adel, Griffin, James D, Kirsch, Ilan R

“…Truncation of Notch1 has been shown to cause a subtype of acute leukemia, and activation of Notch4 has been associated with mammary and salivary gland…”
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Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic AMP/CREB regulated genes by COXON, Amy, ROZENBLUM, Ester, PARK, Yoon-Soo, JOSHI, Nina, TSURUTANI, Junji, DENNIS, Phillip A, KIRSCH, Ilan R, KAYE, Frederic J

“…Malignant salivary gland tumors can arise from a t(11;19) translocation that fuses 42 residues from Mect1/Torc1, a cyclic AMP (cAMP)/cAMP-responsive element…”
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Low-penetrant RB allele in small-cell cancer shows geldanamycin instability and discordant expression with mutant ras by Park, Yoonsoo, Kubo, Akihito, Komiya, Takefumi, Coxon, Amy, Beebe, Kristin, Neckers, Len, Meltzer, Paul S., Kaye, Frederic J.

“…Certain kindreds with low-penetrant (lp) retinoblastoma carry mutant alleles which retain partial tumor suppressor activity and we previously showed that these…”
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Incomplete Penetrance of Familial Retinoblastoma Linked to Germ-Line Mutations that Result in Partial Loss of RB Function by Otterson, G A, Chen, W d, Coxon, A B, Khleif, S N, Kaye, F J

“…To study the molecular basis for the clinical phenotype of incomplete penetrance of familial retinoblastoma, we have examined the functional properties of…”
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Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer by MODI, Sanjay, KUBO, Akihito, OIE, Herbert, COXON, Amy B, REHMATULLA, Ahad, KAYE, Frederic J

“…Mutational inactivation of the RB-related gene RBL2/p130 has been reported as a common and important prognostic factor in human lung cancer. To examine the…”
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Apoptosis is associated with cleavage of a 5 kDa fragment from RB which mimics dephosphorylation and modulates E2F binding by CHEN, W.-D, OTTERSON, G. A, LIPKOWITZ, S, KHLEIF, S. N, COXON, A. B, KAYE, F. J

“…Dephosphorylation of the RB protein has been reported to be associated with apoptosis. In contrast, we show that treatment of HL60 cells with etoposide or…”
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Abstract 114: Oncogenomic analysis of Merkel cell carcinoma by Gelb, Tara, Daily, Kenneth, Coxon, Amy, Brownell, Isaac

“…Abstract We used an integrative oncogenomic approach to investigate the molecular etiology of Merkel Cell Carcinoma (MCC) in an effort to identify novel…”
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RET cooperates with RB/p53 inactivation in a somatic multi-step model for murine thyroid cancer by COXON, A. B, WARD, J. M, GERADTS, J, OTTERSON, G. A, ZAJAC-KAYE, M, KAYE, F. J

“…Mice bred to carry germline Rb and p53 null alleles are associated with a tumor spectrum that overlaps with the inherited multiple endocrine neoplasia-1 (MEN1)…”
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Assessment of Cancer Cell Line Representativeness Using Microarrays for Merkel Cell Carcinoma by Daily, Kenneth, Coxon, Amy, Williams, Jonathan S., Lee, Chyi-Chia R., Coit, Daniel G., Busam, Klaus J., Brownell, Isaac

“…When using cell lines to study cancer, phenotypic similarity to the original tumor is paramount. Yet, little has been done to characterize how closely Merkel…”
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Hedgehog Signaling Inhibitors Fail to Reduce Merkel Cell Carcinoma Viability by Carroll, Thomas M., Williams, Jonathan S., Daily, Kenneth, Rogers, Tova, Gelb, Tara, Coxon, Amy, Wang, Steven Q., Crago, Aimee M., Busam, Klaus J., Brownell, Isaac

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Enhanced activity of the CREB co-activator Crtc1 in LKB1 null lung cancer by Komiya, T, Coxon, A, Park, Y, Chen, W-D, Zajac-Kaye, M, Meltzer, P, Karpova, T, Kaye, F J

“…Activation of Crtc1 (also known as Mect1/Torc1) by a t(11;19) chromosomal rearrangement underlies the etiology of malignant salivary gland tumors. As LKB1 is a…”
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Abstract 1135: Enhanced activity of the CREB co-activator Crtc1 in LKB1 null lung cancer by Park, Yoonsoo, Coxon, Amy, Komiya, Takefumi, Chen, Wei-Dong, Zajac-Kaye, Maria, Meltzer, Paul, Karpova, Tatiana, Kaye, Frederic

“…Abstract Activation of Crtc1 (also known as Mect1/Torc1) by a t(11;19) chromosomal rearrangement underlies the etiology of malignant salivary gland tumors…”
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RB protein status and clinical correlation from 171 cell lines representing lung cancer, extrapulmonary small cell carcinoma, and mesothelioma by Shimizu, E, Coxon, A, Otterson, G A, Steinberg, S M, Kratzke, R A, Kim, Y W, Fedorko, J, Oie, H, Johnson, B E, Mulshine, J L

“…We have studied RB protein expression in 171 cell lines derived from patients with small cell lung cancer (SCLC), non-small cell lung cancer (NSCLC), pulmonary…”
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Temperature-Sensitive RB Mutations Linked to Incomplete Penetrance of Familial Retinoblastoma in 12 Families by Otterson, Gregory A., Modi, Sanjay, Nguyen, Kari, Coxon, Amy B., Kaye, Frederic J.

“…The tumor-suppressor activity of the retinoblastoma protein (RB) is encoded within a protein-binding (“pocket”) domain that is targeted for mutations in all…”
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Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein by Kim, Y W, Otterson, G A, Kratzke, R A, Coxon, A B, Kaye, F J

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Partial inactivation of the RB product in a family with incomplete penetrance of familial retinoblastoma and benign retinal tumors by Kratzke, R A, Otterson, G A, Hogg, A, Coxon, A B, Geradts, J, Cowell, J K, Kaye, F J

“…While familial retinoblastoma has served as the paradigm for the two-hit theory of tumorigenesis and for the concept of the tumor suppressor gene, the etiology…”
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Expression analysis of RNA14, a gene involved in mRNA 3' end maturation in yeast: characterization of the rna14-5 mutant strain by Brendolise, C, Rouillard, J-M, Dufour, M-E, Lacroute, F

“…In Saccharomyces cerevisiae, Rna14 protein is involved in both cleavage and polyadenylation of mRNA in the nucleus. Previous work has demonstrated that this…”
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A mouse model for neuroendocrine tumorigenesis by Coxon, Amy Beth

“…To study the genetic and molecular basis for the development of neuroendocrine tumors, we generated a colony of Rb+/– p53+/– mice that develop a tumor spectrum…”
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Hedgehog Signaling Inhibitors Fail to Reduce Merkel Cell Carcinoma Viability by Carroll, Thomas M, Williams, Jonathan S, Daily, Kenneth, Rogers, Tova, Gelb, Tara, Coxon, Amy, Wang, Steven Q, Crago, Aimee M, Busam, Klaus J, Brownell, Isaac

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Differential Specificity for Binding of Retinoblastoma Binding Protein 2 to RB, pl07, and TATA-Binding Protein by Kim, Young Whan, Otterson, Gregory A, Kratzke, Robert A., Coxon, Amy B., Kaye, Frederic J.

“…The growth suppressor activities of the RB and p107 products are believed to be mediated by the reversible binding of a heterogeneous family of cellular…”
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