Search Results - "COWSILL, C"

Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: Implications for clinical trials by Castro, M.G, Löwenstein, P.R, Dewey, R. A, Morrissey, G, Cowsill, C. M, Stone, D, Bolognani, F, Dodd, N.J.F, Southgate, T. D, Klatzmann, D, Lassmann, H

“…The long-term consequences of adenovirus-mediated conditional cytotoxic gene therapy for gliomas remain uncharacterized. We report here detection of active…”
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Central nervous system toxicity of two adenoviral vectors encoding variants of the herpes simplex virus type 1 thymidine kinase : reduced cytotoxicity of a truncated HSV1-TK by COWSILL, C, SOUTHGATE, T. D, CASTRO, M. G, MORRISSEY, G, DEWEY, R. A, MORELLI, A. E, MALENIAK, T. C, FORREST, Z, KLATZMANN, D, WILKINSON, G. W. G, LÖWENSTEIN, P. R

“…Herpes simplex virus type 1-thymidine kinase (HSV1-TK) in combination with ganciclovir is an efficient and widely used strategy in brain tumour gene therapy…”
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Towards Global and Long-Term Neurological Gene Therapy: Unexpected Transgene Dependent, High-Level, and Widespread Distribution of HSV-1 Thymidine Kinase throughout the CNS by Zermansky, Adam J., Bolognani, Federico, Stone, Daniel, Cowsill, Christine M., Morrissey, Graham, Castro, Maria G., Löwenstein, Pedro R.

“…One of the challenges of neurological gene therapy for the treatment of chronic neurodegener-ative disorders, such as Parkinson's and Alzheimer's diseases, is…”
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A phase 1 dose finding study of CHR-2797, an inhibitor of M1 aminopeptidases, in patients with advanced solid tumours by Reid, A., Protheroe, A., Attard, G., Cowsill, C., Spicer, J., Vidal, L., Bone, E., Hooftman, L., Harris, A., De-Bono, J. S.

“…Abstract only 3053 Background: CHR-2797 is a novel, orally bioavailable inhibitor of the M1 family of aminopeptidases, in particular PuSA, and LTA 4 hydrolase…”
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Anatomically Conformable, Three-Dimensional, Detachable Platinum Microcoil System for the Treatment of Intracranial Aneurysms by Niemann, David, Aviv, Richard, Cowsill, Caroline, Sneade, Mary, Molyneux, Andrew J

“…The configurations of detachable platinum coils have evolved over the last decade. Our objective was to assess the efficacy of the anatomically conformable…”
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Onyx liquid embolic system in the treatment of intracranial aneurysms: experience in 12 patients by Molyneux, A, Nieman, D, Cowsill, C

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