Search Results - "COWELL, J. K"

WASF3 regulates miR-200 inactivation by ZEB1 through suppression of KISS1 leading to increased invasiveness in breast cancer cells by Teng, Y, Mei, Y, Hawthorn, L, Cowell, J K

“…The WASF3 gene promotes invasion and metastasis in breast cancer cells, which have undergone epithelial-to-mesenchyme transition (EMT). Overexpression of WASF3…”
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WASF3 provides the conduit to facilitate invasion and metastasis in breast cancer cells through HER2/HER3 signaling by Teng, Y, Pi, W, Wang, Y, Cowell, J K

“…The WASF3 gene is overexpressed in high-grade breast cancer and promotes invasion and metastasis, but does not affect proliferation. The HER2/ERBB2/NEU gene is…”
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Inactivation of the WASF3 gene in prostate cancer cells leads to suppression of tumorigenicity and metastases by Teng, Y, Ren, M Q, Cheney, R, Sharma, S, Cowell, J K

“…Background: The WASF3 protein is involved in cell movement and invasion, and to investigate its role in prostate cancer progression we studied the phenotypic…”
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Loss of ATF3 promotes hormone-induced prostate carcinogenesis and the emergence of CK5+CK8+ epithelial cells by Wang, Z, Kim, J, Teng, Y, Ding, H-F, Zhang, J, Hai, T, Cowell, J K, Yan, C

“…Steroid sex hormones can induce prostate carcinogenesis, and are thought to contribute to the development of prostate cancer during aging. However, the…”
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Identifying candidate colon cancer tumor suppressor genes using inhibition of nonsense-mediated mRNA decay in colon cancer cells by IVANOV, I, LO, K. C, HAWTHORN, L, COWELL, J. K, IONOV, Y

“…Inhibition of the nonsense-mediated decay (NMD) mechanism in cells results in stabilization of transcripts carrying premature translation termination codons. A…”
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The EVI5 TBC domain provides the GTPase-activating protein motif for RAB11 by Dabbeekeh, J T S, Faitar, S L, Dufresne, C P, Cowell, J K

“…The human EVI5 gene was originally isolated through its involvement with a constitutional chromosome translocation in a patient with stage 4S neuroblastoma…”
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Mitochondrial ATAD3A combines with GRP78 to regulate the WASF3 metastasis-promoting protein by Teng, Y, Ren, X, Li, H, Shull, A, Kim, J, Cowell, J K

“…AAA domain containing 3A (ATAD3A) is an integral mitochondrial membrane protein with unknown function, although we now show that high-level expression is…”
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Transformation of human CD34+ hematopoietic progenitor cells with DEK-NUP214 induces AML in an immunocompromised mouse model by Qin, H, Malek, S, Cowell, J K, Ren, M

“…Acute myeloid leukemia (AML) is a heterogeneous disease comprising a large number of subtypes defined by specific chromosome abnormalities. One such subtype…”
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Distinct molecular signatures in pediatric infratentorial glioblastomas defined by aCGH by Sharma, S., Free, A., Mei, Y., Peiper, S.C., Wang, Z., Cowell, J.K.

“…Glioblastomas (GBM) are rare in children, but reportedly have more varied outcome which suggests differences in tumor etiology compared to typical GBM of…”
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Identification and characterisation of constitutional chromosome abnormalities using arrays of bacterial artificial chromosomes by COWELL, J. K, WANG, Y. D, HEAD, K, CONROY, J, MCQUAID, D, NOWAK, N. J

“…Constitutional chromosome deletions and duplications frequently predispose to the development of a wide variety of cancers. We have developed a microarray of…”
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Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA by KONDO, S, KONDO, Y, GUIYING LI, SILVERMAN, R. H, COWELL, J. K

“…Telomerase is the RNA-protein complex which elongates telomeric DNA (TTAGGG)n and appears to play an important role in cellular immortalization. The almost…”
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Ponatinib suppresses the development of myeloid and lymphoid malignancies associated with FGFR1 abnormalities by Ren, M, Qin, H, Ren, R, Cowell, J K

“…Myeloid and lymphoid malignancies associated with fibroblast growth factor receptor-1 (FGFR1) abnormalities are characterized by constitutively activated FGFR1…”
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Loss of heterozygosity on chromosome 16 in sporadic Wilms' tumour by GRUNDY, R. G, PRITCHARD, J, SCAMBLER, P, COWELL, J. K

“…To establish whether loss of heterozygosity (LOH) for chromosome 16q in Wilms' tumours confers an adverse prognosis, DNA from 40 Wilms' tumour/normal pairs…”
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Inhibition of telomerase increases the susceptibility of human malignant glioblastoma cells to cisplatin-induced apoptosis by KONDO, Y, KONDO, S, TANAKA, Y, HAQQI, T, BARNA, B. P, COWELL, J. K

“…Malignant glioblastomas grow very rapidly and are generally resistant to either DNA-damaging drugs or gamma-irradiation. If tumor cells could be made more…”
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NB4S, a Member of the TBC1 Domain Family of Genes, is Truncated as a Result of a Constitutional t(1;10)(p22;q21) Chromosome Translocation in a Patient with Stage 4S Neuroblastoma by Roberts, Terry, Chernova, Olga, Cowell, John K.

“…Molecular cloning of the breakpoints of a t(1;10)(p22q21) constitutional translocation breakpoint in a patient with stage 4S neuroblastoma has identified two…”
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Molecular analysis of two putative tumour suppressor genes, PTEN and DMBT, which have been implicated in glioblastoma multiforme disease progression by SOMERVILLE, R. P. T, SHOSHAN, Y, ENG, C, BARNETT, G, MILLER, D, COWELL, J. K

“…The transition from low grade astrocytoma to glioblastoma multiforme is almost always accompanied by the loss of genetic markers from chromosome 10. Recently…”
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Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon by STILL, I. H, HAMILTON, M, VINCE, P, WOLFMAN, A, COWELL, J. K

“…Amplification of several chromosomal regions have been observed in human breast carcinomas. One such region, 8p11, is amplified in 10-15% of tumor samples…”
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The Third Member of the Transforming Acidic Coiled Coil-Containing Gene Family, TACC3, Maps in 4p16, Close to Translocation Breakpoints in Multiple Myeloma, and Is Upregulated in Various Cancer Cell Lines by Still, Ivan H, Vince, Pauline, Cowell, John K

“…We have recently identified a novel gene, TACC1 (transforming acidic coiled coil-containing gene 1), which is located close to FGFR1 within a region amplified…”
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Rapid detection of allelic losses in brain tumours using microsatellite repeat markers and high-performance liquid chromatography by CHERNOVA, O. B, BARNETT, G. H, COWELL, J. K

“…High-performance liquid chromatography (HPLC) is a recently introduced high-capacity automated method for detecting unknown mutations (denaturing HPLC) or for…”
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Radiation-Induced Meningioma: A Distinct Molecular Genetic Pattern? by SHOSHAN, YIGAL, CHERNOVA, OLGA, JEUN, SIN-SOO, SOMERVILLE, ROBERT P, ISRAEL, ZVI, BARNETT, GENE H, COWELL, JOHN K

“…Radiation-induced meningiomas arise after low-dose irradiation treatment of certain medical conditions and are recognized as clinically separate from sporadic…”
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