Search Results - "COWART, T. D"

Acute cardiovascular effects of OPC-18790 in patients with congestive heart failure : time- and dose-dependence analysis based on pressure-volume relations by FELDMAN, M. D, PAK, P. H, KASS, D. A, WU, C. C, HABER, H. L, HEESCH, C. M, BERGIN, J. D, POWERS, E. R, COWART, T. D, JOHNSON, W, FELDMAN, A. M

“…OPC-18790 is a water-soluble quinolinone derivative that shares the pharmacological properties of vesnarinone and that may be useful for treating heart…”
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Effect of Disulfiram-Mediated CYP2E1 Inhibition on the Disposition of Vesnarinone by Frye, Reginald F., Tammara, Brinda, Cowart, T. Douglas, Bramer, Steven L.

“…Vesnarinone is an orally administered inotropic agent that is metabolized in vitro by the cytochrome P450 (CYP) isozymes CYP3A4 and CYP2E1. The purpose of this…”
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Pathway-selective sex differences in the metabolic clearance of propranolol in human subjects by Walle, T, Walle, U K, Cowart, T D, Conradi, E C

“…This study determined the total clearance of propranolol and the partial clearances through each of its three primary metabolic pathways after administration…”
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Selective induction of propranolol metabolism by smoking: additional effects on renal clearance of metabolites by Walle, T, Walle, U K, Cowart, T D, Conradi, E C, Gaffney, T E

“…The objective of this study was to examine the effect of cigarette smoking on the activities of the three primary pathways governing propranolol metabolism in…”
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Effect of Increasing Gastric pH with Famotidine on the Absorption and Oral Pharmacokinetics of the Inotropic Agent Vesnarinone by Koneru, Brinda, Cowart, Douglas T., Noorisa, Manizhe, Kisicki, James, Bramer, Steven L.

“…The effect of famotidine, an H2 receptor blocker, on the oral absorption and pharmacokinetics of the novel agent vesnarinone was investigated after oral…”
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Direct Myocardial Effects of OPC-18790 in Human Heart Failure: Beneficial Effects on Contractile and Diastolic Function Demonstrated by Intracoronary Infusion With Pressure–Volume Analysis by MacGowan, Guy A, Haber, Howard L, Cowart, T.Douglas, Tedesco, Christine, Wu, Clarence, Feldman, Marc D

“…Objectives. We sought to determine the precise myocardial effects of OPC-18790 as demonstrated by intracoronary administration. Background. Although previous…”
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LC/MS/MS analysis of vesnarinone and its principal metabolites in plasma and urine by Tata, PrasadN.V., Schorno, KarlS, Cowart, T.Douglas, Bramer, StevenL

“…An LC/MS/MS assay was developed and successfully used to quantitate vesnarinone and its principal metabolites (OPC-8230, OPC-18136, and OPC-18137) in human…”
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Food effects on propranolol systemic and oral clearance: support for a blood flow hypothesis by Olanoff, L S, Walle, T, Cowart, T D, Walle, U K, Oexmann, M J, Conradi, E C

“…The influence of a high-protein meal as compared to fasting on the disposition of simultaneous intravenous and oral doses of propranolol, as well as on…”
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Verapamil-induced natriuretic and diuretic effects: dependency on sodium intake by Hughes, Jr, G S, Cowart, T D, Oexmann, M J, Conradi, E C

“…The influence of dietary sodium on the antihypertensive effects of verapamil and on components of sodium, water, and calcium metabolism was studied in nine…”
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Pharmacokinetics and metabolism of oral doses of a 4'-methylthio derivative of propranolol in man by Walle, T, Walle, U K, Cowart, T D, Conradi, E C, Gaffney, T E

“…1. The objective of this study was to determine the oral dose pharmacokinetics and metabolism of 4'-methylthiopropranolol (MTP) in man and compare the results…”
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Stereoselective clearance and distribution of intravenous propranolol by Olanoff, L S, Walle, T, Walle, U K, Cowart, T D, Gaffney, T E

“…Our objective was to determine the kinetics of (+)- and (-)-propranolol after intravenous doses of racemic drug. Five normal subjects received 0.1 mg/kg of a…”
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Acetaminophen overdosage by Sawyer, P R, Cowart, Jr, T D, Hurwitz, G A, Halushka, P V, Jollow, D J

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Efficacy of verapamil--hydrochlorothiazide-spironolactone therapy in hypertensive black patients by Hughes, Jr, G S, Cowart, Jr, T D, Conradi, E C

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Use of nifedipine as an adjunct to current antihypertensive therapy by Evans, Jr, M G, Olanoff, L S, Hurwitz, G, Cowart, T D, Conradi, E C

“…Ten hypertensive patients with poor responses to standard antihypertensive therapy were treated with the calcium channel antagonist nifedipine in an attempt to…”
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Antihypertensive effects of lofexidine in patients with essential hypertension by Fagan, TC, Bloomfield, SS, Cowart, TD, Corns‐Hurwitz, RH, Lipicky, RJ, Conradi, EC, Hsu, CY, Grossman, WJ, Harmon, GE, Degenhart, WJ, Sinkfield, AW, Gaffney, TE

“…1 Single oral doses of lofexidine, 0.1, 0.3, and 0.6 mg produced dose related decreases in supine and standing arterial pressure and heart rate in nineteen…”
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