Search Results - "COURTNEY, Harry S"

Novel Antibiotic-loaded Point-of-care Implant Coating Inhibits Biofilm by Jennings, Jessica Amber, Carpenter, Daniel P., Troxel, Karen S., Beenken, Karen E., Smeltzer, Mark S., Courtney, Harry S., Haggard, Warren O.

“…Background Orthopaedic biomaterials are susceptible to biofilm formation. A novel lipid-based material has been developed that may be loaded with antibiotics…”
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Non-immune binding of human IgG to M-related proteins confers resistance to phagocytosis of group A streptococci in blood by Courtney, Harry S, Li, Yi

“…The non-immune binding of immunoglobulins by bacteria is thought to contribute to the pathogenesis of infections. M-related proteins (Mrp) are group A…”
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Relationship between expression of the family of M proteins and lipoteichoic acid to hydrophobicity and biofilm formation in Streptococcus pyogenes by Courtney, Harry S, Ofek, Itzhak, Penfound, Thomas, Nizet, Victor, Pence, Morgan A, Kreikemeyer, Bernd, Podbielski, Andreas, Podbielbski, Andreas, Hasty, David L, Dale, James B

“…Hydrophobicity is an important attribute of bacteria that contributes to adhesion and biofilm formation. Hydrophobicity of Streptococcus pyogenes is primarily…”
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Blended Chitosan Paste for Infection Prevention: Preliminary and Preclinical Evaluations by Berretta, Joel M., Jennings, Jessica A., Courtney, Harry S., Beenken, Karen E., Smeltzer, Mark S., Haggard, Warren O.

“…Background Local drug delivery devices offer a promising method for delivering vancomycin and amikacin for musculoskeletal wounds. However, current local…”
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Composite chitosan and calcium sulfate scaffold for dual delivery of vancomycin and recombinant human bone morphogenetic protein-2 by Doty, Heather A., Leedy, Megan R., Courtney, Harry S., Haggard, Warren O., Bumgardner, Joel D.

“…A biodegradable, composite bone graft, composed of chitosan microspheres embedded in calcium sulfate, was evaluated in vitro for point-of-care loading and…”
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Chitosan coatings deliver antimicrobials from titanium implants: a preliminary study by Norowski, Peter A, Courtney, Harry S, Babu, Jegdish, Haggard, Warren O, Bumgardner, Joel D

“…Chitosan was investigated as a coating for local delivery of antimicrobials for prevention of acute implant infection. The objectives of this study were to (1)…”
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Apolipoprotein E Mediates Enhanced Plasma High-Density Lipoprotein Cholesterol Clearance by Low-Dose Streptococcal Serum Opacity Factor via Hepatic Low-Density Lipoprotein Receptors In Vivo by Rosales, Corina, Tang, Daming, Gillard, Baiba K, Courtney, Harry S, Pownall, Henry J

“…OBJECTIVE—Recombinant streptococcal serum opacity factor (rSOF) mediates the in vitro disassembly of human plasma high-density lipoprotein (HDL) into…”
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Antibiotic-loaded chitosan film for infection prevention: A preliminary in vitro characterization by Smith, J. Keaton, Bumgardner, Joel D., Courtney, Harry S., Smeltzer, Mark S., Haggard, Warren O.

“…The growing infection rate by methicillin‐resistant Staphylococcus aureus, especially with bone fracture fixation implants, is a major concern in extremity…”
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Trivalent M-related protein as a component of next generation group A streptococcal vaccines by Courtney, Harry S, Niedermeyer, Shannon E, Penfound, Thomas A, Hohn, Claudia M, Greeley, Adam, Dale, James B

“…There is a need to broaden protective coverage of M protein-based vaccines against group A streptococci (GAS) because coverage of the current 30-valent M…”
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Apolipoprotein Modulation of Streptococcal Serum Opacity Factor Activity against Human Plasma High-Density Lipoproteins by Rosales, Corina, Gillard, Baiba K, Courtney, Harry S, Blanco-Vaca, Francisco, Pownall, Henry J

“…Human plasma HDL are the target of streptococcal serum opacity factor (SOF), a virulence factor that clouds human plasma. Recombinant (r) SOF transfers…”
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Inactivation of DltA modulates virulence factor expression in Streptococcus pyogenes by Cox, Kathleen H, Ruiz-Bustos, Eduardo, Courtney, Harry S, Dale, James B, Pence, Morgan A, Nizet, Victor, Aziz, Ramy K, Gerling, Ivan, Price, Susan M, Hasty, David L

“…D-alanylated lipoteichoic acid is a virtually ubiquitous component of gram-positive cell walls. Mutations in the dltABCD operon of numerous species exhibit…”
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Serum Opacity Factor Is a Streptococcal Receptor for the Extracellular Matrix Protein Fibulin-1 by Courtney, Harry S., Li, Yi, Twal, Waleed O., Argraves, W. Scott

“…The adhesion of bacteria to host tissues is often mediated by interactions with extracellular matrices. Herein, we report on the interactions of the group A…”
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Serum Opacity Factor, a Streptococcal Virulence Factor That Binds to Apolipoproteins A-I and A-II and Disrupts High Density Lipoprotein Structure by Courtney, Harry S., Zhang, Yong-Mei, Frank, Matthew W., Rock, Charles O.

“…Serum opacity factor (SOF) is a virulence determinant of group A streptococci that opacifies mammalian sera. We analyzed the specificity and mechanism of the…”
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Disruption of Human Plasma High-Density Lipoproteins by Streptococcal Serum Opacity Factor Requires Labile Apolipoprotein A-I by Han, Mikyung, Gillard, Baiba K, Courtney, Harry S, Ward, Kathryn, Rosales, Corina, Khant, Htet, Ludtke, Steven J, Pownall, Henry J

“…Human plasma high-density lipoproteins (HDL), the primary vehicle for reverse cholesterol transport, are the target of serum opacity factor (SOF), a virulence…”
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Cis-2-decenoic Acid Inhibits S. aureus Growth and Biofilm In Vitro: A Pilot Study by Jennings, Jessica Amber, Courtney, Harry S., Haggard, Warren O.

“…Background Cis-2 decenoic acid (C2DA) disperses biofilm in many strains of microorganisms. However, whether C2DA inhibits bacterial growth or has potential to…”
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Opacity Factor Activity and Epithelial Cell Binding by the Serum Opacity Factor Protein of Streptococcus pyogenes Are Functionally Discrete by Gillen, Christine M., Courtney, Harry S., Schulze, Kai, Rohde, Manfred, Wilson, Mark R., Timmer, Anjuli M., Guzman, Carlos A., Nizet, Victor, Chhatwal, G.S., Walker, Mark J.

“…Serum opacity factor (SOF) is a unique multifunctional virulence determinant expressed at the surface of Streptococcus pyogenes and has been shown to elicit…”
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Identification of a group B streptococcal fibronectin binding protein, SfbA, that contributes to invasion of brain endothelium and development of meningitis by Mu, Rong, Kim, Brandon J, Paco, Czarinah, Del Rosario, Yvette, Courtney, Harry S, Doran, Kelly S

“…Group B Streptococcus (GBS) is currently the leading cause of neonatal meningitis. This is due to its ability to survive and multiply in the bloodstream and…”
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Serum Opacity Factor (SOF) of Streptococcus pyogenes Evokes Antibodies That Opsonize Homologous and Heterologous SOF-Positive Serotypes of Group A Streptococci by COURTNEY, Harry S, HASTY, David L, DALE, James B

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Structure-based design of broadly protective group a streptococcal M protein-based vaccines by Dale, James B, Smeesters, Pierre R, Courtney, Harry S, Penfound, Thomas A, Hohn, Claudia M, Smith, Jeremy C, Baudry, Jerome Y

“…Highlights • emm clusters were used as the basis for structure-based design of vaccines. • 3-D structures and physicochemical properties identified five M…”
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Chitosan Sponges to Locally Deliver Amikacin and Vancomycin: A Pilot In Vitro Evaluation by Noel, Scott P., Courtney, Harry S., Bumgardner, Joel D., Haggard, Warren O.

“…Background Open orthopaedic wounds are ideal sites for infection. Preventing infection in these wounds is critical for reducing patient morbidity and…”
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