Search Results - "COUGHLIN, P. B"

Implementation of a clinical prediction tool for pulmonary embolism diagnosis in a tertiary teaching hospital reduces the number of computed tomography pulmonary angiograms performed by Ong, C. W., Malipatil, V., Lavercombe, M., Teo, K. G. W., Coughlin, P. B., Leach, D., Spanger, M. C., Thien, F.

“…Aim To evaluate the effect of implementing the Wells score clinical prediction tool (CPT) on rationalising the use of computed tomography pulmonary angiography…”
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The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature by Silverman, G A, Bird, P I, Carrell, R W, Church, F C, Coughlin, P B, Gettins, P G, Irving, J A, Lomas, D A, Luke, C J, Moyer, R W, Pemberton, P A, Remold-O'Donnell, E, Salvesen, G S, Travis, J, Whisstock, J C

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Warfarin reversal: consensus guidelines, on behalf of the Australasian Society of Thrombosis and Haemostasis by Baker, Ross I, Coughlin, Paul B, Salem, Hatem H, Gallus, Alex S, Harper, Paul L, Wood, Erica M

“…For most warfarin indications, the target maintenance international normalised ratio (INR) is 2–3. Risk factors for bleeding complications with warfarin use…”
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Identification and purification of a novel serine proteinase inhibitor by COUGHLIN, P. B, TETAZ, T, SALEM, H. H

“…We report the identification, purification, and partial amino acid sequence of a novel serine proteinase inhibitor which is present in extracts from human…”
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A Cytosolic Granzyme B Inhibitor Related to the Viral Apoptotic Regulator Cytokine Response Modifier A Is Present in Cytotoxic Lymphocytes by Sun, Jiuru, Bird, Catherina H., Sutton, Vivien, McDonald, Lisa, Coughlin, Paul B., De Jong, Tanya A., Trapani, Joseph A., Bird, Phillip I.

“…Using a polymerase chain reaction strategy we identified a serine proteinase inhibitor (serpin) in human bone marrow that is related to the cellular serpin…”
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Angiotensinogen cleavage by renin: importance of a structurally constrained N-terminus by Streatfeild-James, Rosa M.A, Williamson, David, Pike, Robert N, Tewksbury, Duane, Carrell, Robin W, Coughlin, Paul B

“…Angiotensinogen, a plasma serpin, functions as a donor of the decapeptide angiotensin I, which is cleaved from the N-terminus by renin. To assess the…”
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Proteinase Inhibitor 6 Cannot Be Secreted, Which Suggests It Is a New Type of Cellular Serpin (∗) by Scott, Fiona L., Coughlin, Paul B., Bird, Catherina, Cerruti, Loretta, Hayman, John A., Bird, Phillip

“…We have recently described a new serine proteinase inhibitor, proteinase inhibitor 6 (PI-6). This serpin has features that suggest it may function…”
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Intracellular serpins in haemopoietic and peripheral blood cells by Morris, Emma C., Carrell, Robin W., Coughlin, Paul B.

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Proteinase Inhibitor 6 (PI-6) Expression in Human Skin: Induction of PI-6 and a PI-6/Proteinase Complex during Keratinocyte Differentiation by Scott, Fiona L., Paddle-Ledinek, Joanna E., Cerruti, Loretta, Coughlin, Paul B., Salem, Hatem H., Bird, Phillip I.

“…Proteinase inhibitor 6 (PI-6) is a 42-kDa intracellular protein present in epithelial cells and endothelial cells. It is capable of inhibiting a number of…”
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Two missense mutations identified in venous thrombosis patients impair the inhibitory function of the protein Z dependent protease inhibitor by Young, Laura K, Birch, Nigel P, Browett, Peter J, Coughlin, Paul B, Horvath, Anita J, Van de Water, Neil S, Ockelford, Paul A, Harper, Paul L

“…Protein Z-dependent protease inhibitor (ZPI) is a plasma inhibitor of factor (F)Xa and FXIa. In an earlier study, five mutations were identified within the ZPI…”
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Expression of the Serpin Centerin Defines a Germinal Center Phenotype in B-Cell Lymphomas by PATERSON, Melinda A, HOSKING, Patrick S, COUGHLIN, Paul B

“…Centerin (SERPINA9/GCET1) is a protease inhibitor with expression restricted to germinal center B cells and lymphoid malignancies with germinal center B-cell…”
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Antiplasmin: the forgotten serpin? by Coughlin, Paul B

“…Much of the basic biochemistry of antiplasmin was described more than 20 years ago and yet it remains an enigmatic member of the serine protease inhibitor…”
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The murine orthologue of human antichymotrypsin: a structural paradigm for clade A3 serpins by Horvath, Anita J, Irving, James A, Rossjohn, Jamie, Law, Ruby H, Bottomley, Stephen P, Quinsey, Noelene S, Pike, Robert N, Coughlin, Paul B, Whisstock, James C

“…Antichymotrypsin (SERPINA3) is a widely expressed member of the serpin superfamily, required for the regulation of leukocyte proteases released during an…”
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Management and prevention of venous thromboembolism by Coughlin, P B, Salem, H H

“…Venous thromboembolism constitutes a major cause of illness and death in this community. Awareness of the clinical circumstances predisposing to thrombosis,…”
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Correction: Warfarin reversal: consensus guidelines, on behalf of the Australasian Society of Haemostasis and Thrombosis by Baker, Ross I, Coughlin, Paul B, Salem, Hatem H, Gallus, Alex S, Harper, Paul L, Wood, Erica M

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Expression patterns of murine antichymotrypsin-like genes reflect evolutionary divergence at the Serpina3 locus by Horvath, Anita J, Forsyth, Sharon L, Coughlin, Paul B

“…Members of the serpin (serine protease inhibitor) superfamily of genes are well represented in both human and murine genomes. In many cases it is possible to…”
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The Australian Cancer Anaemia Survey: a snapshot of anaemia in adult patients with cancer by Seshadri, Tara, Prince, H Miles, Bell, David R, Coughlin, Paul B, James, Philip P B, Richardson, Gary E, Chern, Boris, Briggs, Peter, Norman, John, Olver, Ian N, Karapetis, Chris, Stewart, John

“…Objective: To evaluate the frequency and management of anaemia in Australian adults with solid and haematological malignancies. Design: 6‐month observational,…”
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Murine serpin 2A is a redox-sensitive intracellular protein by Morris, Emma C, Dafforn, Timothy R, Forsyth, Sharon L, Missen, Melinda A, Horvath, Anita J, Hampson, Lynne, Hampson, Ian N, Currie, Graeme, Carrell, Robin W, Coughlin, Paul B

“…Murine serpin 2A is expressed at high levels in haemopoietic progenitors and down-regulated on differentiation. When it is constitutively expressed in the…”
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