Search Results - "COUCH, F"

PREDICT Plus: development and validation of a prognostic model for early breast cancer that includes HER2 by Wishart, G C, Bajdik, C D, Dicks, E, Provenzano, E, Schmidt, M K, Sherman, M, Greenberg, D C, Green, A R, Gelmon, K A, Kosma, V-M, Olson, J E, Beckmann, M W, Winqvist, R, Cross, S S, Severi, G, Huntsman, D, Pylkäs, K, Ellis, I, Nielsen, T O, Giles, G, Blomqvist, C, Fasching, P A, Couch, F J, Rakha, E, Foulkes, W D, Blows, F M, Bégin, L R, van't Veer, L J, Southey, M, Nevanlinna, H, Mannermaa, A, Cox, A, Cheang, M, Baglietto, L, Caldas, C, Garcia-Closas, M, Pharoah, P D P

“…Background: Predict ( www.predict.nhs.uk ) is an online, breast cancer prognostication and treatment benefit tool. The aim of this study was to incorporate the…”
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BRCA1 and BRCA2 genetic testing—pitfalls and recommendations for managing variants of uncertain clinical significance by Eccles, D.M., Mitchell, G., Monteiro, A.N.A., Schmutzler, R., Couch, F.J., Spurdle, A.B., Gómez-García, E.B., Driessen, R., Lindor, N.M., Blok, M.J., Moller, P., de la Hoya, M., Pal, T., Domchek, S., Nathanson, K., Van Asperen, C., Diez, O., Rheim, K., Stoppa-Lyonnet, D., Parsons, M., Goldgar, D.

“…Increasing use of BRCA1/2 testing for tailoring cancer treatment and extension of testing to tumour tissue for somatic mutation is moving BRCA1/2 mutation…”
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Mutant K-Ras increases GSK-3β gene expression via an ETS-p300 transcriptional complex in pancreatic cancer by Zhang, J-S, Koenig, A, Harrison, A, Ugolkov, A V, Fernandez-Zapico, M E, Couch, F J, Billadeau, D D

“…Glycogen synthase kinase-3 beta (GSK-3β) is overexpressed in a number of human malignancies and has been shown to contribute to tumor cell proliferation and…”
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Efficacy of Bilateral Prophylactic Mastectomy in BRCA1 and BRCA2 Gene Mutation Carriers by Hartmann, Lynn C., Sellers, Thomas A., Schaid, Daniel J., Frank, Thomas S., Soderberg, Cheryl L., Sitta, Diana L., Frost, Marlene H., Grant, Clive S., Donohue, John H., Woods, John E., McDonnell, Shannon K., Vockley, Catherine Walsh, Deffenbaugh, Amie, Couch, Fergus J., Jenkins, Robert B.

“…Background: In women with a family history of breast cancer, bilateral prophylactic mastectomy is associated with a decreased risk of subsequent breast cancer…”
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Gene‐panel testing of breast and ovarian cancer patients identifies a recurrent RAD51C duplication by Pelttari, L.M., Shimelis, H., Toiminen, H., Kvist, A., Törngren, T., Borg, Å., Blomqvist, C., Bützow, R., Couch, F., Aittomäki, K., Nevanlinna, H.

“…Gene‐panel sequencing allows comprehensive analysis of multiple genes simultaneously and is now routinely used in clinical mutation testing of high‐risk breast…”
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Association of Childhood and Adolescent Anthropometric Factors, Physical Activity, and Diet with Adult Mammographic Breast Density by Sellers, TA, Vachon, CM, Pankratz, VS, Janney, CA, Fredericksen, Z, Brandt, KR, Huang, Y, Couch, FJ, Kushi, LH, Cerhan, JR

“…Early-life exposures may influence the development of breast cancer. The authors examined the association of childhood and adolescent anthropometric factors,…”
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Genetic counselors' practices and confidence regarding variant of uncertain significance results and reclassification from BRCA testing by Scherr, C.L., Lindor, N.M., Malo, T.L., Couch, F.J., Vadaparampil, S.T.

“…Studies indicate variant of uncertain significance (VUS) results are challenging for genetic counselors and patients, often resulting in negative patient…”
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Rapid progression of prostate cancer in men with a BRCA2 mutation by Narod, S A, Neuhausen, S, Vichodez, G, Armel, S, Lynch, H T, Ghadirian, P, Cummings, S, Olopade, O, Stoppa-Lyonnet, D, Couch, F, Wagner, T, Warner, E, Foulkes, W D, Saal, H, Weitzel, J, Tulman, A, Poll, A, Nam, R, Sun, P

“…Men with BRCA2 mutations have been found to be at increased risk of developing prostate cancer. There is a recent report that BRCA2 carriers with prostate…”
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Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis by Cunningham, J M, Vierkant, R A, Sellers, T A, Phelan, C, Rider, D N, Liebow, M, Schildkraut, J, Berchuck, A, Couch, F J, Wang, X, Fridley, B L, Gentry-Maharaj, A, Menon, U, Hogdall, E, Kjaer, S, Whittemore, A, DiCioccio, R, Song, H, Gayther, S A, Ramus, S J, Pharaoh, P D P, Goode, E L

“…Background: Dysregulation of the cell cycle is a hallmark of many cancers including ovarian cancer, a leading cause of gynaecologic cancer mortality worldwide…”
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Variation in genes required for normal mitosis and risk of breast cancer by Olson, J. E, Wang, X, Goode, E. L, Pankratz, V. S, Fredericksen, Z. S, Vierkant, R. A, Pharoah, P. D. P, Cerhan, J. R, Couch, F. J

“…The down-regulation of genes involved in normal cell division can cause aberrant mitoses and increased cell death. Surviving cells exhibit aneuploidy and/or…”
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BRCA1 Mutations in Women Attending Clinics That Evaluate the Risk of Breast Cancer by Couch, Fergus J, DeShano, Michelle L, Blackwood, M. Anne, Calzone, Kathleen, Stopfer, Jill, Campeau, Lisa, Ganguly, Arupa, Rebbeck, Timothy, Weber, Barbara L, Jablon, Lisa, Cobleigh, Melody A, Hoskins, Kent, Garber, Judy E

“…Family history is a significant risk factor for the development of breast cancer. The relative lifetime risk of breast cancer ranges from 1.4 for a woman whose…”
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CBP truncating mutations in ovarian cancer by Ward, R, Johnson, M, Shridhar, V, van Deursen, J, Couch, F J

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Impact of hormone receptor status and tumor subtypes of breast cancer in young BRCA carriers by Arecco, L, Bruzzone, M, Bas, R, Kim, H J, Di Meglio, A, Bernstein-Molho, R, Hilbers, F S, Pogoda, K, Carrasco, E, Punie, K, Bajpai, J, Agostinetto, E, Lopetegui-Lia, N, Partridge, A H, Phillips, K A, Toss, A, Rousset-Jablonski, C, Curigliano, G, Renaud, T, Ferrari, A, Paluch-Shimon, S, Fruscio, R, Cui, W, Wong, S M, Vernieri, C, Couch, F J, Dieci, M V, Matikas, A, Rozenblit, M, Aguilar-Y Méndez, D, De Marchis, L, Puglisi, F, Fabi, A, Graff, S L, Witzel, I, Rodriguez Hernandez, A, Fontana, A, Pesce, R, Duchnowska, R, Pais, H L, Sini, V, Sokolović, E, de Azambuja, E, Ceppi, M, Blondeaux, E, Lambertini, M

“…Hormone receptor expression is a known positive prognostic and predictive factor in breast cancer; however, limited evidence exists on its prognostic impact on…”
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Integrated Evaluation of DNA Sequence Variants of Unknown Clinical Significance: Application to BRCA1 and BRCA2 by Goldgar, David E., Easton, Douglas F., Deffenbaugh, Amie M., Monteiro, Alvaro N.A., Tavtigian, Sean V., Couch, Fergus J.

“…Many sequence variants in predisposition genes are of uncertain clinical significance, and classification of these variants into high- or low-risk categories…”
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The Structure and Function of Folliculo-Stellate Cells in the Anterior Pituitary Gland by INOUE, Kinji, COUCH, Ernest F., TAKANO, Kaiya, OGAWA, Satoshi

“…The folliculo-stellate cells (FS cells) in the anterior pituitary gland are characterized by their star-like appearance and their ability to form follicles…”
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Risk of Breast Cancer With Oral Contraceptive Use in Women With a Family History of Breast Cancer by Grabrick, Dawn M, Hartmann, Lynn C, Cerhan, James R, Vierkant, Robert A, Therneau, Terry M, Vachon, Celine M, Olson, Janet E, Couch, Fergus J, Anderson, Kristin E, Pankratz, V. Shane, Sellers, Thomas A

“…CONTEXT Oral contraceptive (OC) use is weakly associated with breast cancer risk in the general population, but the association among women with a familial…”
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Genetic, functional, and histopathological evaluation of two C-terminal BRCA1 missense variants by Lovelock, P K, Healey, S, Au, W, Sum, E Y M, Tesoriero, A, Wong, E M, Hinson, S, Brinkworth, R, Bekessy, A, Diez, O, Izatt, L, Solomon, E, Jenkins, M, Renard, H, Hopper, J, Waring, P, Tavtigian, S V, Goldgar, D, Lindeman, G J, Visvader, J E, Couch, F J, Henderson, B R, Southey, M, Chenevix-Trench, G, Spurdle, A B, Brown, M A

“…Background: The vast majority of BRCA1 missense sequence variants remain uncharacterised for their possible effect on protein expression and function, and…”
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The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds by Tavtigian, S.V, Simard, J, Rommens, J, Couch, F, Shattuck-Eidens, D, Neuhausen, S, Merajver, S, Thorlacius, S, Offit, K, Stoppa-Lyonnet, D, Belanger, C, Bell, R, Berry, S, Bogden, R, Chen, Q, Davis, T, Dumont, M, Frye, C, Hattier, T, Jammulapati, S, Janecki, T, Jiang, P, Kehrer, R, Leblanc, J.-F, Mitchell, J.T, McArthur-Morrison, J, Nguyen, K, Peng, Y, Samson, C, Schroeder, M, Snyder, S.C, Steele, L, Stringfellow, M, Stroup, C, Swedlund, B, Swense, J, Teng, D, Thomas, A, Tran, T, Tranchant, M, Weaver-Feldhaus, J, Wong, A.K.C, Shizuya, H, Eyfjord, J.E, Cannon-Albright, L, Tranchant, M, Labrie, F, Skolnick, M.H, Weber, B, Kamb, A, Goldgar, D.E

“…Breast carcinoma is the most common malignancy among women in developed countries. Because family history remains the strongest single predictor of breast…”
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Mutations in the ryanodine receptor gene in central core disease and malignant hyperthermia by Quane, K. A, Healy, J.M.S, Keating, K. E, Manning, B. M, Couch, F. J, Palmucci, L. M, Doriguzzi, C, Fagerlund, T. H, Berg, K, Ording, H, Bendixen, D, Mortier, W, Linz, U, Muller, C. R, McCarthy, T. V

“…Central core disease (CCD) of muscle is an inherited myopathy which is closely associated with malignant hyperthermia (MH) in humans. CCD has recently been…”
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Centrosome-related genes, genetic variation, and risk of breast cancer by Olson, J. E, Wang, X, Pankratz, V. S, Fredericksen, Z. S, Vachon, C. M, Vierkant, R. A, Cerhan, J. R, Couch, F. J

“…Centrosome amplification has been detected in premalignant lesions and in situ tumors in the breast and in over 70% of invasive breast tumors, and has been…”
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