Search Results - "COTTRELL, Graeme S"

Omega‐3 polyunsaturated fatty acids and hypertension: a review of vasodilatory mechanisms of docosahexaenoic acid and eicosapentaenoic acid by Bercea, Cristiana‐Ioana, Cottrell, Graeme S., Tamagnini, Francesco, McNeish, Alister J.

“…Hypertension is often characterised by impaired vasodilation involving dysfunction of multiple vasodilatory mechanisms. ω‐3 polyunsaturated fatty acids…”
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Impact of 3D cell culture on bone regeneration potential of mesenchymal stromal cells by Bicer, Mesude, Cottrell, Graeme S, Widera, Darius

“…As populations age across the world, osteoporosis and osteoporosis-related fractures are becoming the most prevalent degenerative bone diseases. More than 75…”
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Characterisation of the vasodilation effects of DHA and EPA, n-3 PUFAs (fish oils), in rat aorta and mesenteric resistance arteries by Limbu, Roshan, Cottrell, Graeme S, McNeish, Alister J

“…Increasing evidence suggests that the omega-3 polyunsaturated acids (n-3 PUFA), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are beneficial to…”
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Endosomes: A Legitimate Platform for the Signaling Train by Murphy, Jane E., Padilla, Benjamin E., Hasdemir, Burcu, Cottrell, Graeme S., Bunnett, Nigel W.

“…Although long regarded as a conduit for the degradation or recycling of cell surface receptors, the endosomal system is also an essential site of signal…”
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The TGR5 receptor mediates bile acid-induced itch and analgesia by Alemi, Farzad, Kwon, Edwin, Poole, Daniel P, Lieu, TinaMarie, Lyo, Victoria, Cattaruzza, Fiore, Cevikbas, Ferda, Steinhoff, Martin, Nassini, Romina, Materazzi, Serena, Guerrero-Alba, Raquel, Valdez-Morales, Eduardo, Cottrell, Graeme S, Schoonjans, Kristina, Geppetti, Pierangelo, Vanner, Stephen J, Bunnett, Nigel W, Corvera, Carlos U

“…Patients with cholestatic disease exhibit pruritus and analgesia, but the mechanisms underlying these symptoms are unknown. We report that bile acids, which…”
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Astrocytes and neurons communicate via a monocarboxylic acid shuttle by Roosterman, Dirk, S. Cottrell, Graeme

“…Since formulation of the Astrocyte-Neuron Lactate Shuttle (ANLS) hypothesis in 1994, the hypothesis has provoked criticism and debate. Our review does not…”
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4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1 by Trevisani, Marcello, Siemens, Jan, Materazzi, Serena, Bautista, Diana M, Nassini, Romina, Campi, Barbara, Imamachi, Noritaka, Andrè, Eunice, Patacchini, Riccardo, Cottrell, Graeme S, Gatti, Raffaele, Basbaum, Allan I, Bunnett, Nigel W, Julius, David, Geppetti, Pierangelo

“…TRPA1 is an excitatory ion channel expressed by a subpopulation of primary afferent somatosensory neurons that contain substance P and calcitonin gene-related…”
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Uncovering the gray zone: mapping the global landscape of direct-to-consumer businesses offering interventions based on secretomes, extracellular vesicles, and exosomes by Asadpour, Atiyeh, Yahaya, Badrul Hisham, Bicknell, Katrina, Cottrell, Graeme S, Widera, Darius

“…The last decade has seen a significant increase in media attention, industrial growth, and patient interest in stem cell-based interventions. This led to a…”
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Proton Transport Chains in Glucose Metabolism: Mind the Proton by Roosterman, Dirk, Meyerhof, Wolfgang, Cottrell, Graeme S

“…The Embden-Meyerhof-Parnas (EMP) pathway comprises eleven cytosolic enzymes interacting to metabolize glucose to lactic acid [CH CH(OH)COO ]. Glycolysis is…”
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Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice by Grant, Andrew D., Cottrell, Graeme S., Amadesi, Silvia, Trevisani, Marcello, Nicoletti, Paola, Materazzi, Serena, Altier, Christophe, Cenac, Nicolas, Zamponi, Gerald W., Bautista‐Cruz, Francisco, Lopez, Carlos Barajas, Joseph, Elizabeth K., Levine, Jon D., Liedtke, Wolfgang, Vanner, Stephen, Vergnolle, Nathalie, Geppetti, Pierangelo, Bunnett, Nigel W.

“…Exacerbated sensitivity to mechanical stimuli that are normally innocuous or mildly painful (mechanical allodynia and hyperalgesia) occurs during inflammation…”
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CACHD1: A new activity-modifying protein for voltage-gated calcium channels by Stephens, Gary J., Cottrell, Graeme S.

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Electrical Stimulation of Adipose-Derived Stem Cells in 3D Nanofibrillar Cellulose Increases Their Osteogenic Potential by Bicer, Mesude, Sheard, Jonathan, Iandolo, Donata, Boateng, Samuel Y, Cottrell, Graeme S, Widera, Darius

“…Due to the ageing population, there is a steadily increasing incidence of osteoporosis and osteoporotic fractures. As conventional pharmacological therapy…”
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Omega-3 polyunsaturated fatty acid-induced vasodilation in mouse aorta and mesenteric arteries is not mediated by ATP-sensitive potassium channels by Bercea, Cristiana, Limbu, Roshan, Behnam, Kamila, Ng, Keat-Eng, Aziz, Qadeer, Tinker, Andrew, Tamagnini, Francesco, Cottrell, Graeme S, McNeish, Alister J

“…There is strong evidence that the omega-3 polyunsaturated fatty acids (n-3 PUFAs) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have…”
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Endosomal Deubiquitinating Enzymes Control Ubiquitination and Down-regulation of Protease-activated Receptor 2 by Hasdemir, Burcu, Murphy, Jane E., Cottrell, Graeme S., Bunnett, Nigel W.

“…The E3 ubiquitin ligase c-Cbl ubiquitinates the G protein-coupled receptor protease-activated receptor 2 (PAR2), which is required for postendocytic sorting of…”
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Proteinase-activated Receptors, Targets for Kallikrein Signaling by Oikonomopoulou, Katerina, Hansen, Kristina K., Saifeddine, Mahmoud, Tea, Illa, Blaber, Michael, Blaber, Sachiko I., Scarisbrick, Isobel, Andrade-Gordon, Patricia, Cottrell, Graeme S., Bunnett, Nigel W., Diamandis, Eleftherios P., Hollenberg, Morley D.

“…Serine proteinases like thrombin can signal to cells by the cleavage/activation of proteinase-activated receptors (PARs). Although thrombin is a recognized…”
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G protein-coupled receptors: what a difference a 'partner' makes by Roux, Benoît T, Cottrell, Graeme S

“…G protein-coupled receptors (GPCRs) are important cell signaling mediators, involved in essential physiological processes. GPCRs respond to a wide variety of…”
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Toll-like receptor 4 and protease-activated receptor 2 in physiology and pathophysiology of the nervous system: more than just receptor cooperation? by Widera, Darius, Martínez Aguilar, Rocío, Cottrell, Graeme

“…Toll-like receptor 4 (TLR4) and protease-activated receptor 2 (PAR2) play pivotal roles in the mammalian innate immune response. Notably, in addition to their…”
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Time-Dependent Reduction of Calcium Oscillations in Adipose-Derived Stem Cells Differentiating towards Adipogenic and Osteogenic Lineage by Torre, Enrico C, Bicer, Mesude, Cottrell, Graeme S, Widera, Darius, Tamagnini, Francesco

“…Adipose-derived mesenchymal stromal cells (ASCs) are multipotent stem cells which can differentiate into various cell types, including osteocytes and…”
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Development and Characterisation of a Novel NF-κB Reporter Cell Line for Investigation of Neuroinflammation by Cottrell, Graeme S., Vaiyapuri, Sakthivel, Vallance, Thomas, Zeuner, Marie-Theres, Widera, Darius

“…Aberrant activation of the transcription factor NF-κB, as well as uncontrolled inflammation, has been linked to autoimmune diseases, development and…”
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Protease-Activated Receptor 2 Sensitizes the Capsaicin Receptor Transient Receptor Potential Vanilloid Receptor 1 to Induce Hyperalgesia by Amadesi, Silvia, Nie, Jingjiang, Vergnolle, Nathalie, Cottrell, Graeme S, Grady, Eileen F, Trevisani, Marcello, Manni, Chiara, Geppetti, Pierangelo, McRoberts, James A, Ennes, Helena, Davis, John B, Mayer, Emeran A, Bunnett, Nigel W

“…Inflammatory proteases (mast cell tryptase and trypsins) cleave protease-activated receptor 2 (PAR2) on spinal afferent neurons and cause persistent…”
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