Search Results - "COTTNEY, J"

Synthesis of novel analogues of the delta opioid ligand SNC-80 using REM resin by Cottney, J, Rankovic, Z, Morphy, J.R

“…Focused libraries of delta opioid ligands were synthesised using REM resin methodology. Several high affinity compounds were identified with good selectivity…”
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Parallel synthesis and biological activity of a new class of high affinity and selective δ-opioid ligand by Barn, D.R., Caulfield, W.L., Cottney, J., McGurk, K., Morphy, J.R., Rankovic, Z., Roberts, B.

“…A considerable number of research papers describing the synthesis and testing of the delta opioid receptor (DOR) ligands, SNC-80 and TAN-67, and analogues of…”
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Synthesis of novel analogues of the delta opioid ligand SNC-80 using AlCl3-promoted aminolysis by BARN, D. R, BOM, A, COTTNEY, J, CAULFIELD, W. L, MORPHY, J. R

“…Two focused libraries of delta opioid ligands were synthesised using AlCl3 facilitated aminolysis. Several compounds were identified with DOR binding…”
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Pharmacological and biochemical effects of the cardiotonic agent Org10325 in isolated cardiac and vascular tissue preparations by Shahid, M., Martorana, M.G., Cottney, J.E., Marshall, R.J.

“…1 The pharmacological and biochemical effects of a novel cardiotonic agent, Org10325 have been studied in isolated cardiac and vascular tissue preparations. 2…”
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A comparison of the inotropic activity of Org 30029, IBMX, milrinone and rolipram in rat papillary muscles by Nicholson, C D, Cottney, J, Marsden, G, Shahid, M

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The effect of several immunomodulating agents on a model of humoral and cell mediated immunity in the mouse [proceedings] by Bruin, J, Cottney, J, Gemmel, D K, Lewis, A J

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Arachidonic acid-induced paw oedema in the rat [proceedings] by Cottney, J, Lewis, A J, Nelson, D J

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Action of gold salts in some inflammatory and immunological models by Lewis, A J, Cottney, J, White, D D, Fox, P K, McNeillie, A, Dunlop, J, Smith, W E, Brown, D H

“…Several gold salts were compared in kaolin-induced rat paw oedema, u.v. erythema in guinea pigs, delayed type hypersensitivity and humoral immunity in mice,…”
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Copper distribution and reactivity in serum following administration of cuprous oxide to rats and guinea pigs by Brown, D H, Dunlop, J, Smith, W E, Teape, J

“…Total serum copper levels produced by the administration of a single dose of cuprous oxide (500 mg/kg) both s.c. and orally to rats and guinea pigs are…”
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Synthesis of novel analogues of the delta opioid ligand SNC-80 using AlCl 3-promoted aminolysis by Barn, D.R, Bom, A, Cottney, J, Caulfield, W.L, Morphy, J.R

“…Two focused libraries of delta opioid ligands were synthesised using AlCl 3 facilitated aminolysis. Several compounds were identified with DOR binding…”
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Comparison of gold levels and distribution in guinea pig serum by Kamel, H, Brown, D H, Ottaway, J M, Smith, W E, Cottney, J, Lewis, A J

“…Serum levels after oral administration of 30 mg/kg of sodium aurothiomalate (Myocrisin), triethylphosphine gold chloride, or triphenylphosphine gold chloride…”
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A comparison of tissue gold levels in guinea-pigs after treatment with myocrisin injected intramuscularly and triethylphosphine gold chloride and myocrisin administered orally by Kamel, H, Brown, D H, Ottaway, J M, Smith, W E, Cottney, J, Lewis, A J

“…A comparative study of tissue gold levels produced in guinea-pigs after the oral administration of either triethylphosphine gold chloride or Myocrisin (sodium…”
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Pharmacological and biochemical effects of the cardiotonic agent org10325 in isolated and vascular tissue preparations by SHAHID, M, MARTORANA, M. G, COTTNEY, J. E, MARSHALL, R. J

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Mechanisms of concanavalin A-induced inflammation in the rat by Cottney, J, Lewis, A J

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Proceedings: Mechanisms of concanavalin A-induced inflammation in the rat by Cottney, J, Lewis, A J

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Synthesis and SAR studies of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists by Palin, Ronald, Barn, David R., Clark, John K., Cottney, Jean E., Cowley, Phillip M., Crockatt, Marc, Evans, Louise, Feilden, Helen, Goodwin, Richard R., Griekspoor, Frank, Grove, Simon J.A., Houghton, Andrea K., Jones, Philip S., Morphy, Richard J., Smith, Alasdair R.C., Sundaram, Hardy, Vrolijk, David, Weston, Mark A., Wishart, Grant, Wren, Paul

“…A series of potent and soluble ORL1 agonists was prepared and evaluated. Compound 41 showed antinociceptive properties in mouse formalin paw test (ED 50 = 1.07…”
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The use of phytohaemagglutinin P and concanavalin A as models of inflammation by Lewis, A. J., Cottney, J.

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Mechanisms of phytohaemagglutinin-P-, concanavalin-A- and kaolin-induced oedemas in the rat by Lewis, A J, Cottney, J, Nelson, D J

“…Subplantar administration of either Phytohaemagglutinin-P (PHA), Concanavalin-A (Con A) or kaolin into the rat hind paw produced a dose related oedema which…”
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Comparative effects of drugs on four paw oedema models in the rat by Gemmell, D K, Cottney, J, Lewis, A J

“…The development of novel anti-inflammatory drugs (AID) has been claimed to be dependent on the discovery of models of inflammation that differ from those…”
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Modulation of the immune system in the mouse. 2. Drug administration following antigen sensitization by Cottney, J, Bruin, J, Lewis, A J

“…The effects of administering drugs 2 days after antigen sensitization in a combined model of delayed type hypersensitivity (DTH) and humoral immunity (HI) in…”
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