Search Results - "COSTELLO, C."

A comprehensive review of the role of zinc in normal prostate function and metabolism; and its implications in prostate cancer by Costello, Leslie C., Franklin, Renty B.

“…The human prostate gland contains extremely high zinc levels; which is due to the specialized zinc-accumulating acinar epithelial of the peripheral zone. These…”
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Next-Generation Machine Learning for Biological Networks by Camacho, Diogo M., Collins, Katherine M., Powers, Rani K., Costello, James C., Collins, James J.

“…Machine learning, a collection of data-analytical techniques aimed at building predictive models from multi-dimensional datasets, is becoming integral to…”
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Tumor-Derived Cell Lines as Molecular Models of Cancer Pharmacogenomics by Goodspeed, Andrew, Heiser, Laura M, Gray, Joe W, Costello, James C

“…Compared with normal cells, tumor cells have undergone an array of genetic and epigenetic alterations. Often, these changes underlie cancer development,…”
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Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in Mammalian cells by Kalghatgi, Sameer, Spina, Catherine S, Costello, James C, Liesa, Marc, Morones-Ramirez, J Ruben, Slomovic, Shimyn, Molina, Anthony, Shirihai, Orian S, Collins, James J

“…Prolonged antibiotic treatment can lead to detrimental side effects in patients, including ototoxicity, nephrotoxicity, and tendinopathy, yet the mechanisms…”
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Marine spatial planning makes room for offshore aquaculture in crowded coastal waters by Lester, S. E., Stevens, J. M., Gentry, R. R., Kappel, C. V., Bell, T. W., Costello, C. J., Gaines, S. D., Kiefer, D. A., Maue, C. C., Rensel, J. E., Simons, R. D., Washburn, L., White, C.

“…Marine spatial planning (MSP) seeks to reduce conflicts and environmental impacts, and promote sustainable use of marine ecosystems. Existing MSP approaches…”
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Crowdsourcing biomedical research: leveraging communities as innovation engines by Saez-Rodriguez, Julio, Costello, James C., Friend, Stephen H., Kellen, Michael R., Mangravite, Lara, Meyer, Pablo, Norman, Thea, Stolovitzky, Gustavo

“…Key Points Crowdsourcing is emerging as a novel framework to tackle scientific problems. A variant of crowdsourcing, scientific competitions known as…”
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Wisdom of crowds for robust gene network inference by Marbach, Daniel, Costello, James C, Küffner, Robert, Vega, Nicole M, Prill, Robert J, Camacho, Diogo M, Allison, Kyle R, Kellis, Manolis, Collins, James J, Stolovitzky, Gustavo

“…This analysis comprehensively compares methods for gene regulatory network inference submitted through the DREAM5 challenge. It demonstrates that integration…”
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Decreased zinc in the development and progression of malignancy: an important common relationship and potential for prevention and treatment of carcinomas by Costello, Leslie C, Franklin, Renty B

“…Efficacious chemotherapy does not exist for treatment or prevention of prostate, liver, and pancreatic carcinomas, and some other cancers that exhibit…”
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Zinc as an anti-tumor agent in prostate cancer and in other cancers by Franklin, Renty B., Costello, Leslie C.

“…Human prostate glandular epithelial cells have the unique capability of accumulating high levels of zinc. This is essential to inhibit m-aconitase activity so…”
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Neutral endopeptidase inhibition and the natriuretic peptide system: an evolving strategy in cardiovascular therapeutics by Mangiafico, Sarah, Costello-Boerrigter, Lisa C, Andersen, Ingrid A, Cataliotti, Alessandro, Burnett, Jr, John C

“…Hypertension and heart failure (HF) are common diseases that, despite advances in medical therapy, continue to be associated with high morbidity and mortality…”
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Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors by Powers, Rani K., Culp-Hill, Rachel, Ludwig, Michael P., Smith, Keith P., Waugh, Katherine A., Minter, Ross, Tuttle, Kathryn D., Lewis, Hannah C., Rachubinski, Angela L., Granrath, Ross E., Carmona-Iragui, María, Wilkerson, Rebecca B., Kahn, Darcy E., Joshi, Molishree, Lleó, Alberto, Blesa, Rafael, Fortea, Juan, D’Alessandro, Angelo, Costello, James C., Sullivan, Kelly D., Espinosa, Joaquin M.

“…Trisomy 21 (T21) causes Down syndrome (DS), affecting immune and neurological function by ill-defined mechanisms. Here we report a large metabolomics study of…”
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Molecular analysis of urothelial cancer cell lines for modeling tumor biology and drug response by Nickerson, M L, Witte, N, Im, K M, Turan, S, Owens, C, Misner, K, Tsang, S X, Cai, Z, Wu, S, Dean, M, Costello, J C, Theodorescu, D

“…The utility of tumor-derived cell lines is dependent on their ability to recapitulate underlying genomic aberrations and primary tumor biology. Here, we…”
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stochastic nature of larval connectivity among nearshore marine populations by Siegel, D.A, Mitarai, S, Costello, C.J, Gaines, S.D, Kendall, B.E, Warner, R.R, Winters, K.B

“…Many nearshore fish and invertebrate populations are overexploited even when apparently coherent management structures are in place. One potential cause of…”
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Metastatic cells are preferentially vulnerable to lysosomal inhibition by Morgan, Michael J., Fitzwalter, Brent E., Owens, Charles R., Powers, Rani K., Sottnik, Joseph L., Gamez, Graciela, Costello, James C., Theodorescu, Dan, Thorburn, Andrew

“…Molecular alterations that confer phenotypic advantages to tumors can also expose specific therapeutic vulnerabilities. To search for potential treatments that…”
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Responsive harvest control rules provide inherent resilience to adverse effects of climate change and scientific uncertainty by Kritzer, J P, Costello, C, Mangin, T, Smith, S L

“…Abstract Climate change is altering marine ecosystem and fish stock dynamics worldwide. These effects add to scientific uncertainties that compromise fisheries…”
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Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes by Stern, Josh Lewis, Paucek, Richard D., Huang, Franklin W., Ghandi, Mahmoud, Nwumeh, Ronald, Costello, James C., Cech, Thomas R.

“…A mutation in the promoter of the Telomerase Reverse Transcriptase (TERT) gene is the most frequent noncoding mutation in cancer. The mutation drives unusual…”
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Zinc is decreased in prostate cancer: an established relationship of prostate cancer by Costello, Leslie C, Franklin, Renty B

“…This minireview is prompted by the recent report of Banas et al. (J Biol Inorg Chem 15:1147-1155, 2010), which purports to show and concludes that zinc levels…”
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Inhibition of the CCL2 receptor, CCR2, enhances tumor response to immune checkpoint therapy by Tu, Megan M., Abdel-Hafiz, Hany A., Jones, Robert T., Jean, Annie, Hoff, Katelyn J., Duex, Jason E., Chauca-Diaz, Ana, Costello, James C., Dancik, Garrett M., Tamburini, Beth A. Jirón, Czerniak, Bogdan, Kaye, Jonathan, Theodorescu, Dan

“…Immunotherapies targeting the PD-1/PD-L1 axis are now a mainstay in the clinical management of multiple cancer types, however, many tumors still fail to…”
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Concurrent alterations in TERT, KDM6A, and the BRCA pathway in bladder cancer by Nickerson, Michael L, Dancik, Garrett M, Im, Kate M, Edwards, Michael G, Turan, Sevilay, Brown, Joseph, Ruiz-Rodriguez, Christina, Owens, Charles, Costello, James C, Guo, Guangwu, Tsang, Shirley X, Li, Yingrui, Zhou, Quan, Cai, Zhiming, Moore, Lee E, Lucia, M Scott, Dean, Michael, Theodorescu, Dan

“…Genetic analysis of bladder cancer has revealed a number of frequently altered genes, including frequent alterations of the telomerase (TERT) gene promoter,…”
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ProstaMine: a bioinformatics tool for identifying subtype-specific co-alterations associated with aggressiveness in prostate cancer by Orman, Michael V, Sreekanth, Varsha, Laajala, Teemu D, Cramer, Scott D, Costello, James C

“…Prostate cancer is a leading cause of cancer-related deaths among men, marked by heterogeneous clinical and molecular characteristics. The complexity of the…”
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