Search Results - "COSTANTINO, Gabriele"

New promises for manipulation of kynurenine pathway in cancer and neurological diseases by Costantino, Gabriele

“…The kynurenine pathway (KP), the primary route of tryptophan degradation in mammalian cells, consists of a cascade of enzymatic reactions eventually leading to…”
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Extraction and Quantification of Azelaic Acid from Different Wheat Samples ( Triticum durum Desf. ) and Evaluation of Their Antimicrobial and Antioxidant Activities by Spaggiari, Chiara, Annunziato, Giannamaria, Spadini, Costanza, Montanaro, Sabrina Lucia, Iannarelli, Mattia, Cabassi, Clotilde Silvia, Costantino, Gabriele

“…Azelaic Acid (AzA) is a 9-carbon atom dicarboxylic acid, with numerous pharmacological uses in dermatology. Its effectiveness in papulopustular rosacea and…”
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Integration of Enhanced Sampling Methods with Saturation Transfer Difference Experiments to Identify Protein Druggable Pockets by Magalhães, Joana, Annunziato, Giannamaria, Franko, Nina, Pieroni, Marco, Campanini, Barbara, Bruno, Agostino, Costantino, Gabriele

“…Saturation transfer difference (STD) is an NMR technique conventionally applied in drug discovery to identify ligand moieties relevant for binding to protein…”
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Amine- and Amino Acid-Based Compounds as Carbonic Anhydrase Activators by Angeli, Andrea, Berrino, Emanuela, Carradori, Simone, Supuran, Claudiu T, Cirri, Marzia, Carta, Fabrizio, Costantino, Gabriele

“…After being rather neglected as a research field in the past, carbonic anhydrase activators (CAAs) were undoubtedly demonstrated to be useful in diverse…”
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Inhibition studies of bacterial α-carbonic anhydrases with phenols by Giovannuzzi, Simone, Hewitt, Chad S, Nocentini, Alessio, Capasso, Clemente, Costantino, Gabriele, Flaherty, Daniel P, Supuran, Claudiu T

“…The α-class carbonic anhydrases (CAs, EC 4.2.1.1) from the bacterial pathogens (NgCAα) and (VchCAα) were investigated for their inhibition by a panel of…”
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Development of Praziquantel sulphonamide derivatives as antischistosomal drugs by Angeli, Andrea, Ferraroni, Marta, Carta, Fabrizio, Häberli, Cécile, Keiser, Jennifer, Costantino, Gabriele, Supuran, Claudiu T.

“…The almost empty armamentarium to treat schistosomiasis, a neglected parasitic disorder caused by trematode flatworms of the genus Schistosoma, except…”
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Alpha-synuclein/synapsin III pathological interplay boosts the motor response to methylphenidate by Faustini, Gaia, Longhena, Francesca, Bruno, Agostino, Bono, Federica, Grigoletto, Jessica, La Via, Luca, Barbon, Alessandro, Casiraghi, Andrea, Straniero, Valentina, Valoti, Ermanno, Costantino, Gabriele, Benfenati, Fabio, Missale, Cristina, Pizzi, Marina, Spillantini, Maria Grazia, Bellucci, Arianna

“…Loss of dopaminergic nigrostriatal neurons and fibrillary α-synuclein (α-syn) aggregation in Lewy bodies (LB) characterize Parkinson's disease (PD). We…”
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Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases by Vincetti, Paolo, Caporuscio, Fabiana, Kaptein, Suzanne, Gioiello, Antimo, Mancino, Valentina, Suzuki, Youichi, Yamamoto, Naoki, Crespan, Emmanuele, Lossani, Andrea, Maga, Giovanni, Rastelli, Giulio, Castagnolo, Daniele, Neyts, Johan, Leyssen, Pieter, Costantino, Gabriele, Radi, Marco

“…This study describes the discovery of novel dengue virus inhibitors targeting both a crucial viral protein–protein interaction and an essential host cell…”
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Inhibitors of the sulfur assimilation pathway in bacterial pathogens as enhancers of antibiotic therapy by Campanini, Barbara, Pieroni, Marco, Raboni, Samanta, Bettati, Stefano, Benoni, Roberto, Pecchini, Chiara, Costantino, Gabriele, Mozzarelli, Andrea

“…The rising emergence of antibiotic resistance urges the search for new strategies to defeat microorganisms that lead to persistent infections of the host…”
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Preliminary structure−activity relationships analysis on N-(3,5-dichlorophenyl)-4,5-dihydronaphtho[1,2-d]thiazol-2-amine, a disruptor of mycobacterial energetics by Girardini, Miriam, Machado, Diana, Annunziato, Giannamaria, Papotti, Bianca, Palumbo, Marcella, Spaggiari, Chiara, Costantino, Gabriele, Viveiros, Miguel, Pieroni, Marco

“…The increasing emergence of drug-resistance among mycobacteria represents a serious global health threat, requiring novel and effective therapeutic strategies…”
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LiGen: A High Performance Workflow for Chemistry Driven de Novo Design by Beccari, Andrea R, Cavazzoni, Carlo, Beato, Claudia, Costantino, Gabriele

“…Tools for molecular de novo design are actively sought incorporating sets of chemical rules for fast and efficient identification of structurally new…”
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Farnesoid X Receptor:  From Structure to Potential Clinical Applications by Pellicciari, Roberto, Costantino, Gabriele, Fiorucci, Stefano

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Evaluation of oxidative stress markers in Rwanda during the SARS-CoV-2 pandemic: A cross-sectional study by Habyarimana, Thierry, Nshimiyimana, Alexis, Niyonzima, William, Kankindi, Janvere, Izere, Cedrick, Spaggiari, Chiara, Costantino, Gabriele

“…COVID-19 is mainly described as endothelial dysfunction, and due to the bidirectional link between oxidative stress and endothelial dysfunction, we initiated a…”
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Pharmacophore modeling and virtual screening studies to identify novel selective SIRT2 inhibitors by Eren, Gokcen, Bruno, Agostino, Guntekin-Ergun, Sezen, Cetin-Atalay, Rengul, Ozgencil, Fikriye, Ozkan, Yesim, Gozelle, Mahmut, Kaya, Selen Gozde, Costantino, Gabriele

“…Sirtuins (SIRTs) are a class of NAD+-dependent protein histone deacetylases (HDACs) that catalyse the reversible deacetylation of lysine residues in the…”
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Chemical Markers in Italian Propolis: Chrysin, Galangin and CAPE as Indicators of Geographic Origin by Miraldi, Elisabetta, Cappellucci, Giorgio, Baini, Giulia, Pistone, Elia Silvia, Allodi, Marika, Costantino, Gabriele, Spaggiari, Chiara, Biagi, Marco

“…Knowledge of the chemical composition of propolis is crucial for understanding the characteristics of products of different origins, but also for quality…”
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Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief by Moriconi, Alessio, Cunha, Thiago M., Souza, Guilherme R., Lopes, Alexandre H., Cunha, Fernando Q., Carneiro, Victor L., Pinto, Larissa G., Brandolini, Laura, Aramini, Andrea, Bizzarri, Cinzia, Bianchini, Gianluca, Beccari, Andrea R., Fanton, Marco, Bruno, Agostino, Costantino, Gabriele, Bertini, Riccardo, Galliera, Emanuela, Locati, Massimo, Ferreira, Sérgio H., Teixeira, Mauro M., Allegretti, Marcello

“…Significance Persistent pain in inflammatory and neuropathic conditions is often refractory to conventional analgesic therapy, with most patients suffering…”
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Inhibition of O-acetylserine sulfhydrylase by fluoroalanine derivatives by Franko, Nina, Grammatoglou, Konstantinos, Campanini, Barbara, Costantino, Gabriele, Jirgensons, Aigars, Mozzarelli, Andrea

“…O-acetylserine sulfhydrylase (OASS) is the pyridoxal 5′-phosphate dependent enzyme that catalyses the formation of L-cysteine in bacteria and plants. Its…”
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The Aryl Hydrocarbon Receptor (AhR) Mediates the Counter-Regulatory Effects of Pelargonidins in Models of Inflammation and Metabolic Dysfunctions by Biagioli, Michele, Carino, Adriana, Fiorucci, Chiara, Annunziato, Giannamaria, Marchianò, Silvia, Bordoni, Martina, Roselli, Rosalinda, Giorgio, Cristina Di, Castiglione, Federica, Ricci, Patrizia, Bruno, Agostino, Faccini, Andrea, Distrutti, Eleonora, Baldoni, Monia, Costantino, Gabriele, Fiorucci, Stefano

“…Pelargonidins are anthocyanidins thought to be beneficial for the human health, although controversies exist over the doses needed and the unclear mechanism of…”
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Porous titanium microsphere kyphoplasty for augmentation treatment of osteoporotic vertebral fractures: Technical report and case series by Tartara, Fulvio, Armocida, Daniele, Garbossa, Diego, Meli, Francesco, Costantino, Gabriele, Cofano, Fabio, Francaviglia, Natale

“…Vertebral augmentation procedures (VAPs) are used in cases of persistent and unresponsive pain in patients with vertebral compression fractures (VCFs)…”
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Irreversible Inhibition of Epidermal Growth Factor Receptor Activity by 3-Aminopropanamides by Carmi, Caterina, Galvani, Elena, Vacondio, Federica, Rivara, Silvia, Lodola, Alessio, Russo, Simonetta, Aiello, Stefania, Bordi, Fabrizio, Costantino, Gabriele, Cavazzoni, Andrea, Alfieri, Roberta R, Ardizzoni, Andrea, Petronini, Pier Giorgio, Mor, Marco

“…Irreversible epidermal growth factor receptor (EGFR) inhibitors contain a reactive warhead which covalently interacts with a conserved cysteine residue in the…”
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