Search Results - "COSTANTINI, SUSAN"

Polysaccharides from the Marine Environment with Pharmacological, Cosmeceutical and Nutraceutical Potential by Ruocco, Nadia, Costantini, Susan, Guariniello, Stefano, Costantini, Maria

“…Carbohydrates, also called saccharides, are molecules composed of carbon, hydrogen, and oxygen. They are the most abundant biomolecules and essential…”
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Aflatoxin B1 and M1: Biological Properties and Their Involvement in Cancer Development by Marchese, Silvia, Polo, Andrea, Ariano, Andrea, Velotto, Salvatore, Costantini, Susan, Severino, Lorella

“…Aflatoxins are fungal metabolites found in feeds and foods. When the ruminants eat feedstuffs containing Aflatoxin B1 (AFB1), this toxin is metabolized and…”
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New Prognostic and Predictive Markers in Cancer Progression by Costantini, Susan, Budillon, Alfredo

“…Biomarkers are a critical medical need for oncologists to predict and detect disease and to determine the best course of action for cancer patient care [...]…”
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Valosin-Containing Protein (VCP)/p97: A Prognostic Biomarker and Therapeutic Target in Cancer by Costantini, Susan, Capone, Francesca, Polo, Andrea, Bagnara, Palmina, Budillon, Alfredo

“…Valosin-containing protein (VCP)/p97, a member of the AAA+ ATPase family, is a molecular chaperone recruited to the endoplasmic reticulum (ER) membrane by…”
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Ascorbic acid: its role in immune system and chronic inflammation diseases by Sorice, Angela, Guerriero, Eliana, Capone, Francesca, Colonna, Giovanni, Castello, Giuseppe, Costantini, Susan

“…Ascorbic acid (AA), also known as vitamin C, was initially identified as the factor preventing the scurvy disease, and became very popular for its antioxidant…”
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NLRP3 inflammasome-mediated cytokine production and pyroptosis cell death in breast cancer by Faria, Sara Socorro, Costantini, Susan, de Lima, Vladmir Cláudio Cordeiro, de Andrade, Victor Pianna, Rialland, Mickaël, Cedric, Rebe, Budillon, Alfredo, Magalhães, Kelly Grace

“…Breast cancer is the most diagnosed malignancy in women. Increasing evidence has highlighted the importance of chronic inflammation at the local and/or…”
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Human MiR-544a Modulates SELK Expression in Hepatocarcinoma Cell Lines by Potenza, Nicoletta, Castiello, Filomena, Panella, Marta, Colonna, Giovanni, Ciliberto, Gennaro, Russo, Aniello, Costantini, Susan

“…Hepatocellular carcinoma (HCC) is a multi-factorial cancer with a very poor prognosis; therefore, there are several investigations aimed at the comprehension…”
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Inhibition of autophagy by chloroquine prevents resistance to PI3K/AKT inhibitors and potentiates their antitumor effect in combination with paclitaxel in triple negative breast cancer models by Cocco, Stefania, Leone, Alessandra, Roca, Maria Serena, Lombardi, Rita, Piezzo, Michela, Caputo, Roberta, Ciardiello, Chiara, Costantini, Susan, Bruzzese, Francesca, Sisalli, Maria José, Budillon, Alfredo, De Laurentiis, Michelino

“…Background Triple negative breast cancer (TNBC) is an aggressive disease characterized by high risk of relapse and development of resistance to different…”
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Marine Sponges and Bacteria as Challenging Sources of Enzyme Inhibitors for Pharmacological Applications by Ruocco, Nadia, Costantini, Susan, Palumbo, Flora, Costantini, Maria

“…Enzymes play key roles in different cellular processes, for example, in signal transduction, cell differentiation and proliferation, metabolic processes, DNA…”
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Blue-Print Autophagy: Potential for Cancer Treatment by Ruocco, Nadia, Costantini, Susan, Costantini, Maria

“…The marine environment represents a very rich source of biologically active compounds with pharmacological applications. This is due to its chemical richness,…”
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Integrated Analysis to Study the Relationship between Tumor-Associated Selenoproteins: Focus on Prostate Cancer by Capone, Francesca, Polo, Andrea, Sorice, Angela, Budillon, Alfredo, Costantini, Susan

“…Selenoproteins are proteins that contain selenium within selenocysteine residues. To date, twenty-five mammalian selenoproteins have been identified; however,…”
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High-quality RNA extraction from the sea urchin Paracentrotus lividus embryos by Ruocco, Nadia, Costantini, Susan, Zupo, Valerio, Romano, Giovanna, Ianora, Adrianna, Fontana, Angelo, Costantini, Maria

“…The sea urchin Paracentrotus lividus (Lamarck, 1816) is a keystone herbivore in the Mediterranean Sea due to its ability to transform macroalgal-dominated…”
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First evidence of Halomicronema metazoicum (Cyanobacteria) free-living on Posidonia oceanica leaves by Ruocco, Nadia, Mutalipassi, Mirko, Pollio, Antonino, Costantini, Susan, Costantini, Maria, Zupo, Valerio

“…Cyanobacteria contribute to the ecology of various marine environments, also for their symbioses, since some of them are common hosts of sponges and ascidians…”
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Potential Anticancer Effects of Polyphenols from Chestnut Shell Extracts: Modulation of Cell Growth, and Cytokinomic and Metabolomic Profiles by Sorice, Angela, Siano, Francesco, Capone, Francesca, Guerriero, Eliana, Picariello, Gianluca, Budillon, Alfredo, Ciliberto, Gennaro, Paolucci, Marina, Costantini, Susan, Volpe, Maria Grazia

“…In this study, a hydroalcoholic chestnut shell extract was characterized and tested on six different human cell lines. Gallic, ellagic, and syringic acids were…”
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Integrated proteomics and metabolomics analyses reveal new insights into the antitumor effects of valproic acid plus simvastatin combination in a prostate cancer xenograft model associated with downmodulation of YAP/TAZ signaling by Iannelli, Federica, Lombardi, Rita, Costantini, Susan, Roca, Maria Serena, Addi, Laura, Bruzzese, Francesca, Di Gennaro, Elena, Budillon, Alfredo, Pucci, Biagio

“…Despite advancements in therapeutic approaches, including taxane-based chemotherapy and androgen receptor-targeting agents, metastatic castration-resistant…”
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Human sirt-1: molecular modeling and structure-function relationships of an unordered protein by Autiero, Ida, Costantini, Susan, Colonna, Giovanni

“…Sirt-1 is a NAD+-dependent nuclear deacetylase of 747 residues that in mammals is involved in various important metabolic pathways, such as glucose metabolism…”
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Vitamin C effect on mitoxantrone-induced cytotoxicity in human breast cancer cell lines by Guerriero, Eliana, Sorice, Angela, Capone, Francesca, Napolitano, Virginia, Colonna, Giovanni, Storti, Gabriella, Castello, Giuseppe, Costantini, Susan

“…In recent years the use of natural dietary antioxidants to minimize the cytotoxicity and the damage induced in normal tissues by antitumor agents is gaining…”
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Synergistic antitumor interaction of valproic acid and simvastatin sensitizes prostate cancer to docetaxel by targeting CSCs compartment via YAP inhibition by Iannelli, Federica, Roca, Maria Serena, Lombardi, Rita, Ciardiello, Chiara, Grumetti, Laura, De Rienzo, Simona, Moccia, Tania, Vitagliano, Carlo, Sorice, Angela, Costantini, Susan, Milone, Maria Rita, Pucci, Biagio, Leone, Alessandra, Di Gennaro, Elena, Mancini, Rita, Ciliberto, Gennaro, Bruzzese, Francesca, Budillon, Alfredo

“…Background Despite the introduction of several novel therapeutic approaches that improved survival, metastatic castration-resistant prostate cancer (mCRPC)…”
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Structural and functional similarities between osmotin from Nicotiana tabacum seeds and human adiponectin by Miele, Marco, Costantini, Susan, Colonna, Giovanni

“…Osmotin, a plant protein, specifically binds a seven transmembrane domain receptor-like protein to exert its biological activity via a RAS2/cAMP signaling…”
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New Insights into the Identification of Metabolites and Cytokines Predictive of Outcome for Patients with Severe SARS-CoV-2 Infection Showed Similarity with Cancer by Costantini, Susan, Madonna, Gabriele, Di Gennaro, Elena, Capone, Francesca, Bagnara, Palmina, Capone, Mariaelena, Sale, Silvia, Nicastro, Carmine, Atripaldi, Lidia, Fiorentino, Giuseppe, Parrella, Roberto, Montesarchio, Vincenzo, Atripaldi, Luigi, Ascierto, Paolo A, Budillon, Alfredo

“…SARS-CoV-2 infection is characterized by several clinical manifestations, ranging from the absence of symptoms to severe forms that necessitate intensive care…”
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