Search Results - "COSTA, PAULO R.R."

The therapeutical potential of a novel pterocarpanquinone LQB-118 to target inhibitor of apoptosis proteins in acute myeloid leukemia cells by de Souza Reis, Flaviana R, de Faria, Fernanda C Casal, Castro, Carolina P, de Souza, Paloma S, da Cunha Vasconcelos, Flavia, Bello, Reinaldo D, da Silva, Alcides J, Costa, Paulo R R, Maia, Raquel C

“…Acute myeloid leukemia (AML) is a challenging neoplasm that despite therapeutic advances requires efforts to overcome the multidrug resistance (MDR) phenotype,…”
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The pterocarpanquinone LQB‑118 compound induces apoptosis of cytarabine‑resistant acute myeloid leukemia cells by Hancio, Thais, Mazzoccoli, Luciano, Guimaraes, Gustavo, Robaina, Marcela, Dos Santos Mendonqa, Bruna, de Moraes, Gabriela Nestal, da Costa Reis Monte-Mor, Barbara, Gutiyama, Luciana Mayumi, de Carvalho, Luize Otero, Netto, Chaquip Daher, Costa, Paulo R.R, de Faria, Fernanda Costas Casal, Maia, Raquel Ciuvalschi

“…Acute myeloid leukemia (AML) is a complex hematological disorder characterized by blockage of differentiation and high proliferation rates of myeloid…”
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LQB‑118 compound inhibits migration and induces cell death in glioblastoma cells by Bernardo, Paula Sabbo, Guimarães, Gustavo Henrique C, De Faria, Fernanda Costas C, Longo, Gabriel M Da Cunha, Lopes, Giselle P De Faria, Netto, Chaquip Daher, Costa, Paulo R R, Maia, Raquel C

“…Glioblastoma (GBM) is the most frequent malignant brain tumor. It represents the most aggressive astrocytoma with an overall survival of 14 months. Despite…”
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Bifunctional primary amine 2-aminobenzimidazole organocatalyst anchored to trans-cyclohexane-1,2-diamine in enantioselective conjugate additions of aldehydes by Fernandes, Talita de A., Vizcaíno-Milla, Pascuala, Ravasco, João M.J.M., Ortega-Martínez, Aitor, Sansano, José M., Nájera, Carmen, Costa, Paulo R.R., Fiser, Béla, Gómez-Bengoa, Enrique

“…[Display omitted] Bifunctional chiral primary amine 8 containing an (S,S)-trans-cyclohexane-1,2-diamine scaffold and a 2-benzimidazole unit is used as a…”
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Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors by Kaushik-Basu, Neerja, Bopda-Waffo, Alain, Talele, Tanaji T, Basu, Amartya, Costa, Paulo R.R, da Silva, Alcides J.M, Sarafianos, Stefan G, Noël, François

“…The hepatitis C virus (HCV) NS5B is essential for viral RNA replication and is therefore a prime target for development of HCV replication inhibitors. Here, we…”
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Binap-silver salts as chiral catalysts for the enantioselective 1,3-dipolar cycloaddition of azomethine ylides and alkenes by Mancebo-Aracil, Juan, Martín-Rodríguez, María, Nájera, Carmen, Sansano, José M., Costa, Paulo R.R., de Lima, Evanoel Crizanto, Dias, Ayres G.

“…Binap-AgSbF6 catalyzed 1,3-dipolar cycloadditions between azomethine ylides and electrophilic alkenes are described and compared with analogous transformations…”
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11a-N-tosyl-5-carbapterocarpans: Synthesis, antineoplastic evaluation and in silico prediction of ADMETox properties by Mendes, Joseane A., Salustiano, Eduardo J., Pires, Carulini de S., Oliveira, Thaís, Barcellos, Julio C.F., Cifuentes, Jhonny M.C., Costa, Paulo R.R., Rennó, Magdalena N., Buarque, Camilla D.

“…[Display omitted] •Palladium-catalyzed azaarylation reaction is the key step for the synthesis of N-tosyl-carbapterocarpans.•Compounds 5b and 7 present higher…”
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The pterocarpanquinone LQB 118 induces apoptosis in tumor cells through the intrinsic pathway and the endoplasmic reticulum stress pathway by de Sá Bacelar, Thiago, da Silva, Alcides J, Costa, Paulo R.R, Rumjanek, Vivian M

“…LQB 118 is a pterocarpanquinone compound synthesized by our group. It has already been shown that it acts against different leukemia cell lines. However,…”
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New Palladacycle-Derived Acylhydrazones as Pre-catalysts in Mirozoki-Heck Coupling and Oxyarylations by Leão, Raquel A C, Pinho, Vagner D, Coelho, Artur S, Kümmerle, Arthur E, Costa, Paulo R R

“…New acylhydrazone-based palladacycles are prepared and evaluated as pre-catalysts in Mirozoki-Heck and oxyarylation reactions…”
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NFκB pathway and microRNA-9 and -21 are involved in sensitivity to the pterocarpanquinone LQB-118 in different CML cell lines by de Faria, Fernanda Costas C, Leal, Maria Eduarda Bento, Bernardo, Paula Sabbo, Costa, Paulo R R, Maia, Raquel C

“…Chronic myeloid leukemia (CML), a myeloproliferative disorder characterized by the BCR-ABL oncoprotein, presents its treatment based on tyrosine kinase…”
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Palladium-catalyzed oxyarylation of olefins using silver carbonate as the base. Probing the mechanism by electrospray ionization mass spectrometry by Buarque, Camilla D., Pinho, Vagner D., Vaz, Boniek Gontijo, Eberlin, Marcos N., da Silva, Alcides J.M., Costa, Paulo R.R.

“…The Pd(OAc) 2-catalyzed oxyarylation of electron-rich ( 8 and 12) and electron-poor ( 10) olefins by ortho-iodophenols ( 3a– d) was studied using Ag 2CO 3 as…”
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Reactive Oxygen Species Release, Alkylating Ability, and DNA Interactions of a Pterocarpanquinone: A Test Case for Electrochemistry by Silva, Thaissa L., Ferreira, Fabricia R., de Vasconcelos, Camila C., da Silva, Rosanny Christhinny, Lima, Dimas José da P., Costa, Paulo R. R., Netto, Chaquip D., Goulart, Marília O. F.

“…The electrochemistry of a redox‐based bioactive pterocarpanquinone, designated as LQB‐118, and its precursor chromenquinone (CQ) was investigated in protic and…”
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Synthesis and preliminary pharmacological evaluation of new (±) 1,4-naphthoquinones structurally related to lapachol by DA SILVA, Alcides J. M, BUARQUE, Camilla D, SILVA, Noelson M. V, MELO, Paulo A, CARUSO, Rodrigo R. B, CASTRO, Newton G, COSTA, Paulo R. R, BRITO, Flavia V, AURELIAN, Laure, MACEDO, Luciana F, MALKAS, Linda H, HICKEY, Robert J, LOPES, Daniele V. S, NOËL, Francois, MURAKAMI, Yugo L. B

“…Seven new 1,4-naphthoquinones structurally related to lapachol were synthesized from lawsone and oxygenated arylmercurials. These compounds can also be seen as…”
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Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation by DA SILVA, Alcides J. M, MELO, Paulo A, COSTA, Paulo R. R, SILVA, Noelson M. V, BRITO, Flavia V, BUARQUE, Camilla D, DE SOUZA, Daniele V, RODRIGUES, Veronica P, POCAS, Elisa S. C, NOËL, Francois, ALBUQUERQUE, Edson X

“…Five coumestans with different patterns of oxygenation in rings A and D were synthesized from resorcinol and aromatic aldehydes, and screened for their…”
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Stereoselective preparation of pyrrolidin-2-ones from a Z-enoate derived from d-(+)-mannitol by Domingos, Jorge L.O, Lima, Evanoel C, Dias, Ayres G, Costa, Paulo R.R

“…Graphic Chiral pyrrolidin-2-ones have been prepared through the reductive cyclisation of γ-nitro-esters. These intermediates were obtained by…”
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Synthesis of β-amino arylketones through the addition of ArLi derivatives to β-aminoesters by Lima, Paulo G, Sequeira, Lucia C, Costa, Paulo R.R

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Characterization of a new synthetic isoflavonoid with inverse agonist activity at the central benzodiazepine receptor by Lopes, Daniele V.S, Caruso, Rodrigo R.B, Castro, Newton G, Costa, Paulo R.R, da Silva, Alcides J.M, Noël, François

“…Research aimed at developing selective drugs acting on γ-aminobutyric acid (GABA) A receptors introduced compounds from diverse chemical classes unrelated to…”
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Ru(II)-Catalyzed Asymmetric Transfer Hydrogenation of Chalcones in Water: Application to the Enantioselective Synthesis of Flavans BW683C and Tephrowatsin E by Demidoff, Felipe C., Caleffi, Guilherme S., Figueiredo, Marcella, Costa, Paulo R. R.

“…The oxo-tethered-Ru­(II) precatalyst promoted the one-pot CC/CO reduction of chalcones using sodium formate as the hydrogen source in water through…”
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Regioselective lithiations of a pterocarpan skeleton: the first synthesis of (±)-4′-dehydroxycabenegrin A-I by Simas, Alessandro B.C, da Silva, Alcides J.M, Coelho, Antonio L, Costa, Paulo R.R

“…Maackiain O-MOM derivative 3b was regioselectively lithiated at the C-10 position of D-ring and reacted with electrophiles. Regioselective lithiation of the…”
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Enantioselective Synthesis, DFT Calculations, and Preliminary Antineoplastic Activity of Dibenzo 1‑Azaspiro[4.5]decanes on Drug-Resistant Leukemias by Mendes, Joseane A, Merino, Pedro, Soler, Tatiana, Salustiano, Eduardo J, Costa, Paulo R. R, Yus, Miguel, Foubelo, Francisco, Buarque, Camilla D

“…The addition of 2-bromobenzylmagnesium bromide to chiral N-tert-butanesulfinyl imines derived from tetralone-type ketones proceeds with high levels of…”
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