Search Results - "COPPETA, Jonathan"

High-throughput continuous-flow microfluidic electroporation of mRNA into primary human T cells for applications in cellular therapy manufacturing by Lissandrello, Charles A., Santos, Jose A., Hsi, Peter, Welch, Michaela, Mott, Vienna L., Kim, Ernest S., Chesin, Jordan, Haroutunian, Nerses J., Stoddard, Aaron G., Czarnecki, Andrew, Coppeta, Jonathan R., Freeman, Daniel K., Flusberg, Deborah A., Balestrini, Jenna L., Tandon, Vishal

“…Implementation of gene editing technologies such as CRISPR/Cas9 in the manufacture of novel cell-based therapeutics has the potential to enable…”
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A Sub-millimeter, Inductively Powered Neural Stimulator by Freeman, Daniel K, O'Brien, Jonathan M, Kumar, Parshant, Daniels, Brian, Irion, Reed A, Shraytah, Louis, Ingersoll, Brett K, Magyar, Andrew P, Czarnecki, Andrew, Wheeler, Jesse, Coppeta, Jonathan R, Abban, Michael P, Gatzke, Ronald, Fried, Shelley I, Lee, Seung Woo, Duwel, Amy E, Bernstein, Jonathan J, Widge, Alik S, Hernandez-Reynoso, Ana, Kanneganti, Aswini, Romero-Ortega, Mario I, Cogan, Stuart F

“…Wireless neural stimulators are being developed to address problems associated with traditional lead-based implants. However, designing wireless stimulators on…”
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Measurement of oxygen consumption rates of human renal proximal tubule cells in an array of organ-on-chip devices to monitor drug-induced metabolic shifts by Kann, Samuel H., Shaughnessey, Erin M., Coppeta, Jonathan R., Azizgolshani, Hesham, Isenberg, Brett C., Vedula, Else M., Zhang, Xin, Charest, Joseph L.

“…Measurement of cell metabolism in moderate-throughput to high-throughput organ-on-chip (OOC) systems would expand the range of data collected for studying drug…”
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Fibroblast activation in response to TGFβ1 is modulated by co-culture with endothelial cells in a vascular organ-on-chip platform by Luu, Rebeccah J, Hoefler, B Christopher, Gard, Ashley L, Ritenour, Casey R, Rogers, Miles T, Kim, Ernest S, Coppeta, Jonathan R, Cain, Brian P, Isenberg, Brett C, Azizgolshani, Hesham, Fajardo-Ramirez, Oscar R, García-Cardeña, Guillermo, Lech, Matthew P, Tomlinson, Lindsay, Charest, Joseph L, Williams, Corin

“…Tissue fibrosis is a major healthcare burden that affects various organs in the body for which no effective treatments exist. An underlying, emerging theme…”
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Proteomic Profiling of Fallopian Tube-Derived Extracellular Vesicles Using a Microfluidic Tissue-on-Chip System by Zha, Didi, Rayamajhi, Sagar, Sipes, Jared, Russo, Angela, Pathak, Harsh B, Li, Kailiang, Sardiu, Mihaela E, Bantis, Leonidas E, Mitra, Amrita, Puri, Rajni V, Trinidad, Camille V, Cain, Brian P, Isenberg, Brett C, Coppeta, Jonathan, MacLaughlan, Shannon, Godwin, Andrew K, Burdette, Joanna E

“…The human fallopian tube epithelium (hFTE) is the site of fertilization, early embryo development, and the origin of most high-grade serous ovarian cancers…”
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Glucocorticoid Clearance and Metabolite Profiling in an In Vitro Human Airway Epithelium Lung Model by Rivera-Burgos, Dinelia, Sarkar, Ujjal, Lever, Amanda R, Avram, Michael J, Coppeta, Jonathan R, Wishnok, John S, Borenstein, Jeffrey T, Tannenbaum, Steven R

“…The emergence of microphysiologic epithelial lung models using human cells in a physiologically relevant microenvironment has the potential to be a powerful…”
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Exposure of human fallopian tube epithelium to elevated testosterone results in alteration of cilia gene expression and beating by Jackson-Bey, Tia, Colina, José, Isenberg, Brett C, Coppeta, Jonathan, Urbanek, Margrit, Kim, J Julie, Woodruff, Teresa K, Burdette, Joanna E, Russo, Angela

“…Abstract STUDY QUESTION How does exposure to a testosterone rich environment affect the function and gene expression of human fallopian tube epithelium (hFTE)?…”
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A thermoplastic microfluidic microphysiological system to recapitulate hepatic function and multicellular interactions by Bale, Shyam Sundhar, Manoppo, Andrea, Thompson, Rebecca, Markoski, Alex, Coppeta, Jonathan, Cain, Brian, Haroutunian, Nerses, Newlin, Veronica, Spencer, Abbie, Azizgolshani, Hesham, Lu, Mingjian, Gosset, James, Keegan, Philip, Charest, Joseph L.

“…Hepatic in vitro platforms ranging from multi‐well cultures to bioreactors and microscale systems have been developed as tools to recapitulate cellular…”
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Versican secreted by the ovary links ovulation and migration in fallopian tube derived serous cancer by Russo, Angela, Yang, Zizhao, Heyrman, Georgette Moyle, Cain, Brian P., Lopez Carrero, Alfredo, Isenberg, Brett C., Dean, Matthew J., Coppeta, Jonathan, Burdette, Joanna E.

“…High grade serous ovarian cancers (HGSOC) predominantly arise in the fallopian tube epithelium (FTE) and colonize the ovary first, before further metastasis to…”
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Reply: Exposure of human fallopian tube epithelium to elevated testosterone results in alteration of cilia gene expression and beating by Jackson-Bey, Tia, Colina, José, Isenberg, Brett C, Coppeta, Jonathan, Urbanek, Margrit, Kim, J Julie, Woodruff, Teresa K, Burdette, Joanna E, Russo, Angela

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Scalable Units for Building Cardiac Tissue by Ye, Xiaofeng, Lu, Liang, Kolewe, Martin E., Hearon, Keith, Fischer, Kristin M., Coppeta, Jonathan, Freed, Lisa E.

“…Scalable units for building cardiac tissue are fabricated from biodegradable elastomeric polymers by pairwise stacking of heart‐cell scaffolds with sinusoidal…”
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Increased Local Testosterone Levels Alter Human Fallopian Tube mRNA Profile and Signaling by Russo, Angela, Cain, Brian P, Jackson-Bey, Tia, Lopez Carrero, Alfredo, Miglo, Jane, MacLaughlan, Shannon, Isenberg, Brett C, Coppeta, Jonathan, Burdette, Joanna E

“…Fallopian tube epithelium (FTE) plays a critical role in reproduction and can be the site where High Grade Serous Ovarian Carcinoma (HGSOC) originates…”
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High‐Throughput CRISPR/Cas9 Mediated Gene Editing of Primary Human T Cells in a Microfluidic Device for Cellular Therapy Manufacturing by Welch, Michaela, Flusberg, Deborah A., Hsi, Peter, Haroutunian, Nerses J., Santos, Jose A., Kim, Ernest S., Markovic, Stacey, Coppeta, Jonathan R., Lissandrello, Charles A., Balestrini, Jenna L., Tandon, Vishal

“…Autologous cellular therapies have been highly successful in treating hematological cancers and have the potential to be used for a variety of indications…”
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High‐Throughput CRISPR/Cas9 Mediated Gene Editing of Primary Human T Cells in a Microfluidic Device for Cellular Therapy Manufacturing (Adv. Mater. Technol. 17/2023) by Welch, Michaela, Flusberg, Deborah A., Hsi, Peter, Haroutunian, Nerses J., Santos, Jose A., Kim, Ernest S., Markovic, Stacey, Coppeta, Jonathan R., Lissandrello, Charles A., Balestrini, Jenna L., Tandon, Vishal

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Tissue: Scalable Units for Building Cardiac Tissue (Adv. Mater. 42/2014) by Ye, Xiaofeng, Lu, Liang, Kolewe, Martin E., Hearon, Keith, Fischer, Kristin M., Coppeta, Jonathan, Freed, Lisa E.

“…Scalable units for building cardiac tissue are created from biodegradable elastomeric polymers by L. E. Freed and co‐workers on page 7202. The multilayered…”
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Scalable Unit for Building Cardiac Tissue by Ye, Xiaofeng, Lu, Liang, Kolewe, Martin E., Hearon, Keith, Fischer, Kristin M., Coppeta, Jonathan, Freed, Lisa E.

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Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device by Santini, John T, Prescott, James H, Lipka, Sara, Baldwin, Samuel, Sheppard, Norman F, Maloney, John M, Coppeta, Jonathan, Yomtov, Barry, Staples, Mark A

“…Implanted drug delivery systems are being increasingly used to realize the therapeutic potential of peptides and proteins. Here we describe the controlled…”
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Systems pharmacology guided platform development for the integrated Microphysiological Systems by Yu, Jiajie, Cirit, Murat, Carrier, Rebecca, Chen, Kelly, Cilfone, Nicholas, Coppeta, Jonathan, Griffith, Linda, Hughes, David, Large, Emma, Lauffenburger, Douglas, Lever, Amanda, Mescher, Mark, Prantil‐Baun, Rachelle, Sarkar, Ujjal, Stokes, Cynthia, Tannenbaum, Steven, Wishnok, John

“…Abstract only The current drug clinical development is suffering a high attrition rate. More robust preclinical tools are needed to identify unpredicted…”
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Single transverse mode optical resonators by Kuznetsov, Mark, Stern, Margaret, Coppeta, Jonathan

“…We use quantum mechanical analogy to introduce a new class of optical resonators with finite deflection profile mirrors that support a finite number of…”
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A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle by Xiao, Shuo, Coppeta, Jonathan R., Rogers, Hunter B., Isenberg, Brett C., Zhu, Jie, Olalekan, Susan A., McKinnon, Kelly E., Dokic, Danijela, Rashedi, Alexandra S., Haisenleder, Daniel J., Malpani, Saurabh S., Arnold-Murray, Chanel A., Chen, Kuanwei, Jiang, Mingyang, Bai, Lu, Nguyen, Catherine T., Zhang, Jiyang, Laronda, Monica M., Hope, Thomas J., Maniar, Kruti P., Pavone, Mary Ellen, Avram, Michael J., Sefton, Elizabeth C., Getsios, Spiro, Burdette, Joanna E., Kim, J. Julie, Borenstein, Jeffrey T., Woodruff, Teresa K.

“…The endocrine system dynamically controls tissue differentiation and homeostasis, but has not been studied using dynamic tissue culture paradigms. Here we show…”
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