Search Results - "COPP, Andrew J"

Neural tube defects by Greene, Nicholas D E, Copp, Andrew J

“…Neural tube defects (NTDs), including spina bifida and anencephaly, are severe birth defects of the central nervous system that originate during embryonic…”
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Neural tube closure: cellular, molecular and biomechanical mechanisms by Nikolopoulou, Evanthia, Galea, Gabriel L, Rolo, Ana, Greene, Nicholas D E, Copp, Andrew J

“…Neural tube closure has been studied for many decades, across a range of vertebrates, as a paradigm of embryonic morphogenesis. Neurulation is of particular…”
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Neural tube defects: recent advances, unsolved questions, and controversies by Copp, Andrew J, Prof, Stanier, Philip, PhD, Greene, Nicholas DE, PhD

“…Summary Neural tube defects are severe congenital malformations affecting around one in every 1000 pregnancies. An innovation in clinical management has come…”
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Genetics and development of neural tube defects by Copp, Andrew J, Greene, Nicholas DE

“…Congenital defects of neural tube closure (neural tube defects; NTDs) are among the commonest and most severe disorders of the fetus and newborn. Disturbance…”
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Infectious causes of microcephaly: epidemiology, pathogenesis, diagnosis, and management by Devakumar, Delan, Bamford, Alasdair, Ferreira, Marcelo U, Broad, Jonathan, Rosch, Richard E, Groce, Nora, Breuer, Judith, Cardoso, Marly A, Copp, Andrew J, Alexandre, Paula, Rodrigues, Laura C, Abubakar, Ibrahim

“…Microcephaly is an important sign of neurological malformation and a predictor of future disability. The 2015–16 outbreak of Zika virus and congenital Zika…”
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The relationship between sonic Hedgehog signaling, cilia, and neural tube defects by Murdoch, Jennifer N., Copp, Andrew J.

“…The Hedgehog signaling pathway is essential for many aspects of normal embryonic development, including formation and patterning of the neural tube. Absence of…”
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Hindbrain neuropore tissue geometry determines asymmetric cell-mediated closure dynamics in mouse embryos by Maniou, Eirini, Staddon, Michael F., Marshall, Abigail R., Greene, Nicholas D. E., Copp, Andrew J., Banerjee, Shiladitya, Galea, Gabriel L.

“…Gap closure is a common morphogenetic process. In mammals, failure to close the embryonic hindbrain neuropore (HNP) gap causes fatal anencephaly. We observed…”
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Cell non-autonomy amplifies disruption of neurulation by mosaic Vangl2 deletion in mice by Galea, Gabriel L., Maniou, Eirini, Edwards, Timothy J., Marshall, Abigail R., Ampartzidis, Ioakeim, Greene, Nicholas D. E., Copp, Andrew J.

“…Post-zygotic mutations that generate tissue mosaicism are increasingly associated with severe congenital defects, including those arising from failed neural…”
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Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice by Pai, Yun Jin, Leung, Kit-Yi, Savery, Dawn, Hutchin, Tim, Prunty, Helen, Heales, Simon, Brosnan, Margaret E., Brosnan, John T., Copp, Andrew J., Greene, Nicholas D.E.

“…Glycine decarboxylase (GLDC) acts in the glycine cleavage system to decarboxylate glycine and transfer a one-carbon unit into folate one-carbon metabolism…”
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Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure by Leung, Kit-Yi, Pai, Yun Jin, Chen, Qiuying, Santos, Chloe, Calvani, Enrica, Sudiwala, Sonia, Savery, Dawn, Ralser, Markus, Gross, Steven S., Copp, Andrew J., Greene, Nicholas D.E.

“…Abnormal folate one-carbon metabolism (FOCM) is implicated in neural tube defects (NTDs), severe malformations of the nervous system. MTHFR mediates…”
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Rho-kinase-dependent actin turnover and actomyosin disassembly are necessary for mouse spinal neural tube closure by Escuin, Sarah, Vernay, Bertrand, Savery, Dawn, Gurniak, Christine B, Witke, Walter, Greene, Nicholas D E, Copp, Andrew J

“…The cytoskeleton is widely considered essential for neurulation, yet the mouse spinal neural tube can close despite genetic and non-genetic disruption of the…”
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Spinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by Grhl2 by Nikolopoulou, Evanthia, Hirst, Caroline S., Galea, Gabriel, Venturini, Christina, Moulding, Dale, Marshall, Abigail R., Rolo, Ana, De Castro, Sandra C. P., Copp, Andrew J., Greene, Nicholas D. E.

“…Lack or excess expression of the surface ectoderm-expressed transcription factor Grainyhead-like2 (Grhl2), each prevent spinal neural tube closure. Here we…”
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Neural tube defects--disorders of neurulation and related embryonic processes by Copp, Andrew J, Greene, Nicholas D E

“…Neural tube defects (NTDs) are severe congenital malformations affecting 1 in every 1000 pregnancies. 'Open' NTDs result from failure of primary neurulation as…”
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Development of the vertebrate central nervous system: formation of the neural tube by Greene, Nicholas D. E., Copp, Andrew J.

“…The developmental process of neurulation involves a series of coordinated morphological events, which result in conversion of the flat neural plate into the…”
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Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure by Ybot-Gonzalez, Patricia, Savery, Dawn, Gerrelli, Dianne, Signore, Massimo, Mitchell, Claire E, Faux, Clare H, Greene, Nicholas D E, Copp, Andrew J

“…Planar-cell-polarity (PCP) signalling is necessary for initiation of neural tube closure in higher vertebrates. In mice with PCP gene mutations, a broad…”
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Neurulation in the cranial region – normal and abnormal by Copp, Andrew J.

“…Cranial neurulation is the embryonic process responsible for formation of the brain primordium. In the mouse embryo, cranial neurulation is a piecemeal process…”
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Author Correction: Cell non-autonomy amplifies disruption of neurulation by mosaic Vangl2 deletion in mice by Galea, Gabriel L., Maniou, Eirini, Edwards, Timothy J., Marshall, Abigail R., Ampartzidis, Ioakeim, Greene, Nicholas D. E., Copp, Andrew J.

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Vangl2 disruption alters the biomechanics of late spinal neurulation leading to spina bifida in mouse embryos by Galea, Gabriel L, Nychyk, Oleksandr, Mole, Matteo A, Moulding, Dale, Savery, Dawn, Nikolopoulou, Evanthia, Henderson, Deborah J, Greene, Nicholas D E, Copp, Andrew J

“…Human mutations in the planar cell polarity component VANGL2 are associated with the neural tube defect spina bifida. Homozygous Vangl2 mutation in mice…”
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Dual mechanism underlying failure of neural tube closure in the Zic2 mutant mouse by Escuin, Sarah, Raza-Knight, Saba Rose, Savery, Dawn, Gaston-Massuet, Carles, Galea, Gabriel L, Greene, Nicholas D E, Copp, Andrew J

“…Understanding the molecular mechanisms that lead to birth defects is an important step towards improved primary prevention. Mouse embryos homozygous for the…”
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Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion by Quétier, Ivan, Marshall, Jacqueline J.T., Spencer-Dene, Bradley, Lachmann, Sylvie, Casamassima, Adele, Franco, Claudio, Escuin, Sarah, Worrall, Joseph T., Baskaran, Priththivika, Rajeeve, Vinothini, Howell, Michael, Copp, Andrew J., Stamp, Gordon, Rosewell, Ian, Cutillas, Pedro, Gerhardt, Holger, Parker, Peter J., Cameron, Angus J.M.

“…In animals, the protein kinase C (PKC) family has expanded into diversely regulated subgroups, including the Rho family-responsive PKN kinases. Here, we…”
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